An updated role of microRNA-124 in central nervous system disorders: a review
Open accessAbstract
MicroRNA-124 (miR-124) is the most abundant miRNA in the brain. Biogenesis of miR-124 displays specific temporal and spatial profiles in various cell and tissue types and affects a broad spectrum of biological functions in the central nervous system (CNS). Recently, the link between dysregulation of miR-124 and CNS disorders, such as neurodegeneration, CNS stress, neuroimmune disorders, stroke, and brain tumors, has become evident. Here, we provide an overview of the specific molecular function of miR-124 in the CNS and a revealing insight for the therapeutic potential of miR-124 in the treatment of human CNS diseases.
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miR-124 is one of the most abundant miRNAs in the CNS and has been implicated in various pathologies within this system.
“miR-124, one of the most abundant miRNAs in the CNS, has been implicated in various pathologies within this system [165].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [165]
The Introduction says miR-124 is highly expressed across brain regions and that aberrant expression contributes to CNS pathological conditions. It does not establish the comparative claim that miR-124 is one of the most abundant miRNAs in the CNS. (LLM, conf=0.78)
Experimental — accuracy not yet measuredmiR-124 plays key roles in neurogenesis, synaptic strength and transmission, and glia-neuronal interactions essential for brain homeostasis.
“MiR-124 is a brain-enriched miRNA that plays key roles in neurogenesis, synaptic strength and transmission, and glia-neuronal interactions essential for the maintenance of brain homeostasis (Sun et al., 2015; Han et al., 2019).”
From Engineered Extracellular Vesicles Loaded With miR-124 Attenuate Cocaine-Mediated Activation of Microglia (2020) · cites this paper as Sun et al., 2015
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Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714 · see citing works
Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855 · see citing works
The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728 · see citing works
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
Lim, L. P., Lau, N. C., Garrett-Engele, P., Grimson, A., Schelter, J. M., Castle, J., Bartel, D. P., Linsley, P. S., & Johnson, J. M. (2005) · Nature · doi:10.1038/nature03315 · Cited by 4,755 · see citing works
Mechanisms underlying inflammation in neurodegeneration
Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580 · see citing works
Non-coding RNAs and cancer: microRNAs and beyond
Raia, R. M., & Călin, G. A. (2011) · Journal of Nucleic Acids Investigation · doi:10.4081/jnai.2011.e5 · Cited by 3,394 · see citing works
Identification of tissue-specific microRNAs from mouse
Lagos-Quintana, M., Rauhut, R., Yalcin, A., Meyer, J., Lendeckel, W., & Tuschl, T. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00809-6 · Cited by 2,859 · see citing works
Physiological and pathological roles for microRNAs in the immune system
O’Connell, R. M., Rao, D. S., Chaudhuri, A. A., & Baltimore, D. (2010) · Nature reviews. Immunology · doi:10.1038/nri2708 · Cited by 1,538 · see citing works
Makeyev, E. V., Zhang, J., Carrasco, M. A., & Maniatis, T. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.015 · Cited by 1,395 · see citing works
A MicroRNA Feedback Circuit in Midbrain Dopamine Neurons
Kim, J., Inoue, K., Ishii, J., Vanti, W. B., Voronov, S. V., Murchison, E., Hannon, G., & Abeliovich, A. (2007) · Science · doi:10.1126/science.1140481 · Cited by 1,187 · see citing works
Hébert, S. S., Horré, K., Nicolaï, L., Papadopoulou, A. S., Mandemakers, W., Silahtaroglu, A. N., Kauppinen, S., Delacourte, A., & De Strooper, B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710263105 · Cited by 1,183 · see citing works
Martinou, J., Dubois‐Dauphin, M., Staple, J. K., Rodríguez, I., Frankowski, H., Missotten, M., Albertini, P., Talabot, D., Catsicas, S., & Pietra, C. (1994) · Neuron · doi:10.1016/0896-6273(94)90266-6 · Cited by 1,087 · see citing works
miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche
Cheng, L.-C., Pastrana, E., Tavazoie, M., & Doetsch, F. (2009) · Nature Neuroscience · doi:10.1038/nn.2294 · Cited by 865 · see citing works
Ponomarev, E. D., Veremeyko, T., Barteneva, N., Krichevsky, A. M., & Weiner, H. L. (2011) · Nature Medicine · doi:10.1038/nm.2266 · Cited by 787 · see citing works
The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation
Pavlov, V. A., Wang, H., Czura, C. J., Friedman, S. G., & Tracey, K. J. (2003) · Molecular Medicine · doi:10.1007/bf03402177 · Cited by 772 · see citing works
Silber, J., Lim, D. A., Petritsch, C., Persson, A. I., Maunakea, A. K., Yu, M., Vandenberg, S. R., Ginzinger, D. G., James, C. D., Costello, J. F., et al. (2008) · BMC Medicine · doi:10.1186/1741-7015-6-14 · Cited by 765 · see citing works
Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease
Yang, L.-B., Lindholm, K., Yan, R., Citron, M., Xia, W., Yang, X.-L., Beach, T., Sue, L., Wong, P., Price, D., et al. (2003) · Nature Medicine · doi:10.1038/nm0103-3 · Cited by 729 · see citing works
Regulation of miRNA expression during neural cell specification
Smirnova, L., Gräfe, A., Seiler, A., Schumacher, S., Nitsch, R., & Wulczyn, F. G. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03978.x · Cited by 707 · see citing works
Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus
Lukiw, W. J. (2007) · Neuroreport · doi:10.1097/wnr.0b013e3280148e8b · Cited by 662 · see citing works
Reciprocal actions of REST and a microRNA promote neuronal identity
Conaco, C., Otto, S., Han, J.-J., & Mandel, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511041103 · Cited by 641 · see citing works
Plasma MicroRNAs as Sensitive and Specific Biomarkers of Tissue Injury
Laterza, O., Lim, L. P., Garrett-Engele, P. W., Vlasáková, K., Muniappa, N., Tanaka, W. K., Johnson, J. M., Sina, J. F., Fare, T. L., Sistare, F. D., et al. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2009.131797 · Cited by 618 · see citing works
Jeyaseelan, K., Lim, K. Y., & Armugam, A. (2008) · Stroke · doi:10.1161/strokeaha.107.500736 · Cited by 586 · see citing works
The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development
Visvanathan, J., Lee, S., Lee, B., Lee, J. W., & Lee, S.-K. (2007) · Genes & Development · doi:10.1101/gad.1519107 · Cited by 579 · see citing works
Specific microRNAs modulate embryonic stem cell-derived neurogenesis.
