Functional and mechanical evaluation of nerve stretch injury
Abstract
Peripheral nerves undergo tensile loading in common physiological conditions, but stretch can also induce nerve pathology, impairing electrophysiological conduction. The level of strain nerves can tolerate and the functional deficits which result from exceeding this threshold are not thoroughly understood. To examine these phenomena, a novel system for tensile electrophysiology was created using a grease gap-recording chamber paired with a computerized micromanipulator and load cell. Guinea pig sciatic nerves were stretched beyond their maximum physiologic length to examine the effects of tension on signal conduction. Mechanical and electrophysiological data such as load, position, compound action potential amplitude, and signal latency were recorded in real-time. While 5% strain did not affect conduction, further elongation decreased amplitude approximately linearly with strain. These experiments verify the findings of prior studies into nerve stretch, and demonstrate the utility of this apparatus for investigating the mechanical and electrophysiological properties of nerves undergoing strain.
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These complications have particularly been observed in larger nerve fibers and in chronically implanted intrafascicular devices.
“These events have particularly been observed in larger nerve fibers [4, 31, 32] and in chronically implanted intrafascicular devices [30, 33, 34].”
From Directed stimulation with interfascicular interfaces for peripheral nerve stimulation (2021) · cites this paper as [31]
During surgery, peripheral nerves are sensitive to stretching, blood toxicity, and drying out.
“However, during surgery, peripheral nerves are sensitive to stretching [41], blood toxicity, and drying out [42].”
From Safety of long-term electrical peripheral nerve stimulation: review of the state of the art (2019) · cites this paper as [41]
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Safety of long-term electrical peripheral nerve stimulation: review of the state of the art
Günter, C., Delbeke, J., & Ortiz-Catalan, M. (2019) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/s12984-018-0474-8 · Cited by 198 · see citing works
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Directed stimulation with interfascicular interfaces for peripheral nerve stimulation
Koppaka, S., Hess-Dunning, A., & Tyler, D. J. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/ac33e8 · Cited by 7 · see citing works
“These events have particularly been observed in larger nerve fibers [4, 31, 32] and in chronically implanted intrafascicular devices [30, 33, 34].”
Background
- Authors
- Rickett, T., Connell, S., Bastijanic, J., Hegde, S., & Shi, R.
- Affiliations
- Purdue University West Lafayette (US)
- Corresponding author
- Shi, Riyi
- ORCID
- Shi, Riyi
- Venue
- Journal of Medical Systems
- Published
- 2010-04-06
- Volume
- 35
- Issue
- 5
- Pages
- 787-793
- ISSN
- 0148-5598 (ISSN-L)
- 1573-689X
- OpenAlex
- W2059455555
- Cited by
- 64
- References
- 18
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 6 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 6 · 2012: 4
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Medical Systems (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Purdue University
- Indiana Clinical and Translational Sciences Institute
- National Center for Research Resources (TL1RR025759, UL1RR025761, RR-025761)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Surgery › Nerve Injury and Rehabilitation
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Peripheral Nerve Disorders
- Keywords
- nerve stretch injury, tensile loading, nerve conduction, compound action potential, signal delay, sciatic nerve, threshold strain, load cell, micromanipulator
- MeSH terms
- Animals, Guinea Pigs, Neural Conduction, Nerve Expansion, Peripheral Nerve Injuries
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