Interactive Effects of Prenatal Antidepressant Exposure and Likely Gene Disrupting Mutations on the Severity of Autism Spectrum Disorder
Open accessAbstract
To examine the interactive effects of two proposed risk factors which may contribute to symptom severity of Autism Spectrum Disorder (ASD): prenatal antidepressant exposure and likely gene-disrupting (LGD) mutations. Participants included 2748 individuals with ASD from the Simons Simplex Collection. We examined the effects of prenatal antidepressant exposure, maternal depression, presence of an LGD mutation and their interaction on ASD severity. We found a significant interactive effect between antidepressant exposure and the presence of an LGD mutation on ASD severity in the ADOS and ADI-R verbal communication domains. We consider a "two-hit" model in which one variable lays the foundation for an initial risk which is compounded by a second variable.
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The literature contains several attempts to design multi-hit risk models for ASD, for example examining the association between genetic disposition and maternal antidepressant use.
“The literature contains several attempts to design such risk models, for example in examining the association between genetic disposition and maternal antidepressant use [261].”
From The contribution of environmental exposure to the etiology of autism spectrum disorder (2019) · cites this paper as [261]
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Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369 · see citing works
Lord, C., Rutter, M., & Le Couteur, A. (1994) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02172145 · Cited by 9,065 · see citing works
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005592401947 · Cited by 7,520 · see citing works
The contribution of de novo coding mutations to autism spectrum disorder
Iossifov, I., O’Roak, B. J., Sanders, S. J., Ronemus, M., Krumm, N., Levy, D., Stessman, H. A., Witherspoon, K. T., Vives, L., Patterson, K. E., et al. (2014) · Nature · doi:10.1038/nature13908 · Cited by 2,585 · see citing works
Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations
O’Roak, B. J., Vives, L., Girirajan, S., Karakoc, E., Krumm, N., Coe, B. P., Levy, R., Ko, A., Lee, C., Smith, J. D., et al. (2012) · Nature · doi:10.1038/nature10989 · Cited by 2,165 · cited 1× · see citing works
“The SSC represents a collaboration among 12 universityaffiliated research clinics to recruit, evaluate and record data from over 2000 simplex families (Fischbach and Lord 2010; O’Roak et al. 2012; Iossifov et al. 2014; Sanders et al. 2011).”
Self-citationAssociation between Microdeletion and Microduplication at 16p11.2 and Autism
Weiss, L. A., Shen, Y., Korn, J. M., Arking, D. E., Miller, D. T., Fossdal, R., Saemundsen, E., Stefansson, H., Ferreira, M. A. R., Green, T., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa075974 · Cited by 1,666 · see citing works
Standardizing ADOS Scores for a Measure of Severity in Autism Spectrum Disorders
Gotham, K., Pickles, A., & Lord, C. (2009) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0674-3 · Cited by 1,605 · see citing works
Insights into autism spectrum disorder genomic architecture and biology from 71 risk loci
Sanders, S. J., He, X., Willsey, A. J., Ercan-Sencicek, A. G., Samocha, K. E., Cicek, A. E., Murtha, M. T., Bal, V. H., Bishop, S. L., Dong, S., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.016 · Cited by 1,430 · see citing works
Sanders, S. J., Ercan-Sencicek, A. G., Hus, V., Luo, R., Murtha, M. T., Moreno-De-Luca, D., Chu, S. H., Moreau, M. P., Gupta, A. R., Thomson, S. A., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.002 · Cited by 1,263 · see citing works
Medication use during pregnancy, with particular focus on prescription drugs: 1976-2008
Mitchell, A. A., Gilboa, S. M., Werler, M. M., Kelley, K. E., Louik, C., & Hernández–Dı́az, S. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2011.02.029 · Cited by 813 · see citing works
Autism risk factors: genes, environment, and gene-environment interactions
Chaste, P., & Leboyer, M. (2012) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2012.14.3/pchaste · Cited by 807 · see citing works
Prenatal risk factors for autism: comprehensive meta-analysis
Gardener, H., Spiegelman, D., & Buka, S. L. (2009) · British Journal of Psychiatry · doi:10.1192/bjp.bp.108.051672 · Cited by 736 · see citing works