Krichevsky, A. M., Sonntag, K.-C., Isacson, O., & Kosik, K. S. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0441 · Cited by 574 · see citing works
Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits
Xue, Y., Ouyang, K., Huang, J., Zhou, Y., Ouyang, H., Li, H., Wang, G., Wu, Q., Wei, C., Bi, Y., et al. (2013) · Cell · doi:10.1016/j.cell.2012.11.045 · Cited by 562 · see citing works
MicroRNA-mediated switching of chromatin-remodelling complexes in neural development
Yoo, A. S., Staahl, B. T., Chen, L., & Crabtree, G. R. (2009) · Nature · doi:10.1038/nature08139 · Cited by 537 · see citing works
Zhang, P., Iwasaki-Arai, J., Iwasaki, H., Fenyus, M. L., Dayaram, T., Owens, B. M., Shigematsu, H., Levantini, E., Huettner, C. S., Lekstrom-Himes, J. A., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.11.006 · Cited by 506 · see citing works
Liu, D.-Z., Tian, Y., Ander, B. P., Xu, H., Stamova, B. S., Zhan, X., Turner, R. J., Jickling, G. C., & Sharp, F. R. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.186 · Cited by 496 · see citing works
Transient Focal Ischemia Induces Extensive Temporal Changes in Rat Cerebral MicroRNAome
Dharap, A. A., Bowen, K. K., Place, R. F., Li, L., & Vemuganti, R. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.157 · Cited by 445 · see citing works
Rajasethupathy, P., Fiumara, F., Sheridan, R., Betel, D., Puthanveettil, S. V., Russo, J. J., Sander, C., Tuschl, T., & Kandel, E. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.029 · Cited by 406 · see citing works
A functional study of miR-124 in the developing neural tubePreprint
Cao, X., Pfaff, S. L., & Gage, F. H. (2007) · Genes & Development · doi:10.1101/gad.1519207 · Cited by 336 · see citing works
MicroRNA miR-124 regulates neurite outgrowth during neuronal differentiation
Yu, J., Chung, K.-H., Deo, M., Thompson, R. C., & Turner, D. L. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.06.002 · Cited by 310 · see citing works
Uchida, S., Hara, K., Kobayashi, A., Funato, H., Hobara, T., Otsuki, K., Yamagata, H., McEwen, B. S., & Watanabe, Y. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1436-10.2010 · Cited by 310 · see citing works
Detection of mammalian microRNA expression by in situ hybridization with RNA oligonucleotides
Deo, M., Yu, J., Chung, K.-H., Tippens, M., & Turner, D. L. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20847 · Cited by 283 · see citing works
microRNAs miR-124, let-7d and miR-181a regulate Cocaine-induced Plasticity
Chandrasekar, V., & Dreyer, J. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.08.009 · Cited by 280 · see citing works
miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression
Sanuki, R., Onishi, A., Koike, C., Muramatsu, R., Watanabe, S., Muranishi, Y., Irie, S., Uneo, S., Koyasu, T., Matsui, R., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2897 · Cited by 276 · see citing works
Vreugdenhil, E., Veríssimo, C. S., Mariman, R., Kamphorst, J. T., Barbosa, J. S., Zweers, T. J., Champagne, D. L., Schouten, T. G., Meijer, O. C., de Kloet, E. R., et al. (2009) · Endocrinology · doi:10.1210/en.2008-1335 · Cited by 260 · see citing works
Sun, Y., Li, Q., Gui, H., Xu, D.-P., Yang, Y., Su, D., & Liu, X. (2013) · Cell Research · doi:10.1038/cr.2013.116 · Cited by 253 · see citing works
Self-citationLee, H. K., Finniss, S., Cazacu, S., Bucris, E. D., Ziv-Av, A., Xiang, C., Bobbitt, K. R., Rempel, S. A., Hasselbach, L. A., Mikkelsen, T., et al. (2013) · Oncotarget · doi:10.18632/oncotarget.868 · Cited by 226 · see citing works
Liu, X., Chopp, M., Zhang, R. L., Tao, T., Wang, X. L., Kassis, H., Hozeska‐Solgot, A., Zhang, L., Chen, C., & Zhang, Z. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023461 · Cited by 215 · see citing works
Self-citationFang, M., Wang, J., Zhang, X., Geng, Y., Hu, Z., Rudd, J. A., Ling, S., Chen, W., & Han, S. (2011) · Toxicology Letters · doi:10.1016/j.toxlet.2011.11.032 · Cited by 215 · see citing works
In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs
Smith, P. Y., Hashimi, A. A., Girard, J., Delay, C., & Hébert, S. S. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07097.x · Cited by 209 · see citing works
MicroRNA-124 is a subventricular zone neuronal fate determinant
Akerblom, M., Sachdeva, R., Barde, I., Verp, S., Gentner, B., Trono, D., & Jakobsson, J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0558-12.2012 · Cited by 207 · see citing works
Changes in Brain MicroRNAs Contribute to Cholinergic Stress Reactions
Meerson, A., Cacheaux, L. P., Goosens, K. A., Sapolsky, R. M., Soreq, H., & Kaufer, D. (2009) · Journal of Molecular Neuroscience · doi:10.1007/s12031-009-9252-1 · Cited by 203 · see citing works
NeurimmiRs: microRNAs in the neuroimmune interface
