Cited by 325Treatment of Major DepressionTryptophan and brain disordersPharmacological Receptor Mechanisms and Effects

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New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors

Maes, Michael, Fišar, Zdenĕk, Medina, Miguel, Scapagnini, Giovanni, Nowak, Gabriel, Berk, Michael·2012·Inflammopharmacology

DOI 10.1007/s10787-011-0111-7

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Abstract

This paper reviews new drug targets in the treatment of depression and new drug candidates to treat depression. Depression is characterized by aberrations in six intertwined pathways: (1) inflammatory pathways as indicated by increased levels of proinflammatory cytokines, e.g. interleukin-1 (IL-1), IL-6, and tumour necrosis factor α. (2) Activation of cell-mediated immune pathways as indicated by an increased production of interferon γ and neopterin. (3) Increased reactive oxygen and nitrogen species and damage by oxidative and nitrosative stress (O&NS), including lipid peroxidation, damage to DNA, proteins and mitochondria. (4) Lowered levels of key antioxidants, such as coenzyme Q10, zinc, vitamin E, glutathione, and glutathione peroxidase. (5) Damage to mitochondria and mitochondrial DNA and reduced activity of respiratory chain enzymes and adenosine triphosphate production. (6) Neuroprogression, which is the progressive process of neurodegeneration, apoptosis, and reduced neurogenesis and neuronal plasticity, phenomena that are probably caused by inflammation and O&NS. Antidepressants tend to normalize the above six pathways. Targeting these pathways has the potential to yield antidepressant effects, e.g. using cytokine antagonists, minocycline, Cox-2 inhibitors, statins, acetylsalicylic acid, ketamine, ω3 poly-unsaturated fatty acids, antioxidants, and neurotrophic factors. These six pathways offer new, pathophysiologically guided drug targets suggesting that novel therapies could be developed that target these six pathways simultaneously. Both nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activators and glycogen synthase kinase-3 (GSK-3) inhibitors target the six above-mentioned pathways. GSK-3 inhibitors have antidepressant effects in animal models of depression. Nrf2 activators and GSK-3 inhibitors have the potential to be advanced to phase-2 clinical trials to examine whether they augment the efficacy of antidepressants or are useful as monotherapy.

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Romeo, L., Intrieri, M., D’Agata, V., Mangano, N. G., Oriani, G., Ontario, M. L., & Scapagnini, G. (2009) · Journal of the American College of Nutrition · doi:10.1080/07315724.2009.10718116 · Cited by 105
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Retracted
The phosphoinositide 3-kinase pathway
Cantley, L. C. (2002) · Science · doi:10.1126/science.296.5573.1655 · Cited by 5,621
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729
Mitochondria, Oxidants, and Aging
Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388
An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements
Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999
Ischemic Cell Death in Brain Neurons
Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043
Assessing mitochondrial dysfunction in cells
Brand, M. D., & Nicholls, D. G. (2011) · Biochemical Journal · doi:10.1042/bj20110162 · Cited by 2,436

Show all 300 references

Research works printed but not linked: 3

Maes M, Meltzer HY (1995) The serotonin hypothesis of major depression. selected chapters on mood disorders. In: Bloom F, Kupfer D (eds) Psychopharmacology. The fourth generation of progress. Raven Press, USA, pp 933–944
Malhi GS, Berk M (2011) Balance restored: lithium remains a safe and sound choice. Lancet (in press)
Scapagnini G, Caruso C, Calabrese V (2011a) Therapeutic potential of dietary polyphenols against brain ageing and neurodegenerative disorders. Adv Exp Med Biol 698:27–35 · DOI

