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Cited by 27Genetic Associations and EpidemiologyNutrition, Genetics, and DiseaseDiabetes, Cardiovascular Risks, and Lipoproteins

Mendelian Randomization and Type 2 Diabetes

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Swerdlow, Daniel I.·2016·Cardiovascular Drugs and Therapy
DOI 10.1007/s10557-016-6638-5PMC PMC4789194
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Abstract

Type 2 diabetes (T2DM) is a common, complex disease that poses a substantial burden on individual and population health, but we have relatively limited understanding of its underlying pathophysiology. Observational studies have highlighted large numbers of risk factors for T2DM, some of which are modifiable through behavioural or pharmacological intervention. Determining which of these risk factors plays a causal role in the development of T2DM has been a challenge, but Mendelian randomisation (MR) studies are harnessing genetic data in population studies to offer new insights. Using evolving analytical methods, MR studies continue to address questions of causality related to T2DM, including exploring the roles of adiposity, blood lipids and inflammation. The causal roles of a number of important modifiable risk factors have been confirmed by MR studies, while the relevance of others has been called into question. As more MR studies are conducted, methods are developed and refined in order to make the most efficient and reliable use of available genetic and phenotypic data. In this review, the design and findings of some important MR studies related to T2DM are explored and their relevance for translation to clinical practice considered.

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  • Studies investigating variants in the genes that encode CRP and IL-1 have not detected statistically significant associations with T2DM.

    “Studies investigating variants in the genes that encode CRP and IL-1 have not detected statistically significant associations with T2DM 45.”

    From Type 2 diabetes mellitus and psychological stress — a modifiable risk factor (2017) · cites this paper as [45]

    The Systemic Inflammation section reports no association between CRP-gene variants and T2DM risk. It also reports no association for variants in IL1RN, but specifies that IL1RN encodes the IL-1 receptor antagonist, not IL-1 itself. The claim therefore identifies the second gene imprecisely. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Swerdlow, D. I.
Affiliations
Imperial College London (GB)
Corresponding author
Swerdlow, Daniel I.
ORCID
Swerdlow, Daniel I.
Venue
Cardiovascular Drugs and Therapy
Publisher
Springer Science and Business Media LLC
Published
2016-01-26
Volume
30
Issue
1
Pages
51-57
ISSN
  • 0920-3206 (ISSN-L)
  • 1573-7241
DOI
10.1007/s10557-016-6638-5
PMC
PMC4789194
OpenAlex
W2257892681
Cited by
27
References
9
Citations by year
2024: 5 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 2 · 2019: 3 · 2017: 6 · 2016: 3
FWCI
0.54
Type
journal article
Language
en
Open access
Licence
Locations
  • Cardiovascular Drugs and Therapy (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Spiral (Imperial College London) (submittedVersion, cc-by)
Funders
National Institute of Health Research
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
type 2 diabetes, Mendelian randomization, causal inference, modifiable risk factors, adiposity, serum lipids, inflammation, genetic variants, diabetes pathophysiology
MeSH terms
Diabetes Mellitus, Type 2, Humans, Inflammation, Lipids, Risk Factors, Adiposity, Mendelian Randomization Analysis, Observational Studies as Topic

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