Piezo1 Is as a Novel Trefoil Factor Family 1 Binding Protein that Promotes Gastric Cancer Cell Mobility In Vitro

Role of integrins in cell invasion and migration

Hood, J. D., & Cheresh, D. A. (2002) · Nature reviews. Cancer · doi:10.1038/nrc727 · Cited by 1,798

Piezo proteins are pore-forming subunits of mechanically activated channels

Coste, B., Xiao, B., Santos, J. S., Syeda, R., Grandl, J. M., Spencer, K. S. R., Kim, S. E., Schmidt, M., Mathur, J., Dubin, A. E., et al. (2012) · Nature · doi:10.1038/nature10812 · Cited by 1,205

U6 promoter–driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells

Miyagishi, M., & Taira, K. (2002) · Nature Biotechnology · doi:10.1038/nbt0502-497 · Cited by 706

Trefoil factors: initiators of mucosal healing

Taupin, D. R., & Podolsky, D. K. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1203 · Cited by 643

Gastric Mucosa Abnormalities and Tumorigenesis in Mice Lacking the pS2 Trefoil Protein

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The trefoil factor family – small peptides with multiple functionalities

Kjellev, S. L. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8646-5 · Cited by 261

Integrins in invasive growth

Brakebusch, C., Bouvard, D., Stanchi, F., Sakai, T., & Fässler, R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15468 · Cited by 239

Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum

McHugh, B. J., Buttery, R. C., Lad, Y., Banks, S., Haslett, C., & Sethi, T. (2009) · Journal of Cell Science · doi:10.1242/jcs.056424 · Cited by 217

Integrins in invasive growth

Brakebusch, C., Bouvard, D., Stanchi, F., Sakai, T., & Fässler, R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215468 · Cited by 187

Blockade of the Stromal Cell–Derived Factor-1/CXCR4 Axis Attenuates In vivo Tumor Growth by Inhibiting Angiogenesis in a Vascular Endothelial Growth Factor–Independent Manner

Guleng, B., Tateishi, K., Ohta, M., Kanai, F., Jazag, A., Ijichi, H., Tanaka, Y., Washida, M., Morikane, K., Fukushima, Y., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3833 · Cited by 185

Matrix Metalloproteinases Shape the Tumor Microenvironment in Cancer Progression

Niland, S., Riscanevo, A. X., & Eble, J. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010146 · Cited by 546

Ion Channels in Cancer: Are Cancer Hallmarks Oncochannelopathies?

Prevarskaya, N. B., Skryma, R. N., & Шуба, Я. М. (2018) · Physiological Reviews · doi:10.1152/physrev.00044.2016 · Cited by 505

Feeling Stress: The Mechanics of Cancer Progression and Aggression

Northcott, J. M., Dean, I. S., Mouw, J. K., & Weaver, V. M. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00017 · Cited by 423

Piezo Proteins: Regulators of Mechanosensation and Other Cellular Processes

Bagriantsev, S. N., Gracheva, E. O., & Gallagher, P. G. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.r114.612697 · Cited by 249

Force Sensing by Piezo Channels in Cardiovascular Health and Disease

Beech, D. J., & Kalli, A. C. (2019) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.119.313348 · Cited by 242

Roles of mechanosensitive channel Piezo1/2 proteins in skeleton and other tissues

Qin, L., He, T., Chen, S., Yang, D., Yi, W., Cao, H., & Xiao, G. (2021) · Bone Research · doi:10.1038/s41413-021-00168-8 · Cited by 251

How cells channel their stress: Interplay between Piezo1 and the cytoskeleton

Nourse, J. L., & Pathak, M. M. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.06.018 · Cited by 241

Piezo channels: from structure to function

Volkers, L., Mechioukhi, Y., & Coste, B. (2014) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-014-1578-z · Cited by 223

Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers

Ellefsen, K. L., Holt, J. R., Chang, A. C., Nourse, J. L., Arulmoli, J., Mekhdjian, A. H., Abuwarda, H., Tombola, F., Flanagan, L. A., Dunn, A. R., et al. (2019) · Communications Biology · doi:10.1038/s42003-019-0514-3 · Cited by 217

YAP signaling induces PIEZO1 to promote oral squamous cell carcinoma cell proliferation

