Mechanisms of Fibrosis Development in Nonalcoholic Steatohepatitis

Notch Signaling: Cell Fate Control and Signal Integration in Development

Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909 · see citing works

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

Younossi, Z., Anstee, Q. M., Marietti, M., Hardy, T., Henry, L., Eslam, M., George, J., & Bugianesi, E. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.109 · Cited by 5,249 · see citing works

Mechanisms of NAFLD development and therapeutic strategies

Friedman, S. L., Neuschwander-Tetri, B. A., Rinella, M., & Sanyal, A. J. (2018) · Nature Medicine · doi:10.1038/s41591-018-0104-9 · Cited by 4,354 · see citing works

The Extracellular Matrix: Not Just Pretty Fibrils

Hynes, R. O. (2009) · Science · doi:10.1126/science.1176009 · Cited by 3,527 · see citing works

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

Romeo, S., Kozlitina, J., Xing, C., Pertsemlidis, A., Cox, D., Pennacchio, L. A., Boerwinkle, E., Cohen, J. C., & Hobbs, H. H. (2008) · Nature Genetics · doi:10.1038/ng.257 · Cited by 3,416 · see citing works

Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease

Angulo, P., Kleiner, D. E., Dam-Larsen, S., Adams, L. A., Bjornsson, E. S., Charatcharoenwitthaya, P., Mills, P. R., Keach, J. C., Lafferty, H. D., Stahler, A., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.043 · Cited by 2,987 · see citing works

Mechanisms of hepatic stellate cell activation

Tsuchida, T., & Friedman, S. L. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.38 · Cited by 2,909 · see citing works

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

Friedman, S. L. (2008) · Physiological Reviews · doi:10.1152/physrev.00013.2007 · Cited by 2,842 · see citing works

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339 · see citing works

TLR4 enhances TGF-β signaling and hepatic fibrosis

Seki, E., De Minicis, S., Österreicher, C. H., Kluwe, J., Osawa, Y., Brenner, D. A., & Schwabe, R. F. (2007) · Nature Medicine · doi:10.1038/nm1663 · Cited by 1,942 · see citing works

Nonalcoholic Steatohepatitis Is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the United States

Wong, R. J., Aguilar, M. E. F., Cheung, R. C., Perumpail, R. B., Harrison, S. A., Younossi, Z. M., & Ahmed, A. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.11.039 · Cited by 1,821 · see citing works

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

Ramachandran, P., Dobie, R., Wilson-Kanamori, J. R., Dora, E. F., Henderson, B. E. P., Luu, N. T., Portman, J. R., Matchett, K. P., Brice, M., Marwick, J. A., et al. (2019) · Nature · doi:10.1038/s41586-019-1631-3 · Cited by 1,784 · see citing works

Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair

Duffield, J. S., Forbes, S. J., Constandinou, C. M., Clay, S., Partolina, M., Vuthoori, S., Wu, S., Lang, R., & Iredale, J. P. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200522675 · Cited by 1,649 · see citing works

Gut microbial metabolites in obesity, NAFLD and T2DM

Canfora, E. E., Meex, R. C. R., Venema, K., & Blaak, E. E. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0156-z · Cited by 1,493 · see citing works

The gut-liver axis and the intersection with the microbiome

Tripathi, A., Debelius, J., Brenner, D. A., Karin, M., Loomba, R., Schnabl, B., & Knight, R. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0011-z · Cited by 1,480 · see citing works

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

Mederacke, I., Hsu, C. C., Troeger, J. S., Huebener, P., Mu, X., Dapito, D. H., Pradere, J.-P., & Schwabe, R. F. (2013) · Nature Communications · doi:10.1038/ncomms3823 · Cited by 1,443 · see citing works

A lipidomic analysis of nonalcoholic fatty liver disease

Puri, P., Baillie, R. A., Wiest, M. M., Mirshahi, F., Choudhury, J., Cheung, O., Sargeant, C., Contos, M. J., & Sanyal, A. J. (2007) · Hepatology · doi:10.1002/hep.21763 · Cited by 1,338 · see citing works

Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis

Diehl, A. M., & Day, C. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1503519 · Cited by 1,283 · see citing works

Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

Kozlitina, J., Smagris, E., Stender, S., Nordestgaard, B. G., Zhou, H. H., Tybjærg-Hansen, A., Vogt, T. F., Hobbs, H. H., & Cohen, J. C. (2014) · Nature Genetics · doi:10.1038/ng.2901 · Cited by 1,234 · see citing works

Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis

Feldstein, A. E., Canbay, A., Angulo, P., Taniai, M., Burgart, L. J., Lindor, K. D., & Gores, G. J. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00907-7 · Cited by 1,085 · see citing works

Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites†

Neuschwander‐Tetri, B. A. (2010) · Hepatology · doi:10.1002/hep.23719 · Cited by 1,077 · see citing works

Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors

Iredale, J. P., Benyon, R. C., Pickering, J., McCullen, M., Northrop, M., Pawley, S., Hovell, C., & Arthur, M. J. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1018 · Cited by 1,075 · see citing works

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

Fu, S., Yang, L., Li, P., Hofmann, O., Dicker, L. H., Hide, W. A., Lin, X., Watkins, S. M., Ivanov, A. R., & Hotamışlıgil, G. S. (2011) · Nature · doi:10.1038/nature09968 · Cited by 1,024 · see citing works

The role of the gut microbiota in NAFLD

Leung, C., Rivera, L., Furness, J. B., & Angus, P. W. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.85 · Cited by 1,020 · see citing works

Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis

Yamaguchi, K., Yang, L., McCall, S. J., Huang, J., Yu, X. X., Pandey, S., Bhanot, S., Monia, B. P., Li, Y.-X., & Diehl, A. M. (2007) · Hepatology · doi:10.1002/hep.21655 · Cited by 1,019 · see citing works

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

Ramachandran, P., Pellicoro, A., Vernon, M. A., Boulter, L., Aucott, R. L., Ali, A., Hartland, S. N., Snowdon, V. K., Cappon, A., Gordon-Walker, T. T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119964109 · Cited by 1,001 · see citing works

Hepatic inflammation and fibrosis: Functional links and key pathways

Seki, E., & Schwabe, R. F. (2015) · Hepatology · doi:10.1002/hep.27332 · Cited by 972 · see citing works

The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Kazankov, K., Jørgensen, S. M. D., Thomsen, K. L., Møller, H. J., Vilstrup, H., George, J., Schuppan, D., & Grønbæk, H. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0082-x · Cited by 941 · see citing works

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

Henderson, N. C., Arnold, T. D., Katamura, Y., Giacomini, M. M., Rodriguez, J. D., McCarty, J. H., Pellicoro, A., Raschperger, E., Betsholtz, C., Ruminski, P. G., et al. (2013) · Nature Medicine · doi:10.1038/nm.3282 · Cited by 866 · see citing works

Hepatic lipocytes: the principal collagen-producing cells of normal rat liver.

Friedman, S. L., Roll, F. J., Boyles, J., & Bissell, D. M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.24.8681 · Cited by 859 · see citing works

Hippo Pathway Activity Influences Liver Cell Fate

Yimlamai, D., Christodoulou, C., Galli, G. G., Yanger, K., Pepe-Mooney, B., Gurung, B., Shrestha, K., Cahan, P., Stanger, B. Z., & Camargo, F. D. (2014) · Cell · doi:10.1016/j.cell.2014.03.060 · Cited by 857 · see citing works

Fibrosis severity as a determinant of cause-specific mortality in patients with advanced nonalcoholic fatty liver disease: a multi-national cohort study

Vilar-Gomez, E., Calzadilla-Bertot, L., Wai-Sun Wong, V., Castellanos, M., Aller-de la Fuente, R., Metwally, M., Eslam, M., Gonzalez-Fabian, L., Alvarez-Quiñones Sanz, M., Conde-Martin, A. F., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.04.034 · Cited by 806 · see citing works

Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

Xiong, X., Kuang, H., Ansari, S., Liu, T., Gong, J., Wang, S., Zhao, X.-Y., Ji, Y., Li, C., Guo, L., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.07.028 · Cited by 784 · see citing works

Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis

Karlmark, K. R., Weiskirchen, R., Zimmermann, H. W., Gassler, N., Ginhoux, F., Weber, C., Merad, M., Luedde, T., Trautwein, C., & Tacke, F. (2009) · Hepatology · doi:10.1002/hep.22950 · Cited by 782 · see citing works

Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance

Luedde, T., Kaplowitz, N., & Schwabe, R. F. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.07.018 · Cited by 760 · see citing works

The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer

Affo, S., Yu, L.-X., & Schwabe, R. F. (2017) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100322 · Cited by 757 · see citing works

Hepatocyte growth factor/ <i>c-met</i> signaling pathway is required for efficient liver regeneration and repair

Huh, C.-G., Factor, V. M., Sánchez, A., Uchida, K., Conner, E. A., & Thorgeirsson, S. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306068101 · Cited by 750 · see citing works

Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

Miura, K., Kodama, Y., Inokuchi, S., Schnabl, B., Aoyama, T., Ohnishi, H., Olefsky, J. M., Brenner, D. A., & Seki, E. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.03.052 · Cited by 741 · see citing works

Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice

Meng, F., Wang, K., Aoyama, T., Grivennikov, S. I., Paik, Y., Scholten, D., Cong, M., Iwaisako, K., Liu, X., Zhang, M., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.05.049 · Cited by 711 · see citing works

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

Wolf, M. J., Adili, A., Piotrowitz, K., Abdullah, Z., Boege, Y., Stemmer, K., Ringelhan, M., Simonavicius, N., Egger, M., Wohlleber, D., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.003 · Cited by 678 · see citing works

A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis

Friedman, S. L., Ratziu, V., Harrison, S. A., Abdelmalek, M. F., Aithal, G. P., Caballeria, J., Francque, S., Farrell, G., Kowdley, K. V., Craxi, A., et al. (2018) · Hepatology · doi:10.1002/hep.29477 · Cited by 671 · see citing works

The extracellular matrix: an active or passive player in fibrosis?

