The DOI matches its Crossref record; 73 of the 74 references it cites were found in a registry or an index.
The Science of Vascular Contributions to Cognitive Impairment and Dementia (VCID): A Framework for Advancing Research Priorities in the Cerebrovascular Biology of Cognitive Decline
Open accessAbstract
The World Health Organization reports that 47.5 million people are affected by dementia worldwide. With aging populations and 7.7 million new cases each year, the burden of illness due to dementia approaches crisis proportions. Despite significant advances in our understanding of the biology of Alzheimer's disease (AD), the leading dementia diagnosis, the actual causes of dementia in affected individuals are unknown except for rare fully penetrant genetic forms. Evidence from epidemiology and pathology studies indicates that damage to the vascular system is associated with an increased risk of many types of dementia. Both Alzheimer's pathology and cerebrovascular disease increase with age. How AD affects small blood vessel function and how vascular dysfunction contributes to the molecular pathology of Alzheimer's are areas of intense research. The science of vascular contributions to cognitive impairment and dementia (VCID) integrates diverse aspects of biology and incorporates the roles of multiple cell types that support the function of neural tissue. Because of the proven ability to prevent and treat cardiovascular disease and hypertension with population benefits for heart and stroke outcomes, it is proposed that understanding and targeting the biological mechanisms of VCID can have a similarly positive impact on public health.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A framework for research priorities in the cerebrovascular biology of cognitive decline has been proposed 164 . The priorities include the development and validation of imaging and biospecimen‐based biomarkers, better experimental models, and increased understanding of the underlying molecular and physiological mechanisms – white matter disease, infarction, microhemorrhage, vascular autoregulation”
From Mental health care for older adults: recent advances and new directions in clinical practice and research (2022) · cites this paper as [164]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.005 · Cited by 18,657
Self-citationDiagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR)
American Psychiatric Association (2000) · doi:10.1176/appi.books.9780890423349 · Cited by 11,069
Diagnostic and Statistical Manual of Mental Disorders(DSM)
Leong, F. T. L. (2008) · Sage eBooks · doi:10.4135/9781412963978.n182 · Cited by 10,861
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155
Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404
Feigin, V. L., Forouzanfar, M. H., Krishnamurthi, R., Mensah, G. A., Connor, M., Bennett, D. A., Moran, A. E., Sacco, R. L., Anderson, L., Truelsen, T., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(13)61953-4 · Cited by 3,899
Gorelick, P. B., Scuteri, A., Black, S. E., DeCarli, C., Greenberg, S. M., Iadecola, C., Launer, L. J., Laurent, S., Lopez, O. L., Nyenhuis, D., et al. (2011) · Stroke · doi:10.1161/str.0b013e3182299496 · Cited by 3,811
Hyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., et al. (2012) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.10.007 · Cited by 3,092
A protein factor essential for microtubule assembly
Weingarten, M. D., Lockwood, A. H., Hwo, S. Y., & Kirschner, M. W. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.5.1858 · Cited by 3,089
Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders
Zlokovic, B. V. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3114 · Cited by 2,969
Cited by
Sorted by citations
Items 201–239 of 239
Circulating sphingolipids and subclinical brain pathology: the cardiovascular health study
Moseholm, K. F., Horn, J. W., Fitzpatrick, A. L., Djoussé, L., Longstreth, W. T., Jr., López, O. L., Hoofnagle, A. N., Jensen, M. K., Lemaître, R. N., & Mukamal, K. J. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1385623 · Cited by 1
Advances in Plasma Biomarkers of Vascular Cognitive Impairment
王, 建. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.1492448 · Cited by 1
Hayden, M. R. (2024) · Journal of Vascular Diseases · doi:10.3390/jvd3040033 · Cited by 3
Hu, Y., Chen, W., Wu, L., Jiang, L., Chen, L., & Tang, N. (2020) · All Life · doi:10.1080/26895293.2020.1729869 · Cited by 1
de Havenon, A., Sharma, R., Falcone, G. J., Prabhakaran, S., & Sheth, K. N. (2022) · Stroke · doi:10.1161/strokeaha.122.038818 · Cited by 1
Ge, Y., Zivadinov, R., Wang, M., Charidimou, A., & Haacke, E. M. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.797486 · Cited by 1
Patil, S., Lantz, C. W., Marinovic, A., Sarkar, R., Lee, B. R., & DeBerge, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.10.675257 · Cited by 1
The Role of Astrocytic Calcineurin Activation and Downstream Signaling in Neurodegenerative Diseases
Pleiss, M. M. (2016) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2016.470
Jogia, J. (2017) · OBM Neurobiology · doi:10.21926/obm.neurobiol.1702006
Studying Vascular Morphologies in the Aged Human Brain Using Large Autopsy Datasets
