Cited by 54Gut microbiota and healthPhytochemicals and Antioxidant ActivitiesTryptophan and brain disorders

Gut Microbiota: A Pivotal Hub for Polyphenols as Antidepressants

Zhou, Nian, Gu, Xinyi, Zhuang, Tongxi, Xu, Ying, Yang, Li, Zhou, Mingmei·2020·Journal of Agricultural and Food Chemistry

Abstract

Polyphenols, present in a broad range of plants, have been thought to be responsible for many beneficial health effects, such as an antidepressant. Despite that polyphenols can be absorbed in the small intestine directly, most of them have low bioavailability and reach the large intestine without any modifications due to their complex structures. The interaction between microbial communities and polyphenols in the intestine is important for the latter to exert antidepressant effects. Gut microbiota can improve the bioavailability of polyphenols; in turn, polyphenols can maintain the intestinal barrier as well as the community of the gut microbiota in normal status. Furthermore, gut microbita catabolize polyphenols to more active, better-absorbed metabolites, further ameliorating depression through the microbial-gut-brain (MGB) axis. Based on this evidence, the review illustrates the potential role of gut microbiota in the processes of polyphenols or their metabolites acting as antidepressants and further envisions the gut microbiota as therapeutic targets for depression.

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Crossref · 10.1021/acs.jafc.0c01461

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164 of 164 references verified0 citation errors · 0 not checkable

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  • The formation of short-chain fatty acids induces the secretion of hormones, including leptin, which has beneficial effects on depressive symptoms in animal experiments.

    “The formation of SCFAs induces the secretion of hormones, including leptin, which showed beneficial effects on depressive symptoms in animal experiments [11].”

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Authors
Zhou, N., Gu, X., Zhuang, T., Xu, Y., Yang, L., & Zhou, M.
Affiliations
Shanghai University of Traditional Chinese Medicine (CN)
Corresponding author
  • Yang, Li
  • Zhou, Mingmei
Venue
Journal of Agricultural and Food Chemistry
Published
2020-05-12
Volume
68
Issue
22
Pages
6007-6020
ISSN
  • 0021-8561 (ISSN-L)
  • 1520-5118
OpenAlex
W3024654823
Cited by
54
References
164
Citations by year
2026: 6 · 2025: 10 · 2024: 9 · 2023: 4 · 2022: 19 · 2021: 5 · 2020: 1
FWCI
0.69
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Agricultural and Food Chemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Shanghai University (ZYX-CXYJ-018)
  • Shanghai Municipal Education Commission (2013JW17)
  • Shanghai University of Traditional Chinese Medicine (2019SHUTCM183)
  • Science and Technology Commission of Shanghai Municipality (17XD1403500)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
gut microbiota, polyphenols, antidepressants, depression, polyphenol bioavailability, intestinal barrier, polyphenol metabolites, therapeutic target
MeSH terms
Gastrointestinal Microbiome, Animals, Antidepressive Agents, Depression, Humans, Intestinal Mucosa, Polyphenols

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