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Retracted
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Richard, A., Rohrmann, S., Mohler‐Kuo, M., Rodgers, S., Moffat, R., Güth, U., & Eichholzer, M. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.12.029 · Cited by 33
Lowered zinc and copper levels in drug-naïve patients with major depression: Effects of antidepressants, ketoprofen and immune activation
Twayej, A. J., Al‐Hakeim, H. K., Al-Dujaili, A. H., & Maes, M. H. J. (2019) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2019.1612090 · Cited by 33
Self-citation
The impact of repetitive transcranial magnetic stimulation and fluoxetine on the brain lipidome in a rat model of chronic unpredictable stress
Xue, S., Zhou, C., Xue, F., Liu, L., Cai, Y., Luo, J., Wang, Y., Tan, Q., Wang, H., & Peng, Z. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109946 · Cited by 32
Antioxidant-Rich Woodfordia fruticosa Leaf Extract Alleviates Depressive-Like Behaviors and Impede Hyperglycemia
Tayab, M. A., Chowdhury, K. A. A., Jabed, M., Tareq, S. M., Kamal, A. T. M. M., Islam, M. N., Uddin, A. M. K., Hossain, M. A., Emran, T. B., & Simal‐Gándara, J. (2021) · Plants · doi:10.3390/plants10020287 · Cited by 32
Major Depression in Children with Transfusion-Dependent Thalassemia Is Strongly Associated with the Combined Effects of Blood Transfusion Rate, Iron Overload, and Increased Pro-inflammatory Cytokines
Al‐Hakeim, H. K., Najm, A. H., Al-Dujaili, A. H., & Maes, M. H. J. (2020) · Neurotoxicity Research · doi:10.1007/s12640-020-00193-1 · Cited by 31
Self-citation
Neuromodulatory effect of curcumin on catecholamine systems and inflammatory cytokines in ovariectomized female rats
Saied, N. M., Georgy, G. S., Hussien, R. M., & Hassan, W. A. (2020) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13427 · Cited by 30
Understanding the relationship between GSK-3 and Alzheimer’s disease: a focus on how GSK-3 can modulate synaptic plasticity processes
Medina, M., & Ávila, J. (2013) · Expert Review of Neurotherapeutics · doi:10.1586/ern.13.39 · Cited by 33
Self-citation
Secondary Metabolites from Rosemary (Rosmarinus officinalis L.): Structure, Biochemistry and Therapeutic Implications Against Neurodegenerative Diseases
Alvi, S. S., Ahmad, P., Ishrat, M., Iqbal, D., & Khan, M. S. (2019) · Springer eBooks · doi:10.1007/978-981-13-7205-6_1 · Cited by 31
Hippocampal Over-Expression of Cyclooxygenase-2 (COX-2) Is Associated with Susceptibility to Stress-Induced Anhedonia in Mice
Strekalova, T. V., Pavlov, D., Трофимов, А. Н., Anthony, D. C., Svistunov, A. A., Proshin, A. T., Umriukhin, A., Lyundup, A. V., Lesch, K., & Cespuglio, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042061 · Cited by 31
Development of RNA Interference–Based Therapeutics and Application of Multi-Target Small Interfering RNAs
Li, T., Wu, M., Zhu, Y. Y., Chen, J., & Chen, L. (2014) · Nucleic Acid Therapeutics · doi:10.1089/nat.2014.0480 · Cited by 29
Role of Aspirin and Dexamethasone against Experimentally Induced Depression in Rats
Bhatt, S., Shukla, P., Raval, J., & Goswami, S. (2015) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12539 · Cited by 29
Plasma Indoleamine-2,3-Dioxygenase (IDO) is Increased in Drug-Naï ve Major Depressed Patients and Treatment with Sertraline and Ketoprofen Normalizes IDO in Association with Pro-Inflammatory and Immune- Regulatory Cytokines
Al‐Hakeim, H. K., Twayej, A. J., Al-Dujaili, A. H., & Maes, M. H. J. (2020) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527319666200102100307 · Cited by 30
Self-citation
Apigenin attenuates depressive-like behavior via modulating monoamine oxidase A enzyme activity in chronically stressed mice
Olayinka, J. N., Akawa, O. B., Ogbu, E. K., Eduviere, A. T., Ozolua, R. I., & Soliman, M. E. S. (2023) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2023.100161 · Cited by 30
Protective effect of hydroxytyrosol in arsenic‐induced mitochondrial dysfunction in rat brain
Soni, M., Prakāsh, C., Sehwag, S., & Kumar, V. J. (2017) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.21906 · Cited by 28
Insights into the potential antidepressant mechanisms of cilostazol in chronically restraint rats: impact on the Nrf2 pathway
Abuelezz, S. A., & Hendawy, N. (2017) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000335 · Cited by 28
Anti-Oxidative Effects of Melatonin Receptor Agonist and Omega-3 Polyunsaturated Fatty Acids in Neuronal SH-SY5Y Cells: Deciphering Synergic Effects on Anti-Depressant Mechanisms
Satyanarayanan, S. K., Shih, Y.-H., Chien, Y.-C., Huang, S., Gałecki, P., Kasper, S. F., Chang, J. P., & Su, K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0899-x · Cited by 28
Activation of the kynurenine pathway and mitochondrial respiration to face allostatic load in a double-hit model of stress
Nold, V., Sweatman, C., Karabatsiakis, A., Böck, C., Bretschneider, T., Lawless, N., Fundel‐Clemens, K., Kolassa, I., & Allers, K. A. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.04.006 · Cited by 27
Protective Effect of Epigallocatechin-3-Gallate in Hydrogen Peroxide-Induced Oxidative Damage in Chicken Lymphocytes
Chi, X., Ma, X., Li, Z., Zhang, Y., Wang, Y., Yuan, L., Wu, Y., Xu, W., & Hu, S. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/7386239 · Cited by 28