Wight, T. N., & Potter‐Perigo, S. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00132.2011 · Cited by 669 · see citing works

Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

Yecies, J. L., Zhang, H., Menon, S., Liu, S., Yecies, D. W., Lipovsky, A. I., Görgün, C. Z., Kwiatkowski, D. J., Hotamışlıgil, G. S., Lee, C., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.002 · Cited by 662 · see citing works

The gut microbiome and liver cancer: mechanisms and clinical translation

Yu, L.-X., & Schwabe, R. F. (2017) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/nrgastro.2017.72 · Cited by 634 · see citing works

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice

Pradere, J.-P., Kluwe, J., De Minicis, S., Jiao, J.-J., Gwak, G.-Y., Dapito, D. H., Jang, M.-K., Guenther, N. D., Mederacke, I., Friedman, R., et al. (2013) · Hepatology · doi:10.1002/hep.26429 · Cited by 613 · see citing works

Natural Killer Cells Ameliorate Liver Fibrosis by Killing Activated Stellate Cells in NKG2D-Dependent and Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Dependent Manners

Radaeva, S., Sun, R., Jaruga, B., Nguyen, V. T., Tian, Z., & Gao, B. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.10.055 · Cited by 610 · see citing works

Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis

Marı́, M., Caballero, F. G., Colell, A., Morales, A., Caballería, J., Fernandez, A., Enrich, C., Fernández-Checa, J. C., & García‐Ruiz, C. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.07.006 · Cited by 605 · see citing works

Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease

Puri, P., Mirshahi, F., Cheung, O., Natarajan, R., Maher, J. W., Kellum, J. M., & Sanyal, A. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.10.039 · Cited by 596 · see citing works

Apoptosis and necroptosis in the liver: a matter of life and death

Schwabe, R. F., & Luedde, T. (2018) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-018-0065-y · Cited by 582 · see citing works

NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis

Bataller, R. A., Schwabe, R. F., Choi, Y. H., Yang, L., Paik, Y. H., Lindquist, J. N., Qian, T., Schoonhoven, R., Hagedorn, C. H., Lemasters, J. J., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18212 · Cited by 566 · see citing works

Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis

Krenkel, O., Puengel, T., Govaere, O., Abdallah, A. T., Mossanen, J. C., Kohlhepp, M., Liepelt, A., Lefebvre, E., Luedde, T., Hellerbrand, C., et al. (2018) · Hepatology · doi:10.1002/hep.29544 · Cited by 557 · see citing works

Nuclear Trapping of the Forkhead Transcription Factor FoxO1 via Sirt-dependent Deacetylation Promotes Expression of Glucogenetic Genes*

Frescas, D., Valenti, L. N., & Accili, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412357200 · Cited by 554 · see citing works

Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis

Argo, C. K., Northup, P. G., Al‐Osaimi, A. M. S., & Caldwell, S. H. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.03.019 · Cited by 551 · see citing works

The role of the microbiome in NAFLD and NASH

Kolodziejczyk, A. A., Zheng, D., Shibolet, O., & Elinav, E. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201809302 · Cited by 523 · see citing works

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

Huang, W., Metlakunta, A., Dedousis, N., Zhang, P., Sipula, I., Dube, J. J., Scott, D. K., & O'Doherty, R. M. (2010) · Diabetes · doi:10.2337/db09-0016 · Cited by 520 · see citing works

Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

Troeger, J. S., Mederacke, I., Gwak, G., Dapito, D. H., Mu, X., Hsu, C. C., Pradere, J., Friedman, R. A., & Schwabe, R. F. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.036 · Cited by 515 · see citing works

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

Miura, K., Yang, L., van Rooijen, N., Ohnishi, H., & Seki, E. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00365.2011 · Cited by 503 · see citing works

A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury

Dal-Secco, D., Wang, J., Zeng, Z., Kołaczkowska, E., Wong, C. H. Y., Petri, B., Ransohoff, R. M., Charo, I. F., Jenne, C. N., & Kubes, P. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20141539 · Cited by 453 · see citing works

Kupffer Cells Promote Hepatic Steatosis Via Interleukin-1β–Dependent Suppression of Peroxisome Proliferator-Activated Receptor α Activity

Stienstra, R., Saudale, F., Duval, C., Keshtkar, S., Groener, J. E. M., van Rooijen, N., Staels, B., Kersten, S., & Müller, M. (2010) · Hepatology · doi:10.1002/hep.23337 · Cited by 452 · see citing works

Gene Expression Profiles During Hepatic Stellate Cell Activation in Culture and In Vivo

Minicis, S. D., Seki, E., Uchinami, H., Kluwe, J., Zhang, Y., Brenner, D. A., & Schwabe, R. F. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.033 · Cited by 425 · see citing works

Single-cell transcriptomics uncovers zonation of function in the mesenchyme during liver fibrosis

Dobie, R., Wilson-Kanamori, J. R., Henderson, B. E. P., Smith, J. R., Matchett, K. P., Portman, J. R., Wallenborg, K., Picelli, S., Zagorska, A., Pendem, S. V., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.024 · Cited by 420 · see citing works

Apoptotic Body Engulfment by a Human Stellate Cell Line Is Profibrogenic

Canbay, A., Taimr, P., Torok, N., Higuchi, H., Friedman, S., & Gores, G. J. (2003) · Laboratory Investigation · doi:10.1097/01.lab.0000069036.63405.5c · Cited by 417 · see citing works

Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis

Wang, X., Zheng, Z., Caviglia, J. M., Corey, K. E., Herfel, T. M., Cai, B., Masia, R., Chung, R. T., Lefkowitch, J. H., Schwabe, R. F., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.016 · Cited by 413 · see citing works

Role of Differentiation of Liver Sinusoidal Endothelial Cells in Progression and Regression of Hepatic Fibrosis in Rats

Xie, G., Wang, X., Wang, L., Wang, L., Atkinson, R. D., Kanel, G. C., Gaarde, W. A., & DeLeve, L. D. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.12.017 · Cited by 410 · see citing works

The Hippo pathway effector YAP controls mouse hepatic stellate cell activation

Mannaerts, I., Leite, S. B., Verhulst, S., Claerhout, S., Eysackers, N., Thoen, L. F. R., Hoorens, A., Reynaert, H., Halder, G., & van Grunsven, L. A. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.04.011 · Cited by 410 · see citing works

Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence

DeLeve, L. D., Wang, X., & Guo, Y. (2008) · Hepatology · doi:10.1002/hep.22351 · Cited by 408 · see citing works

Progression of fibrosis in chronic hepatitis C

Ghany, M. G., Kleiner, D. E., Alter, H. J., Doo, E. C., Khokar, F., Promrat, K., Herion, D. W., Park, Y., Liang, T. J., & Hoofnagle, J. H. (2003) · Gastroenterology · doi:10.1053/gast.2003.50018 · Cited by 402 · see citing works

Hepatic Lipid Partitioning and Liver Damage in Nonalcoholic Fatty Liver Disease

Li, Z.-Z., Berk, M. P., McIntyre, T. M., & Feldstein, A. E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807616200 · Cited by 401 · see citing works

Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease

Hernández‐Álvarez, M. I., Sebastián, D., Vives, S., Ivanova, S., Bartoccioni, P., Kakimoto, P. A., Plana, N., Veiga, S. R., Hernandez, V. A., Vasconcelos, N., et al. (2019) · Cell · doi:10.1016/j.cell.2019.04.010 · Cited by 400 · see citing works

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Malehmir, M., Pfister, D., Gallage, S., Szydlowska, M., Inverso, D., Kotsiliti, E., Leone, V., Peiseler, M., Surewaard, B. G. J., Rath, D., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0379-5 · Cited by 398 · see citing works

Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology

Morioka, S., Maueröder, C., & Ravichandran, K. S. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.018 · Cited by 391 · see citing works

Regression of Liver Fibrosis

Iredale, J. P., & Campana, L. (2017) · Seminars in Liver Disease · doi:10.1055/s-0036-1597816 · Cited by 382 · see citing works

A lipase-independent pathway of lipid release and immune modulation by adipocytes

Flaherty, S. E., Grijalva, A., Xu, X., Ables, E. V., Nomani, A., & Ferrante, A. W. (2019) · Science · doi:10.1126/science.aaw2586 · Cited by 378 · see citing works

Low frequency of cirrhosis in a hepatitis C (genotype 1b) single-source outbreak in germany: A 20-year multicenter study

Wiese, M., Berr, F., Lafrenz, M., Porst, H., & Oesen, U. (2000) · Hepatology · doi:10.1053/jhep.2000.8169 · Cited by 349 · see citing works

Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function

Thomas, J. A., Pope, C., Wojtacha, D., Robson, A. J., Gordon-Walker, T. T., Hartland, S., Ramachandran, P., Van Deemter, M., Hume, D. A., Iredale, J. P., et al. (2011) · Hepatology · doi:10.1002/hep.24315 · Cited by 346 · see citing works

