Cited by 137Aquaculture disease management and microbiotaAquaculture Nutrition and GrowthAnimal Nutrition and Physiology

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Enrichment of gilthead seabream (Sparus aurata L.) diet with microalgae: effects on the immune system

Cerezuela, Rebeca, Guardiola, Francisco Antonio, Meseguer, José, Esteban, M. Ángeles·2012·Fish Physiology and Biochemistry

DOI 10.1007/s10695-012-9670-9

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Abstract

The present study assessed the effects of three orally administered microalgae (Nannochloropsis gaditana, Tetraselmis chuii and Phaeodactylum tricornutum) on different immune parameters and immune-related gene expression of gilthead seabream (Sparus aurata L.). Fish were fed a control or one of six experimental diets and sampled at 2 and 4 weeks of treatment. At the end of the trial, growth performance and different systemic and local immune activities were measured (natural haemolytic complement activity, IgM levels, phagocytosis and respiratory burst). The expression levels of different immune-associated genes (EF-1α, IgM(H), TCR-β, MHCIα, MHCIIα, CSF-1R and β-defensin) were analysed in head-kidney and gut. Administration of N. gaditana and T. chuii resulted in a significant increase in haemolytic complement activity, phagocytic capacity, as well expression level of β-defensin, as well as MHCIIα and CSF-1R, respectively. The P. tricornutum-supplemented diet provoked immunostimulation, and very little effect on gene expression was observed. These results suggest that dietary microalgae enhance gilthead seabream defence activity, which could be very important in order to consider such microalgae as a possible additive in fish diets.

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Authors: Cerezuela, R., Guardiola, F. A., Meseguer, J., & Esteban, M. Á.
Affiliations: Universidad de Murcia (ES)
Corresponding author: Esteban, M. Ángeles
ORCID: Guardiola, Francisco Antonio
Esteban, M. Ángeles
Venue: Fish Physiology and Biochemistry
Publisher: Springer Science and Business Media LLC
Published: 2012-12
Volume: 38
Issue: 6
Pages: 1729-1739
ISSN: 0920-1742 (ISSN-L)
1573-5168
DOI: 10.1007/s10695-012-9670-9
OpenAlex: W2048560883
Cited by: 137
References: 41
Citations by year: 2026: 8 · 2025: 11 · 2024: 11 · 2023: 10 · 2022: 21 · 2021: 22 · 2020: 17 · 2019: 11 · 2018: 4 · 2017: 9 · 2016: 2 · 2015: 4 · 2014: 4 · 2013: 2 · 2012: 1
FWCI: 1.53
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Fish Physiology and Biochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Aquaculture disease management and microbiota
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords: Sparus aurata, Nannochloropsis gaditana, Tetraselmis chuii, Phaeodactylum tricornutum, fish immunity, immunostimulation, IgM, phagocytosis, respiratory burst, immune gene expression, beta-defensins, MHC class II, CSF1R, head kidney, intestine, fish feed additives
MeSH terms: Animals, Animal Feed, Animal Nutritional Physiological Phenomena, Diet, Immunoglobulin M, Leukocytes, Respiratory Burst, Sea Bream, Microalgae, Real-Time Polymerase Chain Reaction

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Enrichment of gilthead seabream (Sparus aurata L.) diet with microalgae: effects on the immune system

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