Hasegawa, K., Fujii, S., Matsumoto, S., Tajiri, Y., Kikuchi, A., & Kiyoshima, T. (2020) · The Journal of Pathology · doi:10.1002/path.5553 · Cited by 200

Piezo1 mediates angiogenesis through activation of MT1-MMP signaling

Kang, H., Hong, Z., Zhong, M., Klomp, J. E., Bayless, K. J., Mehta, D., Karginov, A. V., Hu, G., & Malik, A. B. (2018) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00346.2018 · Cited by 188

Activation of Piezo1 contributes to matrix stiffness‐induced angiogenesis in hepatocellular carcinoma

Li, M., Zhang, X., Wang, M., Wang, Y., Qian, J., Xing, X., Wang, Z., You, Y., Guo, K., Chen, J., et al. (2022) · Cancer Communications · doi:10.1002/cac2.12364 · Cited by 181

Mechanical stretch promotes hypertrophic scar formation through mechanically activated cation channel Piezo1

He, J., Fang, B., Shan, S., Xie, Y., Wang, C., Zhang, Y., Zhang, X., & Li, Q. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03481-6 · Cited by 178

Piezo1 forms mechanosensitive ion channels in the human MCF-7 breast cancer cell line

Li, C., Rezania, S., Kammerer, S., Sokolowski, A., DeVaney, T. T. J., Gorischek, A., Jahn, S. W., Hackl, H., Groschner, K., Windpassinger, C., et al. (2015) · Scientific Reports · doi:10.1038/srep08364 · Cited by 169

Mechanosensitive ion channel Piezo1 promotes prostate cancer development through the activation of the Akt/mTOR pathway and acceleration of cell cycle

Yu, H., Liu, C., Zhang, D., Men, H., Huo, L., Geng, Q., Wang, S., Gao, Y., Zhang, W., Zhang, Y., et al. (2019) · International Journal of Oncology · doi:10.3892/ijo.2019.4839 · Cited by 143

Piezo1 regulates calcium oscillations and cytokine release from astrocytes

Velasco‐Estevez, M., Rolle, S. O., Mampay, M., Dev, K. K., & Sheridan, G. K. (2019) · Glia · doi:10.1002/glia.23709 · Cited by 144

Genetic Diseases of PIEZO1 and PIEZO2 Dysfunction

Alper, S. L. (2017) · Current topics in membranes · doi:10.1016/bs.ctm.2017.01.001 · Cited by 137

Piezo1 channels restrain regulatory T cells but are dispensable for effector CD4 + T cell responses

Jairaman, A., Othy, S., Dynes, J. L., Yeromin, A. V., Zavala, A., Greenberg, M. L., Nourse, J. L., Holt, J. R., Cahalan, S. M., Marangoni, F., et al. (2021) · Science Advances · doi:10.1126/sciadv.abg5859 · Cited by 133

Mechanosensitive ion channels push cancer progression

Pethő, Z., Najder, K., Bulk, E., & Schwab, A. (2019) · Cell Calcium · doi:10.1016/j.ceca.2019.03.007 · Cited by 125

Cell Extrusion: A Stress-Responsive Force for Good or Evil in Epithelial Homeostasis

Ohsawa, S., Vaughen, J. P., & Igaki, T. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.01.009 · Cited by 124

Piezo-Type Mechanosensitive Ion Channel Component 1 (Piezo1): A Promising Therapeutic Target and Its Modulators: Miniperspective

Tang, H., Zeng, R., He, E., Zhang, I., Ding, C., & Zhang, A. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00085 · Cited by 120

The function of Piezo1 in colon cancer metastasis and its potential regulatory mechanism

Sun, Y., Li, M., Liu, G., Zhang, X., Zhi, L., Zhao, J., & Wang, G. (2020) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-020-03179-w · Cited by 120

PIEZO1 functions as a potential oncogene by promoting cell proliferation and migration in gastric carcinogenesis

Zhang, J., Zhou, Y., Huang, T., Wu, F., Liu, L., Kwan, J. S. H., Cheng, A. S. L., Yu, J. Q., To, K. F., & Kang, W. (2018) · Molecular Carcinogenesis · doi:10.1002/mc.22831 · Cited by 117

Chemical activation of the Piezo1 channel drives mesenchymal stem cell migration via inducing ATP release and activation of P2 receptor purinergic signaling

Mousawi, F., Peng, H., Li, J., Ponnambalam, S., Roger, S., Zhao, H., Yang, X., & Jiang, L. (2019) · Stem Cells · doi:10.1002/stem.3114 · Cited by 112

Mechanosensitive Piezo Channels in Cancer: Focus on altered Calcium Signaling in Cancer Cells and in Tumor Progression

Felice, D. D., & Alaimo, A. (2020) · Cancers · doi:10.3390/cancers12071780 · Cited by 117

Astrocytes in the optic nerve head express putative mechanosensitive channels.