Soreq, H., & Wolf, Y. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.06.009 · Cited by 183 · see citing works
Yang, Y., Shu, X., Liu, D., Shang, Y., Wu, Y., Pei, L., Xu, X., Tian, Q., Zhang, J., Qian, K., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.003 · Cited by 178 · see citing works
miR-124 is frequently down-regulated in medulloblastoma and is a negative regulator of SLC16A1
Li, K. K., Pang, J. C., Ching, A. K.-K., Wong, C. K., Kong, X., Wang, Y., Zhou, L., Chen, Z., & Ng, H. (2009) · Human Pathology · doi:10.1016/j.humpath.2009.02.003 · Cited by 176 · see citing works
Loss of Brain-enriched miR-124 MicroRNA Enhances Stem-like Traits and Invasiveness of Glioma Cells
Xia, H., Cheung, W. K. C., Ng, S. S., Jiang, X., Jiang, S., Sze, J., Leung, G., Lü, G., Chan, D. T. M., Bian, X., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.332627 · Cited by 172 · see citing works
MicroRNA‐124 Protects Neurons Against Apoptosis in Cerebral Ischemic Stroke
Sun, Y., Gui, H., Li, Q., Luo, Z., Zheng, M., Duan, J., & Liu, X. (2013) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12142 · Cited by 163 · see citing works
Self-citationDoeppner, T. R., Doehring, M., Bretschneider, E., Zechariah, A., Kaltwasser, B., Müller, B., Koch, J. C., Bähr, M., Hermann, D. M., & Michel, U. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1142-5 · Cited by 155 · see citing works
miR-124a is frequently down-regulated in glioblastoma and is involved in migration and invasion
Fowler, A., Thomson, D. W., Giles, K. M., Maleki, S., Mreich, E., Wheeler, H. T., Leedman, P. J., Biggs, M. T., Cook, R., Little, N., et al. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2010.11.026 · Cited by 132 · see citing works
Identification of Novel Brain Biomarkers
Laterza, O., Modur, V. R., Crimmins, D. L., Olander, J. V., Landt, Y., Lee, J., & Ladenson, J. H. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2006.070912 · Cited by 132 · see citing works
Plasma miR-124 as a biomarker for cerebral infarction
Weng, H., Shen, C.-S., Hirokawa, G., Ji, X., Takahashi, R., Shimada, K., Kishimoto, C., & Iwai, N. (2011) · Biomedical Research · doi:10.2220/biomedres.32.135 · Cited by 125 · see citing works
MicroRNAs and deregulated gene expression networks in neurodegeneration
Sonntag, K. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.106 · Cited by 124 · see citing works
RT-PCR-based analysis of microRNA (miR-1 and -124) expression in mouse CNS
Mishima, T., Mizuguchi, Y., Kawahigashi, Y., Takizawa, T., & Takizawa, T. (2007) · Brain Research · doi:10.1016/j.brainres.2006.11.035 · Cited by 120 · see citing works
REST Controls Self-Renewal and Tumorigenic Competence of Human Glioblastoma Cells
Conti, L., Crisafulli, L., Caldera, V., Tortoreto, M., Brilli, E., Conforti, P., Zunino, F., Magrassi, L., Schiffer, D., & Cattaneo, E. F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038486 · Cited by 115 · see citing works
Lang, M., Su, Y., Zhao, C., Sun, G., Murai, K., Wu, X., Wang, J., Gao, H., Brown, C. E., Liu, X., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036248 · Cited by 108 · see citing works
Self-citationAssayag, E. B., Shenhar‐Tsarfaty, S., Ofek, K., Soreq, L., Bova, I., Shopin, L., Berg, R. M. G., Berliner, S. A., Shapira, I., Bornstein, N. M., et al. (2010) · Molecular Medicine · doi:10.2119/molmed.2010.00015 · Cited by 106 · see citing works
Liu, X., Li, F., Zhao, S., Luo, Y., Kang, J. P., Zhao, H., Yan, F., Li, S., & Ji, X. (2013) · Stroke · doi:10.1161/strokeaha.111.000613 · Cited by 103 · see citing works
Self-citationFunction of microRNA‐375 and microRNA‐124a in pancreas and brain
Baroukh, N., & OBBERGHEN, E. V. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07353.x · Cited by 102 · see citing works
Wang, X., Wang, Z.-H., Wu, Y., Tang, H. R., Tan, L., Wang, X., Gao, X., Xiong, Y., Liu, D., Wang, J., et al. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8355-9 · Cited by 102 · see citing works
Zhu, F., Liu, J., Li, J.-P., Xiao, F., Zhang, Z., & Zhang, L. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0155-9 · Cited by 102 · see citing works
Bcl-2 Family Gene Products in Cerebral Ischemia and Traumatic Brain Injury
Graham, S. H., Chen, J., & Clark, R. S. B. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.831 · Cited by 100 · see citing works
microRNA-124 Inhibits Migration and Invasion by Down-Regulating ROCK1 in Glioma
An, L., Liu, Y., Wu, A., & Guan, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069478 · Cited by 99 · see citing works
MicroRNAs and glioblastoma; the stem cell connection
Godlewski, J. A., Newton, H. B., Chiocca, E. A., & Lawler, S. E. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.71 · Cited by 98 · see citing works