Resolving the paradox of hepatic insulin resistance

Santoleri, D., & Titchenell, P. M. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.10.016 · Cited by 336 · see citing works

ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P

Kim, J. Y., Garcia-Carbonell, R., Yamachika, S., Zhao, P., Dhar, D., Loomba, R., Kaufman, R. J., Saltiel, A. R., & Karin, M. (2018) · Cell · doi:10.1016/j.cell.2018.08.020 · Cited by 333 · see citing works

Antifibrotic effects of the dual CCR2/CCR5 antagonist cenicriviroc in animal models of liver and kidney fibrosis

Lefebvre, E., Moyle, G., Reshef, R., Richman, L. P., Thompson, M., Hong, F., Chou, H.-L., Hashiguchi, T., Plato, C., Poulin, D., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0158156 · Cited by 323 · see citing works

Hepatic Gene Expression Profiles Differentiate Presymptomatic Patients With Mild Versus Severe Nonalcoholic Fatty Liver Disease

Moylan, C. A., Pang, H., Dellinger, A. E., Suzuki, A., Garrett, M. E., Guy, C. D., Murphy, S. K., Ashley‐Koch, A. E., Choi, S. S., Michelotti, G. A., et al. (2013) · Hepatology · doi:10.1002/hep.26661 · Cited by 316 · see citing works

A positive feedback loop between RIP3 and JNK controls non‐alcoholic steatohepatitis

Gautheron, J., Vucur, M., Reisinger, F., Cardenas, D. V., Roderburg, C., Koppe, C., Kreggenwinkel, K., Schneider, A. T., Bartneck, M., Neumann, U. P., et al. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201403856 · Cited by 314 · see citing works

Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy

Pak, E., & Segal, R. A. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.07.026 · Cited by 302 · see citing works

Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors

Tanimizu, N., & Miyajima, A. (2004) · Journal of Cell Science · doi:10.1242/jcs.01169 · Cited by 290 · see citing works

Gastric Bypass Surgery Improves Metabolic and Hepatic Abnormalities Associated With Nonalcoholic Fatty Liver Disease

Klein, S., Mittendorfer, B., Eagon, J. C., Patterson, B. W., Grant, L. M., Feirt, N. M., Seki, E., Brenner, D. A., Korenblat, K., & McCrea, J. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.01.042 · Cited by 288 · see citing works

Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo

Zhan, S.-S., Jiang, J. X., Wu, J., Halsted, C., Friedman, S. L., Zern, M. A., & Torok, N. J. (2006) · Hepatology · doi:10.1002/hep.21093 · Cited by 284 · see citing works

Macrophages in obesity and non-alcoholic fatty liver disease: crosstalk with metabolism

Lefere, S., & Tacke, F. (2019) · JHEP Reports · doi:10.1016/j.jhepr.2019.02.004 · Cited by 278 · see citing works

Attenuated liver fibrosis in the absence of B cells

Novobrantseva, T. I. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24798 · Cited by 277 · see citing works

Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis

Syn, W.-K., Choi, S. S., Liaskou, E., Karaca, G. F., Agboola, K. M., Oo, Y. H., Mi, Z., Pereira, T. A., Zdanowicz, M., Malladi, P., et al. (2011) · Hepatology · doi:10.1002/hep.23998 · Cited by 275 · see citing works

Anti-Fibrotic Activity of NK Cells in Experimental Liver Injury Through Killing of Activated HSC

Melhem, A., Muhanna, N., Bishara, A., Alvarez, C. E., Ilan, Y., Bishara, T., Horani, A., Nassar, M., Friedman, S. L., & Safadi, R. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2005.12.025 · Cited by 270 · see citing works

NKT-Associated Hedgehog and Osteopontin Drive Fibrogenesis in Non-Alcoholic Fatty Liver Disease

Syn, W.-K., Agboola, K. M., Swiderska, M., Michelotti, G. A., Liaskou, E., Pang, H., Xie, G., Philips, G., Chan, I. S., Karaca, G. F., et al. (2012) · Gut · doi:10.1136/gutjnl-2011-301857 · Cited by 266 · see citing works

Bariatric surgery improves nonalcoholic fatty liver disease: A contemporary systematic review and meta-analysis

Fakhry, T. K., Mhaskar, R., Schwitalla, T., Muradova, E., Gonzalvo, J. P., & Murr, M. M. (2019) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2018.12.002 · Cited by 259 · see citing works

Hepatic cholesterol crystals and crown-like structures distinguish NASH from simple steatosis

Ioannou, G. N., Haigh, W. G., Thorning, D., & Savard, C. E. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m034876 · Cited by 256 · see citing works

Pivotal role of liver sinusoidal endothelial cells in NAFLD/NASH progression

Miyao, M., Kotani, H., Ishida, T., Kawai, C., Manabe, S., Abiru, H., & Tamaki, K. (2015) · Laboratory Investigation · doi:10.1038/labinvest.2015.95 · Cited by 255 · see citing works

Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis

Zhu, C., Kim, K., Wang, X., Bartolome, A., Salomao, M., Dongiovanni, P., Meroni, M., Graham, M. J., Yates, K. P., Diehl, A. M., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat0344 · Cited by 250 · see citing works

Hepatocellular ballooning in NASH

Caldwell, S. H., Ikura, Y., Dias, D., Isomoto, K., Yabu, A., Moskaluk, C. A., Pramoonjago, P., Simmons, W., Scruggs, H., Rosenbaum, N., et al. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.04.031 · Cited by 244 · see citing works

Single Cell RNA Sequencing Identifies Subsets of Hepatic Stellate Cells and Myofibroblasts in Liver Fibrosis

Krenkel, O., Hundertmark, J., Ritz, T., Weiskirchen, R., & Tacke, F. (2019) · Cells · doi:10.3390/cells8050503 · Cited by 241 · see citing works

A High-Cholesterol Diet Exacerbates Liver Fibrosis in Mice via Accumulation of Free Cholesterol in Hepatic Stellate Cells

Teratani, T., Tomita, K., Suzuki, T., Oshikawa, T., Yokoyama, H., Shimamura, K., Tominaga, S., Hiroi, S., Irie, R., Okada, Y., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.09.049 · Cited by 241 · see citing works

Long-term outcome of chronic hepatitis B in Caucasian patients: mortality after 25 years

Fattovich, G., Olivari, N., Pasino, M., D’Onofrio, M., Martone, E., & Donato, F. (2007) · Gut · doi:10.1136/gut.2007.128496 · Cited by 240 · see citing works

PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis

Martin, K., Pritchett, J. P., Llewellyn, J., Mullan, A. F., Athwal, V. S., Dobie, R., Harvey, E., Zeef, L. A. H., Farrow, S. N., Streuli, C. H., et al. (2016) · Nature Communications · doi:10.1038/ncomms12502 · Cited by 220 · see citing works

Unraveling the Mechanobiology of Extracellular Matrix

Viola Vogel, B. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021317-121312 · Cited by 213 · see citing works

Report on the AASLD/EASL joint workshop on clinical trial endpoints in NAFLD

Rinella, M. E., Tacke, F., Sanyal, A. J., & Anstee, Q. M. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.04.019 · Cited by 209 · see citing works

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner

Pajvani, U. B., Shawber, C. J., Samuel, V. T., Birkenfeld, A. L., Shulman, G. I., Kitajewski, J., & Accili, D. (2011) · Nature Medicine · doi:10.1038/nm.2378 · Cited by 203 · see citing works

Safety profile of autologous macrophage therapy for liver cirrhosis

Moroni, F., Dwyer, B. J., Graham, C., Pass, C., Bailey, L., Ritchie, L., Mitchell, D., Glover, A., Laurie, A., Doig, S., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0599-8 · Cited by 202 · see citing works

Increased production of sonic hedgehog by ballooned hepatocytes

Rangwala, F., Guy, C. D., Lu, J., Suzuki, A., Burchette, J. L., Abdelmalek, M. F., Chen, W., & Diehl, A. M. (2011) · The Journal of Pathology · doi:10.1002/path.2888 · Cited by 201 · see citing works

Cholesterol crystallization within hepatocyte lipid droplets and its role in murine NASH

Ioannou, G. N., Subramanian, S., Chait, A., Haigh, W. G., Yeh, M. M., Farrell, G. C., Lee, S. P., & Savard, C. E. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m072454 · Cited by 173 · see citing works

Association of Adipokines with Development and Progression of Nonalcoholic Fatty Liver Disease

Boutari, C., Perakakis, N., & Mantzoros, C. S. (2018) · Endocrinology and Metabolism · doi:10.3803/enm.2018.33.1.33 · Cited by 172 · see citing works

Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability

Pajvani, U. B., Qiang, L., Kangsamaksin, T., Kitajewski, J., Ginsberg, H. N., & Accili, D. (2013) · Nature Medicine · doi:10.1038/nm.3259 · Cited by 168 · see citing works

Magnetic Resonance Imaging Proton Density Fat Fraction Associates With Progression of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

Ajmera, V. H., Park, C. C., Caussy, C., Singh, S., Hernandez, C., Bettencourt, R., Hooker, J. C., Sy, E. Z., Behling, C. A., Xu, R., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.04.014 · Cited by 167 · see citing works

Attenuation of CCl ₄ -induced hepatic fibrosis by GdCl ₃ treatment or dietary glycine

Rivera, C. A., Bradford, B. U., Hunt, K. J., Adachi, Y., Schrum, L. W., Koop, D. R., Burchardt, E.-R., Rippe, R. A., & Thurman, R. G. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.1.g200 · Cited by 165 · see citing works