Ighodaro, E. T. (2018) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2018.049
Promoters of cerebral small vessel integrity for cognitive disorder prevention
Shaaban, C. E. (2018) · D-Scholarship@Pitt (University of Pittsburgh)
Neurochemical Aspects of Poststroke Dementia
Farooqui, A. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816347-4.00002-7
Cognitive Rehabilitation and Neuroimaging in Stroke
Dacosta‐Aguayo, R., & Auer, T. (2020) · Springer eBooks · doi:10.1007/978-3-030-48382-1_9
Gliovascular Mechanisms and White Matter Injury in Vascular Cognitive Impairment and Dementia
Rosenberg, G. A., Maki, T., Arai, K., & Lo, E. H. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-69424-7.00013-2
Zotin, M. C. Z. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2022.tde-01122022-122130
Sexually dimorphic differences in angiogenesis markers predict brain aging trajectoriesPreprint
Espin, A. T., Rabadaugh, H., Fitzsimons, S., Harvey, D. J., Chou, A., Lindberg, C., Casaletto, K. B., Goldberger, L., Staffaroni, A. M., Maillard, P., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.16.549192
Comorbidity of cerebral amyloid angiopathy and Alzheimer's disease. Clinical case analysis
Emelin, А. Y., Lobzin, V. Y., Efimtsev, A. Y., & Владиславович, В. С. (2023) · Neurology neuropsychiatry Psychosomatics · doi:10.14412/20742711-2023-6-85-94 · Cited by 1
Sarfo, F. S., Gyamfi, R. A., Opare‐Addo, P. A., Agyei, B. A., Ampofo, M., Nguah, S. B., & Ovbiagele, B. I. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.124.034346
Editorial. CCCB: The journal at age 5
Hainsworth, A. H., Paracampo, R., & Wallin, A. (2024) · Cerebral Circulation - Cognition and Behavior · doi:10.1016/j.cccb.2024.100368
Mechanisms of neurovascular dysfunction in chronic ischemic stroke: insights from sex and aging
Clary, B. L. (2025) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.12822
Platelets and Alzheimer Disease
Prodan, C. I., & Dale, G. L. (2025) · Neurology · doi:10.1212/wnl.0000000000214438
Carey, A. M., Buzhdygan, T. P., & Fossati, S. (2026) · Cells · doi:10.3390/cells15050424
Li, W., Karakaya, E., Edwards, J. M., Li, A. A., McCrorey, M. K., Butler, H. M., Beusecum, J. P. V., Jamil, S., Abdul, Y., & Ergul, A. (2026) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2025-0350
An Integrated Approach on Vascular Cognitive Impairment
Jianu, D. C., Jianu, S. N., Bora, B. I., Munteanu, G., Bertici, R.-A., Dan, T. F., & Petrică, L. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1014841
Imaging markers of vascular cognitive impairment: Current advances and future directions
Duering, M., & Vemuri, P. (2026) · Cerebral Circulation - Cognition and Behavior · doi:10.1016/j.cccb.2026.100538
Constans, A. (2019) · theses.fr (ABES) · doi:10.70675/93486891z6065z449cz992az7390677dca22
Hugues, N. (2023) · theses.fr (ABES) · doi:10.70675/3c52cc4bze9dfz499cza28az42945d38cbd6
Zedde, M., Basso, G., Piazza, F., & Pascarella, R. (2026) · Springer eBooks · doi:10.1007/978-3-032-23618-0_7
Rivera, D., Krick, K. E., Rogers, C. B., Seaks, C. E., Sudduth, T. L., Bottiglieri, T., Weekman, E. M., & Wilcock, D. M. (2026) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x261473355
Zhou, S., Conston, J., Suthprasertporn, N., Denis‐Romero, R., Lucente, J. D., White, J. L., Mielke, M. M., Harvey, D. J., Rajan, K. B., Johnson, D. K., et al. (2026) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.70435
Deng, S., Gao, S., Zhou, C., Lan, Z., Li, H., Chen, J., Xu, Y., Li, J., Liu, P., Zhang, S., et al. (2026) · CNS Neuroscience & Therapeutics · doi:10.1002/cns.71150 · Cited by 1
What is new in delirium: A vascular etiology outlook
Terrando, N., Maze, M., & Yang, T. (2026) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.70324
Kumar, S., Paswan, S. K., Verma, P., Chaturvedi, S., Vishwakarma, V. K., & Yadav, H. N. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06263-3
Karimi, H., Exell, T., Peltier, S., Noll, D. C., Hampstead, B. M., Iordan, A. D., Damoiseaux, J. S., Daugherty, A. M., & Mishra, S. (2026) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2026.10.004
Metadata
- Authors
- Corriveau, R. A., Bosetti, F., Emr, M., Gladman, J. T., Koenig, J. I., Moy, C. S., Pahigiannis, K., Waddy, S. P., & Koroshetz, W.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Corriveau, Roderick A.
- ORCID
- Venue
- Cellular and Molecular Neurobiology
- Published
- 2016-03
- Volume
- 36
- Issue
- 2
- Pages
- 281-288
- ISSN
- 0272-4340 (ISSN-L)
- 1573-6830
- PMC
- PMC4859348
- OpenAlex
- W2340837185
- Cited by
- 240
- References
- 74
- Citations by year
- 2026: 22 · 2025: 32 · 2024: 29 · 2023: 22 · 2022: 30 · 2021: 20 · 2020: 22 · 2019: 21 · 2018: 14 · 2017: 16 · 2016: 12
- FWCI
- 1.83
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Neurobiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (Z99 NS999999)
- Topics
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- cerebrovascular disease, Alzheimer's disease, cognitive decline, vascular dysfunction, dementia risk factors, research priorities, vascular biology, dementia prevention
- MeSH terms
- Animals, Humans, Models, Biological, Research, Dementia, Vascular, Cost of Illness, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