The Simons Simplex Collection: a resource for identification of autism genetic risk factors
Fischbach, G. D., & Lord, C. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.006 · Cited by 725 · see citing works
CNVs conferring risk of autism or schizophrenia affect cognition in controls
Stefansson, H., Meyer-Lindenberg, A., Steinberg, S., Magnusdottir, B., Morgen, K., Arnarsdottir, S., Bjornsdottir, G., Walters, G. B., Jonsdottir, G. A., Doyle, O. M., et al. (2014) · Nature · doi:10.1038/nature12818 · Cited by 699 · see citing works
A recurrent 16p12.1 microdeletion supports a two-hit model for severe developmental delay
Girirajan, S., Rosenfeld, J. A., Cooper, G. M., Antonacci, F., Siswara, P., Itsara, A., Vives, L., Walsh, T., McCarthy, S. E., Baker, C., et al. (2010) · Nature Genetics · doi:10.1038/ng.534 · Cited by 667 · see citing works
Phenotypic Heterogeneity of Genomic Disorders and Rare Copy-Number Variants
Girirajan, S., Rosenfeld, J. A., Coe, B. P., Parikh, S., Friedman, N., Goldstein, A., Filipink, R. A., McConnell, J. S., Angle, B., Meschino, W. S., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1200395 · Cited by 621 · see citing works
Hus, V., Gotham, K., & Lord, C. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1719-1 · Cited by 568 · see citing works
Stessman, H. A. F., Xiong, B., Coe, B. P., Wang, T., Hoekzema, K., Fenckova, M., Kvarnung, M., Gerdts, J., Trinh, S., Cosemans, N., et al. (2017) · Nature Genetics · doi:10.1038/ng.3792 · Cited by 559 · see citing works
Self-citationShelton, J. F., Geraghty, E. M., Tancredi, D. J., Delwiche, L. D., Schmidt, R. J., Ritz, B., Hansen, R. L., & Hertz-Picciotto, I. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1307044 · Cited by 536 · see citing works
Antidepressant Use During Pregnancy and Childhood Autism Spectrum Disorders
Croen, L. A. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.73 · Cited by 510 · see citing works
Increasing use of antidepressants in pregnancy
Cooper, W. O., Willy, M. E., Pont, S. J., & Ray, W. A. (2007) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2007.01.033 · Cited by 458 · see citing works
What causes autism? Exploring the environmental contribution
Landrigan, P. J. (2010) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e328336eb9a · Cited by 429 · see citing works
Leblond, C. S., Heinrich, J., Delorme, R., Proepper, C., Betancur, C., Huguet, G., Konyukh, M., Chaste, P., Ey, E., Rastam, M., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002521 · Cited by 429 · see citing works
A de novo convergence of autism genetics and molecular neuroscience
Krumm, N., O’Roak, B. J., Shendure, J., & Eichler, E. E. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2013.11.005 · Cited by 423 · see citing works
Autism After Infection, Febrile Episodes, and Antibiotic Use During Pregnancy: An Exploratory Study
Atladóttir, H. Ó., Henriksen, T. B., Schendel, D. E., & Parner, E. T. (2012) · Pediatrics · doi:10.1542/peds.2012-1107 · Cited by 369 · see citing works
Rai, D., Lee, B. K., Dalman, C., Golding, J., Lewis, G., & Magnusson, C. (2013) · BMJ · doi:10.1136/bmj.f2059 · Cited by 365 · see citing works
A 600 kb deletion syndrome at 16p11.2 leads to energy imbalance and neuropsychiatric disorders
Zufferey, F., Sherr, E. H., Beckmann, N. D., Hanson, E., Maillard, A. M., Hippolyte, L., Macé, A., Ferrari, C., Kutalik, Z., Andrieux, J., et al. (2012) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2012-101203 · Cited by 326 · see citing works
Self-citationAmerican Journal of Obstetrics and Gynecology
&NA; (1921) · The American Journal of the Medical Sciences · doi:10.1097/00000441-192106000-00034 · Cited by 310 · see citing works
Antidepressant use during pregnancy and the risk of autism spectrum disorder in children
Boukhris, T., Sheehy, O., Mottron, L., & Bérard, A. (2016) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2015.3356 · Cited by 297 · see citing works
Girirajan, S., Dennis, M. Y., Baker, C. A., Malig, M., Coe, B. P., Campbell, C. D., Mark, K. M. K., Vu, T. H., Alkan, C., Cheng, Z., et al. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.12.016 · Cited by 292 · see citing works
Self-citationHanson, E., Bernier, R., Porche, K., Jackson, F. I., Goin-Kochel, R. P., Snyder, L. G., Snow, A. V., Wallace, A. S., Campe, K. L., Zhang, Y., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.04.021 · Cited by 277 · see citing works