Extrahepatic platelet-derived growth factor-β, delivered by platelets, promotes activation of hepatic stellate cells and biliary fibrosis in mice

Yoshida, S., Ikenaga, N., Liu, S. B., Peng, Z.-W., Chung, J., Sverdlov, D. Y., Miyamoto, M., Kim, Y. O., Ogawa, S., Arch, R. H., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.08.038 · Cited by 164 · see citing works

Long‐term outcome of hepatitis B e antigen–negative hepatitis B surface antigen carriers in relation to changes of alanine aminotransferase levels over time†

Tai, D., Lin, S., Sheen, I., Chu, C., Lin, D., & Liaw, Y. (2009) · Hepatology · doi:10.1002/hep.22878 · Cited by 164 · see citing works

Crosstalk between YAP/TAZ and Notch Signaling

Totaro, A., Castellan, M., Biagio, D. D., & Piccolo, S. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.03.001 · Cited by 163 · see citing works

Caspase 3 Inactivation Protects Against Hepatic Cell Death and Ameliorates Fibrogenesis in a Diet-Induced NASH Model

Thapaliya, S., Wree, A., Povero, D., Inzaugarat, M. E., Berk, M., Dixon, L., Papouchado, B. G., & Feldstein, A. E. (2014) · Digestive Diseases and Sciences · doi:10.1007/s10620-014-3167-6 · Cited by 162 · see citing works

Hepatocyte Stress Increases Expression of Yes‐Associated Protein and Transcriptional Coactivator With PDZ‐Binding Motif in Hepatocytes to Promote Parenchymal Inflammation and Fibrosis

Mooring, M., Fowl, B. H., Lum, S. Z. C., Liu, Y., Yao, K., Softic, S., Kirchner, R., Bernstein, A., Singhi, A. D., Jay, D. G., et al. (2020) · Hepatology · doi:10.1002/hep.30928 · Cited by 162 · see citing works

Natural killer and natural killer T cells in liver fibrosis

Gao, B., & Radaeva, S. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.09.008 · Cited by 158 · see citing works

Reversal of liver fibrosis: From fiction to reality

Zoubek, M. E., Trautwein, C., & Strnad, P. (2017) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2017.04.005 · Cited by 157 · see citing works

TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy

Akalu, Y. T., Rothlin, C. V., & Ghosh, S. (2017) · Immunological Reviews · doi:10.1111/imr.12522 · Cited by 156 · see citing works

Endoplasmic Reticulum Stress in Metabolic Liver Diseases and Hepatic Fibrosis

Maiers, J. L., & Malhi, H. (2019) · Seminars in Liver Disease · doi:10.1055/s-0039-1681032 · Cited by 151 · see citing works

Resolution of nonalcoholic steatohepatits after gastric bypass surgery

Liu, X., Lazenby, A. J., Clements, R. H., Jhala, N., & Abrams, G. A. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9086-2 · Cited by 149 · see citing works

Hedgehog signalling in liver pathophysiology

Machado, M. V., & Diehl, A. M. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.10.017 · Cited by 149 · see citing works

Beneficial effects of SGLT2 inhibitors on fatty liver in type 2 diabetes: A common comorbidity associated with severe complications

Scheen, A. J. (2019) · Diabetes & Metabolism · doi:10.1016/j.diabet.2019.01.008 · Cited by 146 · see citing works

Signalling via the Osteopontin and High Mobility Group Box-1 Axis Drives the Fibrogenic Response to Liver Injury

Arriazu, E., Ge, X., Leung, T.-M., Magdaleno, F., Lopategi, A., Lu, Y., Kitamura, N., Urtasun, R., Theise, N., Antoine, D. J., et al. (2017) · Gut · doi:10.1136/gutjnl-2015-310752 · Cited by 144 · see citing works

Type 2 immunity is protective in metabolic disease but exacerbates NAFLD collaboratively with TGF-β

Hart, K. M., Fabre, T., Sciurba, J. C., Gieseck, R. L., Borthwick, L. A., Vannella, K. M., Acciani, T. H., de Queiroz Prado, R., Thompson, R. W., White, S., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aal3694 · Cited by 143 · see citing works

Gene-silencing technology gets first drug approval after 20-year wait

Ledford, H. (2018) · Nature · doi:10.1038/d41586-018-05867-7 · Cited by 131 · see citing works

A comparison in the progression of liver fibrosis in chronic hepatitis C between persistently normal and elevated transaminase

Hui, C., Belaye, T., Montegrande, K., & Wright, T. L. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(03)00004-7 · Cited by 127 · see citing works

Yes-associated protein in kupffer cells enhances the production of proinflammatory cytokines and promotes the development of nonalcoholic steatohepatitis

Song, K., Kwon, H., Han, C., Chen, W., Zhang, J., Ma, W., Dash, S., Gandhi, C. R., & Wu, T. (2020) · Hepatology · doi:10.1002/hep.30990 · Cited by 110 · see citing works

HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis

Hernandez, C., Huebener, P., Pradere, J.-P., Antoine, D. J., Friedman, R. A., & Schwabe, R. F. (2018) · Journal of Clinical Investigation · doi:10.1172/jci91786 · Cited by 110 · see citing works

Hepatic Notch Signaling Correlates With Insulin Resistance and Nonalcoholic Fatty Liver Disease

Valenti, L. V. C., Mendoza, R. M., Rametta, R., Maggioni, M., Kitajewski, C., Shawber, C. J., & Pajvani, U. B. (2013) · Diabetes · doi:10.2337/db13-0769 · Cited by 109 · see citing works

Roux-en-Y Gastric Bypass Improves the Nonalcoholic Steatohepatitis (NASH) of Morbid Obesity

Sanches, S. R. D. A., Rocha, P. S., Sanches, M. D., Leite, V. R., Pinto-Silva, R. A., Diniz, M. T. C., Diniz, M. D. F. H. S., & Rocha, A. S. (2006) · Obesity Surgery · doi:10.1381/096089206776116462 · Cited by 107 · see citing works

HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers

Khambu, B., Huda, N., Chen, X., Antoine, D. J., Li, Y., Dai, G., Köhler, U. A., Zong, W., Waguri, S., Werner, S., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci91814 · Cited by 105 · see citing works

Anti-fibrotic therapy: Lost in translation?

Schuppan, D., & Pinzani, M. (2012) · Journal of Hepatology · doi:10.1016/s0168-8278(12)60008-7 · Cited by 97 · see citing works

Noninvasive fatty liver markers predict liver disease mortality in the U.S. population

Ünalp–Arida, A., & Ruhl, C. E. (2015) · Hepatology · doi:10.1002/hep.28390 · Cited by 96 · see citing works

Transcriptional regulation of Hepatic Stellate Cell activation in NASH

Marcher, A.-B., Bendixen, S. M., Terkelsen, M. K., Hohmann, S. S., Hansen, M. H., Larsen, B. D., Mandrup, S., Dimke, H., Detlefsen, S., & Ravnskjaer, K. (2019) · Scientific Reports · doi:10.1038/s41598-019-39112-6 · Cited by 95 · see citing works

Evaluation of liver disease progression in the German hepatitis C virus (1b)-contaminated anti-D cohort at 35 years after infection

Wiese, M., Fischer, J., Löbermann, M., Göbel, U., Grüngreiff, K., Güthoff, W., Kullig, U., Richter, F., Schiefke, I., Tenckhoff, H., et al. (2013) · Hepatology · doi:10.1002/hep.26644 · Cited by 94 · see citing works

Differential Activation of Hepatic Invariant NKT Cell Subsets Plays a Key Role in Progression of Nonalcoholic Steatohepatitis

Maricic, I., Marrero, I., Eguchi, A., Nakamura, R., Johnson, C. D., Dasgupta, S., Hernandez, C. D., Nguyen, P. S., Swafford, A. D., Knight, R., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800614 · Cited by 92 · see citing works

Blockade of YAP alleviates hepatic fibrosis through accelerating apoptosis and reversion of activated hepatic stellate cells

Yu, H., Yao, Y., Bu, F., Chen, Y., Wu, Y., Yang, Y., Chen, X., Zhu, Y., Wang, Q., Pan, X., et al. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.01.004 · Cited by 92 · see citing works

Good fat/bad fat

McClain, C. J., Barve, S. S., & Deaciuc, I. V. (2007) · Hepatology · doi:10.1002/hep.21788 · Cited by 88 · see citing works

Trapping of oxidized LDL in lysosomes of K upffer cells is a trigger for hepatic inflammation

Bieghs, V., Walenbergh, S. M. A., Hendrikx, T., van Gorp, P. J., Verheyen, F., Damink, S. W. M. O., Masclee, A., Koek, G. H., Hofker, M. H., Binder, C. J., et al. (2013) · Liver International · doi:10.1111/liv.12170 · Cited by 88 · see citing works

Origin and function of myofibroblasts in the liver

Schwabe, R., & Wells, R. (2015) · Seminars in Liver Disease · doi:10.1055/s-0035-1550061 · Cited by 86 · see citing works

Nonalcoholic steatohepatitis (NASH) with diabetes: predictors of liver fibrosis

Amarapurkar, D. N., Amarapurkar, A. D., Patel, N. D., Agal, S., Baigal, R., Gupte, P., & PRAMANIK, S. (2006) · Annals of Hepatology · doi:10.1016/s1665-2681(19)32036-8 · Cited by 85 · see citing works

c-Met Confers Protection Against Chronic Liver Tissue Damage and Fibrosis Progression After Bile Duct Ligation in Mice

