Expression of GABAB Receptors Is Altered in Brains of Subjects with Autism
Open accessAbstract
Autism is a neurodevelopmental disorder that is often comorbid with seizures. Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in brain. GABA(B) receptors play an important role in maintaining excitatory-inhibitory balance in brain and alterations may lead to seizures. We compared levels of GABA(B) receptor subunits GABA(B) receptor 1 (GABBR1) and GABA(B) receptor 2 (GABBR2) in cerebellum, Brodmann's area 9 (BA9), and BA40 of subjects with autism and matched controls. Levels of GABBR1 were significantly decreased in BA9, BA40, and cerebellum, while GABBR2 was significantly reduced in the cerebellum. The presence of seizure disorder did not have a significant impact on the observed reductions in GABA(B) receptor subunit expression. Decreases in GABA(B) receptor subunits may help explain the presence of seizures that are often comorbid with autism, as well as cognitive difficulties prevalent in autism.
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Reduced GABAA and GABAB receptor density and system activity have been reported in the brains of autistic patients.
“Additionally, other studies have reported reduced GABAA [129, 130] and GABAB [124, 130] receptor density and system activity in the brains of autistic patients.”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [124]
GABAergic dysfunction in the cerebellum in autism has been demonstrated repeatedly.
“GABAergic dysfunction in the cerebellum in autism has been demonstrated repeatedly [70, 124, 261].”
From Consensus Paper: Pathological Role of the Cerebellum in Autism (2012) · cites this paper as [124]
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- Authors
- Fatemi, S. H., Folsom, T. D., Reutiman, T. J., & Thuras, P. D.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Fatemi, S. Hossein
- Venue
- The Cerebellum
- Published
- 2008-11-12
- Volume
- 8
- Issue
- 1
- Pages
- 64-69
- ISSN
- 1473-4222 (ISSN-L)
- 1473-4230
- PMC
- PMC2732344
- OpenAlex
- W2143252579
- Cited by
- 227
- References
- 29
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 10 · 2023: 9 · 2022: 10 · 2021: 17 · 2020: 12 · 2019: 5 · 2018: 7 · 2017: 13 · 2016: 15 · 2015: 15 · 2014: 23 · 2013: 21 · 2012: 15
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- The Cerebellum (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Parkinson Foundation
- University of Minnesota
- Parkinson's Foundation
- National Institutes of Health
- National Institute of Mental Health (R24MH068855)
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD052074)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- autism spectrum disorder, GABAB receptors, GABBR1, GABBR2, receptor subunit expression, cerebellum, Brodmann area 9, seizures, excitation-inhibition balance, GABAergic inhibition, cognitive difficulties
- MeSH terms
- Adolescent, Adult, Autistic Disorder, Cerebellum, Child, Child, Preschool, Female, Frontal Lobe, Humans, Male, Parietal Lobe, Reference Values, Receptors, GABA-B, Young Adult
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