Caspase 3 Inactivation Protects Against Hepatic Cell Death and Ameliorates Fibrogenesis in a Diet-Induced NASH Model

Design and validation of a histological scoring system for nonalcoholic fatty liver disease†

Kleiner, D. E., Brunt, E. M., Van Natta, M., Behling, C., Contos, M. J., Cummings, O. W., Ferrell, L. D., Liu, Y., Torbenson, M. S., Unalp‐Arida, A., et al. (2005) · Hepatology · doi:10.1002/hep.20701 · Cited by 10,791 · see citing works

Nonalcoholic Fatty Liver Disease

Angulo, P. (2002) · New England Journal of Medicine · doi:10.1056/nejmra011775 · Cited by 5,228 · see citing works

Prevalence of Hepatic Steatosis in An Urban Population in the United States: Impact of Ethnicity

Browning, J. D., Szczepaniak, L. S., Dobbins, R., Nuremberg, P., Horton, J. D., Cohen, J. C., Grundy, S. M., & Hobbs, H. H. (2004) · Hepatology · doi:10.1002/hep.20466 · Cited by 3,664 · see citing works

Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity.

MATTEONI, C., YOUNOSSI, Z., GRAMLICH, T., BOPARAI, N., LIU, Y., & MCCULLOUGH, A. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70506-8 · Cited by 3,345 · see citing works

The Natural History of Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study

Adams, L. A., Lymp, J. F., St. Sauver, J., Sanderson, S. O., Lindor, K. D., Feldstein, A., & Angulo, P. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.04.014 · Cited by 2,890 · see citing works

Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis

Earnshaw, W. C., Martins, L. M., & Kaufmann, S. H. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.383 · Cited by 2,758 · see citing works

Long-term follow-up of patients with NAFLD and elevated liver enzymes

Ekstedt, M., Franzén, L. E., Mathiesen, U. L., Thorelius, L., Holmqvist, M., Bodemar, G., & Kechagias, S. (2006) · Hepatology · doi:10.1002/hep.21327 · Cited by 2,302 · see citing works

Nonalcoholic fatty liver disease

Adams, L. A. (2005) · Canadian Medical Association Journal · doi:10.1503/cmaj.045232 · Cited by 1,652 · see citing works

Prevalence of Fatty Liver in Children and Adolescents

Schwimmer, J. B., Deutsch, R., Kahen, T., Lavine, J. E., Stanley, C. R., & Behling, C. A. (2006) · PEDIATRICS · doi:10.1542/peds.2006-1212 · Cited by 1,477 · see citing works

Caspases in apoptosis and beyond

Li, J., & Yuan, J. (2008) · Oncogene · doi:10.1038/onc.2008.297 · Cited by 1,090 · see citing works

Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis

Feldstein, A. E., Canbay, A., Angulo, P., Taniai, M., Burgart, L. J., Lindor, K. D., & Gores, G. J. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00907-7 · Cited by 1,085 · see citing works

The protein structures that shape caspase activity, specificity, activation and inhibition

Fuentes‐Prior, P., & Salvesen, G. S. (2004) · Biochemical Journal · doi:10.1042/bj20041142 · Cited by 877 · see citing works

Free fatty acids promote hepatic lipotoxicity by stimulating TNF-α expression via a lysosomal pathway

Feldstein, A. E., Werneburg, N. W., Canbay, A. E., Guicciardi, M. E., Bronk, S. F., Rydzewski, R. M., Burgart, L. J., & Gores, G. J. (2004) · Hepatology · doi:10.1002/hep.20283 · Cited by 833 · see citing works

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changesPreprint

Woo, M., Hakem, R., Soengas, M. S., Duncan, G. S., Shahinian, A., Kägi, D., Hakem, A., McCurrach, M. E., Khoo, W., Kaufman, S. A., et al. (1998) · Genes & Development · doi:10.1101/gad.12.6.806 · Cited by 832 · see citing works

Apoptotic Pathways: Ten Minutes to Dead

Green, D. R. (2005) · Cell · doi:10.1016/j.cell.2005.05.019 · Cited by 826 · see citing works

Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis

Karlmark, K. R., Weiskirchen, R., Zimmermann, H. W., Gassler, N., Ginhoux, F., Weber, C., Merad, M., Luedde, T., Trautwein, C., & Tacke, F. (2009) · Hepatology · doi:10.1002/hep.22950 · Cited by 782 · see citing works

Human Caspases: Activation, Specificity, and Regulation

Pop, C., & Salvesen, G. S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.r800084200 · Cited by 757 · see citing works

In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease

Wieckowska, A., Zein, N. N., Yerian, L. M., López, R., McCullough, A. J., & Feldstein, A. E. (2006) · Hepatology · doi:10.1002/hep.21223 · Cited by 668 · see citing works

Animal Models of Steatosis

Koteish, A. A., & Diehl, A. M. (2001) · Seminars in Liver Disease · doi:10.1055/s-2001-12932 · Cited by 447 · see citing works

CCR1 and CCR5 promote hepatic fibrosis in mice

Seki, E., De Minicis, S., Gwak, G.-Y., Kluwe, J., Inokuchi, S., Bursill, C. A., Llovet, J. M., Brenner, D. A., & Schwabe, R. F. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37444 · Cited by 431 · see citing works

