The DOI matches its Crossref record; 299 of the 300 references it cites were found in a registry or an index.
New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates—Nrf2 activators and GSK-3 inhibitors
Abstract
This paper reviews new drug targets in the treatment of depression and new drug candidates to treat depression. Depression is characterized by aberrations in six intertwined pathways: (1) inflammatory pathways as indicated by increased levels of proinflammatory cytokines, e.g. interleukin-1 (IL-1), IL-6, and tumour necrosis factor α. (2) Activation of cell-mediated immune pathways as indicated by an increased production of interferon γ and neopterin. (3) Increased reactive oxygen and nitrogen species and damage by oxidative and nitrosative stress (O&NS), including lipid peroxidation, damage to DNA, proteins and mitochondria. (4) Lowered levels of key antioxidants, such as coenzyme Q10, zinc, vitamin E, glutathione, and glutathione peroxidase. (5) Damage to mitochondria and mitochondrial DNA and reduced activity of respiratory chain enzymes and adenosine triphosphate production. (6) Neuroprogression, which is the progressive process of neurodegeneration, apoptosis, and reduced neurogenesis and neuronal plasticity, phenomena that are probably caused by inflammation and O&NS. Antidepressants tend to normalize the above six pathways. Targeting these pathways has the potential to yield antidepressant effects, e.g. using cytokine antagonists, minocycline, Cox-2 inhibitors, statins, acetylsalicylic acid, ketamine, ω3 poly-unsaturated fatty acids, antioxidants, and neurotrophic factors. These six pathways offer new, pathophysiologically guided drug targets suggesting that novel therapies could be developed that target these six pathways simultaneously. Both nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activators and glycogen synthase kinase-3 (GSK-3) inhibitors target the six above-mentioned pathways. GSK-3 inhibitors have antidepressant effects in animal models of depression. Nrf2 activators and GSK-3 inhibitors have the potential to be advanced to phase-2 clinical trials to examine whether they augment the efficacy of antidepressants or are useful as monotherapy.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“More than that, oxidative stress evaluation through F2-isoprostanes quantification [269] in depressed patients treated with sertraline or bupropion for eight months revealed high rates of oxidation, despite some psychiatric improvements [139].”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [139]
In the citing paper
“Curcumin is a pleiotropic agent that targets immune-inflammatory and oxidative and nitrosative stress pathways and promotes neuroprotection and improved neurogenesis [165, 166].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [166]
Citations
Cites
3 retracted
Romeo, L., Intrieri, M., D’Agata, V., Mangano, N. G., Oriani, G., Ontario, M. L., & Scapagnini, G. (2009) · Journal of the American College of Nutrition · doi:10.1080/07315724.2009.10718116 · Cited by 105
Self-citationRetractedCuzzocrea, S., Mazzon, E., Paola, R. D., Muià, C., Crisafulli, C., Dugo, L., Collin, M., Britti, D., Caputi, A. P., & Thiemermann, C. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.03.005 · Cited by 89
RetractedCuzzocrea, S., Mazzon, E., Esposito, E., Muià, C., Abdelrahman, M. S. I., Paola, R. D., Crisafulli, C., Bramanti, P., & Thiemermann, C. (2007) · Intensive Care Medicine · doi:10.1007/s00134-007-0595-1 · Cited by 57
RetractedThe phosphoinositide 3-kinase pathway
Cantley, L. C. (2002) · Science · doi:10.1126/science.296.5573.1655 · Cited by 5,621
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
A Meta-Analysis of Cytokines in Major Depression
Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729
Mitochondria, Oxidants, and Aging
Balaban, R. S., Nemoto, S., & Finkel, T. (2005) · Cell · doi:10.1016/j.cell.2005.02.001 · Cited by 4,388
Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999
Ischemic Cell Death in Brain Neurons
Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043
Assessing mitochondrial dysfunction in cells
Brand, M. D., & Nicholls, D. G. (2011) · Biochemical Journal · doi:10.1042/bj20110162 · Cited by 2,436
Research works printed but not linked: 3
- Maes M, Meltzer HY (1995) The serotonin hypothesis of major depression. selected chapters on mood disorders. In: Bloom F, Kupfer D (eds) Psychopharmacology. The fourth generation of progress. Raven Press, USA, pp 933–944
- Malhi GS, Berk M (2011) Balance restored: lithium remains a safe and sound choice. Lancet (in press)
- Scapagnini G, Caruso C, Calabrese V (2011a) Therapeutic potential of dietary polyphenols against brain ageing and neurodegenerative disorders. Adv Exp Med Biol 698:27–35 · DOI
Cited by
Sorted by citations
Kelly, J. R., Borre, Y., O' Brien, C., Patterson, E., El Aidy, S., Deane, J., Kennedy, P. J., Beers, S., Scott, K., Moloney, G., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.019 · Cited by 1,683
So depression is an inflammatory disease, but where does the inflammation come from?