Choi, H. J., Sun, D., & Jakobs, T. (2015) · PubMed Central · Cited by 107

Piezo1 impairs hepatocellular tumor growth via deregulation of the MAPK-mediated YAP signaling pathway

Liu, S., Xu, X., Fang, Z., Ning, Y., Deng, B., Pan, X., He, Y., Yang, Z., Huang, K., & Li, J. (2021) · Cell Calcium · doi:10.1016/j.ceca.2021.102367 · Cited by 104

H. pylori ‐induced NF‐κB‐PIEZO1‐YAP1‐CTGF axis drives gastric cancer progression and cancer‐associated fibroblast‐mediated tumour microenvironment remodelling

Chen, B., Liu, X., Yu, P., Xie, F., Kwan, J. S. H., Chan, W. N., Fang, C., Zhang, J., Cheung, A. H. K., Chow, C., et al. (2023) · Clinical and Translational Medicine · doi:10.1002/ctm2.1481 · Cited by 95

Mechanosensitive Piezo Channels in the Gastrointestinal Tract

Alcaino, C., Farrugia, G., & Beyder, A. (2017) · Current topics in membranes · doi:10.1016/bs.ctm.2016.11.003 · Cited by 89

Channeling the Force: Piezo1 Mechanotransduction in Cancer Metastasis

Dombroski, J. A., Hope, J. M., Sarna, N. S., & King, M. R. (2021) · Cells · doi:10.3390/cells10112815 · Cited by 94

Piezo type mechanosensitive ion channel component 1 facilitates gastric cancer omentum metastasis

Wang, X., Cheng, G., Miao, Y., Qiu, F., Bai, L.-G., Gao, Z., Huang, Y., Dong, L., Niu, X., Wang, X., et al. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16217 · Cited by 86

Piezo1 and its inhibitors: Overview and perspectives

Thien, N. D., Hai-Nam, N., Anh, D. T., & Baecker, D. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116502 · Cited by 85

Loss of stretch-activated channels, PIEZOs, accelerates non-small cell lung cancer progression and cell migration

Huang, Z., Sun, Z., Zhang, X., Niu, K., Wang, Y., Zheng, J., Li, H., & Liu, Y. (2019) · Bioscience Reports · doi:10.1042/bsr20181679 · Cited by 82

Mechanosensitive ion channels in cell migration

Coutiño, B. C., & Mayor, R. (2021) · Cells and Development · doi:10.1016/j.cdev.2021.203683 · Cited by 89

Piezo-type mechanosensitive ion channel component 1 (Piezo1) in human cancer

Yu, J., & Liao, H.-Y. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111692 · Cited by 81

Physiology and Pathophysiology of Mechanically Activated PIEZO Channels

Syeda, R. (2021) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-093020-120939 · Cited by 72

In Touch With the Mechanosensitive Piezo Channels

Geng, J., Zhao, Q., Zhang, T., & Xiao, B. (2017) · Current topics in membranes · doi:10.1016/bs.ctm.2016.11.006 · Cited by 68

Adenosine Triphosphate Release and P2 Receptor Signaling in Piezo1 Channel-Dependent Mechanoregulation

Wei, L., Mousawi, F., Li, D., Roger, S., Li, J., Yang, X., & Jiang, L. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01304 · Cited by 68

Mechanosensitive channel Piezo1 induces cell apoptosis in pancreatic cancer by ultrasound with microbubbles

Song, Y. H., Chen, J., Zhang, C., Lei, X., Li, Q., Liu, Y., Zhang, C., Li, S., & Huang, P. (2022) · iScience · doi:10.1016/j.isci.2022.103733 · Cited by 61