CCR2 promotes hepatic fibrosis in mice #

Seki, E., Minicis, S. D., Inokuchi, S., Taura, K., Miyai, K. N., van Rooijen, N., Schwabe, R. F., & Brenner, D. A. (2009) · Hepatology · doi:10.1002/hep.22952 · Cited by 415 · see citing works

Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal

Alkhouri, N., Dixon, L. J., & Feldstein, A. E. (2009) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.09.32 · Cited by 400 · see citing works

Caspases — An update

Chowdhury, I., Tharakan, B., & Bhat, G. K. (2008) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2008.05.010 · Cited by 374 · see citing works

Adipocyte Apoptosis, a Link between Obesity, Insulin Resistance, and Hepatic Steatosis

Alkhouri, N., Górnicka, A., Berk, M. P., Thapaliya, S., Dixon, L. J., Kashyap, S. R., Schauer, P. R., & Feldstein, A. E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.074252 · Cited by 368 · see citing works

Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice

Feldstein, A. E., Canbay, A. E., Guicciardi, M. E., Higuchi, H., Bronk, S. F., & Gores, G. J. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(03)00460-4 · Cited by 317 · see citing works

Diagnosis of Nonalcoholic Fatty Liver Disease: Invasive versus Noninvasive

Wieckowska, A., & Feldstein, A. E. (2008) · Seminars in Liver Disease · doi:10.1055/s-0028-1091983 · Cited by 299 · see citing works

The pan‐caspase inhibitor Emricasan ( IDN ‐6556) decreases liver injury and fibrosis in a murine model of non‐alcoholic steatohepatitis

Barreyro, F. J., Holod, S., Finocchietto, P. V., Camino, A. M., Aquino, J. B., Avagnina, A., Carreras, M. C., Poderoso, J. J., & Gores, G. J. (2014) · Liver International · doi:10.1111/liv.12570 · Cited by 295 · see citing works

The lysosomal-mitochondrial axis in free fatty acid–induced hepatic lipotoxicity

Li, Z.-Z., Berk, M. P., McIntyre, T. M., Gores, G. J., & Feldstein, A. E. (2008) · Hepatology · doi:10.1002/hep.22183 · Cited by 289 · see citing works

Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis #

Witek, R. P., Stone, C. W., Karaca, G., Syn, W., Pereira, T. A., Agboola, K. M., Omenetti, A., Jung, Y., Teaberry, V. S., Choi, S. S., et al. (2009) · Hepatology · doi:10.1002/hep.23167 · Cited by 252 · see citing works

Apoptosis in alcoholic and nonalcoholic steatohepatitis

Ariel, E. F. (2005) · Frontiers in bioscience · doi:10.2741/1765 · Cited by 203 · see citing works

Caspase-1 as a Central Regulator of High Fat Diet-Induced Non-Alcoholic Steatohepatitis

Dixon, L. J., Flask, C. A., Papouchado, B. G., Feldstein, A. E., & Nagy, L. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056100 · Cited by 188 · see citing works

Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats

Imamura, M., Ogawa, T., Sasaguri, Y., Chayama, K., & Ueno, H. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.10.005 · Cited by 177 · see citing works

Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis

Anstee, Q. M., Concas, D., Kudo, H., Levene, A., Pollard, J. R., Charlton, P., Thomas, H. C., Thursz, M. R., & Goldin, R. D. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.03.016 · Cited by 158 · see citing works

Apoptosis and Cytokines in Non-Alcoholic Steatohepatitis

Syn, W., Choi, S. S., & Diehl, A. M. (2009) · Clinics in Liver Disease · doi:10.1016/j.cld.2009.07.003 · Cited by 124 · see citing works

Nonalcoholic fatty liver disease in the pediatric population: a review

Wieckowska, A., & Feldstein, A. E. (2005) · Current Opinion in Pediatrics · doi:10.1097/01.mop.0000172816.79637.c5 · Cited by 123 · see citing works

Mechanisms and clinical implications of hepatocyte lipoapoptosis

Cazanave, S. C., & Gores, G. J. (2010) · Clinical Lipidology · doi:10.2217/clp.09.85 · Cited by 122 · see citing works

Hepatocyte caspase-8 is an essential modulator of steatohepatitis in rodents

Hatting, M., Zhao, G., Schumacher, F., Sellge, G., Masaoudi, M. A., Gaβler, N., Boekschoten, M. V., Müller, M. M., Liedtke, C., Cubero, F. J., et al. (2013) · Hepatology · doi:10.1002/hep.26271 · Cited by 120 · see citing works

Functional role of intrahepatic monocyte subsets for the progression of liver inflammation and liver fibrosis in vivo

Tacke, F. (2012) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-5-s1-s27 · Cited by 91 · see citing works

Animal models of nonalcoholic fatty liver disease and steatohepatitis

Nanji, A. A. (2004) · Clinics in Liver Disease · doi:10.1016/j.cld.2004.04.002 · Cited by 71 · see citing works

Steatohepatitis and Apoptosis: Therapeutic Implications

Feldstein, A. E., & Gores, G. J. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.40573.x · Cited by 30 · see citing works

Caspases: Structure-Guided Design of Drugs to Control Cell Death

Weber, I. T., Fang, B., & Agniswamy, J. (2008) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955708785909899 · Cited by 15 · see citing works

Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives

Roehlen, N., Crouchet, E., & Baumert, T. F. (2020) · Cells · doi:10.3390/cells9040875 · Cited by 1,237 · see citing works

