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The Science of Vascular Contributions to Cognitive Impairment and Dementia (VCID): A Framework for Advancing Research Priorities in the Cerebrovascular Biology of Cognitive Decline
Open accessAbstract
The World Health Organization reports that 47.5 million people are affected by dementia worldwide. With aging populations and 7.7 million new cases each year, the burden of illness due to dementia approaches crisis proportions. Despite significant advances in our understanding of the biology of Alzheimer's disease (AD), the leading dementia diagnosis, the actual causes of dementia in affected individuals are unknown except for rare fully penetrant genetic forms. Evidence from epidemiology and pathology studies indicates that damage to the vascular system is associated with an increased risk of many types of dementia. Both Alzheimer's pathology and cerebrovascular disease increase with age. How AD affects small blood vessel function and how vascular dysfunction contributes to the molecular pathology of Alzheimer's are areas of intense research. The science of vascular contributions to cognitive impairment and dementia (VCID) integrates diverse aspects of biology and incorporates the roles of multiple cell types that support the function of neural tissue. Because of the proven ability to prevent and treat cardiovascular disease and hypertension with population benefits for heart and stroke outcomes, it is proposed that understanding and targeting the biological mechanisms of VCID can have a similarly positive impact on public health.
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“A framework for research priorities in the cerebrovascular biology of cognitive decline has been proposed 164 . The priorities include the development and validation of imaging and biospecimen‐based biomarkers, better experimental models, and increased understanding of the underlying molecular and physiological mechanisms – white matter disease, infarction, microhemorrhage, vascular autoregulation”
From Mental health care for older adults: recent advances and new directions in clinical practice and research (2022) · cites this paper as [164]
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Metadata
- Authors
- Corriveau, R. A., Bosetti, F., Emr, M., Gladman, J. T., Koenig, J. I., Moy, C. S., Pahigiannis, K., Waddy, S. P., & Koroshetz, W.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Corriveau, Roderick A.
- ORCID
- Venue
- Cellular and Molecular Neurobiology
- Published
- 2016-03
- Volume
- 36
- Issue
- 2
- Pages
- 281-288
- ISSN
- 0272-4340 (ISSN-L)
- 1573-6830
- PMC
- PMC4859348
- OpenAlex
- W2340837185
- Cited by
- 240
- References
- 74
- Citations by year
- 2026: 22 · 2025: 32 · 2024: 29 · 2023: 22 · 2022: 30 · 2021: 20 · 2020: 22 · 2019: 21 · 2018: 14 · 2017: 16 · 2016: 12
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Neurobiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (Z99 NS999999)
- Topics
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- cerebrovascular disease, Alzheimer's disease, cognitive decline, vascular dysfunction, dementia risk factors, research priorities, vascular biology, dementia prevention
- MeSH terms
- Animals, Humans, Models, Biological, Research, Dementia, Vascular, Cost of Illness, Cognitive Dysfunction
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