The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Enrichment of gilthead seabream (Sparus aurata L.) diet with microalgae: effects on the immune system
Abstract
The present study assessed the effects of three orally administered microalgae (Nannochloropsis gaditana, Tetraselmis chuii and Phaeodactylum tricornutum) on different immune parameters and immune-related gene expression of gilthead seabream (Sparus aurata L.). Fish were fed a control or one of six experimental diets and sampled at 2 and 4 weeks of treatment. At the end of the trial, growth performance and different systemic and local immune activities were measured (natural haemolytic complement activity, IgM levels, phagocytosis and respiratory burst). The expression levels of different immune-associated genes (EF-1α, IgM(H), TCR-β, MHCIα, MHCIIα, CSF-1R and β-defensin) were analysed in head-kidney and gut. Administration of N. gaditana and T. chuii resulted in a significant increase in haemolytic complement activity, phagocytic capacity, as well expression level of β-defensin, as well as MHCIIα and CSF-1R, respectively. The P. tricornutum-supplemented diet provoked immunostimulation, and very little effect on gene expression was observed. These results suggest that dietary microalgae enhance gilthead seabream defence activity, which could be very important in order to consider such microalgae as a possible additive in fish diets.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In another study, administration of (Tetraselmis chuii, Nannochloropsis gaditana, and P. tricornutum) orally enhanced the defence activity of gilthead seabream (S. aurata) (Cerezuela et al., 2012).”
From Potential of microalgae as a sustainable feed ingredient for aquaculture (2021) · cites this paper as Cerezuela et al., 2012
Citations
Cites
Commercial Applications of Microalgae
Spolaore, P., Joannis-Cassan, C., Duran, E., & Isambert, A. (2006) · Journal of Bioscience and Bioengineering · doi:10.1263/jbb.101.87 · Cited by 4,285
Nutritional properties of microalgae for mariculture
Brown, M. R., Jeffrey, S. W., Volkman, J. K., & Dunstan, G. A. (1997) · Aquaculture · doi:10.1016/s0044-8486(96)01501-3 · Cited by 1,041
The amino-acid and sugar composition of 16 species of microalgae used in mariculture
Brown, M. R. (1991) · Journal of Experimental Marine Biology and Ecology · doi:10.1016/0022-0981(91)90007-j · Cited by 572
Innovative natural functional ingredients from microalgae
Plaza, M., Herrero, M., Cifuentes, A., & Ibáñez, E. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf901070g · Cited by 509
Microalgae for aquaculture: Opportunities and constraints
Borowitzka, M. A. (1997) · Journal of Applied Phycology · doi:10.1023/a:1007921728300 · Cited by 478
Leiro, J. M., Castro, R., Arranz, J. A., & Lamas, J. (2007) · International Immunopharmacology · doi:10.1016/j.intimp.2007.02.007 · Cited by 316
Total serum immunoglobulin M levels are affected by immunomodulators in seabream (Sparus aurata L.)
Cuesta, A., Meseguer, J., & Esteban, M. Á. (2004) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2004.04.021 · Cited by 302
Microalgae: a novel ingredient in nutrition
Christaki, E. V., Florou-Paneri, P. C., & Bonos, E. (2011) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2011.582460 · Cited by 298
Campa‐Córdova, Á. I., Hernández-Saavedra, N. Y., Philippis, R. D., & Ascencio, F. (2002) · Fish & Shellfish Immunology · doi:10.1006/fsim.2001.0377 · Cited by 285
Guzmán, S., Gato, A., Lamela, M., Freire‐Garabal, M., & Calleja, J. M. (2003) · Phytotherapy Research · doi:10.1002/ptr.1227 · Cited by 283
Research works printed but not linked: 2
- Ghezelbash F, Farboodnia T, Heidari R, Agh N (2008) Biochemical effects of different salinities and luminance on green microalgae Tetraselmis chuii. R J Biol Sci 3:217–221
- Ortuño J, Esteban MA, Mulero V, Meseguer J (1998) Methods for studying the haemolytic, chemoattractant and opsonic activities of seabream (Sparus aurata L.). In: Barnes AC, Davidson GA, Hiney M, McInthos D (eds) Methodology in fish diseases research. Albion Press, Aberdeen, pp 97–100
Cited by
Sorted by citations
(BIOHAZ), E. P. O. B. H., Ricci, A., Allende, A., Bolton, D., Chemaly, M., Davies, R., Gironés, R., Herman, L., Koutsoumanis, K. P., Lindqvist, R., et al. (2017) · EFSA Journal · doi:10.2903/j.efsa.2017.4664 · Cited by 467
Microalgae in aquafeeds for a sustainable aquaculture industry
Shah, M. R., Lutzu, G. A., Alam, A., Sarker, P., Kabir Chowdhury, M. A., Parsaeimehr, A., Liang, Y., & Daroch, M. (2018) · Journal of Applied Phycology · doi:10.1007/s10811-017-1234-z · Cited by 463
Astaxanthin as feed supplement in aquatic animals
Lim, K. C., Yusoff, F. M., Shariff, M., & Kamarudin, M. S. (2017) · Reviews in Aquaculture · doi:10.1111/raq.12200 · Cited by 461
(BIOHAZ), E. P. O. B. H., Koutsoumanis, K., Allende, A., Álvarez‐Ordóñez, A., Bolton, D., Bover‐Cid, S., Chemaly, M., Davies, R., Cesare, A. D., Hilbert, F., et al. (2021) · EFSA Journal · doi:10.2903/j.efsa.2021.6377 · Cited by 446
Mucosal immunity and probiotics in fish
Lazado, C. C., & Caipang, C. M. A. (2014) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2014.04.015 · Cited by 434
Metadata
- Authors
- Cerezuela, R., Guardiola, F. A., Meseguer, J., & Esteban, M. Á.
- Affiliations
- Universidad de Murcia (ES)
- Corresponding author
- Esteban, M. Ángeles
- Venue
- Fish Physiology and Biochemistry
- Published
- 2012-12
- Volume
- 38
- Issue
- 6
- Pages
- 1729-1739
- ISSN
- 0920-1742 (ISSN-L)
- 1573-5168
- OpenAlex
- W2048560883
- Cited by
- 137
- References
- 41
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 11 · 2023: 10 · 2022: 21 · 2021: 22 · 2020: 17 · 2019: 11 · 2018: 4 · 2017: 9 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 2 · 2012: 1
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Fish Physiology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Aquaculture disease management and microbiota
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- Sparus aurata, Nannochloropsis gaditana, Tetraselmis chuii, Phaeodactylum tricornutum, fish immunity, immunostimulation, IgM, phagocytosis, respiratory burst, immune gene expression, beta-defensins, MHC class II, CSF1R, head kidney, intestine, fish feed additives
- MeSH terms
- Animals, Animal Feed, Animal Nutritional Physiological Phenomena, Diet, Immunoglobulin M, Leukocytes, Respiratory Burst, Sea Bream, Microalgae, Real-Time Polymerase Chain Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