Mechanisms of Fibrosis Development in Nonalcoholic Steatohepatitis

Schwabe, R. F., Tabas, I., & Pajvani, U. B. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.11.311 · Cited by 671 · see citing works

Apoptosis and necroptosis in the liver: a matter of life and death

Schwabe, R. F., & Luedde, T. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0065-y · Cited by 582 · see citing works

Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease

Mota, M., Banini, B. A., Cazanave, S. C., & Sanyal, A. J. (2016) · Metabolism · doi:10.1016/j.metabol.2016.02.014 · Cited by 570 · see citing works

Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis

Tsurusaki, S., Tsuchiya, Y., Koumura, T., Nakasone, M., Sakamoto, T., Matsuoka, M., Imai, H., Yuet-Yin Kok, C., Okochi, H., Nakano, H., et al. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-1678-y · Cited by 529 · see citing works

Apoptotic cell death in disease—Current understanding of the NCCD 2023

Vitale, I., Pietrocola, F., Guilbaud, E., Aaronson, S. A., Abrams, J., Adam, D., Agostini, M., Agostinis, P., Alnemri, E. S., Altucci, L., et al. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01153-w · Cited by 359 · see citing works

An AMPK–caspase-6 axis controls liver damage in nonalcoholic steatohepatitis

Zhao, P., Sun, X., Chaggan, C., Liao, Z., Wong, K. I., He, F., Singh, S., Loomba, R. S., Karin, M., Witztum, J. L., et al. (2020) · Science · doi:10.1126/science.aay0542 · Cited by 308 · see citing works

Cell Death in Liver Diseases: A Review

Shojaie, L., Iorga, A., & Dara, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249682 · Cited by 299 · see citing works

A randomized, placebo-controlled trial of emricasan in patients with NASH and F1-F3 fibrosis

Harrison, S. A., Goodman, Z., Jabbar, A., Vemulapalli, R., Younes, Z. H., Freilich, B., Sheikh, M. Y., Schattenberg, J. M., Kayali, Z., Zivony, A., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2019.11.024 · Cited by 260 · see citing works

Death Receptor-Mediated Cell Death and Proinflammatory Signaling in Nonalcoholic Steatohepatitis

Hirsova, P., & Gores, G. (2014) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2014.11.005 · Cited by 184 · see citing works

Inflammasomes in liver fibrosis

Alegre, F., Pelegrin, P., & Feldstein, A. (2017) · Seminars in Liver Disease · doi:10.1055/s-0037-1601350 · Cited by 176 · see citing works

Nonalcoholic steatohepatitis: a search for factual animal models

Sanches, S. C. L., Ramalho, L. N. Z., Augusto, M. J., da Silva, D. M., & Ramalho, F. S. (2015) · BioMed Research International · doi:10.1155/2015/574832 · Cited by 174 · see citing works

Randomised clinical trial: emricasan versus placebo significantly decreases ALT and caspase 3/7 activation in subjects with non‐alcoholic fatty liver disease

Shiffman, M. L., Freilich, B. L., Vuppalanchi, R., Watt, K. D. S., Chan, J. L., Spada, A., Hagerty, D. T., & Schiff, E. R. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15030 · Cited by 112 · see citing works

Role of Oxidative Stress in Liver Disorders

Conde de la Rosa, L., Goicoechea, L., Torres, S., Garcia-Ruiz, C., & Fernandez-Checa, J. C. (2022) · Livers · doi:10.3390/livers2040023 · Cited by 107 · see citing works

Baicalin attenuates non-alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, inflammation and fibrosis in mice

Zhang, J., Zhang, H., Deng, X., Zhang, N., Liu, B., Xin, S., Li, G., & Xu, K. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.11.027 · Cited by 106 · see citing works

Questions and controversies: the role of necroptosis in liver disease

Dara, L., Liu, Z., & Kaplowitz, N. (2016) · Cell Death Discovery · doi:10.1038/cddiscovery.2016.89 · Cited by 100 · see citing works

Dietary butylated hydroxytoluene improves lipid metabolism, antioxidant and anti-apoptotic response of largemouth bass (Micropterus salmoides)

Liu, Y. X., Yu, H., Liang, X., Li, N. Y., Wang, X., Li, F. H., Wu, X., Zheng, Y., Xue, M., & Liang, X. (2017) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2017.10.054 · Cited by 98 · see citing works

Treatment of liver fibrosis: Past, current, and future

Zhang, C., Liu, S., & Yang, M. J. (2023) · World Journal of Hepatology · doi:10.4254/wjh.v15.i6.755 · Cited by 97 · see citing works

Cell death in drug-induced liver injury

Iorga, A., & Dara, L. (2019) · Advances in pharmacology · doi:10.1016/bs.apha.2019.01.006 · Cited by 87 · see citing works

Promising Therapy Candidates for Liver Fibrosis

Wang, P., Koyama, Y., Liu, X., Xu, J., Ma, H., Liang, S., Kim, I. H., Brenner, D. A., & Kisseleva, T. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00047 · Cited by 81 · see citing works

Emerging role of ferroptosis in metabolic dysfunction-associated steatotic liver disease: revisiting hepatic lipid peroxidation

Peleman, C., Francque, S., & Berghe, T. V. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105088 · Cited by 86 · see citing works