Berk, M., Williams, L. J., Jacka, F. N., O’Neil, A., Pasco, J. A., Moylan, S., Allen, N. B., Stuart, A. L., Hayley, A. C., Byrne, M. L., et al. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-200 · Cited by 1,423
Self-citationOsimo, E. F., Pillinger, T., Rodriguez, I. M., Khandaker, G. M., Pariante, C. M., & Howes, O. D. (2020) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.02.010 · Cited by 937
Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling
Jarosz, M., Olbert, M., Wyszogrodzka, G., Młyniec, K., & Librowski, T. (2017) · Inflammopharmacology · doi:10.1007/s10787-017-0309-4 · Cited by 784
Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways
Maes, M., Berk, M., Goehler, L., Song, C., Anderson, G., Gałecki, P., & Leonard, B. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-66 · Cited by 629
Self-citationNutritional psychiatry: The present state of the evidence
Marx, W., Moseley, G., Berk, M., & Jacka, F. (2017) · Proceedings of the Nutrition Society · doi:10.1017/s0029665117002026 · Cited by 469
Self-citationLifestyle medicine for depression
Sarris, J., O’Neil, A., Coulson, C. E., Schweitzer, I., & Berk, M. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-107 · Cited by 450
Self-citationImmune mechanisms linked to depression via oxidative stress and neuroprogression
Bakunina, N., Pariante, C. M., & Zunszain, P. A. (2015) · Immunology · doi:10.1111/imm.12443 · Cited by 444
Oxidative & nitrosative stress in depression: Why so much stress?
Moylan, S., Berk, M., Dean, O. M., Samuni, Y., Williams, L. J., O'Neil, A. E., Hayley, A. C., Pasco, J. A., Anderson, G., Jacka, F. N., et al. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.05.007 · Cited by 412
Self-citationAspirin: a review of its neurobiological properties and therapeutic potential for mental illness
Berk, M., Dean, O. M., Drexhage, H. A., McNeil, J. J., Moylan, S., O'Neil, A. E., Davey, C. G., Sanna, L., & Maes, M. H. J. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-74 · Cited by 395
Self-citationMitochondrial Dysfunction in Depression
Bansal, Y., & Kuhad, A. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160229114755 · Cited by 360
Markers of Oxidative Stress and Neuroprogression in Depression Disorder
Vaváková, M., Ďuračková, Z., & Trebatická, J. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/898393 · Cited by 324
Mitochondrial Dysfunctions in Neurodegenerative Diseases: Relevance to Alzheimer’s Disease
Hroudová, J., Singh, N., & Fišar, Z. (2014) · BioMed Research International · doi:10.1155/2014/175062 · Cited by 319
Self-citationROS and Brain Diseases: The Good, the Bad, and the Ugly
Popa-Wagner, A., Mitran, S., Sivanesan, S., Chang, E., & Buga, A.-M. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/963520 · Cited by 427
Microglial Dysregulation in Psychiatric Disease
Frick, L. R., Williams, K., & Pittenger, C. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/608654 · Cited by 299
Jacka, F. N., Ystrøm, E., Brantsæter, A. L., Karevold, E., Roth, C., Haugen, M. A., Meltzer, H. M., Schjølberg, S., & Berk, M. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.07.002 · Cited by 284
Self-citationCardiovascular disease in autoimmune rheumatic diseases
Hollan, I., Meroni, P. L., Ahearn, J. M., Tervaert, J. W. C., Curran, S., Goodyear, C. S., Hestad, K. A., Kahaleh, B., Riggio, M. P., Shields, K. J., et al. (2013) · Autoimmunity Reviews · doi:10.1016/j.autrev.2013.03.013 · Cited by 278
Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression
Bouvier, E., Brouillard, F., Molet, J., Claverie, D., Cabungcal, J.-H., Cresto, N., Doligez, N., Rivat, C., Do, K. Q., Bernard, C., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.144 · Cited by 248
Cognitive remission: a novel objective for the treatment of major depression?
