The DOI matches its Crossref record; 126 of the 127 references it cites were found in a registry or an index.
Reward Circuitry Function in Autism During Face Anticipation and Outcomes
Open accessAbstract
The aim of this study was to investigate reward circuitry responses in autism during reward anticipation and outcomes for monetary and social rewards. During monetary anticipation, participants with autism spectrum disorders (ASDs) showed hypoactivation in right nucleus accumbens and hyperactivation in right hippocampus, whereas during monetary outcomes, participants with ASDs showed hyperactivation in left midfrontal and anterior cingulate gyrus. Groups did not differ in nucleus accumbens responses to faces. The ASD group demonstrated hyperactivation in bilateral amygdala during face anticipation that predicted social symptom severity and in bilateral insular cortex during face outcomes. These results add to the growing body of evidence that autism is characterized by altered functioning of reward circuitry. Additionally, atypical amygdala activation during the processing of social rewards may contribute to the development or expression of autistic features.
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“Four out of five published fMRI studies reported diminished VS activation in individuals with ASD compared with TDC when processing either social or monetary reward versus non-reward [30,60-62].”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [61]
Experimental — accuracy not yet measuredIn the citing paper
“The ASD group displayed bilateral amygdala hyperactivation during face-reward anticipation and bilateral insular cortex hyperactivation during face-reward outcomes.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [569]
In the citing paper
“Further, activation in the left and right amygdala during face anticipation predicted the severity of social impairments in the ASD sample.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [569]
In the citing paper
“only few neuroimaging studies have directly addressed the basis of social vs. non-social reward processing in ASD and findings to date have not been entirely consistent (perhaps, in part, due to the lack of potent social reward paradigms) [78,80]”
From The social motivation theory of autism (2012) · cites this paper as [80]
In the citing paper
“In a follow-up study applying the same paradigm but with a focus on social (for example, faces) versus monetary reward, adults with ASD again showed lower brain activation in the VS during money anticipation, but did not reveal VS hypoactivation for face rewards [61].”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [61]
In the citing paper
“The study by Dichter and colleagues [61] on reward processing revealed hyperactivation in the amygdala in adult participants with ASD while they were anticipating social reward. This activation correlated positively with social symptom severity (Autism Diagnostic Observation Schedule-Generic ADOS-G).”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [61]
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Cites
Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630
Jenkinson, M., Bannister, P., Brady, M., & Smith, S. (2002) · NeuroImage · doi:10.1006/nimg.2002.1132 · Cited by 11,888
Cortical Surface-Based Analysis
Dale, A. M., Fischl, B., & Sereno, M. I. (1999) · NeuroImage · doi:10.1006/nimg.1998.0395 · Cited by 10,910
Fast robust automated brain extraction
Smith, S. M. (2002) · Human Brain Mapping · doi:10.1002/hbm.10062 · Cited by 10,496
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005592401947 · Cited by 7,520
A global optimisation method for robust affine registration of brain images
Jenkinson, M., & Smith, S. M. (2001) · Medical Image Analysis · doi:10.1016/s1361-8415(01)00036-6 · Cited by 7,018
Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005653411471 · Cited by 6,450
Cortical Surface-Based Analysis
Fischl, B., Sereno, M. I., & Dale, A. M. (1999) · NeuroImage · doi:10.1006/nimg.1998.0396 · Cited by 6,147
Action recognition in the premotor cortex
Gallese, V., Fadiga, L., Fogassi, L., & Rizzolatti, G. (1996) · Brain · doi:10.1093/brain/119.2.593 · Cited by 4,968
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564
Research works printed but not linked: 1
- Weschler, D. (1999). Weschler abbreviated scale of intelligence (WASI). San Antonio, TX: Harcourt Assessment.