The relationship between a plant-based diet and mental health: Evidence from a cross-sectional multicentric community trial (LIPOKAP study)
Haghighatdoost, F., Mahdavi, A., Mohammadifard, N., Hassannejad, R., Najafi, F., Farshidi, H., Lotfizadeh, M., Kazemi, T., Karimi, S., Roohafza, H., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0284446 · Cited by 32
Associations of different types of dairy intakes with depressive symptoms in adults
Sun, J., Wang, W., & Zhang, D. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.05.095 · Cited by 27
Vesicular signalling and immune modulation as hedonic fingerprints: proteomic profiling in the chronic mild stress depression model
Bisgaard, C. F., Bak, S. Y., Christensen, T. T., Jensen, O. N., Enghild, J. J., & Wiborg, O. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112460110 · Cited by 27
An empirical review on oxidative stress markers and their relevance in obsessive-compulsive disorder
Kar, S., & Choudhury, I. (2016) · International journal of Nutrition Pharmacology Neurological Diseases · doi:10.4103/2231-0738.191641 · Cited by 26
Duloxetine Protects Human Neuroblastoma Cells from Oxidative Stress-Induced Cell Death Through Akt/Nrf-2/HO-1 Pathway
Engel, D. F., de Oliveira, J., Lieberknecht, V., Rodrigues, A. L. S., Bem, A. F. D., & Gabilan, N. H. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2433-3 · Cited by 27
The emerging role of KCl cotransport in tumor biology.
Chen, Y., Chou, C.-Y., Ellory, J. C., & Shen, M.-R. (2010) · PubMed Central · Cited by 27
The role of glutamate excitotoxicity and neuroinflammation in depression and suicidal behavior: focus on microglia cells
Serafini, G., Amore, M., & Rihmer, Z. (2015) · Neuroimmunology and Neuroinflammation · doi:10.4103/2347-8659.157955 · Cited by 27
Glutathione alterations in depression: a meta-analysis and systematic review of proton magnetic resonance spectroscopy studies
Bell, C. J. M., Mehta, M., Mirza, L., Young, A. H., & Beck, K. (2025) · Psychopharmacology · doi:10.1007/s00213-024-06735-1 · Cited by 28
Peripheral Immune-Inflammatory Pathways in Major Depressive Disorder, Bipolar Disorder, and Schizophrenia: Exploring Their Potential as Treatment Targets
Almulla, A. F., & Maes, M. H. J. (2025) · CNS Drugs · doi:10.1007/s40263-025-01195-3 · Cited by 29
Self-citation
Cell-bound nanoparticles for tissue targeting and immunotherapy: Engineering of the particle–membrane interface
Prakash, S., Kumbhojkar, N., Clegg, J. R., & Mitragotri, S. (2020) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2020.101408 · Cited by 27
Targeting NRF2 in Type 2 diabetes mellitus and depression: Efficacy of natural and synthetic compounds
Subba, R., Ahmad, M. H., Ghosh, B., & Mondal, A. C. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174993 · Cited by 26
The Potential Role of Monocyte Chemoattractant Protein-1 for Major Depressive Disorder
Pae, C. (2014) · Psychiatry Investigation · doi:10.4306/pi.2014.11.3.217 · Cited by 27
Lacidipine attenuates reserpine-induced depression-like behavior and oxido-nitrosative stress in mice
Khurana, K., & Bansal, N. (2019) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-019-01667-6 · Cited by 27
Statin-Induced Changes in Mitochondrial Respiration in Blood Platelets in Rats and Human With Dyslipidemia
Vevera, J., Fišar, Z., Nekovářová, T., Vrablı́k, M., Zlatohlávek, L., Hroudová, J., Singh, N., Raboch, J., & Valeš, K. (2016) · Physiological Research · doi:10.33549/physiolres.933264 · Cited by 24
Self-citation
ASPREE-D: Aspirin for the prevention of depression in the elderly
Berk, M., Woods, R. L., Nelson, M. R., Shah, R. C., Reid, C. M., Storey, E., Fitzgerald, S. M., Lockery, J. E., Wolfe, R. S., Mohebbi, M., et al. (2016) · International Psychogeriatrics · doi:10.1017/s104161021600079x · Cited by 26
Self-citation
Neuroplasticity and second messenger pathways in antidepressant efficacy: pharmacogenetic results from a prospective trial investigating treatment resistance
Fabbri, C., Crisafulli, C., Calati, R., Albani, D., Forloni, G., Calabrò, M., Martines, R., Kasper, S. F., Zohar, J., Juven‐Wetzler, A., et al. (2017) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-017-0766-1 · Cited by 25
Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Trial
Carillon, J., Notin, C., Schmitt, K., Simoneau, G., & Lacan, D. (2014) · Nutrients · doi:10.3390/nu6062348 · Cited by 23
Brain antioxidant effect of mirtazapine and reversal of sedation by its combination with alpha-lipoic acid in a model of depression induced by corticosterone
Oliveira, T. D. Q., de Sousa, C. N. S., Vasconcelos, G. S., de Sousa, L. C., de Oliveira, A. A., Patrocínio, C. F. V., Medeiros, I. D. S., Júnior, J. E. R. H., Maes, M. H. J., Macêdo, D. S., et al. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.05.022 · Cited by 24
Self-citation
Effects of ketamine administration on the phosphorylation levels of CREB and TrKB and on oxidative damage after infusion of MEK inhibitor
Réus, G. Z., Abaleira, H. M., Titus, S. E., Arent, C. O., Michels, M., da Luz, J. R., dos Santos, M. A. B., Carlessi, A. S., Matias, B. I., Bruchchen, L., et al. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2015.08.010 · Cited by 23