Giebeler, A., Boekschoten, M. V., Klein, C., Borowiak, M., Birchmeier, C., Gaßler, N., Wasmuth, H. E., Müller, M. M., Trautwein, C., & Streetz, K. L. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.068 · Cited by 79 · see citing works

Hepatocellular ballooning in nonalcoholic steatohepatitis: the pathologist’s perspective

Lackner, C. (2011) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.11.8 · Cited by 78 · see citing works

Treatment response in the PIVENS trial is associated with decreased Hedgehog pathway activity

Guy, C. D., Suzuki, A., Abdelmalek, M. F., Burchette, J. L., Diehl, A. M., & CRN, F. T. N. (2015) · Hepatology · doi:10.1002/hep.27235 · Cited by 72 · see citing works

Hepatocyte specific deletion of c-Met leads to the development of severe non-alcoholic steatohepatitis in mice

Kroy, D. C., Schumacher, F., Ramadori, P., Hatting, M., Bergheim, I., Gaßler, N., Boekschoten, M. V., Müller, M. M., Streetz, K. L., & Trautwein, C. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.05.019 · Cited by 70 · see citing works

Dietary macronutrients and the aging liver sinusoidal endothelial cell

Cogger, V. C., Mohamad, M., Solon‐Biet, S. M., Senior, A. M., Warren, A., O'Reilly, J. N., Tùng, B. T., Svistounov, D., McMahon, A. C., Fraser, R., et al. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00949.2015 · Cited by 67 · see citing works

mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2

Kim, K., Qiang, L., Hayden, M. S., Sparling, D. P., Purcell, N. H., & Pajvani, U. B. (2016) · Nature Communications · doi:10.1038/ncomms10255 · Cited by 67 · see citing works

Dextran-Based Therapeutic Nanoparticles for Hepatic Drug Delivery

Foerster, F., Bamberger, D., Schupp, J., Weilbächer, M., Kaps, L., Strobl, S., Radi, L., Diken, M., Strand, D. J., Tuettenberg, A., et al. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0156 · Cited by 66 · see citing works

The hepatic “matrisome” responds dynamically to injury: Characterization of transitional changes to the extracellular matrix in mice

Massey, V. L., Dolin, C. E., Poole, L. G., Hudson, S. V., Siow, D. L., Brock, G. N., Merchant, M. L., Wilkey, D. W., & Arteel, G. E. (2017) · Hepatology · doi:10.1002/hep.28918 · Cited by 64 · see citing works

Clearance of Apoptotic Cells by Tissue Epithelia: A Putative Role for Hepatocytes in Liver Efferocytosis

Davies, S. P., Reynolds, G. M., & Stamataki, Z. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00044 · Cited by 61 · see citing works

Fat-laden macrophages modulate lobular inflammation in nonalcoholic steatohepatitis (NASH)

Jindal, A., Bruzzì, S., Sutti, S., Locatelli, I., Bozzola, C., Paternostro, C., Parola, M., & Albano, E. (2015) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2015.06.015 · Cited by 60 · see citing works

Contributions of Fibroblasts, Extracellular Matrix, Stiffness, and Mechanosensing to Hepatocarcinogenesis

Filliol, A. A., & Schwabe, R. F. (2019) · Seminars in Liver Disease · doi:10.1055/s-0039-1685539 · Cited by 58 · see citing works

Lipoprotein Lipase Up‐regulation in Hepatic Stellate Cells Exacerbates Liver Fibrosis in Nonalcoholic Steatohepatitis in Mice

Teratani, T., Tomita, K., Furuhashi, H., Sugihara, N., Higashiyama, M., Nishikawa, M., Irie, R., Takajo, T., Wada, A., Horiuchi, K., et al. (2019) · Hepatology Communications · doi:10.1002/hep4.1383 · Cited by 56 · see citing works

Therapeutic Approaches to Nonalcoholic Fatty Liver Disease: Exercise Intervention and Related Mechanisms

Takahashi, H., Kotani, K., Tanaka, K., Egucih, Y., & Anzai, K. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00588 · Cited by 55 · see citing works

A Therapeutic Silencing RNA Targeting Hepatocyte TAZ Prevents and Reverses Fibrosis in Nonalcoholic Steatohepatitis in Mice

Wang, X., Sommerfeld, M. R., Jahn‐Hofmann, K., Cai, B., Filliol, A. A., Remotti, H. E., Schwabe, R. F., Kannt, A., & Tabas, I. A. (2019) · Hepatology Communications · doi:10.1002/hep4.1405 · Cited by 55 · see citing works

Degradation of PHLPP2 by KCTD17, via a Glucagon-Dependent Pathway, Promotes Hepatic Steatosis

Kim, K., Ryu, D., Dongiovanni, P., Özcan, L., Nayak, S., Ueberheide, B. M., Valenti, L. V. C., Auwerx, J. H., & Pajvani, U. B. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.08.039 · Cited by 52 · see citing works

Cell death and nonalcoholic steatohepatitis: where is ballooning relevant?

Machado, M. V., & Cortez‐Pinto, H. (2011) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.11.16 · Cited by 50 · see citing works

Inactivation of myofibroblasts during regression of liver fibrosis

Kisseleva, T., & Brenner, D. A. (2013) · Cell Cycle · doi:10.4161/cc.23549 · Cited by 48 · see citing works

Liver Fibrosis Protects Mice From Acute Hepatocellular Injury

Bourbonnais, É., Raymond, V., Éthier, C., Nguyen, B., Saba-El-Leil, M. K., Meloche, S., & Bilodeau, M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.09.033 · Cited by 48 · see citing works

Ballooned hepatocytes, undead cells, sonic hedgehog, and Vitamin E: Therapeutic implications for nonalcoholic steatohepatitis

Hirsova, P., & Gores, G. J. (2014) · Hepatology · doi:10.1002/hep.27279 · Cited by 40 · see citing works

Human germline hedgehog pathway mutations predispose to fatty liver

Sacoto, M. J. G., Martinez, A. F., Abe, Y., Kruszka, P. S., Weiss, K., Everson, J. L., Bataller, R. A., Kleiner, D. E., Ward, J. M., Sulik, K. K., et al. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.06.008 · Cited by 36 · see citing works

Vitamin A‐coupled liposome system targeting free cholesterol accumulation in hepatic stellate cells offers a beneficial therapeutic strategy for liver fibrosis

Furuhashi, H., Tomita, K., Teratani, T., Shimizu, M., Nishikawa, M., Higashiyama, M., Takajo, T., Shirakabe, K., Maruta, K., Okada, Y., et al. (2017) · Hepatology Research · doi:10.1111/hepr.13040 · Cited by 34 · see citing works

Indian Hedgehog links obesity to development of hepatocellular carcinoma

Chong, Y. C., Lim, T. E., Fu, Y., Shin, E. M., Tergaonkar, V., & Han, W. (2019) · Oncogene · doi:10.1038/s41388-018-0585-5 · Cited by 29 · see citing works

Echocardiographic Evaluation of Patients with Blunt Chest Injury

Eisenach, J. C., NUGENT, M., Miller, F. A., & Mucha, P. (1986) · Anesthesiology · doi:10.1097/00000542-198603000-00011 · Cited by 29 · see citing works

Evaluation of ballooned hepatocytes as a risk factor for future progression of fibrosis in patients with non-alcoholic fatty liver disease

Kakisaka, K., Suzuki, Y., Fujiwara, Y., Abe, T., Yonezawa, M., Kuroda, H., Ishida, K., Sugai, T., & Takikawa, Y. (2018) · Journal of Gastroenterology · doi:10.1007/s00535-018-1468-9 · Cited by 28 · see citing works

Hepatic sonic hedgehog protein expression measured by computer assisted morphometry significantly correlates with features of non-alcoholic steatohepatitis

Estep, M., Mehta, R., Bratthauer, G. L., Alaparthi, L. P., Monge, F., Ali, S., Abdelatif, D., Younoszai, Z., Stepanova, M., Goodman, Z. D., et al. (2019) · BMC Gastroenterology · doi:10.1186/s12876-019-0951-y · Cited by 20 · see citing works

Downregulation of hedgehog ligands in human simple steatosis may protect against nonalcoholic steatohepatitis: Is TAZ a crucial regulator?

Khajehahmadi, Z., Mohagheghi, S., Nikeghbalian, S., Geramizadeh, B., Khodadadi, I., Karimi, J., Ghaffari, M. E., & Tavilani, H. (2019) · IUBMB Life · doi:10.1002/iub.2068 · Cited by 18 · see citing works

Signaling Pathways in Liver Diseases

(2015) · Wiley eBooks · doi:10.1002/9781118663387 · Cited by 14 · see citing works

Extracellular Matrix

Friedman, S. L. (2009) · Springer eBooks · doi:10.1007/978-3-642-00150-5_6 · Cited by 5 · see citing works

[Erythrocyte ATPase activity as a function of the age of the subjects and the cell].