To die or not to die: death signaling in nonalcoholic fatty liver disease

Akazawa, Y., & Nakao, K. (2018) · Journal of Gastroenterology · doi:10.1007/s00535-018-1451-5 · Cited by 79 · see citing works

Caspases in metabolic disease and their therapeutic potential

Wilson, C. H., & Kumar, S. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0111-x · Cited by 80 · see citing works

Anti-fibrotic treatments for chronic liver diseases: The present and the future

Odagiri, N., Matsubara, T., Sato-Matsubara, M., Fujii, H., Enomoto, M., & Kawada, N. (2020) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2020.0187 · Cited by 63 · see citing works

Liver Bid suppression for treatment of fibrosis associated with non-alcoholic steatohepatitis

Eguchi, A., du Jeu, X. D. M., Johnson, C. D., Andronikou, N., & Feldstein, A. E. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.11.002 · Cited by 57 · see citing works

Cyclooxygenase-2 expression in hepatocytes attenuates non-alcoholic steatohepatitis and liver fibrosis in mice

Motiño, O., Agrá, N., Contreras, R., Domínguez-Moreno, M., García‐Monzón, C., Vargas‐Castrillón, J., Carnovale, C. E., Boscá, L., Casado, M., Mayoral, R., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.06.009 · Cited by 55 · see citing works

Stearoyl-CoA desaturase 1: A potential target for non-alcoholic fatty liver disease?-perspective on emerging experimental evidence

Jeyakumar, S. M., & Vajreswari, A. (2022) · World Journal of Hepatology · doi:10.4254/wjh.v14.i1.168 · Cited by 54 · see citing works

The liver as a central "hub" of the immune system: pathophysiological implications

Ronca, V., Gerussi, A., Collins, P., Parente, A., Oo, Y. H., & Invernizzi, P. (2025) · Physiological Reviews · doi:10.1152/physrev.00004.2023 · Cited by 59 · see citing works

CD1d protects against hepatocyte apoptosis in non-alcoholic steatohepatitis

Lei, Z., Yu, J., Wu, Y. Z., Shen, J., Lin, S., Xue, W., Mao, C., Tang, R., Sun, H., Qi, X., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.10.025 · Cited by 51 · see citing works

Dietary Radix Bupleuri extracts improves hepatic lipid accumulation and immune response of hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀)

Zou, C., Su, N., Wu, J., Xu, M., Sun, Z., Liu, Q., Chen, L., Zhou, Y., Wang, A., & Ye, C. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.02.052 · Cited by 50 · see citing works

Decrease in fat de novo synthesis and chemokine ligand expression in non‐alcoholic fatty liver disease caused by inhibition of mixed lineage kinase domain‐like pseudokinase

Saeed, W., Jun, D., Jang, K., Oh, J.-H., Chae, Y., Lee, J.-S., Koh, D., & Kang, H. (2019) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.14740 · Cited by 50 · see citing works

Impact of intracellular glyceraldehyde-derived advanced glycation end-products on human hepatocyte cell death

Sakasai-Sakai, A., Takata, T., Takino, J.-I., & Takeuchi, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-14711-3 · Cited by 46 · see citing works

Antifibrotic therapies for metabolic dysfunction-associated steatotic liver disease

Schwabe, R. F., Tacke, F., Sugimoto, A., & Friedman, S. L. (2025) · JHEP Reports · doi:10.1016/j.jhepr.2025.101421 · Cited by 50 · see citing works

Nootkatone confers hepatoprotective and anti‐fibrotic actions in a murine model of liver fibrosis by suppressing oxidative stress, inflammation, and apoptosis

Kurdi, A., Hassan, K., Venkataraman, B., & Rajesh, M. (2017) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22017 · Cited by 46 · see citing works

Current investigations for liver fibrosis treatment: between repurposing the FDA-approved drugs and the other emerging approaches

Mohammed, O. S., Attia, H. G., Mohamed, B. M. S. A., Elbaset, M. A., & Fayed, H. M. (2023) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.3389/jpps.2023.11808 · Cited by 46 · see citing works

Protective effects of Phyllanthus emblica against myocardial ischemia-reperfusion injury: the role of PI3-kinase/glycogen synthase kinase 3β/β-catenin pathway

Thirunavukkarasu, M., Selvaraju, V., Tapias, L., Sánchez, J. A., Palesty, J. A., & Maulik, N. (2015) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-015-0426-8 · Cited by 45 · see citing works

Sulforaphane Attenuates Nonalcoholic Fatty Liver Disease by Inhibiting Hepatic Steatosis and Apoptosis

Li, J., Xie, S., & Teng, W. (2021) · Nutrients · doi:10.3390/nu14010076 · Cited by 44 · see citing works

Barley grass juice (Hordeum vulgare L.) inhibits obesity and improves lipid profile in high fat diet-induced rat model

Jhansyrani, T., Dodoala, S., Koganti, B., & Prasad, K. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.111843 · Cited by 43 · see citing works

Hepatocyte and immune cell crosstalk in non-alcoholic fatty liver disease

Carranza-Trejo, A. M., Vetvicka, V., Vištejnová, L., Králíčková, M., & Montufar, E. (2021) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2021.1887730 · Cited by 41 · see citing works

Benzyl isothiocyanate ameliorates high-fat/cholesterol/cholic acid diet-induced nonalcoholic steatohepatitis through inhibiting cholesterol crystal-activated NLRP3 inflammasome in Kupffer cells.

