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mRNA and Protein Levels for GABAAα4, α5, β1 and GABABR1 Receptors are Altered in Brains from Subjects with Autism

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Fatemi, S. Hossein, Reutiman, Teri J., Folsom, Timothy D., Rooney, Robert J., Patel, Diven H., Thuras, Paul D.·2010·Journal of Autism and Developmental Disorders

DOI 10.1007/s10803-009-0924-zPMC PMC2865581

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Abstract

We have shown altered expression of gamma-aminobutyric acid A (GABA(A)) and gamma-aminobutyric acid B (GABA(B)) receptors in the brains of subjects with autism. In the current study, we sought to verify our western blotting data for GABBR1 via qRT-PCR and to expand our previous work to measure mRNA and protein levels of 3 GABA(A) subunits previously associated with autism (GABRalpha4; GABRalpha5; GABRbeta1). Three GABA receptor subunits demonstrated mRNA and protein level concordance in superior frontal cortex (GABRalpha4, GABRalpha5, GABRbeta1) and one demonstrated concordance in cerebellum (GABBetaR1). These results provide further evidence of impairment of GABAergic signaling in autism.

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Authors: Fatemi, S. H., Reutiman, T. J., Folsom, T. D., Rooney, R. J., Patel, D. H., & Thuras, P. D.
Affiliations: University of Minnesota (US)
Corresponding author: Fatemi, S. Hossein
ORCID: Fatemi, S. Hossein
Rooney, Robert J.
Thuras, Paul D.
Venue: Journal of Autism and Developmental Disorders
Publisher: Springer Science and Business Media LLC
Published: 2010-01-12
Volume: 40
Issue: 6
Pages: 743-750
ISSN: 0162-3257 (ISSN-L)
1573-3432
DOI: 10.1007/s10803-009-0924-z
PMC: PMC2865581
OpenAlex: W2005822031
Cited by: 182
References: 44
Citations by year: 2026: 5 · 2025: 2 · 2024: 7 · 2023: 11 · 2022: 12 · 2021: 7 · 2020: 9 · 2019: 9 · 2018: 5 · 2017: 13 · 2016: 14 · 2015: 16 · 2014: 16 · 2013: 20 · 2012: 14
FWCI: 10.86
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Journal of Autism and Developmental Disorders (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Parkinson Foundation
Parkinson's Foundation
National Institutes of Health
National Institute of Mental Health (R24MH068855)
National Institute of Child Health and Human Development
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD052074)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: autism spectrum disorder, GABAA receptor, GABAB receptors, GABBR1, gene expression, mRNA levels, protein abundance, GABAergic neurotransmission, superior frontal cortex, cerebellum
MeSH terms: Adult, Autistic Disorder, Brain Chemistry, Cerebellum, Electrophoresis, Polyacrylamide Gel, Female, Humans, Male, Middle Aged, Receptors, GABA-A, RNA, Messenger, Blotting, Western, Receptors, GABA-B, Reverse Transcriptase Polymerase Chain Reaction, Young Adult

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mRNA and Protein Levels for GABAAα4, α5, β1 and GABABR1 Receptors are Altered in Brains from Subjects with Autism

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