Canestrari, F., Cucchiarini, L., Giacchi, R., Quirico, M. D., & Biagiarelli, B. (1988) · PubMed · Cited by 1 · see citing works

AASLD practice guidance on the clinical assessment and management of nonalcoholic fatty liver disease

Rinella, M. E., Neuschwander-Tetri, B. A., Siddiqui, M. S., Abdelmalek, M. F., Caldwell, S., Barb, D., Kleiner, D. E., & Loomba, R. (2023) · Hepatology · doi:10.1097/hep.0000000000000323 · Cited by 2,667 · see citing works

Mechanisms and disease consequences of nonalcoholic fatty liver disease

Loomba, R., Friedman, S. L., & Shulman, G. I. (2021) · Cell · doi:10.1016/j.cell.2021.04.015 · Cited by 2,002 · see citing works

Fibrosis: from mechanisms to medicines

Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature · doi:10.1038/s41586-020-2938-9 · Cited by 1,868 · see citing works

Hepatic inflammatory responses in liver fibrosis

Hammerich, L., & Tacke, F. (2023) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-023-00807-x · Cited by 803 · see citing works

Metabolic-associated fatty liver disease and lipoprotein metabolism

Heeren, J., & Scheja, L. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101238 · Cited by 666 · see citing works

Immune cell-mediated features of non-alcoholic steatohepatitis

Huby, T., & Gautier, E. L. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00639-3 · Cited by 573 · see citing works

Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus

Ferguson, D., & Finck, B. N. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00507-z · Cited by 507 · see citing works

Pathophysiology of obesity and its associated diseases

Jin, X., Qiu, T., Li, L., Yu, R., Chen, X., Li, C., Proud, C. G., & Jiang, T. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.01.012 · Cited by 552 · see citing works

The Power of Plasticity—Metabolic Regulation of Hepatic Stellate Cells

Trivedi, P., Wang, S., & Friedman, S. L. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.10.026 · Cited by 427 · see citing works

Metabolic regulation of the immune system in health and diseases: mechanisms and interventions

Hu, T., Liu, C., Lei, M., Zeng, Q., Li, L., Tang, H., & Zhang, N. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01954-6 · Cited by 425 · see citing works

The AMPK pathway in fatty liver disease

Fang, C., Pan, J., Qu, N., Lei, Y., Han, J., Zhang, J., & Han, D. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.970292 · Cited by 364 · see citing works

Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans

Pafili, K., & Roden, M. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101122 · Cited by 330 · see citing works

An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH

Tacke, F., Puengel, T., Loomba, R., & Friedman, S. L. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.03.038 · Cited by 321 · see citing works

The Role of Insulin Resistance and Diabetes in Nonalcoholic Fatty Liver Disease

Fujii, H., Kawada, N., & Japan Study Group of NAFLD (JSG-NAFLD) (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113863 · Cited by 300 · see citing works

Liver fibrosis in NAFLD/NASH: from pathophysiology towards diagnostic and therapeutic strategies

Parola, M., & Pinzani, M. (2023) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2023.101231 · Cited by 226 · see citing works

FGF21: An Emerging Therapeutic Target for Non-Alcoholic Steatohepatitis and Related Metabolic Diseases

Tillman, E. J., & Rolph, T. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.601290 · Cited by 209 · see citing works

The intersection between alcohol-related liver disease and nonalcoholic fatty liver disease

Díaz, L. A., Arab, J. P., Louvet, A., Bataller, R., & Arrese, M. (2023) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-023-00822-y · Cited by 207 · see citing works

Liver fibrosis: from basic science towards clinical progress, focusing on the central role of hepatic stellate cells

Akkız, H., Gieseler, R. K., & Canbay, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147873 · Cited by 191 · see citing works

FXR agonists in NASH treatment

Adorini, L., & Trauner, M. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.07.034 · Cited by 197 · see citing works

Molecular mechanisms in MASLD/MASH-related HCC

Wang, X., Zhang, L., & Dong, B. (2024) · Hepatology · doi:10.1097/hep.0000000000000786 · Cited by 188 · see citing works

An autocrine signaling circuit in hepatic stellate cells underlies advanced fibrosis in nonalcoholic steatohepatitis

Wang, S., Li, K., Pickholz, E., Dobie, R., Matchett, K. P., Henderson, N. C., Carrico, C., Driver, I., Borch Jensen, M., Chen, L., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.add3949 · Cited by 176 · see citing works

Transcriptomics Identify Thrombospondin‐2 as a Biomarker for NASH and Advanced Liver Fibrosis

Kozumi, K., Kodama, T., Murai, H., Sakane, S., Govaere, O., Cockell, S., Motooka, D., Kakita, N., Yamada, Y., Kondo, Y., et al. (2021) · Hepatology · doi:10.1002/hep.31995 · Cited by 165 · see citing works

Metabolic liver disease in diabetes – From mechanisms to clinical trials

Dewidar, B., KAHL, S., Pafili, K., & Roden, M. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154299 · Cited by 160 · see citing works

Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1

Gosis, B. S., Wada, S., Thorsheim, C. L., Li, K., Jung, S., Rhoades, J. H., Yang, Y., Brandimarto, J., Li, L., Uehara, K., et al. (2022) · Science · doi:10.1126/science.abf8271 · Cited by 155 · see citing works

Non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH)-related liver fibrosis: mechanisms, treatment and prevention

Tacke, F., & Weiskirchen, R. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-4354 · Cited by 154 · see citing works

Role of immune responses in the development of NAFLD-associated liver cancer and prospects for therapeutic modulation

Yahoo, N., Dudek, M., Knolle, P. A., & Heikenwälder, M. F. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.02.033 · Cited by 145 · see citing works

Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis

Yu, J., Zhu, C., Wang, X., Kim, K., Bartolome, A., Dongiovanni, P., Yates, K. P., Valenti, L., Carrer, M., Sadowski, T., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abe1692 · Cited by 132 · see citing works

Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication

Loft, A., Alfaro, A. J., Schmidt, S. F., Pedersen, F. B., Terkelsen, M. K., Puglia, M., Chow, K. K., Feuchtinger, A., Troullinaki, M., Maida, A., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.06.005 · Cited by 129 · see citing works

MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH

Gao, H., Jin, Z., Bandyopadhyay, G. K., Rocha, K. C. E., Liu, X., Zhao, H., Zhang, D., Jouihan, H. A., Pourshahian, S., Kisseleva, T., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.05.008 · Cited by 127 · see citing works

Tumor-Associated Macrophages in Hepatocellular Carcinoma Pathogenesis, Prognosis and Therapy

Arvanitakis, K., Koletsa, T., Mitroulis, I., & Germanidis, G. S. (2022) · Cancers · doi:10.3390/cancers14010226 · Cited by 121 · see citing works

Understanding the cellular interactome of non-alcoholic fatty liver disease

Wallace, S. J., Tacke, F., Schwabe, R. F., & Henderson, N. C. (2022) · JHEP Reports · doi:10.1016/j.jhepr.2022.100524 · Cited by 116 · see citing works

Hepatic sexual dimorphism — implications for non-alcoholic fatty liver disease

Lefèbvre, P., & Staels, B. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00538-6 · Cited by 114 · see citing works

Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis

Savage, T. M., Fortson, K. T., de los Santos-Alexis, K., Oliveras-Alsina, A., Rouanne, M., Rae, S. S., Gamarra, J. R., Shayya, H., Kornberg, A., Cavero, R., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.01.009 · Cited by 115 · see citing works

Crosstalk Between Liver Macrophages and Surrounding Cells in Nonalcoholic Steatohepatitis

Li, H., Zhou, Y., Wang, H., Zhang, M., Qiu, P., Zhang, M., Zhang, R., Zhao, Q., & Liu, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01169 · Cited by 114 · see citing works

Maladaptive regeneration - the reawakening of developmental pathways in NASH and fibrosis

Zhu, C., Tabas, I., Schwabe, R. F., & Pajvani, U. B. (2021) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-020-00365-6 · Cited by 112 · see citing works

Hepatic stellate cells: balancing homeostasis, hepatoprotection and fibrogenesis in health and disease

Schwabe, R. F., & Brenner, D. A. (2025) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-025-01068-6 · Cited by 112 · see citing works

Mesenchymal stem cells in fibrotic diseases—the two sides of the same coin

Qin, L., Liu, N., Bao, C.-L.-M., Yang, D.-Z., Ma, G.-X., Yi, W.-H., Xiao, G.-Z., & Cao, H.-L. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00952-0 · Cited by 114 · see citing works

Neutrophil extracellular traps promote MASH fibrosis by metabolic reprogramming of HSC

Xia, Y., Wang, Y., Xiong, Q., He, J., Wang, H., Islam, M., Zhou, X., Kim, A. C., Zhang, H., Huang, H., et al. (2024) · Hepatology · doi:10.1097/hep.0000000000000762 · Cited by 113 · see citing works

Hepatic Stellate Cell Activation and Inactivation in NASH-Fibrosis—Roles as Putative Treatment Targets?