Chen, H.-W., Yen, C., Kuo, L.-L., Lo, C.-W., Huang, C.-S., Chen, C.-C., & Lii, C. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.114941 · Cited by 39 · see citing works

Anti-inflammatory and anti-oxidant effects of aloe vera in rats with non-alcoholic steatohepatitis

Klaikeaw, N., Wongphoom, J., Werawatganon, D., Chayanupatkul, M., & Siriviriyakul, P. (2020) · World Journal of Hepatology · doi:10.4254/wjh.v12.i7.363 · Cited by 38 · see citing works

Targeting AngII/AT1R signaling pathway by perindopril inhibits ongoing liver fibrosis in rat

El‐Rahman, S. S. A., & Fayed, H. M. (2019) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2940 · Cited by 35 · see citing works

Therapeutic inhibition of miR-155 attenuates liver fibrosis via STAT3 signaling

Bala, S., Zhuang, Y., Nagesh, P. T., Catalano, D. E., Zivny, A., Wang, Y., Xie, J., Gao, G., & Szabó, G. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.07.012 · Cited by 34 · see citing works

Immunoregulation by lipids during the development of non-alcoholic steatohepatitis.

Ramadori, P., Kroy, D. C., & Streetz, K. L. (2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2304-3881.2015.01.02 · Cited by 32 · see citing works

Potential therapeutic strategies for MASH: from preclinical to clinical development

Xie, Z., Li, Y., Cheng, L., Huang, Y., Rao, W., Shi, H., & Li, J. (2024) · Life Metabolism · doi:10.1093/lifemeta/loae029 · Cited by 31 · see citing works

HBOA ameliorates CCl4-incuded liver fibrosis through inhibiting TGF-β1/Smads, NF-κB and ERK signaling pathways

Sun, X., Huang, X., Zhu, X., Liu, L., Mo, S., Wang, H., Wei, X., Lu, S., Bai, F., Wang, D., et al. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108901 · Cited by 29 · see citing works

Simultaneous deletion of Bax and Bak is required to prevent apoptosis and interstitial fibrosis in obstructive nephropathy

Jang, H., & Padanilam, B. J. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00170.2015 · Cited by 29 · see citing works

Mechanisms of liver fibrosis in metabolic syndrome

Mehal, W. (2023) · eGastroenterology · doi:10.1136/egastro-2023-100015 · Cited by 28 · see citing works

Regulation of protein O-GlcNAcylation by circadian, metabolic, and cellular signals

Liu, X., Cai, Y. D., & Chiu, J. C. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105616 · Cited by 29 · see citing works

Lentinan Protects against Nonalcoholic Fatty Liver Disease by Reducing Oxidative Stress and Apoptosis via the PPARα Pathway

Du, T., Fang, Q., Zhang, Z., Zhu, C., Xu, R., Chen, G., & Wang, Y. (2022) · Metabolites · doi:10.3390/metabo12010055 · Cited by 28 · see citing works

Dapagliflozin alleviates thioacetamide induced-liver fibrosis in rats via controlling the Nrf2/HO-1 and TLR4/TGF-β1/PI3K signaling pathways

Hassan, N. H., Kamel, G. M., Fayed, H. M., Korany, R. M. S., & Ramadan, A. (2025) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2025.2496661 · Cited by 26 · see citing works

Repositioning gemigliptin for the alleviation of thioacetamide-induced liver fibrosis in rats: Targeting TLR4/MAPK, SIRT1/AMPK/Nrf2, PI3K/AKT/mTOR axis and apoptosis

Almalki, R. S., Gazzaz, M., Miski, S. F., Fayed, H. M., Mohamed, B. M. S. A., Hessin, A. F., Afifi, S. M., Esatbeyoglu, T., Korany, R. M. S., & Elbaset, M. A. (2025) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2025.107192 · Cited by 25 · see citing works

The Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease

Roychowdhury, S., Selvakumar, P. K. C., & Cresci, G. (2018) · Medical Sciences · doi:10.3390/medsci6020047 · Cited by 25 · see citing works

Cell Death in Liver Disease and Liver Surgery

Stoess, C., Choi, Y., Onyuru, J., Friess, H., Hoffman, H. M., Hartmann, D., & Feldstein, A. E. (2024) · Biomedicines · doi:10.3390/biomedicines12030559 · Cited by 25 · see citing works

Sex-Dependent Hepatoprotective Role of IL-22 Receptor Signaling in Non-Alcoholic Fatty Liver Disease-Related Fibrosis

Abdelnabi, M. N., Molina, M. F., Soucy, G., Trinh, V. Q., Bédard, N., Mazouz, S., Jouvet, N., Dion, J., Tran, S., Bilodeau, M., et al. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.08.001 · Cited by 24 · see citing works

Xiaochaihu Decoction reduces hepatic steatosis and improves D-GalN/LPS-induced liver injury in hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀)

Zou, C., Xu, M., Chen, L., Liu, Q., Zhou, Y., Sun, Z., Ye, H., Su, N., Ye, C., & Wang, A. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.05.025 · Cited by 23 · see citing works

Indole-3-carbinol and chlorogenic acid combination modulates gut microbiome and attenuates nonalcoholic steatohepatitis in a murine model

Bacil, G. P., Romualdo, G. R., Rodrigues, J., & Barbisan, L. F. (2023) · Food Research International · doi:10.1016/j.foodres.2023.113513 · Cited by 23 · see citing works