Bortolato, B., Miskowiak, K. W., Köhler, C. A., Maes, M., Fernandes, B. S., Berk, M., & Carvalho, A. F. (2016) · BMC Medicine · doi:10.1186/s12916-016-0560-3 · Cited by 252
Self-citationBiological hypotheses and biomarkers of bipolar disorder
Sigitova, E., Fišar, Z., Hroudová, J., Cikánková, T., & Raboch, J. (2016) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12476 · Cited by 257
Self-citationAntioxidants as potential therapeutics for neuropsychiatric disorders
Pandya, C. D., Howell, K. R., & Pillai, A. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.10.017 · Cited by 222
Peripheral Markers of Depression
Nobis, A., Zalewski, D., & Waszkiewicz, N. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9123793 · Cited by 197
Martín-Subero, M., Anderson, G., Kanchanatawan, B., Berk, M., & Maes, M. H. J. (2015) · CNS Spectrums · doi:10.1017/s1092852915000449 · Cited by 200
Self-citationThe Glutathione System: A New Drug Target in Neuroimmune Disorders
Morris, G., Anderson, G., Dean, O. M., Berk, M., Gałecki, P., Martín-Subero, M., & Maes, M. H. J. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8705-x · Cited by 194
Self-citationMetabolic syndrome, Mediterranean diet, and polyphenols: Evidence and perspectives
Finicelli, M., Squillaro, T., Cristo, F. D., Salle, A. D., Melone, M. A. B., Galderisi, U., & Peluso, G. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27506 · Cited by 196
Pall, M. L., & Levine, S. A. (2015) · PubMed · Cited by 183
Lopresti, A. L., & Drummond, P. D. (2014) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2434 · Cited by 193
Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses
Morris, G., Berk, M., Walder, K. R., & Maes, M. H. J. (2015) · BMC Medicine · doi:10.1186/s12916-014-0259-2 · Cited by 187
Self-citationThe relevance of oxidative stress status in first episode and recurrent depression
Stefanescu, C., & Ciobica, A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.05.022 · Cited by 179
The role of oxidative and nitrosative stress in accelerated aging and major depressive disorder
Maurya, P. K., Noto, C. D. S., Rizzo, L. B., Rios, A. C., Nunes, S. O. V., Barbosa, D. S., Sethi, S., Zeni‐Graiff, M., Mansur, R. B., Maes, M. H. J., et al. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.08.016 · Cited by 174
Self-citationBerk, M., Dean, O. M., Cotton, S. M., Jeavons, S., Tanious, M., Kohlmann, K., Hewitt, K., Moss, K., Allwang, C., Schapkaitz, I., et al. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13m08454 · Cited by 172
Self-citationRodent Models of Depression: Neurotrophic and Neuroinflammatory Biomarkers
Stepanichev, M. Y., Дыгало, Н. Н., Grigoryan, G. A., Shishkina, G. T., & Gulyaeva, N. V. (2014) · BioMed Research International · doi:10.1155/2014/932757 · Cited by 180
GSK3β, CREB, and BDNF in peripheral blood of patients with Alzheimer's disease and depression
Pláteník, J., Fišar, Z., Buchal, R., Jirák, R., Kitzlerová, E., Zvěřová, M., & Raboch, J. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.12.001 · Cited by 164
Self-citationMaes, M. H. J., Song, C., & Yirmiya, R. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2012.718331 · Cited by 158
Self-citationLopresti, A. L., Hood, S. D., & Drummond, P. D. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112458732 · Cited by 151
Oxidative/Nitrosative Stress and Immuno-inflammatory Pathways in Depression: Treatment Implications
Anderson, G., & Maes, M. H. J. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660738 · Cited by 148
Self-citationOxidative/nitrosative stress and antidepressants: Targets for novel antidepressants
Lee, S., Lee, S.-J., Han, C., Patkar, A. A., Masand, P. S., & Pae, C. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.09.008 · Cited by 148
Targeting classical IL-6 signalling or IL-6 trans-signalling in depression?