MiR-124 regulates early neurogenesis in the optic vesicle and forebrain, targeting NeuroD1
Liu, K., Liu, Y. M., Mo, W., Qiu, R., Wang, X., Wu, J. Y., & He, R. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq904 · Cited by 95 · see citing works
Wießner, C., ALLEGRINI, P. R., Rupalla, K., Sauer, D., Oltersdorf, T., McGregor, A. L., Bischoff, S. F., Böttiger, B. W., & van der Putten, H. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00392-4 · Cited by 95 · see citing works
Huang, T., Chang, H., Chen, C., Wu, P., Lee, H., Liao, Y., Hsu, W., Huang, H., & Juan, H. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.10.025 · Cited by 75 · see citing works
Nadorp, B., & Soreq, H. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00009 · Cited by 64 · see citing works
MicroRNA expression changes in the hippocampi of rats subjected to global ischemia
Yuan, Y., Wang, J. Y., Xu, L. Y., Cai, R., Chen, Z., & Luo, B. Y. (2010) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2009.10.009 · Cited by 63 · see citing works
Ephrin-B1 Reverse Signaling Controls a Posttranscriptional Feedback Mechanism via miR-124
Arvanitis, D. N., Jungas, T., Béhar, A., & Davy, A. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01620-09 · Cited by 62 · see citing works
MicroRNA-124 expression counteracts pro-survival stress responses in glioblastoma
Mucaj, V., Lee, S. S., Skuli, N., Giannoukos, D. N., Qiu, B., Eisinger‐Mathason, T. S. K., Nakazawa, M. S., Shay, J. E. S., Gopal, P. P., Venneti, S., et al. (2014) · Oncogene · doi:10.1038/onc.2014.168 · Cited by 61 · see citing works
Noguchi, T., Makino, S., Matsumoto, R., Nakayama, S., Nishiyama, M., Terada, Y., & Hashimoto, K. (2010) · Endocrinology · doi:10.1210/en.2010-0266 · Cited by 60 · see citing works
Ho, C., Bar, E. E., Giannini, C., Marchionni, L., Karajannis, M. A., Zagzag, D., Gutmann, D. H., Eberhart, C. G., & Rodriguez, F. J. (2012) · Neuro-Oncology · doi:10.1093/neuonc/nos269 · Cited by 59 · see citing works
A Catalogue of Glioblastoma and Brain MicroRNAs Identified by Deep Sequencing
Hua, D., Mo, F., Ding, D., Li, L. S. Y., Xu, H., Zhao, N., Foltz, G., Lin, B., Lan, Q., & Huang, Q. (2012) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2012.0069 · Cited by 57 · see citing works
Expression of β-secretase mRNA in transgenic Tg2576 mouse brain with Alzheimer plaque pathology
Bigl, M., Apelt, J., Luschekina, E. A., Lange‐Dohna, C., Roßner, S., & Schliebs, R. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01452-x · Cited by 55 · see citing works
Lawson, S. K., Dobrikova, E. Y., Shveygert, M., & Gromeier, M. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00695-12 · Cited by 46 · see citing works
Localization of β-Secretase Memapsin 2 in the Brain of Alzheimer's Patients and Normal Aged Controls
Sun, A., Koelsch, G., Tang, J., & Bing, G. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.7875 · Cited by 42 · see citing works
Farrell, B. C., Power, E. M., & Dermott, K. M. (2010) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.10.001 · Cited by 37 · see citing works
CDA-2 induces cell differentiation through suppressing Twist/SLUG signaling via miR-124 in glioma
Xie, Y., Huo, S., Zhang, G., Zhang, F., Lian, Z., Tang, X., & Jin, C. (2012) · Journal of Neuro-Oncology · doi:10.1007/s11060-012-0961-x · Cited by 30 · see citing works
Taming of macrophage and microglial cell activation by microRNA-124
Conrad, A., & Dittel, B. N. (2011) · Cell Research · doi:10.1038/cr.2011.9 · Cited by 29 · see citing works
MicroRNAs in Memory Processing
Fischbach, S., & Carew, T. J. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.007 · Cited by 25 · see citing works
Schumacher, S., & Franke, K. (2013) · Small GTPases · doi:10.4161/sgtp.22922 · Cited by 22 · see citing works
A Neuronal Transcriptome Response Involving Stress Pathways is Buffered by Neuronal microRNAs
Manakov, S. A., Morton, A., Enright, A. J., & Grant, S. G. N. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00156 · Cited by 19 · see citing works
The effects of stress on mouse prefrontal cortex microRNA expression
McKennirey, P. (2011) · doi:10.22215/etd/2011-06793 · Cited by 1 · see citing works
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Condrat, C. E., Thompson, D. C., Barbu, M. G., Bugnar, O. L., Boboc, A. E., Crețoiu, D., Suciu, N., Creţoiu, S. M., & Voinea, S. C. (2020) · Cells · doi:10.3390/cells9020276 · Cited by 1,357 · see citing works
Brites, D., & Fernandes, A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00476 · Cited by 599 · see citing works
“MiR-124 is the most abundant in the brain and its dysregulation has been related with neurodegeneration, neuroimmune disorders and CNS stress among others (for review, see Sun et al., 2015).”
BackgroundExosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia
Yang, J., Zhang, X., Chen, X., Wang, L., & Yang, G. (2017) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2017.04.010 · Cited by 592 · see citing works
CircRNA accumulation in the aging mouse brain
Gruner, H. N., Cortés-López, M., Cooper, D. A., Bauer, M. J., & Miura, P. (2016) · Scientific Reports · doi:10.1038/srep38907 · Cited by 366 · see citing works
The Role of Early Growth Response 1 (EGR1) in Brain Plasticity and Neuropsychiatric Disorders
Duclot, F., & Kabbaj, M. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00035 · Cited by 359 · see citing works
Modulators of microglia activation and polarization in ischemic stroke
Jiang, C., Wu, W., Deng, Y.-H., & Ge, J.-W. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11003 · Cited by 355 · see citing works
Gambari, R., Brognara, E., Spandidos, D. A., & Fabbri, E. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3503 · Cited by 261 · see citing works
Lang, F., Hossain, A., Gumin, J., Momin, E. N., Shimizu, Y., Ledbetter, D., Shahar, T., Yamashita, S., Kerrigan, B. C. P., Fueyo-Margareto, J., et al. (2017) · Neuro-Oncology · doi:10.1093/neuonc/nox152 · Cited by 240 · see citing works
The Interleukin-10 Family of Cytokines and Their Role in the CNS
Burmeister, A. R., & Marriott, I. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00458 · Cited by 208 · see citing works
Xia, X., Wang, Y., Huang, Y., Zhang, H., Lu, H., & Zheng, J. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101694 · Cited by 206 · see citing works
MiRNA-124 induces neuroprotection and functional improvement after focal cerebral ischemia
Taj, S. H., Kho, W., Riou, A., Wiedermann, D., & Hoehn, M. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.03.025 · Cited by 191 · see citing works
Mechanisms of Melatonin in Alleviating Alzheimer’s Disease
Shukla, M., Govitrapong, P., Boontem, P., Reiter, R., & Satayavivad, J. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170313123454 · Cited by 173 · see citing works
PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia
Rustenhoven, J., Smith, A. M., Smyth, L. C., Jansson, D., Scotter, E. L., Swanson, M. E. V., Aalderink, M., Coppieters, N., Narayan, P., Handley, R., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0277-1 · Cited by 155 · see citing works
MicroRNA-124 loaded nanoparticles enhance brain repair in Parkinson's disease
Saraiva, C., Paiva, J., Santos, T., Ferreira, L., & Bernardino, L. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.06.005 · Cited by 169 · see citing works
Exosomes as Novel Regulators of Adult Neurogenic Niches
Bátiz, L. F., Castro, M. A., Burgos, P. V., Velásquez, Z. D., Muñoz, R. I., Lafourcade, C., Troncoso-Escudero, P., & Wyneken, Ú. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00501 · Cited by 157 · see citing works
HuR‐regulated lnc RNA NEAT 1 stability in tumorigenesis and progression of ovarian cancer
Chai, Y., Liu, J., Zhang, Z., & Liu, L. (2016) · Cancer Medicine · doi:10.1002/cam4.710 · Cited by 156 · see citing works
Dysregulation of Cortical Neuron DNA Methylation Profile in Autism Spectrum Disorder
Nardone, S., Sams, D. S., Zito, A., Reuveni, E., & Elliott, E. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx250 · Cited by 134 · see citing works
Pinto, S., Cunha, C., Barbosa, M., Vaz, A. R., & Brites, D. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00273 · Cited by 135 · see citing works
How to reprogram microglia toward beneficial functions
Fumagalli, M., Lombardi, M., Gressèns, P., & Verderio, C. (2018) · Glia · doi:10.1002/glia.23484 · Cited by 134 · see citing works
Emerging Roles of miRNAs in Brain Development and Perinatal Brain Injury
Cho, K. H. T., Xu, B., Blenkiron, C., & Fraser, M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00227 · Cited by 114 · see citing works
New progress in the approaches for blood–brain barrier protection in acute ischemic stroke
Li, Y., Zhong, W., Jiang, Z., & Tang, X. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.11.006 · Cited by 114 · see citing works
Human neural stem cell-derived extracellular vesicles mitigate hallmarks of Alzheimer’s disease
Apodaca, L. A., Baddour, A. A. D., Garcia, C., Alikhani, L., Giedzinski, E., Ru, N., Agrawal, A., Acharya, M. M., & Baulch, J. E. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00791-x · Cited by 109 · see citing works
Cunha, C., Santos, C., Gomes, C., Fernandes, A. M. A., Correia, A. M., Sebastião, A. M., Vaz, A. R., & Brites, D. M. T. O. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0631-2 · Cited by 85 · see citing works
MicroRNA Dysregulation in Cutaneous Squamous Cell Carcinoma
García‐Sancha, N., Corchado‐Cobos, R., Pérez‐Losada, J., & Cañueto, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092181 · Cited by 84 · see citing works
Emerging Roles of Exosomes in Huntington’s Disease
Ananbeh, H., Vodička, P., & Skalníková, H. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084085 · Cited by 82 · see citing works
Hong, S., You, J. Y., Paek, K., Park, J., Kang, S. J., Han, E. H., Choi, N., Chung, S. H., Rhee, W. J., & Kim, J. A. (2021) · Theranostics · doi:10.7150/thno.60851 · Cited by 83 · see citing works
Deng, D., Wang, L., Chen, Y., Li, B., Xue, L., Shao, N., Wang, Q., Xia, X., Yang, Y., & Zhi, F. (2016) · Cancer Science · doi:10.1111/cas.12946 · Cited by 81 · see citing works