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Abujadi, C. (2014) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.5.2014.tde-01042014-085145
Bedford, R. (2012) · IOE EPrints
Carlisi, C. O. (2017) · Research Portal (King's College London)
Hudac, C. M., Kurtz‐Nelson, E. C., Rutter, T. M., Peterson, J. L., Hoekzema, K., Beighley, J. S., Kelly, M., Wallace, A. S., Gerdts, J. A., Eichler, E. E., et al. (2020) · doi:10.21203/rs.3.rs-76658/v1
Olive, M. F. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734873110.793555753
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Williams, E. H., Bilbao-Broch, L., Downing, P. E., & Cross, E. S. (2020) · doi:10.31234/osf.io/hz4pa
Wise, R. A. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734873110.793560131
Vanderschuren, L. J. M. J. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734873110.793560144
Wang, L., He, H., Jianxin, F., & Wang, T. (2022) · International Journal of Developmental Disabilities · doi:10.1080/20473869.2022.2077078
Yang, M., Zhang, L., Wei, Z., Zhang, P., Xu, L., Huang, L., Li, H., Lei, Y., Kendrick, K. M., & Kou, J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.04.569509
Dopamine D2R and opioid MOR availability in autism spectrum disorderPreprint
Noppari, T., Tuisku, J., Lukkarinen, L., Tani, P., Lindberg, N., Saure, E., Lauerma, H., Tiihonen, J., Hirvonen, J., Helin, S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.09.588651
Informational and Normative Influence on Conformity in Autism
Kobayashi, A., Makino, T., Mizuno, Y., Kosaka, H., & Izuma, K. (2026) · Autism Research · doi:10.1002/aur.70284 · Cited by 1
Saitovitch, A. (2014) · theses.fr (ABES) · doi:10.70675/ddd5f246z0fe4z4134z8a28z27d0a24aed40
Applying multidimensional approaches to disentangle autism spectrum disorder heterogeneity
Mihailov, A. (2021) · theses.fr (ABES) · doi:10.70675/b9bfc6a7za998z4d56z9380z5ec7781bc4ac
Dopamine dynamics in autism: Unraveling the neurochemical puzzle
Özkan, E. B., & Odabaşı, M. (2023) · Demiroglu Science University Florence Nightingale Journal of Medicine · doi:10.5606/fng.btd.2023.130
Salviati, S., Braccagni, G., Corridori, E., Sabatini, G., Fanti, F., Guzzi, F., M, P., Battista, N., Scheggi, S., & Gambarana, C. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.110996
Intranasal dopamine: Anatomical pathways, biological mechanisms and neuromodulatory potential
Chao, O. Y.-H., Nikolaus, S., Mattern, C., Chiou, L., & Huston, J. P. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106866 · Cited by 1
Autistic interests: wide-ranging and intellectually oriented
Caldwell‐Harris, C. L. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1749552
Suboptimal but intact integration of reward information during perceptual decision-making in autism
Fazioli, L., Hadad, B., Denison, R. N., & Yashar, A. (2026) · Cognition · doi:10.1016/j.cognition.2026.106716
Metadata
- Authors
- Dichter, G. S., Richey, J. A., Rittenberg, A. M., Sabatino, A., & Bodfish, J. W.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Dichter, Gabriel S.
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2011-03-29
- Volume
- 42
- Issue
- 2
- Pages
- 147-160
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- PMC
- PMC8624275
- OpenAlex
- W2073064897
- Cited by
- 222
- References
- 127
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 6 · 2023: 14 · 2022: 12 · 2021: 14 · 2020: 21 · 2019: 18 · 2018: 14 · 2017: 15 · 2016: 14 · 2015: 24 · 2014: 17 · 2013: 23 · 2012: 21
- FWCI
- 9.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH073402)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30-HD03110, P30HD003110)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- autism spectrum disorder, reward systems, reward anticipation, reward outcome, monetary rewards, social reward, face processing, nucleus accumbens, hippocampus, amygdala, insula, anterior cingulate cortex
- MeSH terms
- Adolescent, Adult, Autistic Disorder, Brain, Brain Mapping, Face, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Motivation, Nerve Net, Reaction Time, Reward, Social Perception
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