Maes, M., Anderson, G., Kubera, M., & Berk, M. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.888417 · Cited by 140
Self-citationMolecular aspects of depression: A review from neurobiology to treatment
Boas, G. R. V., de Lacerda, R. B., Paes, M. M., Gubert, P., Almeida, W. L. D. C., Rescia, V. C., Galdino, P. M., de Carvalho, A. A. V., & Oesterreich, S. A. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.02.024 · Cited by 140
Carvalho, A. F., Berk, M., Hyphantis, T. N., & McIntyre, R. S. (2014) · Psychotherapy and Psychosomatics · doi:10.1159/000357500 · Cited by 123
Self-citationUnfolding the Role of BDNF as a Biomarker for Treatment of Depression
Rana, T., Behl, T., Sehgal, A., Srivastava, P., & BUNGAU, S. G. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01754-x · Cited by 136
Lee, S., & Rhee, D. (2017) · Journal of Ginseng Research · doi:10.1016/j.jgr.2017.01.010 · Cited by 132
Sulakhiya, K., Kumar, P., Jangra, A., Dwivedi, S., Hazarika, N. K., Baruah, C. C., & Lahkar, M. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.09.049 · Cited by 116
Pharmacological Applications of Antioxidants: Lights and Shadows
Saso, L., & Firuzi, O. (2014) · Current Drug Targets · doi:10.2174/1389450115666141024113925 · Cited by 119
Mendez‐David, I., Tritschler, L., Ali, Z. E., Damiens, M.-H., Pallardy, M. J., David, D. J. P., Kerdine‐Römer, S., & Gardier, A. M. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.04.036 · Cited by 122
Shared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders
Morris, G., Puri, B. K., Walker, A. J., Maes, M. H. J., Carvalho, A. F., Bortolasci, C. C., Walder, K. R., & Berk, M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.025 · Cited by 119
Self-citationFreitas, A. E., Bettio, L. E. B., Neis, V. B., Santos, D. B., Ribeiro, C. M., da Rosa, P. B., Farina, M., & Rodrigues, A. L. S. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.12.012 · Cited by 108
Mitochondrial respiration in blood platelets of depressive patients
Hroudová, J., Fišar, Z., Kitzlerová, E., Zvěřová, M., & Raboch, J. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.05.005 · Cited by 108
Self-citationFreitas, A. E., Egea, J., Buendía, I., Gómez‐Rangel, V., Parada, E., Navarro, E., Casas, A. I., Wojnicz, A., Ortiz, J. A., Cuadrado, A., et al. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9182-6 · Cited by 108
Evidence for Inflammation-Associated Depression
Liu, C. S., Adibfar, A., Herrmann, N., Gallagher, D., & Lanctôt, K. L. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_2 · Cited by 114
Putative neuroprotective agents in neuropsychiatric disorders
Dodd, S., Maes, M. H. J., Anderson, G., Dean, O. M., Moylan, S., & Berk, M. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.11.007 · Cited by 105
Self-citationBalmus, I. M., Ciobica, A., Antioch, I., Dobrin, R., & Timofte, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3975101 · Cited by 103
“More than that, oxidative stress evaluation through F2-isoprostanes quantification [269] in depressed patients treated with sertraline or bupropion for eight months revealed high rates of oxidation, despite some psychiatric improvements [139].”