The increased expression of Piezo1 and Piezo2 ion channels in human and mouse bladder carcinoma

Etem, E. Ö., Ceylan, G. G., Özaydın, S., Ceylan, C., Özercan, İ. H., & Kuloğlu, T. (2018) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/71080 · Cited by 62

Agonist-induced Piezo1 activation suppresses migration of transformed fibroblasts

Chubinskiy-Nadezhdin, V. I., Vasileva, V. Y., Vassilieva, I. O., Sudarikova, A. V., Morachevskaya, E. A., & Negulyaev, Y. A. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.04.139 · Cited by 58

Upregulation of Piezo1 Is a Novel Prognostic Indicator in Glioma Patients

Qu, S., Li, S., & Hu, Z. (2020) · Cancer Management and Research · doi:10.2147/cmar.s251776 · Cited by 55

Trefoil factors: Gastrointestinal-specific proteins associated with gastric cancer

Xiao, P., Ling, H. Y., Lan, G., Liu, J., Hu, H., & Yang, R. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.08.004 · Cited by 53

Piezo1 promoted hepatocellular carcinoma progression and EMT through activating TGF-β signaling by recruiting Rab5c

Li, Y.-M., Xu, C., Sun, B., Zhong, F.-J., Cao, M., & Yang, L.-Y. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02574-2 · Cited by 52

Mechanosensing Piezo channels in gastrointestinal disorders

Swain, S. M., & Liddle, R. A. (2023) · Journal of Clinical Investigation · doi:10.1172/jci171955 · Cited by 53

pH-Channeling in Cancer: How pH-Dependence of Cation Channels Shapes Cancer Pathophysiology

Pethő, Z., Najder, K., Carvalho, T. M. A., McMorrow, R., Todesca, L. M., Rugi, M., Bulk, E., Chan, A. B., Löwik, C. W. G. M., Reshkin, S. J., et al. (2020) · Cancers · doi:10.3390/cancers12092484 · Cited by 54

Piezo1 activation facilitates ovarian cancer metastasis via Hippo/YAP signaling axis

Xiong, Y., Dong, L., Bai, Y., Tang, H., Li, S., Luo, D., Liu, F., Bai, J., Yang, S., & Song, X. (2022) · Channels · doi:10.1080/19336950.2022.2099381 · Cited by 48

Mechanosensitive Ion Channels and Their Role in Cancer Cells

Karska, J., Kowalski, S., Saczko, J., Moisescu, M. G., & Kulbacka, J. (2023) · Membranes · doi:10.3390/membranes13020167 · Cited by 48

Long noncoding antisense RNA FAM83A‐AS1 promotes lung cancer cell progression by increasing FAM83A

Shi, R., Jiao, Z., Yu, A., & Wang, T. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28336 · Cited by 47

Mechanosensor Piezo1 mediates bimodal patterns of intracellular calcium and FAK signaling

Pan, Y., Shi, L. Z., Preece, D., Gomez‐Godinez, V., Yoon, C. W., Lu, S., Carmona, C., Woo, S., Chien, S., Berns, M. W., et al. (2022) · The EMBO Journal · doi:10.15252/embj.2022111799 · Cited by 46

Mechanosensitive Ion Channel PIEZO1 Signaling in the Hall-Marks of Cancer: Structure and Functions

Zhao, F., Zhang, L., Wei, M., Duan, W., Wu, S., & Kasim, V. (2022) · Cancers · doi:10.3390/cancers14194955 · Cited by 44

The Role of the Piezo1 Mechanosensitive Channel in the Musculoskeletal System

Dienes, B., Bazsó, T., Szabó, L. Z., & Csernoch, L. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076513 · Cited by 45

Immunoregulatory Role of the Mechanosensitive Ion Channel Piezo1 in Inflammation and Cancer

Wang, Y., Zhang, Z., Yang, Q., Cao, Y., Dong, Y., Bi, Y., & Liu, G. (2022) · Molecules · doi:10.3390/molecules28010213 · Cited by 37

Mechanosensitive Ion Channels: Their Physiological Importance and Potential Key Role in Cancer

Otero, Á., Blanco-Carlón, P., Navarro-Aguadero, M. Á., Gallardo, M., Martínez‐López, J., & Velasco‐Estevez, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813710 · Cited by 37

Trefoil factor family peptides – friends or foes?