Adipocyte, Immune Cells, and miRNA Crosstalk: A Novel Regulator of Metabolic Dysfunction and Obesity
Kiran, S., Kumar, V., Kumar, S., Price, R. L., & Singh, U. P. (2021) · Cells · doi:10.3390/cells10051004 · Cited by 75 · see citing works
Regulators of cholinergic signaling in disorders of the central nervous system
Winek, K., Soreq, H., & Meisel, A. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15332 · Cited by 73 · see citing works
Alural, B., Genç, Ş., & Haggarty, S. J. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.03.010 · Cited by 74 · see citing works
The role of microRNAs in glucocorticoid action
Clayton, S. A., Jones, S. W., Kurowska‐Stolarska, M., & Clark, A. R. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.000366 · Cited by 73 · see citing works
Gan, L., Li, Z., Lv, Q.-K., & Huang, W. Y. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118449 · Cited by 72 · see citing works
Genome-wide CRISPR screen identifies suppressors of endoplasmic reticulum stress-induced apoptosis
Panganiban, R. A. M., Park, H., Sun, M., Shumyatcher, M., Himes, B. E., & Lu, Q. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1906275116 · Cited by 71 · see citing works
Dedifferentiation and neuronal repression define familial Alzheimer’s disease
Caldwell, A. B., Liu, Q., Schroth, G. P., Galasko, D. R., Yuan, S. H., Wagner, S. L., & Subramaniam, S. (2020) · Science Advances · doi:10.1126/sciadv.aba5933 · Cited by 69 · see citing works
Chivero, E. T., Liao, K., Niu, F., Tripathi, A., Tian, C., Buch, S., & Hu, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00573 · Cited by 69 · see citing works
MicroRNA in Brain pathology: Neurodegeneration the Other Side of the Brain Cancer
Godlewski, J. A., Lenart, J., & Salińska, E. (2019) · Non-Coding RNA · doi:10.3390/ncrna5010020 · Cited by 67 · see citing works
miR-124-3p attenuates MPP + -induced neuronal injury by targeting STAT3 in SH-SY5Y cells
Geng, L., Liu, W., & Chen, Y. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370217734492 · Cited by 66 · see citing works
Chu‐Tan, J. A., Rutar, M., Saxena, K., Aggio‐Bruce, R., Essex, R. W., Valter, K., Jiao, H., Fernando, N., Wooff, Y., Madigan, M. C., et al. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-24623 · Cited by 65 · see citing works
The Roles of MicroRNAs in Male Infertility
Barbu, M. G., Thompson, D. C., Suciu, N., Voinea, S. C., Crețoiu, D., & Predescu, D. V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062910 · Cited by 65 · see citing works
Periyasamy, P., Thangaraj, A., Guo, M., Hu, G., Callen, S. E., & Buch, S. J. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3474-17.2018 · Cited by 65 · see citing works
Human Brain Injury and miRNAs: An Experimental Study
Sessa, F., Maglietta, F., Bertozzi, G., Salerno, M., Mizio, G. D., Messina, G., Montana, A., Ricci, P., & Pomara, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071546 · Cited by 63 · see citing works
Defining the Teratoma as a Model for Multi-lineage Human Development
McDonald, D., Wu, Y., Dailamy, A., Tat, J., Parekh, U., Zhao, D., Hu, M. Y., Tipps, A. M. P., Zhang, K., & Mali, P. (2020) · Cell · doi:10.1016/j.cell.2020.10.018 · Cited by 58 · see citing works
Microglial Responses to Brain Injury and Disease: Functional Diversity and New Opportunities
Lyu, J., Jiang, X., Leak, R. K., Shi, Y., Hu, X., & Chen, J. (2020) · Translational Stroke Research · doi:10.1007/s12975-020-00857-2 · Cited by 61 · see citing works
Emerging role of microRNAs in ischemic stroke with comorbidities
Yu, Q., Chopp, M., & Chen, J. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113382 · Cited by 58 · see citing works
MicroRNA-124 regulates cardiomyocyte apoptosis and myocardial infarction through targeting Dhcr24
Han, F., Chen, Q., Su, J., Zheng, A., Chen, K., Sun, S., Wu, H., Jiang, L., Xu, X., Yang, M., et al. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.05.007 · Cited by 58 · see citing works
Szymanska, K., Makowska, K., & Gonkowski, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030917 · Cited by 57 · see citing works
Valera, E., Spencer, B., Mott, J., Trejo, M., Adame, A., Mante, M., Rockenstein, E., Troncoso, J. C., Beach, T. G., Masliah, E., et al. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00329 · Cited by 55 · see citing works
Zhang, Y., Liu, H., An, L., Li, L., Wei, M., Ge, D., & Su, Z. Z. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27861 · Cited by 54 · see citing works
Integrated MicroRNA and mRNA Profiling in Zika Virus-Infected Neurons
Azouz, F., Arora, K., Krause, K. K., Nerurkar, V. R., & Kumar, M. (2019) · Viruses · doi:10.3390/v11020162 · Cited by 50 · see citing works
Noncoding RNAs in ischemic stroke: time to translate
Kaur, H., Sarmah, D., Saraf, J., Vats, K., Kalia, K., Borah, A., Yavagal, D. R., Dave, K. R., Ghosh, Z., & Bhattacharya, P. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13612 · Cited by 49 · see citing works
Overexpression of miR-124 in Motor Neurons Plays a Key Role in ALS Pathological Processes
Vaz, A. R., Vizinha, D., Morais, H. M. M., Colaço, A. R. A., Loch-Neckel, G., Barbosa, M., & Brites, D. M. T. O. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116128 · Cited by 45 · see citing works
Ambrogini, P., Albertini, M. C., Betti, M., Galati, C., Lattanzi, D., Savelli, D., Palma, M. D., Saccomanno, S., Bartolini, D., Torquato, P., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0946-7 · Cited by 46 · see citing works