BackgroundDeak, T., Quinn, M., Cidlowski, J. A., Victoria, N. C., Murphy, A. Z., & Sheridan, J. F. (2015) · Stress · doi:10.3109/10253890.2015.1053451 · Cited by 108
Faster, better, stronger: Towards new antidepressant therapeutic strategies
O’Leary, O. F., Dinan, T. G., & Cryan, J. F. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.07.046 · Cited by 104
Kell, G., Rao, A., Beccaria, G., Clayton, P., Inarejos-García, A. M., & Pródanov, M. (2017) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2017.06.001 · Cited by 98
Anderson, G., Berk, M., Dean, O. M., Moylan, S., & Maes, M. H. J. (2013) · CNS Drugs · doi:10.1007/s40263-013-0119-1 · Cited by 95
Self-citationNunes, S. O. V., Vargas, H. O., Prado, E., Barbosa, D. S., de Melo, Moylan, S., Dodd, S., & Berk, M. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.014 · Cited by 94
Self-citationZhang, C., Zeng, M.-J., Zhou, L., Li, Y., Zhao, F., Shang, Z., Deng, X., Ma, Z., Fu, Q., Ma, S., et al. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.09.001 · Cited by 95
Inhibitory Effect of Lycopene on Amyloid-β-Induced Apoptosis in Neuronal Cells
Hwang, S., Lim, J. W., & Kim, H. (2017) · Nutrients · doi:10.3390/nu9080883 · Cited by 92
Protective Effects of Ascorbic Acid on Behavior and Oxidative Status of Restraint-Stressed Mice
Moretti, M., Budni, J., Santos, D. B., Antunes, A. A., Daufenbach, J. F., Manosso, L. M., Farina, M., & Rodrigues, A. L. S. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9892-4 · Cited by 92
Lifestyle management of unipolar depression
Berk, M., Sarris, J., Coulson, C. E., & Jacka, F. N. (2013) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12124 · Cited by 111
Self-citationRege, S., & Hodgkinson, S. J. (2013) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867413499077 · Cited by 90
The Dietary Components Carnosic Acid and Carnosol as Neuroprotective Agents: a Mechanistic View
de Oliveira, M. R. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9519-1 · Cited by 92
Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity
Doboszewska, U., Właź, P., Nowak, G., Radziwoń-Zaleska, M., Cui, R., & Młyniec, K. (2017) · Neural Plasticity · doi:10.1155/2017/3682752 · Cited by 90
Self-citationInflammatory Process and Immune System in Major Depressive Disorder
Ruiz, N. A. L., Ángel, D. S. D., Brizuela, N. O., Peraza, A. V., Olguı́n, H. J., Soto, M. P., & Guzmán, D. C. (2021) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab072 · Cited by 91
Zinc in the Glutamatergic Theory of Depression
Młyniec, K. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150115220617 · Cited by 91
Almulla, A. F., Vasupanrajit, A., Tunvirachaisakul, C., Al‐Hakeim, H. K., Solmi, M., Verkerk, R. M., & Maes, M. H. J. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01552-4 · Cited by 78
Self-citationAtopic disorders and depression: Findings from a large, population-based study
Sanna, L., Stuart, A. L., Pasco, J. A., Jacka, F. N., Berk, M., Maes, M. H. J., O'Neil, A. E., Girardi, P., & Williams, L. J. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.11.009 · Cited by 90
Self-citationAnderson, G., Maes, M. H. J., & Berk, M. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.07.016 · Cited by 86
Self-citationBild, W., Hritcu, L., Stefanescu, C., & Ciobica, A. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.12.009 · Cited by 83
Keap1/Nrf2/ARE redox-sensitive signaling system as a pharmacological target
Зенков, Н. К., Брониславовна, М. Е., & Tkachev, V. (2013) · Biochemistry (Moscow) · doi:10.1134/s0006297913010033 · Cited by 82