Authors: Maes, M., Fišar, Z., Medina, M., Scapagnini, G., Nowak, G., & Berk, M.
Affiliations: University of Molise (IT)
Jagiellonian University (PL)
Mental Health Research Institute (AU)
Corresponding author: Maes, Michael
ORCID: Maes, Michael
Medina, Miguel
Scapagnini, Giovanni
Nowak, Gabriel
Venue: Inflammopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2012-01-24
Volume: 20
Issue: 3
Pages: 127-150
ISSN: 0925-4692 (ISSN-L)
1568-5608
DOI: 10.1007/s10787-011-0111-7
OpenAlex: W2008971294
Cited by: 325
References: 300
Citations by year: 2026: 4 · 2025: 14 · 2024: 11 · 2023: 19 · 2022: 21 · 2021: 14 · 2020: 32 · 2019: 19 · 2018: 18 · 2017: 26 · 2016: 31 · 2015: 29 · 2014: 29 · 2013: 36 · 2012: 21
FWCI: 4.26
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Inflammopharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Receptor Mechanisms and Effects
Keywords: depression, antidepressant targets, neuroinflammation, inflammatory cytokines, cell-mediated immunity, oxidative stress, nitrosative stress, mitochondrial dysfunction, antioxidant pathways, neurodegeneration, apoptosis, neurogenesis, Nrf2 activators, GSK-3 inhibitors, minocycline, ketamine, omega-3 polyunsaturated fatty acids, neurotrophic factors
MeSH terms: Animals, Antioxidants, Depression, Humans, Immunity, Cellular, Mitochondria, Nitrosation, Drug Delivery Systems, Oxidative Stress, Disease Progression, Inflammation Mediators, Glycogen Synthase Kinase 3, NF-E2-Related Factor 2

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New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors

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