Zisser, A., Ipsen, D. H., & Tveden‐Nyborg, P. (2021) · Biomedicines · doi:10.3390/biomedicines9040365 · Cited by 110 · see citing works

The Role of Insulin Resistance in Fueling NAFLD Pathogenesis: From Molecular Mechanisms to Clinical Implications

Palma, R., Pronio, A., Romeo, M., Scognamiglio, F., Ventriglia, L., Ormando, V. M., Lamazza, A., Pontone, S., Federico, A., & Dallio, M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11133649 · Cited by 111 · see citing works

Insights into Nonalcoholic Fatty-Liver Disease Heterogeneity

Arrese, M. A., Arab, J. P., Francisco Barrera, M., Kaufmann, B. K., Valenti, L. V. C., & Feldstein, A. E. (2021) · Seminars in Liver Disease · doi:10.1055/s-0041-1730927 · Cited by 104 · see citing works

The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver

Mederacke, I., Filliol, A., Affo, S., Nair, A., Hernandez, C., Sun, Q., Hamberger, F., Brundu, F., Chen, Y., Ravichandra, A., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abe5795 · Cited by 103 · see citing works

Single-cell and bulk transcriptomics of the liver reveals potential targets of NASH with fibrosis

Wang, Z.-Y., Keogh, A., Waldt, A., Cuttat, R., Neri, M., Zhu, S., Schuierer, S., Ruchti, A., Crochemore, C., Knehr, J., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-98806-y · Cited by 103 · see citing works

Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis

Fondevila, M. F., Fernandez, U., Heras, V., Parracho, T., Gonzalez-Rellan, M. J., Nóvoa, E., Porteiro, B., Alonso, C., Mayo, R., Lima, N. D. S., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.02.003 · Cited by 105 · see citing works

Role of extracellular vesicles in liver diseases and their therapeutic potential

Kostallari, E., Valainathan, S. R., Biquard, L., Shah, V. H., & Rautou, P. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.026 · Cited by 92 · see citing works

Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1α axis to alleviate ferroptosis in metabolic-associated fatty liver disease

Zhuge, A., Li, S., Han, S., Yuan, Y., Shen, J., Wu, W., Wang, K., Xia, J., Wang, Q., Gu, Y., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.10.010 · Cited by 94 · see citing works

The Notch signaling pathway regulates macrophage polarization in liver diseases

Chen, W., Liu, Y., Chen, J., Ma, Y., Song, Y., Cen, Y., You, M., & Yang, G. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107938 · Cited by 87 · see citing works

Emerging Role of Hepatic Ketogenesis in Fatty Liver Disease

Mooli, R. G. R., & Ramakrishnan, S. K. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.946474 · Cited by 84 · see citing works

CD47-SIRPα axis blockade in NASH promotes necroptotic hepatocyte clearance by liver macrophages and decreases hepatic fibrosis

Shi, H., Wang, X., Li, F., Gerlach, B. D., Yurdagul, A., Moore, M. P., Zeldin, S., Zhang, H., Cai, B., Zheng, Z., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abp8309 · Cited by 85 · see citing works

Single-cell RNA sequencing reveals distinct immunology profiles in human keloid

Feng, C., Shan, M., Xia, Y., Zheng, Z., He, K., Wei, Y., Song, K., Meng, T., Liu, H., Hao, Y., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.940645 · Cited by 85 · see citing works

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Kim, K. E., Lee, J., Shin, H. J., Jeong, E. A., Jang, H. M., Ahn, Y. J., An, H. S., Lee, J. Y., Shin, M. C., Kim, S. K., et al. (2022) · Hepatology · doi:10.1002/hep.32569 · Cited by 82 · see citing works

AASLD Practice Statement on the evaluation and management of metabolic dysfunction–associated steatotic liver disease in children

Xanthakos, S. A., Ibrahim, S. H., Adams, K. H., Kohli, R., Sathya, P., Sundaram, S. S., Vos, M. B., Dhawan, A., Caprio, S., Behling, C. A., et al. (2025) · Hepatology · doi:10.1097/hep.0000000000001368 · Cited by 86 · see citing works

Hepatic Stellate Cells: Dictating Outcome in Nonalcoholic Fatty Liver Disease

Wiering, L., Subramanian, P., & Hammerich, L. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.02.010 · Cited by 80 · see citing works

Hepatic Stellate Cell-Immune Interactions in NASH

Carter, J. K., & Friedman, S. L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.867940 · Cited by 79 · see citing works

Targeting cell-intrinsic metabolism for antifibrotic therapy

Gilgenkrantz, H., Mallat, A., Moreau, R., & Lotersztajn, S. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.02.012 · Cited by 76 · see citing works

Hepatic danger signaling triggers TREM2 + macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation

Zhou, L., Qiu, X., Meng, Z., Liu, T., Chen, Z., Zhang, P., Kuang, H., Pan, T., Lu, Y., Qi, L., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adk1866 · Cited by 81 · see citing works

Aramchol downregulates stearoyl CoA-desaturase 1 in hepatic stellate cells to attenuate cellular fibrogenesis

Bhattacharya, D., Basta, B. N., Mato, J. M., Craig, A. J., Fernández‐Ramos, D., Lopitz‐Otsoa, F., Tsvirkun, D., Hayardeny, L., Chandar, V., Schwartz, R. E., et al. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100237 · Cited by 75 · see citing works

Nonalcoholic Fatty Liver Disease and Chronic Kidney Disease: Epidemiology, Pathogenesis, and Clinical and Research Implications

Lonardo, A., Mantovani, A., Targher, G., & Baffy, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113320 · Cited by 75 · see citing works

FGF21 protects against hepatic lipotoxicity and macrophage activation to attenuate fibrogenesis in nonalcoholic steatohepatitis

Liu, C., Schönke, M., Spoorenberg, B., Lambooij, J. M., van der Zande, H. J. P., Zhou, E., Tushuizen, M. E., Andréasson, A., Park, A., Oldham, S. N., et al. (2023) · eLife · doi:10.7554/elife.83075 · Cited by 72 · see citing works

Updates in the quantitative assessment of liver fibrosis for nonalcoholic fatty liver disease: Histological perspective

Soon, G. S. T., & Wee, A. (2020) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2020.0181 · Cited by 71 · see citing works

Loss of MLKL ameliorates liver fibrosis by inhibiting hepatocyte necroptosis and hepatic stellate cell activation

Guo, R., Jia, X., Ding, Z., Wang, G., Jiang, M., Li, B., Chen, S., Xia, B., Zhang, Q., Liu, J., et al. (2022) · Theranostics · doi:10.7150/thno.71400 · Cited by 69 · see citing works

Non-alcoholic fatty liver disease: the pathologist’s perspective

Leow, W. Q., Chan, A. W. H., Mendoza, P. G. L., Lo, R. C., Yap, K., & Kim, H. (2022) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2022.0329 · Cited by 70 · see citing works

Taurocholic acid promotes hepatic stellate cell activation via S1PR2/p38 MAPK/YAP signaling under cholestatic conditions

Yang, J., Tang, X., Zhu, L., Chen, M., & Sun, L. (2023) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2022.0327 · Cited by 70 · see citing works

The pan-PPAR agonist lanifibranor improves cardiometabolic health in patients with metabolic dysfunction-associated steatohepatitis

Cooreman, M. P., Butler, J., Giugliano, R. P., Zannad, F. M., Dzen, L., Huot-Marchand, P., Baudin, M., Beard, D. R., Junien, J., Broqua, P., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47919-9 · Cited by 70 · see citing works

New Insights into AMPK, as a Potential Therapeutic Target in Metabolic Dysfunction-Associated Steatotic Liver Disease and Hepatic Fibrosis

An, H., Jang, Y., Choi, J.-I., Hur, J., Kim, S., & Kwon, Y. (2024) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2024.188 · Cited by 72 · see citing works

Antifibrotic therapy in nonalcoholic steatohepatitis: time for a human-centric approach

Brennan, P. N., Elsharkawy, A. M., Kendall, T. J., Loomba, R., Mann, D. A., & Fallowfield, J. A. (2023) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-023-00796-x · Cited by 68 · see citing works

Liver Fibrosis and MAFLD: From Molecular Aspects to Novel Pharmacological Strategies

Qu, W., Ma, T., Cai, J., Zhang, X., Zhang, P., She, Z., Wan, F., & Li, H. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.761538 · Cited by 68 · see citing works

Metabolic mechanisms for and treatment of NAFLD or NASH occurring after liver transplantation

Lonardo, A., Mantovani, A., Petta, S., Carraro, A., Byrne, C. D., & Targher, G. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00711-5 · Cited by 68 · see citing works

Chlorogenic acids: A pharmacological systematic review on their hepatoprotective effects

Xue, H., Wei, M., & Ji, L. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154961 · Cited by 68 · see citing works

Targeting epigenetically maladapted vascular niche alleviates liver fibrosis in nonalcoholic steatohepatitis

Zhang, H., Ma, Y., Cheng, X., Wu, D., Huang, X., Chen, B., Ren, Y., Jiang, W., Tang, X., Bai, T., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abd1206 · Cited by 65 · see citing works

Metabolic Regulation of Fibroblast Activation and Proliferation during Organ Fibrosis

Wang, S., Liang, Y., & Dai, C. (2022) · Kidney Diseases · doi:10.1159/000522417 · Cited by 60 · see citing works

Targeted Delivery of Notch Inhibitor Attenuates Obesity-Induced Glucose Intolerance and Liver Fibrosis

Richter, L. R., Wan, Q., Wen, D., Zhang, Y., Yu, J., Kang, J. K., Zhu, C., McKinnon, E. L., Gu, Z., Qiang, L., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c01007 · Cited by 59 · see citing works

Insights into the roles and pathomechanisms of ceramide and sphigosine-1-phosphate in nonalcoholic fatty liver disease

Zhu, C., Huai, Q., Zhang, X., Dai, H., Li, X., & Wang, H. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.78525 · Cited by 59 · see citing works

The Role of Nuclear Receptors in the Pathogenesis and Treatment of Non-alcoholic Fatty Liver Disease

Yang, Z., Danzeng, A., Liu, Q., Zeng, C., Xu, L., Mo, J., Ciren, P., Wang, X., Wang, C., Zhang, B., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.87305 · Cited by 60 · see citing works

Auranofin attenuates hepatic steatosis and fibrosis in nonalcoholic fatty liver disease via NRF2 and NF- κB signaling pathways