Martín-Hernández, D., Caso, J. R., Javier Meana, J., Callado, L. F., Madrigal, J. L. M., García-Bueno, B., & Leza, J. C. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1294-2 · Cited by 80
Adjuvant pioglitazone for unremitted depression: Clinical correlates of treatment response
Watson, K. T., Wroolie, T., Robakis, T. K., & Rasgon, N. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.10.013 · Cited by 81
The impact of statins on psychological wellbeing: a systematic review and meta-analysis
O'Neil, A., Sanna, L., Redlich, C., Sanderson, K., Jacka, F., Williams, L. J., Pasco, J. A., & Berk, M. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-154 · Cited by 78
Self-citationInflammation in psychopathology of depression: Clinical, biological, and therapeutic implications
Su, K. (2012) · Biomedicine · doi:10.1016/j.biomed.2012.03.002 · Cited by 78
Contributions of animal models to the study of mood disorders
Valvassori, S. S., Budni, J., Varela, R. B., & Quevedo, J. (2013) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2013-1168 · Cited by 78
Morris, G., Reiche, E. M. V., Murru, A., Carvalho, A. F., Maes, M. H. J., Berk, M., & Puri, B. K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0843-5 · Cited by 75
Self-citationAlmulla, A. F., Thipakorn, Y., Algon, A. A. A., Tunvirachaisakul, C., Al‐Hakeim, H. K., & Maes, M. H. J. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.08.007 · Cited by 79
Self-citationGerbeth, K., Hüsch, J., Fricker, G., Werz, O., Schubert‐Zsilavecz, M., & Tawab, M. A. (2012) · Fitoterapia · doi:10.1016/j.fitote.2012.10.009 · Cited by 73
Connecting Dots between Mitochondrial Dysfunction and Depression
Khan, M., Baussan, Y., & Hébert-Chatelain, É. (2023) · Biomolecules · doi:10.3390/biom13040695 · Cited by 77
Drugs related to monoamine oxidase activity
Fišar, Z. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.02.012 · Cited by 73
Self-citationJin, X., Zhu, L., Lu, S., Li, C., Bai, M., Xu, E., Shen, J.-D., & Li, Y. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175435 · Cited by 73
Inflammation and Immune Regulation as Potential Drug Targets in Antidepressant Treatment
Schmidt, F. M., Kirkby, K. C., & Lichtblau, N. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160115130414 · Cited by 75
Hroudová, J., Singh, N., Fišar, Z., & Ghosh, K. K. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.03.084 · Cited by 71
Self-citationThe role of the GPR39 receptor in zinc deficient-animal model of depression.
Młyniec, K., Budziszewska, B., Reczynski, W., Sowa-Kućma, M., & Nowak, G. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.020 · Cited by 71
Self-citationKanchanatawan, B., Tangwongchai, S., Sughondhabhirom, A., Suppapitiporn, S., Hemrunrojn, S., Carvalho, A. F., & Maes, M. H. J. (2018) · Neurotoxicity Research · doi:10.1007/s12640-017-9860-4 · Cited by 71
Self-citationManosso, L. M., Neis, V. B., Moretti, M., Daufenbach, J. F., Freitas, A. E., Colla, A. R. D. S., & Rodrigues, A. L. S. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.06.012 · Cited by 69
Involvement of PI3K/Akt/GSK-3β and mTOR in the antidepressant-like effect of atorvastatin in mice
Ludka, F. K., Constantino, L. C., Dal-Cim, T. A., Binder, L. B., Zomkowski, A. D. E., Rodrigues, A. L. S., & Tasca, C. I. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.07.004 · Cited by 66
A neuro-immune, neuro-oxidative and neuro-nitrosative model of prenatal and postpartum depression
Roomruangwong, C., Anderson, G., Berk, M., Stoyanov, D., Carvalho, A. F., & Maes, M. H. J. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.09.015 · Cited by 65
