Cited by 240Neurological Disease Mechanisms and TreatmentsDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

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The Science of Vascular Contributions to Cognitive Impairment and Dementia (VCID): A Framework for Advancing Research Priorities in the Cerebrovascular Biology of Cognitive Decline

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Corriveau, Roderick A., Bosetti, Francesca, Emr, Marian, Gladman, Jordan T., Koenig, James I., Moy, Claudia S., Pahigiannis, Katherine, Waddy, Salina P., Koroshetz, Walter·2016·Cellular and Molecular Neurobiology

DOI 10.1007/s10571-016-0334-7PMC PMC4859348

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Abstract

The World Health Organization reports that 47.5 million people are affected by dementia worldwide. With aging populations and 7.7 million new cases each year, the burden of illness due to dementia approaches crisis proportions. Despite significant advances in our understanding of the biology of Alzheimer's disease (AD), the leading dementia diagnosis, the actual causes of dementia in affected individuals are unknown except for rare fully penetrant genetic forms. Evidence from epidemiology and pathology studies indicates that damage to the vascular system is associated with an increased risk of many types of dementia. Both Alzheimer's pathology and cerebrovascular disease increase with age. How AD affects small blood vessel function and how vascular dysfunction contributes to the molecular pathology of Alzheimer's are areas of intense research. The science of vascular contributions to cognitive impairment and dementia (VCID) integrates diverse aspects of biology and incorporates the roles of multiple cell types that support the function of neural tissue. Because of the proven ability to prevent and treat cardiovascular disease and hypertension with population benefits for heart and stroke outcomes, it is proposed that understanding and targeting the biological mechanisms of VCID can have a similarly positive impact on public health.

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Authors: Corriveau, R. A., Bosetti, F., Emr, M., Gladman, J. T., Koenig, J. I., Moy, C. S., Pahigiannis, K., Waddy, S. P., & Koroshetz, W.
Affiliations: National Institutes of Health (US)
Corresponding author: Corriveau, Roderick A.
ORCID: Corriveau, Roderick A.
Bosetti, Francesca
Koenig, James I.
Pahigiannis, Katherine
Koroshetz, Walter
Venue: Cellular and Molecular Neurobiology
Publisher: Springer Science and Business Media LLC
Published: 2016-03
Volume: 36
Issue: 2
Pages: 281-288
ISSN: 0272-4340 (ISSN-L)
1573-6830
DOI: 10.1007/s10571-016-0334-7
PMC: PMC4859348
OpenAlex: W2340837185
Cited by: 240
References: 74
Citations by year: 2026: 22 · 2025: 32 · 2024: 29 · 2023: 22 · 2022: 30 · 2021: 20 · 2020: 22 · 2019: 21 · 2018: 14 · 2017: 16 · 2016: 12
FWCI: 1.83
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Neurobiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (Z99 NS999999)
Topics: Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: cerebrovascular disease, Alzheimer's disease, cognitive decline, vascular dysfunction, dementia risk factors, research priorities, vascular biology, dementia prevention
MeSH terms: Animals, Humans, Models, Biological, Research, Dementia, Vascular, Cost of Illness, Cognitive Dysfunction

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The Science of Vascular Contributions to Cognitive Impairment and Dementia (VCID): A Framework for Advancing Research Priorities in the Cerebrovascular Biology of Cognitive Decline

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