Analysis of gut microbiome and metabolite characteristics in patients with slow transit constipation
Abstract
Background Slow transit constipation (STC) is a type of functional constipation in which colon transit time is extended as a result of a reduction in the high amplitude of colon contraction activity. The utility of gut microbiome and metabolite characteristics in patients with STC is rarely studied. Short-chain fatty acids (SCFAs) enhance colonic fluid and sodium absorption and thus may aggravate the symptoms of STC. However, the content and role of SCFAs in constipation patients are not clear. We speculate that gut microbiome and SCFAs in the colon of STC patients may be abnormal and linked to the underlying mechanism of STC.Methods This observational study is registered at ClinicalTrials.gov (NCT02984969). The high-throughput sequencing was used to analyze the diversity and composition of fecal microbial communities. Gas chromatography-mass spectrometry (GC-MS) was used to determine the properties and concentrations of the SCFAs in the two groups.Results The Shannon diversity and Simpson diversity of the gut microbiome were significantly greater in the STC group than the control group. The two groups also showed significant differences in the species composition of the gut microbiome at different classification levels. The results of GC-MS showed that the acetate concentrations in the STC group were significantly reduced compared with the control group, but the other five types of SCFAs and total SCFAs showed no significant difference between groups. ROC curve analyses revealed that the AUC of Acetate (AUC = 0.758) was higher than Propionate (AUC = 0.660). The largest AUC of gut microbiome for predicting STC was Prevotella (AUC = 0.807). Correlation analysis showed a positive correlation between the concentration of Ruminococcus and Disease history (rs = 0.519). Meanwhile, a positive correlation between the concentration of Roseburia and Acetate (rs = 0.606) or Butyrate (rs = 0.543) was found.Conclusion We found significant differences between the STC and control groups in the main components of the gut microbiome, with greater diversity in the STC group and differences between the groups in species composition at different classification levels. These different microbiome and metabolite may be valuable biomarkers for STC.
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SCFAs are associated with a variety of diseases such as rectal cancer, pancreatitis, abnormal energy metabolism, constipation, blood lipid metabolism, sleep disorders and Alzheimer's disease.
“Studies have found that SCFAs are associated with a variety of diseases such as rectal cancer, 174 pancreatitis, 175 abnormal energy metabolism, 176 constipation, 177 blood lipid metabolism, 178 sleep disorders 179 and Alzheimer's disease.180”
From The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options (2021) · cites this paper as [177]
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- Authors
- Tian, H., Chen, Q., Yang, B., Qin, H., & Li, N.
- Affiliations
- Tongji University (CN)
- Corresponding author
- Chen, Qiyi
- Venue
- Digestive Diseases and Sciences
- Published
- 2020-08-07
- Volume
- 66
- Issue
- 9
- Pages
- 3026-3035
- ISSN
- 0163-2116 (ISSN-L)
- 1573-2568
- OpenAlex
- W3048083926
- Cited by
- 68
- References
- 22
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 11 · 2023: 20 · 2022: 12 · 2021: 5 · 2020: 1
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Digestive Diseases and Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
- Keywords
- slow transit constipation, gut microbiota, short-chain fatty acids, acetate, propionate, butyrate, Prevotella, Ruminococcus, Roseburia, fecal microbiota diversity, biomarkers, functional constipation, colonic transit time
- MeSH terms
- Gastrointestinal Microbiome, Acetates, Adult, Colon, Constipation, Fatty Acids, Volatile, Feces, Female, Gastrointestinal Motility, Humans, Male, Gas Chromatography-Mass Spectrometry, Propionates, RNA, Ribosomal, 16S, ROC Curve, Biomarkers, Prevotella, Area Under Curve, Ruminococcus, High-Throughput Nucleotide Sequencing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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