Self-citationPolygenic risk score, healthy lifestyles, and risk of incident depression
Cao, Z., Yang, H., Ye, Y., Zhang, Y., Li, S., Zhao, H., & Wang, Y. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01306-w · Cited by 69
Association of plant-based dietary patterns with psychological profile and obesity in Iranian women
Zamani, B., Daneshzad, E., Siassi, F., Guilani, B., Bellissimo, N., & Azadbakht, L. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.07.019 · Cited by 66
Fišar, Z., Hansíková, H., Křížová, J., Jirák, R., Kitzlerová, E., Zvěřová, M., Hroudová, J., Wenchich, L., Zeman, J., & Raboch, J. (2019) · Mitochondrion · doi:10.1016/j.mito.2019.07.013 · Cited by 64
Self-citationWalker, A. J., Kim, Y., Price, J. B., Kale, R. P., McGillivray, J., Berk, M., & Tye, S. J. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00034 · Cited by 68
Self-citationAgmatine Induces Nrf2 and Protects Against Corticosterone Effects in Hippocampal Neuronal Cell Line
Freitas, A. E., Egea, J., Buendía, I., Navarro, E., Rada, P., Cuadrado, A., Rodrigues, A. L. S., & López, M. G. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8827-1 · Cited by 59
Kokane, S. S., Armant, R. J., Bolaños‐Guzmán, C. A., & Perrotti, L. I. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112548 · Cited by 63
Cordaro, M., Fusco, R., D’Amico, R., Siracusa, R., Peritore, A. F., Gugliandolo, E., Genovese, T., Crupi, R., Mandalari, G., Cuzzocrea, S., et al. (2020) · Antioxidants · doi:10.3390/antiox9100992 · Cited by 60
Shal, B., Khan, A., Naveed, M., Khan, N. U., Ihsan‐ul‐Haq, AlSharari, S. D., Kim, Y. S., & Khan, S. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.047 · Cited by 58
Moreira, E. G., Correia, D. G., Bonifácio, K. L., Moraes, J. B., Cavicchioli, F. L., Nunes, C. S., Nunes, S. O. V., Vargas, H. O., Barbosa, D. S., & Maes, M. H. J. (2017) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2017.1322219 · Cited by 59
Self-citationKim, K. H., Kim, S. J., Singha, S., Yang, Y. J., Park, S. K., & Ahn, K. H. (2021) · ACS Sensors · doi:10.1021/acssensors.1c00930 · Cited by 57
Maes, M. H. J. (2012) · Metabolic Brain Disease · doi:10.1007/s11011-012-9326-6 · Cited by 55
Self-citation
Metadata
- Authors
- Maes, M., Fišar, Z., Medina, M., Scapagnini, G., Nowak, G., & Berk, M.
- Affiliations
- University of Molise (IT)
- Jagiellonian University (PL)
- Mental Health Research Institute (AU)
- Corresponding author
- Maes, Michael
- Venue
- Inflammopharmacology
- Published
- 2012-01-24
- Volume
- 20
- Issue
- 3
- Pages
- 127-150
- ISSN
- 0925-4692 (ISSN-L)
- 1568-5608
- OpenAlex
- W2008971294
- Cited by
- 325
- References
- 300
- Citations by year
- 2026: 4 · 2025: 14 · 2024: 11 · 2023: 19 · 2022: 21 · 2021: 14 · 2020: 32 · 2019: 19 · 2018: 18 · 2017: 26 · 2016: 31 · 2015: 29 · 2014: 29 · 2013: 36 · 2012: 21
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Inflammopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Receptor Mechanisms and Effects
- Keywords
- depression, antidepressant targets, neuroinflammation, inflammatory cytokines, cell-mediated immunity, oxidative stress, nitrosative stress, mitochondrial dysfunction, antioxidant pathways, neurodegeneration, apoptosis, neurogenesis, Nrf2 activators, GSK-3 inhibitors, minocycline, ketamine, omega-3 polyunsaturated fatty acids, neurotrophic factors
- MeSH terms
- Animals, Antioxidants, Depression, Humans, Immunity, Cellular, Mitochondria, Nitrosation, Drug Delivery Systems, Oxidative Stress, Disease Progression, Inflammation Mediators, Glycogen Synthase Kinase 3, NF-E2-Related Factor 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