Busch, M. A., & Dünker, N. (2015) · BioMolecular Concepts · doi:10.1515/bmc-2015-0020 · Cited by 35

The interplay between physical cues and mechanosensitive ion channels in cancer metastasis

Bera, K., Kiepas, A., Zhang, Y., Sun, S. X., & Κωνσταντόπουλος, Κ. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.954099 · Cited by 33

Fibrotic Matrix Induces Mesenchymal Transformation of Epithelial Cells in Oral Submucous Fibrosis

Xu, H.-Q., Guo, Z.-X., Yan, J.-F., Wang, S.-Y., Gao, J.-L., Han, X.-X., Qin, W.-P., Lu, W.-C., Gao, C.-H., Zhu, W.-W., et al. (2023) · The American Journal of Pathology · doi:10.1016/j.ajpath.2023.05.014 · Cited by 32

Piezo proteins: incidence and abundance in the enteric nervous system. Is there a link with mechanosensitivity?

Mazzuoli‐Weber, G., Kugler, E. M., Bühler, C. I., Kreutz, F., Demir, İ. E., Ceyhan, O. G., Zeller, F., & Schemann, M. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2926-7 · Cited by 33

Channeling Force in the Brain: Mechanosensitive Ion Channels Choreograph Mechanics and Malignancies

Momin, A., Bahrampour, S., Min, H.-K., Chen, X., Wang, X., Sun, Y., & Huang, X. (2021) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2021.02.006 · Cited by 31

A New Hope in Spinal Degenerative Diseases: Piezo1

Zhu, D., Zhang, G., Guo, X., Wang, Y., Liu, M., & Kang, X. (2021) · BioMed Research International · doi:10.1155/2021/6645193 · Cited by 29

Highly specific and non-invasive imaging of Piezo1-dependent activity across scales using GenEPi

Yaganoglu, S., Kalyviotis, K., Vagena-Pantoula, C., Jülich, D., Gaub, B. M., Welling, M., Lopes, T., Lachowski, D., Tang, S. S., Hernández, A. E. D. R., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40134-y · Cited by 29

The role of mechanosensitive Piezo1 channel in diseases

Song, S., Zhang, H., Wang, X., Chen, W., Cao, W., Zhang, Z., & Shi, C. (2022) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2022.04.006 · Cited by 27

The Janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation

Huang, J., Zhang, K., Du, R., Liu, W., Zhang, H., Tian, T., Wang, Y., Wang, G., & Yin, T. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2022.08.015 · Cited by 26

Piezo channels in the intestinal tract

He, H., Zhou, J., Xu, X., Zhou, P., Zhong, H., & Liu, M. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1356317 · Cited by 25

Store-Operated Ca2+ Entry Contributes to Piezo1-Induced Ca2+ Increase in Human Endometrial Stem Cells

Chubinskiy-Nadezhdin, V. I., Semenova, S. B., Vasileva, V. Y., Shatrova, A. N., Pugovkina, N. A., & Negulyaev, Y. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073763 · Cited by 23

Mechanosensitive Channels in Lung Health and Disease

Migulina, N., Kelley, B., Zhang, E. Y., Pabelick, C. M., Prakash, Y. S., & Vogel, E. R. (2023) · Comprehensive physiology · doi:10.1002/j.2040-4603.2023.tb00284.x · Cited by 21

Piezo1 in Digestive System Function and Dysfunction

He, J., Xie, X., Xiao, Z., Qian, W., Zhang, L., & Hou, X. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612953 · Cited by 21

Piezo Mediates the Mechanosensation and Injury-Repair of Pulpo-Dentinal Complex

Xu, X., Guo, Y. C., Liu, P., Zhang, H., Wang, Y., Li, Z., Mei, Y., Niu, L., & Liu, R. (2023) · International Dental Journal · doi:10.1016/j.identj.2023.07.002 · Cited by 20

High Stretch Associated with Mechanical Ventilation Promotes Piezo1-Mediated Migration of Airway Smooth Muscle Cells

Luo, M., Gu, R., Wang, C., Guo, J., Zhang, X., Ni, K., Liu, L., Pan, Y., Li, J., & Deng, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031748 · Cited by 20

