The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Autonomic and Neuroendocrine Responses to a Psychosocial Stressor in Adults with Autistic Spectrum Disorder
Abstract
Objective of the study was to replicate in adults our previous findings of decreased heart rate and normal endocrine responses to stress in autistic children and to elucidate the discrepancy between autonomic and endocrine stress responses by including epinephrine, norepinephrine, oxytocin and vasopressin measurements. Ten autistic spectrum disorder (ASD) adults were compared to 14 healthy controls in their response to a psychosocial stressor (public speaking). ASD patients showed decreased heart rate, but normal cortisol responses, consistent with our prior findings in children. No differences in norepinephrine, epinephrine, oxytocin or vasopressin responses to stress were found. However, in contrast to previous findings in low functioning autistic children, ASD adults showed increased basal oxytocin levels, which may be related to developmental factors.
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In the citing paper
“and was previously suggested to be a manifestation of response saturation due to basal hyperarousal.”
From Functional autonomic nervous system profile in children with autism spectrum disorder (2014) · cites this paper as [16]
In the citing paper
“This pattern has been reported consistently in three studies examining ANS reactivity to psychosocial challenges [15-17]”
From Functional autonomic nervous system profile in children with autism spectrum disorder (2014) · cites this paper as [16]
In the citing paper
“Compared to placebo, oxytocin administered to eight adolescent and adult males with FXS significantly increased overall eye gaze during a brief social interaction.59 Interestingly, lower doses of oxytocin in this sample appeared to show a greater effect than the higher administered dose, consistent with a recent study in healthy adults.60”
From Beyond the hype and hope: critical considerations for intranasal oxytocin research in autism spectrum disorder (2017) · cites this paper as [59]
Citations
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Cited by
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The Peptide That Binds: A Systematic Review of Oxytocin and its Prosocial Effects in Humans
MacDonald, K., & MacDonald, T. M. (2010) · Harvard Review of Psychiatry · doi:10.3109/10673220903523615 · Cited by 585
Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism
Peñagarikano, O., Lázaro, M. T., Lu, X.-H., Gordon, A., Dong, H., Lam, H. A., Peles, E., Maidment, N. T., Murphy, N. P., Yang, X. W., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.3010257 · Cited by 378
Intranasal oxytocin treatment for social deficits and biomarkers of response in children with autism
Parker, K. J., Oztan, O., Libove, R. A., Sumiyoshi, R. D., Jackson, L. P., Karhson, D. S., Summers, J. E., Hinman, K. E., Motonaga, K. S., Phillips, J. M., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705521114 · Cited by 349
Evaluation of enzyme immunoassay and radioimmunoassay methods for the measurement of plasma oxytocin
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Prosocial effects of oxytocin and clinical evidence for its therapeutic potential
Striepens, N., Kendrick, K. M., Maier, W., & Hurlemann, R. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.07.001 · Cited by 283
Metadata
- Authors
- Jansen, L. M. C., Gispen-de Wied, C. C., Wiegant, V. M., Westenberg, H. G. M., Lahuis, B. E., & van Engeland, H.
- Affiliations
- University Medical Center Utrecht (NL)
- Corresponding author
- Jansen, Lucres M. C.
- ORCID
- Jansen, Lucres M. C.
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2006-07-25
- Volume
- 36
- Issue
- 7
- Pages
- 891-899
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- OpenAlex
- W2129921086
- Cited by
- 177
- References
- 39
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 7 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 6 · 2019: 6 · 2018: 14 · 2017: 10 · 2016: 10 · 2015: 19 · 2014: 17 · 2013: 16 · 2012: 8
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Hersenstichting
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- autism spectrum disorder, autistic adults, psychosocial stress, stress response, autonomic nervous system, neuroendocrine response, heart rate, cortisol, epinephrine, norepinephrine, oxytocin, vasopressin, public speaking, developmental differences
- MeSH terms
- Adrenocorticotropic Hormone, Adult, Autistic Disorder, Autonomic Nervous System, Epinephrine, Female, Humans, Male, Norepinephrine, Oxytocin, Psychology, Speech, Stress, Psychological, Vasopressins
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