The DOI matches its Crossref record; 139 of the 139 references it cites were found in a registry or an index.
Epicardial adipose tissue as a metabolic transducer: role in heart failure and coronary artery disease
Abstract
Obesity and diabetes are strongly associated with metabolic and cardiovascular disorders including dyslipidemia, coronary artery disease, hypertension, and heart failure. Adipose tissue is identified as a complex endocrine organ, which by exerting a wide array of regulatory functions at the cellular, tissue and systemic levels can have profound effects on the cardiovascular system. Different terms including "epicardial," "pericardial," and "paracardial" have been used to describe adipose tissue deposits surrounding the heart. Epicardial adipose tissue (EAT) is a unique and multifaceted fat depot with local and systemic effects. The functional and anatomic proximity of EAT to the myocardium enables endocrine, paracrine, and vasocrine effects on the heart. EAT displays a large secretosome, which regulates physiological and pathophysiological processes in the heart. Perivascular adipose tissue (PVAT) secretes adipose-derived relaxing factor, which is a "cocktail" of cytokines, adipokines, microRNAs, and cellular mediators, with a potent effect on paracrine regulation of vascular tone, vascular smooth muscle cell proliferation, migration, atherosclerosis-susceptibility, and restenosis. Although there are various physiological functions of the EAT and PVAT, a phenotypic transformation can lead to a major pathogenic role in various cardiovascular diseases. The equilibrium between the physiological and pathophysiological properties of EAT is very delicate and susceptible to the influences of intrinsic and extrinsic factors. Various adipokines secreted from EAT and PVAT have a profound effect on the myocardium and coronary arteries; targeting these adipokines could be an important therapeutic approach to counteract cardiovascular disease.
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“In other words, the anatomic proximity of EAT to the myocardium may characterize this structure as a transducer that address and amplify systemic derangements onto the heart through paracrine and vasocrine mechanisms [18,90].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [90]
In the citing paper
“More interestingly, according to a suggestive and convincing pathophysiological reconstruction formulated by some experts, an EAT enlarged and biologically transformed by diabetes and/or obesity, may transfer intrinsic injury towards the heart already damaged by the same systemic metabolic disorders.”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [90]
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Gheblawi, M., Wang, K., Viveiros, A., Nguyen, Q., Zhong, J.-C., Turner, A. J., Raizada, M. K., Grant, M. B., & Oudit, G. Y. (2020) · Circulation Research · doi:10.1161/circresaha.120.317015 · Cited by 1,882
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Verma, S., & McMurray, J. J. V. (2018) · Diabetologia · doi:10.1007/s00125-018-4670-7 · Cited by 999
Self-citationPacker, M. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.03.509 · Cited by 656
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Self-citationThe renin-angiotensin system: going beyond the classical paradigms
Santos, R. A. S., Oudit, G. Y., Verano‐Braga, T., Canta, G., Steckelings, U. M., & Bäder, M. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00723.2018 · Cited by 347
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Metadata
- Authors
- Patel, V. B., Shah, S., Verma, S., & Oudit, G. Y.
- Affiliations
- University of Alberta (CA)
- St. Michael's Hospital (CA)
- Corresponding author
- Oudit, Gavin Y.
- Venue
- Heart Failure Reviews
- Published
- 2017-07-31
- Volume
- 22
- Issue
- 6
- Pages
- 889-902
- ISSN
- 1382-4147 (ISSN-L)
- 1573-7322
- OpenAlex
- W2741189758
- Cited by
- 218
- References
- 139
- Citations by year
- 2026: 11 · 2025: 20 · 2024: 26 · 2023: 13 · 2022: 35 · 2021: 27 · 2020: 37 · 2019: 31 · 2018: 18
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Heart Failure Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Heart and Stroke Foundation of Canada
- Alberta Innovates
- Canadian Institutes of Health Research (88341)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- epicardial adipose tissue, pericardial adipose tissue, adipokines, adipose tissue endocrine function, paracrine signaling, heart failure, coronary artery disease, obesity, diabetes mellitus, vascular smooth muscle cell proliferation, atherosclerosis, restenosis, dyslipidemia, hypertension
- MeSH terms
- Adipose Tissue, Coronary Artery Disease, Heart Failure, Humans, Myocardium, Pericardium, Cytokines, Adipokines
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