Processes exacerbating apoptosis in non-alcoholic steatohepatitis

Afonso, M. B., Castro, R. E., & Rodrigues, C. M. P. (2019) · Clinical Science · doi:10.1042/cs20190068 · Cited by 23 · see citing works

Effects of high fructose diet on lipid metabolism and the hepatic NF-κB/ SIRT-1 pathway

İskender, H., Yenice, G., Kapakin, K. A. T., Dokumacıoğlu, E., Sevim, Ç., Hayırlı, A., & Altun, S. (2021) · Biotechnic & Histochemistry · doi:10.1080/10520295.2021.1890214 · Cited by 19 · see citing works

SGLT-2 Inhibitors for Non-Alcoholic Fatty Liver Disease: A Review

Xu, R., Lian, D., Xie, Y., Chen, Z., Wang, Y., Mu, L., Wang, Y., & Zhang, B. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2807134 · Cited by 20 · see citing works

Pathogenesis of Nonalcoholic Fatty Liver Disease

Machado, M. V., & Diehl, A. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-37591-7.00025-2 · Cited by 17 · see citing works

The concealed side of caspases: beyond a killer of cells

Abdelghany, L., Sillapachaiyaporn, C., & Zhivotovsky, B. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05495-7 · Cited by 16 · see citing works

Combined quercetin and simvastatin attenuate hepatic fibrosis in rats by modulating SphK1/NLRP3 pathways

Salama, Y., Hassan, H. M., El-Gayar, A. M., & Abdel‐Rahman, N. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122349 · Cited by 15 · see citing works

Emerging mechanisms of non-alcoholic steatohepatitis and novel drug therapies

Hao, C. H. E. N., Zhou, Y., Hao, H., & XIONG, J. (2024) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(24)60690-4 · Cited by 15 · see citing works

Hypoxia-Inducible Factor-2α Promotes Liver Fibrosis by Inducing Hepatocellular Death

Mooli, R. G. R., Mukhi, D., Watt, M., Nagati, V., Reed, S. M., Gandhi, N. K., Oertel, M., & Ramakrishnan, S. K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252313114 · Cited by 13 · see citing works

The Ameliorative Potential of Probiotics and/or Silymarin on Thioacetamide Induced Hepatotoxicity in Rats: Histological and Immunohistochemical Study

Emam, M. A., Farouk, S. M., & Abdo, M. (2018) · International Journal of Morphology · doi:10.4067/s0717-95022018000200661 · Cited by 13 · see citing works

Protective effects of hydrogen inhalation during the warm ischemia phase against lung ischemia-reperfusion injury in rat donors after cardiac death

Zhang, J., Zhou, H., Liu, J., Meng, C., Deng, L., & Li, W. (2019) · Microvascular Research · doi:10.1016/j.mvr.2019.103885 · Cited by 13 · see citing works

A model of alcoholic liver disease based on different hepatotoxics leading to liver cancer

Alarcón‐Sánchez, B. R., Idelfonso-García, O. G., Guerrero‐Escalera, D., Piña‐Vázquez, C., de Anda‐Jáuregui, G., Pérez-Hernández, J. L., de la Garza, M., García‐Sierra, F., Sánchez-Pérez, Y., Baltiérrez‐Hoyos, R., et al. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116209 · Cited by 14 · see citing works

Nicotinamide Adenine Dinucleotide Phosphate Oxidases and Metabolic Dysfunction-Associated Steatotic Liver Disease

Cammisotto, V., Valeriani, E., Pignatelli, P., & Violi, F. (2025) · Antioxidants · doi:10.3390/antiox14010083 · Cited by 12 · see citing works

Impact of Mlkl or Ripk3 deletion on age-associated liver inflammation, metabolic health, and lifespan

Mohammed, S., Ohene-Marfo, P., Jiang, C. Y., Peng, Z., Thadathil, N., Tran, A., Nicklas, E. H., Bhaskaran, S., Wang, D., Selvarani, R., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01553-5 · Cited by 12 · see citing works

Bitter melon extract ameliorates palmitate-induced apoptosis via inhibition of endoplasmic reticulum stress in HepG2 cells and high-fat/high-fructose-diet-induced fatty liver

Lee, H. J., Cui, R., Choi, S., Jeon, J. Y., Kim, H. J., Kim, T. H., KANG, Y. Y., & Lee, K. W. (2018) · Food & Nutrition Research · doi:10.29219/fnr.v62.1319 · Cited by 12 · see citing works

Zoledronic acid prevents the hepatic changes associated with high fat diet in rats; the potential role of mevalonic acid pathway in nonalcoholic steatohepatitis

Mohamed, R. H., Tarek, M., Hamam, G. G., & Ezzat, S. F. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172469 · Cited by 12 · see citing works

Hyoscyamus albus nortropane alkaloids reduce hyperglycemia and hyperinsulinemia induced in HepG2 cells through the regulation of SIRT1/NF-kB/JNK pathway

Kowalczuk, A. P., Bourebaba, N., Kornicka‐Garbowska, K., Turlej, E., Marycz, K., & Bourebaba, L. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00735-w · Cited by 12 · see citing works

Tanshinone IIA Ameliorates Nonalcoholic Steatohepatitis in Mice by Modulating Neutrophil Extracellular Traps and Hepatocyte Apoptosis

