Gut Microbiota: A Pivotal Hub for Polyphenols as Antidepressants
Abstract
Polyphenols, present in a broad range of plants, have been thought to be responsible for many beneficial health effects, such as an antidepressant. Despite that polyphenols can be absorbed in the small intestine directly, most of them have low bioavailability and reach the large intestine without any modifications due to their complex structures. The interaction between microbial communities and polyphenols in the intestine is important for the latter to exert antidepressant effects. Gut microbiota can improve the bioavailability of polyphenols; in turn, polyphenols can maintain the intestinal barrier as well as the community of the gut microbiota in normal status. Furthermore, gut microbita catabolize polyphenols to more active, better-absorbed metabolites, further ameliorating depression through the microbial-gut-brain (MGB) axis. Based on this evidence, the review illustrates the potential role of gut microbiota in the processes of polyphenols or their metabolites acting as antidepressants and further envisions the gut microbiota as therapeutic targets for depression.
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The formation of short-chain fatty acids induces the secretion of hormones, including leptin, which has beneficial effects on depressive symptoms in animal experiments.
“The formation of SCFAs induces the secretion of hormones, including leptin, which showed beneficial effects on depressive symptoms in animal experiments [11].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [11]
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Self-citation
- Authors
- Zhou, N., Gu, X., Zhuang, T., Xu, Y., Yang, L., & Zhou, M.
- Affiliations
- Shanghai University of Traditional Chinese Medicine (CN)
- Corresponding author
- Yang, Li
- Zhou, Mingmei
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-05-12
- Volume
- 68
- Issue
- 22
- Pages
- 6007-6020
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W3024654823
- Cited by
- 54
- References
- 164
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 9 · 2023: 4 · 2022: 19 · 2021: 5 · 2020: 1
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Shanghai University (ZYX-CXYJ-018)
- Shanghai Municipal Education Commission (2013JW17)
- Shanghai University of Traditional Chinese Medicine (2019SHUTCM183)
- Science and Technology Commission of Shanghai Municipality (17XD1403500)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- gut microbiota, polyphenols, antidepressants, depression, polyphenol bioavailability, intestinal barrier, polyphenol metabolites, therapeutic target
- MeSH terms
- Gastrointestinal Microbiome, Animals, Antidepressive Agents, Depression, Humans, Intestinal Mucosa, Polyphenols
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