The DOI matches its Crossref record; 276 of the 277 references it cites were found in a registry or an index.
miR-124: A Promising Therapeutic Target for Central Nervous System Injuries and Diseases
Open accessAbstract
Central nervous system injuries and diseases, such as ischemic stroke, spinal cord injury, neurodegenerative diseases, glioblastoma, multiple sclerosis, and the resulting neuroinflammation often lead to death or long-term disability. MicroRNAs are small, non-coding, single-stranded RNAs that regulate posttranscriptional gene expression in both physiological and pathological cellular processes, including central nervous system injuries and disorders. Studies on miR-124, one of the most abundant microRNAs in the central nervous system, have shown that its dysregulation is related to the occurrence and development of pathology within the central nervous system. Herein, we review the molecular regulatory functions, underlying mechanisms, and effective delivery methods of miR-124 in the central nervous system, where it is involved in pathological conditions. The review also provides novel insights into the therapeutic target potential of miR-124 in the treatment of human central nervous system injuries or diseases.
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“Recent therapeutic approaches involving the delivery of miRNA-124 have demonstrated a neuroprotective role, showing promise in treating neurodegenerative disorders and brain traumas [167, 168].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [167]
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Cites
5 retracted
MiR-124 acts as a target for Alzheimer’s disease by regulating BACE1
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RetractedMiR-124 regulates osteoblast differentiation through GSK-3β in ankylosing spondylitis.
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The 2007 WHO Classification of Tumours of the Central Nervous System
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MicroRNA-based therapeutics for inflammatory disorders of the microbiota-gut-brain axis
Datta, N., Johnson, C., Kao, D. H., Gurnani, P., Alexander, C., Polytarchou, C., & Monaghan, T. M. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106870 · Cited by 42
Biomarkers in neurodegenerative diseases: a broad overview
Sathish, S., & Ayyavoo, V. (2024) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2024.00075 · Cited by 39
Li, Y., Peng, B., Li, Y., Huang, A., Peng, Y., Yu, Q., & Li, Y. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.109900 · Cited by 33
Self-citationQu, X., Zhang, L., & Wang, L. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c06238 · Cited by 29
Self-citationKim, C., Koo, K., Kim, H. J., & Kim, T. P. (2024) · Biosensors · doi:10.3390/bios14080407 · Cited by 28
Metadata
- Authors
- Xu, J., Zheng, Y., Wang, L., Liu, Y., Wang, X., Li, Y., & Chi, G.
- Affiliations
- Jilin University (CN)
- Corresponding author
- Li, Yulin
- Chi, Guangfan
- Venue
- Cellular and Molecular Neurobiology
- Published
- 2021-04-22
- Volume
- 42
- Issue
- 7
- Pages
- 2031-2053
- ISSN
- 0272-4340 (ISSN-L)
- 1573-6830
- PMC
- PMC11421642
- OpenAlex
- W3155646278
- Cited by
- 55
- References
- 277
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 9 · 2023: 7 · 2022: 7
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cellular and Molecular Neurobiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81571199, 81870974)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- miR-124, microRNA, central nervous system injury, ischemic stroke, spinal cord injury, neurodegenerative diseases, glioblastoma, multiple sclerosis, neuroinflammation, post-transcriptional regulation, microRNA delivery, therapeutic target
- MeSH terms
- Central Nervous System, Central Nervous System Diseases, Humans, Spinal Cord Injuries, Neurodegenerative Diseases, Trauma, Nervous System, MicroRNAs
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