Xu, L., Liu, X., Jia, T., Sun, Y., Du, Y., Wei, S., Wang, W., Zhang, Y., Chen, W., & Zhang, S. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/5769350 · Cited by 12 · see citing works

Splenectomy Prior to Experimental Induction of Autoimmune Hepatitis Promotes More Severe Hepatic Inflammation, Production of IL-17 and Apoptosis

Buitrago‐Molina, L. E., Dywicki, J., Noyan, F., Trippler, M., Pietrek, J., Schlué, J., Manns, M. P., Wedemeyer, H. H., Jaeckel, E., & Hardtke‐Wolenski, M. (2021) · Biomedicines · doi:10.3390/biomedicines9010058 · Cited by 12 · see citing works

Life-threatening risk factors contribute to the development of diseases with the highest mortality through the induction of regulated necrotic cell death

Zsuzsa, M., Jenei, V., Mácsik, R., Mezhonova, E., Diyab, S., Csősz, R., Bácsi, A., Mázló, A., & Koncz, G. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07563-7 · Cited by 13 · see citing works

Protective effects of Kangxian ruangan capsule against nonalcoholic fatty liver disease fibrosis in rats induced by MCD diet

Liu, L., Zhou, Y., Dai, D., Xia, H., Zhao, K. F., & Zhang, J. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.06.134 · Cited by 11 · see citing works

Apomorphine Suppresses the Progression of Steatohepatitis by Inhibiting Ferroptosis

Maeda, H., Miura, K., Aizawa, K., Bat-Erdene, O., Sashikawa, M., Noguchi, E., Watanabe, M., Yamada, N., Osaka, H., Morimoto, N., et al. (2024) · Antioxidants · doi:10.3390/antiox13070805 · Cited by 10 · see citing works

Methyl donor ameliorates CCl4-induced liver fibrosis by inhibiting inflammation, and fibrosis through the downregulation of EGFR and DNMT-1 expression

Bishnolia, M., Yadav, P., Singh, S. K., Manhar, N., Rajput, S., Khurana, A., Bhatti, J. S., & Navik, U. (2024) · Food and Chemical Toxicology · doi:10.1016/j.fct.2024.115230 · Cited by 10 · see citing works

Exploring the mechanism of Cassiae semen in regulating lipid metabolism through network pharmacology and experimental validation

Huang, L., Zhu, H., Tang, Y., Luo, Z., Xia, L.-Y., Zhang, C., Wang, Y., Huai, W., Fang, Z., Li, S., et al. (2023) · Bioscience Reports · doi:10.1042/bsr20221375 · Cited by 10 · see citing works

A trans fatty acid substitute enhanced development of liver proliferative lesions induced in mice by feeding a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet

Suzuki‐Kemuriyama, N., Abe, A., Uno, K., Ogawa, S., Watanabe, A., Sano, R., Yuki, M., Miyajima, K., & Nakae, D. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01423-3 · Cited by 9 · see citing works

Mechanisms of Cynarine for treatment of non-alcoholic fatty liver disease based on the integration of network pharmacology, molecular docking and cell experiment

Sun, C.-Y., Yang, L., Zhao, P., Yan, P., Li, J., & Zhao, D. (2022) · Hereditas · doi:10.1186/s41065-022-00256-7 · Cited by 9 · see citing works

Glabridin ameliorates intracellular events caused by palmitic acid and alcohol in mouse hepatocytes and fast food diet and alcohol -induced steatohepatitis and fibrosis in C57BL/6J mice model

Sharma, R. R., Rashid, H., Bhat, A. M., Archoo, S., Gupta, R., & Abdullah, S. T. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.114038 · Cited by 8 · see citing works

The Ways to Die: Cell Death in Liver Pathophysiology

Cao, P., Jaeschke, H., Ni, H., & Ding, W. (2025) · Seminars in Liver Disease · doi:10.1055/a-2576-4332 · Cited by 8 · see citing works

Interleukin-33 / Cyclin D1 imbalance in severe liver steatosis predicts susceptibility to ischemia reperfusion injury

Núñez, K., Frank, A. R., Gonzalez-Rosario, J., Galliano, G. E., Bridle, K. R., Crawford, D. H., Seal, J. B., Abbruscato, F. C., Vashistha, H., Thevenot, P., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216242 · Cited by 8 · see citing works

Human Platelet Rich Plasma Alleviates Liver Fibrosis in Murine Schistosomiasis Mansoni

EL-ASWAD, P. D. S. A. E.-R. B. E.-D. W., & MAHMOUD, M. D. M. A. H. S. F. (2018) · The Medical Journal of Cairo University/The Medical Journal of Cairo University · doi:10.21608/mjcu.2018.61850 · Cited by 8 · see citing works

Cardioprotective potential of sesamol against ischemia/reperfusion injury induced oxidative myocardial damage

Tian, H., & Guo, R. (2017) · Biomedical Research-tokyo · Cited by 8 · see citing works

Cell Death in Drug-Induced Liver Injury

Dara, L., & Kaplowitz, N. (2017) · Springer eBooks · doi:10.1007/978-3-319-53774-0_1 · Cited by 8 · see citing works

Integrated profiling of adiponectin and cytokine signaling pathways in high-fat diet-induced MASLD reveals early markers of disease progression