Shukla, M., & Vincent, B. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101062 · Cited by 48 · see citing works
Role of MicroRNAs, Aptamers in Neuroinflammation and Neurodegenerative Disorders
Khan, I., Kumari, P., Fernandes, V., Khatri, D. K., & Singh, S. B. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01093-4 · Cited by 48 · see citing works
Finch‐Edmondson, M., Morgan, C., Hunt, R. W., & Novak, I. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00015 · Cited by 47 · see citing works
MicroRNA‑124: an emerging therapeutic target in central nervous system disorders
Zhang, W.-H., Jiang, L., Li, M., & Liu, J. (2023) · Experimental Brain Research · doi:10.1007/s00221-022-06524-2 · Cited by 43 · see citing works
Gene expression profiling of brain samples from patients with Lewy body dementia
Pietrzak, M., Papp, A. C., Curtis, A., Handelman, S. K., Kataki, M., Scharre, D. W., Rempała, G. A., & Sadée, W. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.09.114 · Cited by 43 · see citing works
He, F., Liu, H., Guo, J., Yang, D., Yu, Y., Yu, J., Yan, X., Hu, J., & Du, Z. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000495173 · Cited by 43 · see citing works
Forró, T., Bajkó, Z., Bălașa, A. F., & Bălașa, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115621 · Cited by 45 · see citing works
Hafez, H. A., Kamel, M. A. E.-N., Osman, M. Y. H., Osman, H., Elblehi, S. S., & Mahmoud, S. A. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04079-4 · Cited by 42 · see citing works
miR-124 dosage regulates prefrontal cortex function by dopaminergic modulation
Kozuka, T., Omori, Y., Watanabe, S., Tarusawa, E., Yamamoto, H., Chaya, T., Furuhashi, M., Morita, M., Sato, T., Hirose, S., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-38910-2 · Cited by 42 · see citing works
Jin, J., Jia, Z., Luo, X., & Zhai, H.-F. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1706921 · Cited by 42 · see citing works
Li, T., Wang, Y., Chen, J., Gao, X., Pan, S., Su, Y., & Zhou, X. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1731861 · Cited by 42 · see citing works
Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage
Bustelo, M., Barkhuizen, M., van den Hove, D., Steinbusch, H. W. M., Bruno, M. A., Loidl, C. F., & Gavilanes, A. W. D. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00483 · Cited by 41 · see citing works
MicroRNA-135a regulates NHE9 to inhibit proliferation and migration of glioblastoma cells
Zubieta, D. M. G., Hamood, M. A., Beydoun, R. S., Pall, A. E., & Kondapalli, K. C. (2017) · Cell Communication and Signaling · doi:10.1186/s12964-017-0209-7 · Cited by 40 · see citing works
Biological functions, regulatory mechanisms, and disease relevance of RNA localization pathways
Bovaird, S., Patel, D., Padilla, J.-C. A., & Lécuyer, É. (2018) · FEBS Letters · doi:10.1002/1873-3468.13228 · Cited by 40 · see citing works
Diagnostic and theranostic microRNAs in the pathogenesis of atherosclerosis
Shoeibi, S. (2020) · Acta Physiologica · doi:10.1111/apha.13353 · Cited by 38 · see citing works
Rasheed, M., Asghar, R., Firdoos, S., Ahmad, N., Nazir, A., Ullah, K. M., Li, N., Zhuang, F., Chen, Z., & Deng, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031294 · Cited by 41 · see citing works
Cocaine-mediated downregulation of microglial miR-124 expression involves promoter DNA methylation.
Guo, M.-L., Periyasamy, P., Liao, K., Kook, Y. H., Niu, F., Callen, S. E., & Buch, S. (2016) · Epigenetics · doi:10.1080/15592294.2016.1232233 · Cited by 39 · see citing works
MiR-375 attenuates injury of cerebral ischemia/reperfusion via targetting Ctgf
Ou, J., Kou, L., Liang, L., & Tang, C. (2017) · Bioscience Reports · doi:10.1042/bsr20171242 · Cited by 39 · see citing works
Ponnusamy, V., Kapellou, O., Yip, E., Evanson, J., Wong, L., Michael-Titus, A. T., Yip, P. K., & Shah, D. K. (2015) · Pediatric Research · doi:10.1038/pr.2015.276 · Cited by 38 · see citing works
Dash, S., Balasubramaniam, M., Martínez-Rivera, F. J., Godino, A., Peck, E. G., Patnaik, S., Suar, M., Calipari, E. S., Nestler, E. J., Villalta, F., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-68144-6 · Cited by 36 · see citing works
Li, X., Zhao, J., Li, Z., Zhang, L., & Huo, Z. (2020) · Neural Plasticity · doi:10.1155/2020/8850653 · Cited by 35 · see citing works
MicroRNA-124 Regulates Fatty Acid and Triglyceride Homeostasis
Shaw, T. A., Singaravelu, R., Powdrill, M. H., Nhan, J., Ahmed, N., Özcelik, D., & Pezacki, J. P. (2018) · iScience · doi:10.1016/j.isci.2018.11.028 · Cited by 34 · see citing works
Sessa, F., Salerno, M., Cipolloni, L., Bertozzi, G., Messina, G., Mizio, G. D., Asmundo, A., & Pomara, C. (2020) · Aging · doi:10.18632/aging.103512 · Cited by 33 · see citing works
Garcia, G., Fernandes, A., Stein, F., & Brites, D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.833066 · Cited by 32 · see citing works
Majdi, A., Mahmoudi, J., Sadigh‐Eteghad, S., Farhoudi, M., & Shotorbani, S. S. (2016) · Neurological Sciences · doi:10.1007/s10072-016-2643-5 · Cited by 32 · see citing works
Nolan, J., Salvucci, M., Carberry, S., Barat, A., Segura, M. F., Fenn, J., Prehn, J. H. M., Stallings, R. L., & Piskareva, O. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.559553 · Cited by 32 · see citing works