PIEZO2 promotes cell proliferation and metastasis in colon carcinoma through the SLIT2/ROBO1/VEGFC pathway

Shang, H., Xu, A., Yan, H.-C., Xu, D., Zhang, J., & Fang, X. (2023) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/157515 · Cited by 17

Involvement of MicroRNA-1-FAM83A Axis Dysfunction in the Growth and Motility of Lung Cancer Cells

Liu, P.-J., Chen, Y., Tsai, K., Yeah, H.-Y., Yeh, C.-Y., Tu, Y.-T., & Yang, C.-Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228833 · Cited by 17

The increased matrix stiffness caused by LOXL2 activates Piezo1 channels to promote the migration and invasion of cervical cancer cells

Liu, T., Liang, H., Li, Y., Liao, W., Deng, J., Zhang, L., & Shen, F. (2025) · Discover Oncology · doi:10.1007/s12672-025-02456-9 · Cited by 17

Piezo1 regulates actin cytoskeleton remodeling to drive EMT in cervical cancer through the RhoA/ROCK1/PIP2 signaling pathway

Deng, J., Li, Y., Zhang, L., Liao, W., Liu, T., & Shen, F. (2025) · Discover Oncology · doi:10.1007/s12672-025-02474-7 · Cited by 16

Pleiotropic physiological functions of Piezo1 in human body and its effect on malignant behavior of tumors

Zhang, Y., Zou, W., Dou, W., Luo, H., & Ouyang, X. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1377329 · Cited by 16

Increased PIEZO1 Expression Is Associated with Worse Clinical Outcomes in Hormone-Receptor-Negative Breast Cancer Patients

Poole, R. A., Wang, Q., Ray, A., Takabe, K., Opyrchal, M., & Katsuta, E. (2024) · Cancers · doi:10.3390/cancers16040683 · Cited by 15

Roles of Mechanosensitive Channel Piezo1 in Wound Healing and Scar Formation

Rennekampff, H., Tenenhaus, M., Rennekampff, I., & Alharbi, Z. (2024) · Life · doi:10.3390/life14030377 · Cited by 15

The Structural Basis for Sensing by the Piezo1 Protein

Li, W., Gao, N., & Yang, M. (2016) · Current topics in membranes · doi:10.1016/bs.ctm.2016.10.001 · Cited by 14

Role of mechanosensitive channel Piezo1 protein in intestinal inflammation regulation: A potential target

Jiang, Q., Li, Z., Dang, D., Wei, J., & Wu, H. M. (2024) · The FASEB Journal · doi:10.1096/fj.202401323r · Cited by 14

Piezo Family: From Structure to Therapeutic Agents in Cancer

Xu, K., Liu, M., Wang, L., Zhan, G., & He, G. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c03200 · Cited by 12

The Piezo1 ion channel in glaucoma: a new perspective on mechanical stress

Chen, Y., Su, Y., & Wang, F. (2022) · Human Cell · doi:10.1007/s13577-022-00738-w · Cited by 13

Forces Bless You: Mechanosensitive Piezo Channels in Gastrointestinal Physiology and Pathology

Guo, J., Li, L., Chen, F., Fu, M., Cheng, C., Wang, M., Hu, J. X., Pei, L., & Sun, J. (2024) · Biomolecules · doi:10.3390/biom14070804 · Cited by 11

Genetics and gastric cancer susceptibility.

Lü, Y., Lu, F. Y., Sha, Z., Sun, S., Li, L., & Liu, L. (2015) · Europe PMC (PubMed Central) · Cited by 11

Mechanosensitive calcium ion channels Piezo1: A therapeutic target in liver disease

Liu, J., Wang, X., He, F., Chen, X., & Yi, X. (2025) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2025.102695 · Cited by 10

The mechanism and potential therapeutic target of piezo channels in pain

Xu, Y., Wang, Y., Mei, S., Hu, J., Wu, L., Xu, L., Bao, L., & Fang, X. (2024) · Frontiers in Pain Research · doi:10.3389/fpain.2024.1452389 · Cited by 10

Myosin-II Mediated Traction Forces Evoke Localized Piezo1 Ca2+ Flickers

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Mechanosensitive Piezo1 channel in rat epididymal epithelial cells promotes transepithelial K+ secretion

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