Cited by 55MicroRNA in disease regulationNeuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

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miR-124: A Promising Therapeutic Target for Central Nervous System Injuries and Diseases

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Xu, Jinying, Zheng, Yangyang, Wang, Liangjia, Liu, Yining, Wang, Xishu, Li, Yulin, Chi, Guangfan·2022·Cellular and Molecular Neurobiology

DOI 10.1007/s10571-021-01091-6PMC PMC11421642

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Abstract

Central nervous system injuries and diseases, such as ischemic stroke, spinal cord injury, neurodegenerative diseases, glioblastoma, multiple sclerosis, and the resulting neuroinflammation often lead to death or long-term disability. MicroRNAs are small, non-coding, single-stranded RNAs that regulate posttranscriptional gene expression in both physiological and pathological cellular processes, including central nervous system injuries and disorders. Studies on miR-124, one of the most abundant microRNAs in the central nervous system, have shown that its dysregulation is related to the occurrence and development of pathology within the central nervous system. Herein, we review the molecular regulatory functions, underlying mechanisms, and effective delivery methods of miR-124 in the central nervous system, where it is involved in pathological conditions. The review also provides novel insights into the therapeutic target potential of miR-124 in the treatment of human central nervous system injuries or diseases.

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See all 55

Authors: Xu, J., Zheng, Y., Wang, L., Liu, Y., Wang, X., Li, Y., & Chi, G.
Affiliations: Jilin University (CN)
Corresponding author: Li, Yulin
Chi, Guangfan
ORCID: Xu, Jinying
Zheng, Yangyang
Liu, Yining
Li, Yulin
Chi, Guangfan
Venue: Cellular and Molecular Neurobiology
Publisher: Springer Science and Business Media LLC
Published: 2021-04-22
Volume: 42
Issue: 7
Pages: 2031-2053
ISSN: 0272-4340 (ISSN-L)
1573-6830
DOI: 10.1007/s10571-021-01091-6
PMC: PMC11421642
OpenAlex: W3155646278
Cited by: 55
References: 277
Citations by year: 2026: 14 · 2025: 18 · 2024: 9 · 2023: 7 · 2022: 7
FWCI: 0.70
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Cellular and Molecular Neurobiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (81571199, 81870974)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: miR-124, microRNA, central nervous system injury, ischemic stroke, spinal cord injury, neurodegenerative diseases, glioblastoma, multiple sclerosis, neuroinflammation, post-transcriptional regulation, microRNA delivery, therapeutic target
MeSH terms: Central Nervous System, Central Nervous System Diseases, Humans, Spinal Cord Injuries, Neurodegenerative Diseases, Trauma, Nervous System, MicroRNAs

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miR-124: A Promising Therapeutic Target for Central Nervous System Injuries and Diseases

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