Llorens, F., Thüne, K., Martı́, E., Kanata, Ε., Dafou, D., Lucena, D. D., Vivancos, A. P., Shomroni, O., Zafar, S., Schmitz, M., et al. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006802 · Cited by 32 · see citing works
Ralston, K., Newman, C., Clauson, A. L., Guthrie, J. F., & Buzby, J. C. (2008) · Cited by 33 · see citing works
miR-124 Regulates Diverse Aspects of Rhythmic Behavior inDrosophila
Garaulet, D. L., Sun, K., Li, W., Wen, J., Panzarino, A. M., O'Neil, J. L., Hiesinger, P. R., Young, M. W., & Lai, E. C. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3287-15.2016 · Cited by 31 · see citing works
Feng, C., Yin, J., Yang, J., & Cao, L. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.12.017 · Cited by 31 · see citing works
Yang, C., Sui, G., Wang, L., Chen, Z., & Wang, F. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-021-01921-8 · Cited by 31 · see citing works
Long-term epigenetic alterations in a rat model of Gulf War Illness
Pierce, L. M., Kurata, W. E., Matsumoto, K. W., Clark, M. E., & Farmer, D. M. (2016) · NeuroToxicology · doi:10.1016/j.neuro.2016.05.007 · Cited by 31 · see citing works
Bazrgar, M., Khodabakhsh, P., Dargahi, L., Mohagheghi, F., & Ahmadiani, A. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111812 · Cited by 31 · see citing works
Abdelmaksoud, N. M., Sallam, A.-A. M., Abulsoud, A. I., El‐Dakroury, W. A., Mageed, S. S. A., AL‐Noshokaty, T. M., Elrebehy, M. A., Elshaer, S. S., Mahmoud, N. A., Fathi, D., et al. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.155007 · Cited by 30 · see citing works
Extracellular miRNAs in redox signaling: Health, disease and potential therapies
Ruiz, G. P., Camara, H., Fazolini, N. P. B., & Mori, M. A. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.05.004 · Cited by 29 · see citing works
Évora, A., Garcia, G., Rubi, A., Vitis, E. D., Matos, A. T., Vaz, A. R., Gervaso, F., Gigli, G., Polini, A., & Brites, D. M. T. O. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1474012 · Cited by 30 · see citing works
Nassar, A., Satarker, S., Gurram, P. C., Upadhya, D., Fayaz, S., & Nampoothiri, M. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03437-1 · Cited by 27 · see citing works
Sánchez, S. V., Otavalo, G. N., Gazeau, F., Silva, A. K. A., & Morales, J. O. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.01.018 · Cited by 28 · see citing works
Molecular Mechanisms Involved in the Regulation of Neurodevelopment by miR-124
Gu, X., Xu, X., Jia, C., Wang, J., Zhang, J., Gao, Q., & Chen, J. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03271-5 · Cited by 27 · see citing works
Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions
Choi, H. K., Chen, M., Goldston, L. L., & Lee, K.-B. (2024) · Nano Convergence · doi:10.1186/s40580-024-00426-5 · Cited by 26 · see citing works
Roy, B., Ochi, S., & Dwivedi, Y. (2022) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyac068 · Cited by 25 · see citing works
Zhou, X., & Qi, L. (2021) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/10760296211035446 · Cited by 26 · see citing works
Temporal Profile of Circulating microRNAs after Global Hypoxia-Ischemia in Newborn Piglets
Garberg, H. T., Huun, M. U., Baumbusch, L. O., Atneosen‐Åsegg, M., Solberg, R., & Saugstad, O. D. (2016) · Neonatology · doi:10.1159/000449032 · Cited by 26 · see citing works
Genome‐wide identification of microRNAs regulating the human prion protein
Pease, D., Scheckel, C., Schaper, E., Eckhardt, V., Emmenegger, M., Xénarios, I., & Aguzzi, A. (2018) · Brain Pathology · doi:10.1111/bpa.12679 · Cited by 24 · see citing works
D-4F increases microRNA-124a and reduces neuroinflammation in diabetic stroke rats
Ning, R., Venkat, P., Chopp, M., Zacharek, A., Yan, T., Cui, X., Seyfried, D., & Chen, J. (2017) · Oncotarget · doi:10.18632/oncotarget.20751 · Cited by 24 · see citing works
de Cauwer, A., Mariotte, A., Sibilia, J., Bahram, S., & Georgel, P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01647 · Cited by 24 · see citing works
ELF4 Is a Target of miR-124 and Promotes Neuroblastoma Proliferation and Undifferentiated State
Kosti, A., Du, L., Shivram, H., Qiao, M., Burns, S. S., Garcia, J. G., Pertsemlidis, A., Iyer, V. R., Kokovay, E., & Penalva, L. O. F. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-19-0187 · Cited by 23 · see citing works
Non-coding RNAs and their bioengineering applications for neurological diseases
Das, T., Das, T. K., Khodarkovskaya, A., & Dash, S. (2021) · Bioengineered · doi:10.1080/21655979.2021.2003667 · Cited by 24 · see citing works
- Authors
- Sun, Y., Luo, Z.-M., Guo, X.-M., Su, D.-F., & Liu, X.
- Affiliations
- Second Military Medical University (CN)
- Corresponding author
- Liu, Xia
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2015-05-20
- Volume
- 9
- Pages
- 193-193
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC4438253
- OpenAlex
- W1601508141
- Cited by
- 223
- References
- 85
- Citations by year
- 2026: 8 · 2025: 21 · 2024: 11 · 2023: 18 · 2022: 20 · 2021: 29 · 2020: 32 · 2019: 20 · 2018: 25 · 2017: 15 · 2016: 19 · 2015: 4
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81230083, 81473259, 81273606)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- miR-124, central nervous system disorders, neurodegeneration, neuroimmunological diseases, stroke, brain tumors, microRNA biogenesis, therapeutic target
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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