Cited by 228MicroRNA in disease regulationNeurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

An updated role of microRNA-124 in central nervous system disorders: a review

Open access
Sun, Yang, Luo, Zhu-Min, Guo, Xiu-Ming, Su, Ding-Feng, Liu, Xia·2015·Frontiers in Cellular Neuroscience

Abstract

MicroRNA-124 (miR-124) is the most abundant miRNA in the brain. Biogenesis of miR-124 displays specific temporal and spatial profiles in various cell and tissue types and affects a broad spectrum of biological functions in the central nervous system (CNS). Recently, the link between dysregulation of miR-124 and CNS disorders, such as neurodegeneration, CNS stress, neuroimmune disorders, stroke, and brain tumors, has become evident. Here, we provide an overview of the specific molecular function of miR-124 in the CNS and a revealing insight for the therapeutic potential of miR-124 in the treatment of human CNS diseases.

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Crossref · 10.3389/fncel.2015.00193

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  • miR-124 is one of the most abundant miRNAs in the CNS and has been implicated in various pathologies within this system.

    “miR-124, one of the most abundant miRNAs in the CNS, has been implicated in various pathologies within this system [165].”

    From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [165]

    The Introduction says miR-124 is highly expressed across brain regions and that aberrant expression contributes to CNS pathological conditions. It does not establish the comparative claim that miR-124 is one of the most abundant miRNAs in the CNS. (LLM, conf=0.78)

    Experimental — accuracy not yet measured
  • miR-124 plays key roles in neurogenesis, synaptic strength and transmission, and glia-neuronal interactions essential for brain homeostasis.

    “MiR-124 is a brain-enriched miRNA that plays key roles in neurogenesis, synaptic strength and transmission, and glia-neuronal interactions essential for the maintenance of brain homeostasis (Sun et al., 2015; Han et al., 2019).”

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Authors
Sun, Y., Luo, Z.-M., Guo, X.-M., Su, D.-F., & Liu, X.
Affiliations
Second Military Medical University (CN)
Corresponding author
Liu, Xia
Venue
Frontiers in Cellular Neuroscience
Published
2015-05-20
Volume
9
Pages
193-193
ISSN
1662-5102 (ISSN-L)
OpenAlex
W1601508141
Cited by
223
References
85
Citations by year
2026: 8 · 2025: 21 · 2024: 11 · 2023: 18 · 2022: 20 · 2021: 29 · 2020: 32 · 2019: 20 · 2018: 25 · 2017: 15 · 2016: 19 · 2015: 4
FWCI
2.05
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Natural Science Foundation of China (81230083, 81473259, 81273606)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
miR-124, central nervous system disorders, neurodegeneration, neuroimmunological diseases, stroke, brain tumors, microRNA biogenesis, therapeutic target

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