Association of rigid-compulsive behavior with functional constipation in autism spectrum disorder
Open accessAbstract
Based upon checklist data from the Autism Speaks Autism Treatment Network, we hypothesized that functional constipation (FC) would be associated with rigid-compulsive behavior in children with autism spectrum disorder (ASD). We used the Questionnaire on Pediatric Gastrointestinal Symptoms-Rome III to assess FC symptoms in 108 children with ASD. As hypothesized, FC was associated with parent ratings on the Repetitive Behavior Scales-Revised (RBS-R) Compulsive, Ritualistic, and Sameness subscales in the overall population. Of note, FC was less common in children who were not taking medications that target behavior or treat FC. In the medication-free children, rigid-compulsive behavior was not significantly associated with FC. More research is needed to understand the mechanisms underlying these associations.
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Functional constipation has been associated with rigid-compulsive behavior in children with ASD.
“and functional constipation has been associated with rigid-compulsive behavior in children with ASD 39.”
From Gastrointestinal Issues and Autism Spectrum Disorder (2020) · cites this paper as [39]
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Self-citation
- Authors
- Marler, S., Ferguson, B. J., Lee, E. B., Peters, B., Williams, K. C., McDonnell, E., Macklin, E. A., Levitt, P., Margolis, K. G., Beversdorf, D. Q., & Veenstra-VanderWeele, J.
- Affiliations
- Vanderbilt University (US)
- University of Missouri (US)
- Nationwide Children's Hospital (US)
- Massachusetts General Hospital (US)
- University of Southern California (US)
- Columbia University Irving Medical Center (US)
- NewYork–Presbyterian Hospital (US)
- Corresponding author
- Veenstra-VanderWeele, Jeremy
- ORCID
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2017-03-13
- Volume
- 47
- Issue
- 6
- Pages
- 1673-1681
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- PMC
- PMC5526215
- OpenAlex
- W2597185815
- Cited by
- 94
- References
- 43
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 16 · 2023: 8 · 2022: 15 · 2021: 11 · 2020: 10 · 2019: 9 · 2018: 7 · 2017: 1
- FWCI
- 7.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Maternal and Child Health Bureau (UA3MC11054)
- Autism Speaks (Autism Treatment Network)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- functional constipation, autism spectrum disorder, repetitive behavior, compulsive behavior, ritual behavior, sameness, children, medication use, gastrointestinal symptoms
- MeSH terms
- Autism Spectrum Disorder, Adolescent, Child, Compulsive Behavior, Constipation, Female, Gastrointestinal Diseases, Humans, Male, Parents, Prospective Studies, Surveys and Questionnaires, Checklist
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