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mRNA and Protein Levels for GABAAα4, α5, β1 and GABABR1 Receptors are Altered in Brains from Subjects with Autism
Open accessAbstract
We have shown altered expression of gamma-aminobutyric acid A (GABA(A)) and gamma-aminobutyric acid B (GABA(B)) receptors in the brains of subjects with autism. In the current study, we sought to verify our western blotting data for GABBR1 via qRT-PCR and to expand our previous work to measure mRNA and protein levels of 3 GABA(A) subunits previously associated with autism (GABRalpha4; GABRalpha5; GABRbeta1). Three GABA receptor subunits demonstrated mRNA and protein level concordance in superior frontal cortex (GABRalpha4, GABRalpha5, GABRbeta1) and one demonstrated concordance in cerebellum (GABBetaR1). These results provide further evidence of impairment of GABAergic signaling in autism.
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“In cerebellum, concordant reductions have been observed in mRNA and protein levels for GABAB R1 receptor in subjects with autism [130].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [130]
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“Additionally, other studies have reported reduced GABAA [129, 130] and GABAB [124, 130] receptor density and system activity in the brains of autistic patients.”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [130]
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Metadata
- Authors
- Fatemi, S. H., Reutiman, T. J., Folsom, T. D., Rooney, R. J., Patel, D. H., & Thuras, P. D.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Fatemi, S. Hossein
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2010-01-12
- Volume
- 40
- Issue
- 6
- Pages
- 743-750
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- PMC
- PMC2865581
- OpenAlex
- W2005822031
- Cited by
- 182
- References
- 44
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 7 · 2023: 11 · 2022: 12 · 2021: 7 · 2020: 9 · 2019: 9 · 2018: 5 · 2017: 13 · 2016: 14 · 2015: 16 · 2014: 16 · 2013: 20 · 2012: 14
- FWCI
- 10.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Parkinson Foundation
- Parkinson's Foundation
- National Institutes of Health
- National Institute of Mental Health (R24MH068855)
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD052074)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, GABAA receptor, GABAB receptors, GABBR1, gene expression, mRNA levels, protein abundance, GABAergic neurotransmission, superior frontal cortex, cerebellum
- MeSH terms
- Adult, Autistic Disorder, Brain Chemistry, Cerebellum, Electrophoresis, Polyacrylamide Gel, Female, Humans, Male, Middle Aged, Receptors, GABA-A, RNA, Messenger, Blotting, Western, Receptors, GABA-B, Reverse Transcriptase Polymerase Chain Reaction, Young Adult
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