Johnson, R., Shabalala, S. C., Mabasa, L., Kotzé-Hörstmann, L. M., Sangweni, N. F., Ramharack, P., Sharma, J. R., Pheiffer, C., Arowolo, A., & Gijsen, H. S. (2025) · Scientific Reports · doi:10.1038/s41598-025-02001-2 · Cited by 8 · see citing works

Nano-encapsulated ferulic acid in sesame protein isolate alleviates acrylamide-induced liver toxicity and genotoxicity in rats via oxidative stress and DNA damage modulation

Essa, H. A., Ali, E., El-Hakam, F. E.-Z. A., & Akl, E. M. (2025) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-025-00946-8 · Cited by 7 · see citing works

Mechanistic Biomarkers in Liver Diseases

McGill, M. R., Woolbright, B. L., Weemhoff, J. L., & Jaeschke, H. (2017) · Biomarkers in disease · doi:10.1007/978-94-007-7675-3_5 · Cited by 6 · see citing works

Les mécanismes de mort cellulaire dans la stéatohépatite non alcoolique

Magusto, J., Majdi, A., & Gautheron, J. (2020) · Biologie Aujourd hui · doi:10.1051/jbio/2020002 · Cited by 6 · see citing works

Selenium enriched yeast and Gum Arabic combination attenuate oxidative liver damage via suppression of oxidative stress, inhibition of caspase-3 and pro-inflammatory genes expression in carbon tetrachloride-intoxicated rats

Hamid, M., Abdulrahim, Y., Liu, D., Awad, F. N., Omer, N. A., Khan, A., & Huang, K. (2021) · Bioactive Carbohydrates and Dietary Fibre · doi:10.1016/j.bcdf.2021.100267 · Cited by 6 · see citing works

Efficacy and Safety of Emricasan in Liver Cirrhosis and/or Fibrosis

Li-ya, M., Li, S., Tang, L., & Li, R. (2021) · Clinics · doi:10.6061/clinics/2021/e2409 · Cited by 5 · see citing works

Protective role of Saikosaponin d in d-galactosamine and lipopolysaccharide-induced liver injury in hybrid grouper (Epinephelus lanceolatus♂ × Epinephelus fuscoguttatus♀)

Zou, C., Hu, X., Wu, Y., Zhao, L., Liang, R., Cao, D., Zhou, M., & Lin, L. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.737601 · Cited by 5 · see citing works

Immunohistochemical expression of NRF2 is correlated with the magnitude of inflammation and fibrosis in chronic liver disease

To, K., Okada, K., Watahiki, T., Suzuki, H., Tsuchiya, K., Tokushige, K., Yamamoto, M., Ariizumi, S., & Shoda, J. (2023) · Cancer Medicine · doi:10.1002/cam4.6538 · Cited by 5 · see citing works

Molecular Mechanisms of Lipotoxicity in Nonalcoholic Fatty Liver Disease

Cazanave, S. C., & Sanyal, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-25065-6_5 · Cited by 20 · see citing works

Exploring the Hepatoprotective Effects of Naringin: A Systematic Review and Meta-Analysis of Preclinical Evidence

Fayaz, M., Viswanatha, G. L., Shylaja, H., & Nandakumar, K. (2025) · Planta Medica · doi:10.1055/a-2595-7650 · Cited by 4 · see citing works

Amyloid precursor protein promotes MASH progression by upregulating death receptor 6–mediated hepatocyte apoptosis

Guo, Y., Huang, H., Yang, L., Shen, Q., Liu, Z., Wang, Q., Chen, S., Pan, J., Zhai, H., Li, Y., et al. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108285 · Cited by 4 · see citing works

Gluten worsens non-alcoholic fatty liver disease by affecting lipogenesis and fatty acid oxidation in diet-induced obese apolipoprotein E-deficient mice

Aguilar, E. C., Fernandes‐Braga, W., dos Santos, E. A., Leocádio, P. C. L., Capettini, L. D. S. A., Orellano, L. A. A., Campos, P. P., Lemos, V. S., Soares, F. L. P., Pelaez, J. M. N., et al. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04802-3 · Cited by 4 · see citing works

Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis

Dixon, L. J., Berk, M. P., Thapaliya, S., Papouchado, B. G., & Feldstein, A. E. (2012) · Laboratory Investigation · doi:10.1038/labinvest.2012.45 · Cited by 159 · see citing works

The Role and Regulation of Caspase-2 in Lipoapoptosis

Lindblom, K. (2015) · DukeSpace (Duke University)

Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis

Machado, M. V., Michelotti, G. A., Pereira, T. A., Boursier, J., Krüger, L., Swiderska‐Syn, M., Karaca, G., Xie, G., Guy, C. D., Bohinc, B. N., et al. (2014) · Gut · doi:10.1136/gutjnl-2014-307362 · Cited by 102 · see citing works

Hepatocyte caspase-8 is an essential modulator of steatohepatitis in rodents

Hatting, M., Zhao, G., Schumacher, F., Sellge, G., Masaoudi, M. A., Gaβler, N., Boekschoten, M. V., Müller, M. M., Liedtke, C., Cubero, F. J., et al. (2013) · Hepatology · doi:10.1002/hep.26271 · Cited by 120 · see citing works

A novel function of necroptosis in Non-Alcoholic Steatohepatitis

Gautheron, J., Vucur, M., Reisinger, F., Canbay, A. E., Tacke, F., Trautwein, C., Heikenwälder, M. F., & Luedde, T. (2015) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0034-1397127