Self-citationPhenotypic variability and genetic susceptibility to genomic disorders
Girirajan, S., & Eichler, E. E. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq366 · Cited by 271 · see citing works
Kalkbrenner, A. E., Windham, G. C., Serre, M. L., Akita, Y., Wang, X., Hoffman, K., Thayer, B. P., & Daniels, J. L. (2014) · Epidemiology · doi:10.1097/ede.0000000000000173 · Cited by 200 · see citing works
Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism
Hviid, A., Melbye, M., & Pasternak, B. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301449 · Cited by 195 · see citing works
Prenatal SSRI use and offspring with autism spectrum disorder or developmental delay
Harrington, R. A., Lee, L.-C., Crum, R. M., Zimmerman, A. W., & Hertz-Picciotto, I. (2014) · Pediatrics · doi:10.1542/peds.2013-3406 · Cited by 174 · see citing works
Antidepressant exposure in pregnancy and risk of autism spectrum disorders
Sorensen, M. J., Christensen, J., Parner, E. T., Grønborg, T. K., Vestergaard, M., Schendel, D., & Pedersen, L. H. (2013) · Clinical Epidemiology · doi:10.2147/clep.s53009 · Cited by 163 · see citing works
Man, K. K. C., Tong, H. H. Y., Wong, L. Y. L., Chan, E. W., Simonoff, E., & Wong, I. C. K. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.11.020 · Cited by 126 · see citing works
In utero exposure to selective serotonin reuptake inhibitors and risk for autism spectrum disorder
Gidaya, N. B., Lee, B. K., Burstyn, I., Yudell, M., Mortensen, E. L., & Newschaffer, C. J. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-014-2128-4 · Cited by 115 · see citing works
Epigenetics of Autism-related Impairment: Copy Number Variation and Maternal Infection
Mazina, V., Gerdts, J., Trinh, S., Ankenman, K., Ward, T., Dennis, M. Y., Girirajan, S., Eichler, E. E., & Bernier, R. (2015) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0000000000000126 · Cited by 101 · see citing works
Self-citationGentile, S. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.04.048 · Cited by 67 · see citing works
Autism risk following antidepressant medication during pregnancy
Viktorin, A., Uher, R., Reichenberg, A., Levine, S. Z., & Sandin, S. (2017) · Psychological Medicine · doi:10.1017/s0033291717001301 · Cited by 62 · see citing works
Copy‐number variation in the pathogenesis of autism spectrum disorder
Shishido, E., Aleksić, B., & Ozaki, N. (2013) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12128 · Cited by 58 · see citing works
Zimmerberg, B., & Germeyan, S. C. (2014) · Developmental Psychobiology · doi:10.1002/dev.21264 · Cited by 42 · see citing works
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Research works printed but not linked: 1
- Mazina V, Gerdts J, Trinh S, (2015b). Epigenetics of autism-related impairment: Copy number variation and maternal infection. Journal of Developmental and Behavioral Pediatrics: JDBP, 36(2), 61– 67. 25629966 PMC4318761
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The contribution of environmental exposure to the etiology of autism spectrum disorder
Bölte, S., Girdler, S., & Marschik, P. B. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2988-4 · Cited by 509 · see citing works
- Authors
- Ackerman, S., Schoenbrun, S., Hudac, C., & Bernier, R.
- Affiliations
- University of Washington (US)
- Corresponding author
- Ackerman, Sean
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 2017-08-02
- Volume
- 47
- Issue
- 11
- Pages
- 3489-3496
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- PMC
- PMC7549414
- OpenAlex
- W4234863392
- Cited by
- 12
- References
- 43
- Citations by year
- 2025: 1 · 2024: 3 · 2022: 3 · 2021: 2 · 2019: 1 · 2018: 2
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Update notices
- erratum (2017-09-08)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Simons Foundation (89368)
- National Institute of Mental Health (01MH100047)
- Medical Student Research Training Program (MSRTP), University of Washington School of Medicine (None)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- autism spectrum disorder, ASD severity, prenatal antidepressant exposure, maternal depression, gene-environment interaction, two-hit model, verbal communication, Simons Simplex Collection
- MeSH terms
- Autism Spectrum Disorder, Adult, Antidepressive Agents, Child, Depressive Disorder, Female, Humans, Male, Mutation, Pregnancy, Prenatal Exposure Delayed Effects
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