Lee, S. M., Koh, D. H., Jun, D. W., Roh, Y. J., Kang, H. T., Oh, J., & Kim, H. S. (2022) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2022.0068 · Cited by 59 · see citing works

Alleviation of liver fibrosis by inhibiting a non-canonical ATF4-regulated enhancer program in hepatic stellate cells

Yang, L.-X., Qi, C., Lu, S., Ye, X.-S., Merikhian, P., Zhang, D.-Y., Yao, T., Zhao, J.-S., Wu, Y., Jia, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55738-1 · Cited by 57 · see citing works

Reprogramming of Hepatic Metabolism and Microenvironment in Nonalcoholic Steatohepatitis

Rui, L., & Lin, J. D. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-062220-105200 · Cited by 56 · see citing works

ASGR1 promotes liver injury in sepsis by modulating monocyte-to-macrophage differentiation via NF-κB/ATF5 pathway

Shi, R., Wang, J., Zhang, Z., Leng, Y., & Chen, A. F. (2023) · Life Sciences · doi:10.1016/j.lfs.2022.121339 · Cited by 57 · see citing works

Hepatic fibrosis: Targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines

Gong, L., Wei, F., Gonzalez, F. J., & Li, G. (2023) · Hepatology · doi:10.1097/hep.0000000000000182 · Cited by 58 · see citing works

Caffeine Inhibits NLRP3 Inflammasome Activation by Downregulating TLR4/MAPK/NF-κB Signaling Pathway in an Experimental NASH Model

Vargas-Pozada, E. E., Ramos‐Tovar, E., Rodríguez-Callejas, J. D., Cardoso-Lezama, I., Galindo‐Gómez, S., Talamás‐Lara, D., Vásquez-Garzón, V. R., Arellanes‐Robledo, J., Tsutsumi, V., Villa‐Treviño, S., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179954 · Cited by 56 · see citing works

Myocardial infarction accelerates the progression of MASH by triggering immunoinflammatory response and induction of periostin

Xie, W., Gan, J., Zhou, X., Tian, H., Pan, X., Liu, W., Li, X., Du, J., Xu, A., Zheng, M., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.04.020 · Cited by 55 · see citing works

Liver X Receptors and Liver Physiology

Russo-Savage, L., & Schulman, I. (2021) · Biochimica et Biophysica Acta - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166121 · Cited by 53 · see citing works

Fibroblast growth factor 18 stimulates the proliferation of hepatic stellate cells, thereby inducing liver fibrosis

Tsuchiya, Y., Seki, T., Kobayashi, K., Komazawa‐Sakon, S., Shichino, S., Nishina, T., Fukuhara, K., Ikejima, K., Nagai, H., Igarashi, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42058-z · Cited by 55 · see citing works

Atf3-mediated metabolic reprogramming in hepatic macrophage orchestrates metabolic dysfunction–associated steatohepatitis

Hu, S., Li, R., Gong, D., Hu, P., Xu, J., Ai, Y., Zhao, X., Hu, C., Xu, M., Liu, C., et al. (2024) · Science Advances · doi:10.1126/sciadv.ado3141 · Cited by 54 · see citing works

The role of the gut microbiota and probiotics associated with microbial metabolisms in cancer prevention and therapy

Wang, Z., Li, L., Wang, S., Wei, J., Qu, L., Pan, L., & Xu, K. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1025860 · Cited by 52 · see citing works

The Crosstalk Between Liver Sinusoidal Endothelial Cells and Hepatic Microenvironment in NASH Related Liver Fibrosis

Du, W., & Wang, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.936196 · Cited by 51 · see citing works

Fibroblasts in liver cancer: functions and therapeutic translation

Affo, S., Filliol, A., Gores, G. J., & Schwabe, R. F. (2023) · The Lancet Gastroenterology &amp; Hepatology · doi:10.1016/s2468-1253(23)00111-5 · Cited by 49 · see citing works

Antifibrotic therapies for metabolic dysfunction-associated steatotic liver disease

Schwabe, R. F., Tacke, F., Sugimoto, A., & Friedman, S. L. (2025) · JHEP Reports · doi:10.1016/j.jhepr.2025.101421 · Cited by 50 · see citing works

Regulation of peroxisome proliferator-activated receptor-gamma activity affects the hepatic stellate cell activation and the progression of NASH via TGF-β1/Smad signaling pathway

Ni, X., Li, X., Wang, Q., & Hua, J. (2020) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-020-00777-7 · Cited by 49 · see citing works

Dually fibronectin/CD44-mediated nanoparticles targeted disrupt the Golgi apparatus and inhibit the hedgehog signaling in activated hepatic stellate cells to alleviate liver fibrosis

Li, Y., Zhang, T., Zhang, J., Liu, Q., Jia, Q., Chen, W., Tang, Q., Xiong, Y., Xia, Y., Xu, Y., et al. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122232 · Cited by 50 · see citing works

Advanced Liver Fibrosis Is Associated with Chronic Kidney Disease in Patients with Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease

Seo, D. H., Suh, Y. J., Cho, Y., Ahn, S. H., Seo, S., Hong, S., Lee, Y., Choi, Y. J., Lee, E. J., & Kim, S. H. (2022) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2021.0130 · Cited by 48 · see citing works

MASLD development: From molecular pathogenesis toward therapeutic strategies

Yang, Z., Zhao, J., Xie, K., Tang, C., Gan, C., & Gao, J. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003629 · Cited by 47 · see citing works

Inflammation and Fibrogenesis in MAFLD: Role of the Hepatic Immune System

Torre, P., Motta, B., Sciorio, R., Masarone, M., & Persico, M. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.781567 · Cited by 41 · see citing works

Nonalcoholic fatty liver disease: Current therapies and future perspectives in drug delivery

Domingues, I., Leclercq, I. A., & Beloqui, A. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.09.040 · Cited by 44 · see citing works

Down-Regulating the High Level of 17-Beta-Hydroxysteroid Dehydrogenase 13 Plays a Therapeutic Role for Non-Alcoholic Fatty Liver Disease

Wang, M., Li, J., Li, H., Dong, B., Jiang, J., Liu, N., Tan, J., Wang, X., Lei, L., Li, H., et al. (2022) · International Journal of Molecular Sciences · doi:10.2139/ssrn.4065600 · Cited by 43 · see citing works

Thyroid hormones as a disease modifier and therapeutic target in nonalcoholic steatohepatitis

Wirth, E. K., Puengel, T., Spranger, J., & Tacke, F. (2022) · Expert Review of Endocrinology &amp; Metabolism · doi:10.1080/17446651.2022.2110864 · Cited by 42 · see citing works

ROS mediated pyroptosis-M1 polarization crosstalk participates in inflammation of chicken liver induced by bisphenol A and selenium deficiency

Xu, S., Xu, T., Li, X., Sun, X., Zhang, W., Liu, X., Wang, Y., Zhang, Y., & Xu, S. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121392 · Cited by 42 · see citing works

Extracellular vesicles containing GAS6 protect the liver from ischemia-reperfusion injury by enhancing macrophage efferocytosis via MerTK-ERK-COX2 signaling

Miao, L., Yu, C., Guan, G., Luan, X., Jin, X., Pan, M., Yang, Y., Yan, J., Chen, P., & Di, G. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02169-y · Cited by 42 · see citing works

Sphingosine 1-Phosphate Receptor 4 Promotes Nonalcoholic Steatohepatitis by Activating NLRP3 Inflammasome

Hong, C. H., Ko, M. S., Kim, J. H., Cho, H.-K., Lee, C., Yoon, J. E., Yun, J.-Y., Baek, I., Jang, J. E., Lee, S. E., et al. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.12.002 · Cited by 42 · see citing works

US Quantification of Liver Fat: Past, Present, and Future

Fetzer, D. T., Pierce, T. T., Robbin, M. L., Cloutier, G., Mufti, A., Hall, T. J., Chauhan, A., Kubale, R., & Tang, A. (2023) · Radiographics · doi:10.1148/rg.220178 · Cited by 41 · see citing works

Chronic inflammation as a molecular basis of nonalcoholic steatohepatitis: role of macrophages and fibroblasts in the liver.

Itoh, M., Ogawa, Y., & Suganami, T. (2020) · Europe PMC (PubMed Central) · doi:10.18999/nagjms.82.3.391 · Cited by 5 · see citing works

Role of Hepatic Progenitor Cells in Nonalcoholic Fatty Liver Disease Development: Cellular Cross-Talks and Molecular Networks

Carpino, G., Renzi, A., Onori, P., & Gaudio, E. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141020112 · Cited by 69 · see citing works

Hepatocyte Injury and Hepatic Stem Cell Niche in the Progression of Non-Alcoholic Steatohepatitis

Overi, D., Carpino, G., Franchitto, A., Onori, P., & Gaudio, E. (2020) · Cells · doi:10.3390/cells9030590 · Cited by 61 · see citing works

The cellular pathways of liver fibrosis in non-alcoholic steatohepatitis

Méndez‐Sánchez, N., Valencia-Rodríguez, A., Coronel-Castillo, C. E., Vera-Barajas, A., Contreras-Carmona, J., Ponciano‐Rodríguez, G., & Zamora‐Valdés, D. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.02.184 · Cited by 54 · see citing works

Fibrogenic Pathways in Metabolic Dysfunction Associated Fatty Liver Disease (MAFLD)

Subramanian, P., Hampe, J., Tacke, F., & Chavakis, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23136996 · Cited by 32 · see citing works