Cited by 126Antioxidant Activity and Oxidative StressSeaweed-derived Bioactive CompoundsPhytochemicals and Antioxidant Activities

Comparative effects of β-carotene and fucoxanthin on retinol deficiency induced oxidative stress in rats

Sangeetha, R. K., Bhaskar, N., Baskaran, V.·2009·Molecular and Cellular Biochemistry

Abstract

This study aimed at comparing antioxidant potential of fucoxanthin (FUCO) with beta-carotene in relieving lipid peroxidation (Lpx) caused by retinol deficiency (RD) in rats. RD rats (n = 45) were fed a dose of either beta-carotene (0.81 mumol) or FUCO (0.83 mumol). Plasma and liver lipid peroxide levels and activity of antioxidant enzymes catalase (CAT) and glutathione transferase (GST) were measured for 8 h. Results revealed that RD increased (P < 0.05) Lpx in plasma and liver by 34.3% and 19.4%, while the CAT activity in plasma (89%) and liver microsomes (91%) and GST in liver homogenate (31%) and liver microsomes (30%) were decreased (P < 0.05) compared to control (rats fed basal diet). FUCO suppressed (P < 0.05) the Lpx level by 7-85% (plasma) and 24-72% (liver) as compared to beta-carotene (51-76%, 33-65%) over a period of 8 h. The activity of CAT in plasma and liver microsomes was higher (P < 0.05) in FUCO (90-95%, 85-93%) and beta-carotene (87-96%, 79-91%) groups as compared to RD group. Similarly, the activity of GST in liver and its microsomes was also elevated (P < 0.05) in FUCO (44-51%, 22-51%) and beta-carotene (19-54%, 30-43%) groups as compared to RD group. Results demonstrate that FUCO has greater potential than beta-carotene in modulating Lpx, CAT, GST in plasma and liver of RD rats.

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Crossref · 10.1007/s11010-009-0145-y

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Authors
Sangeetha, R. K., Bhaskar, N., & Baskaran, V.
Affiliations
Central Food Technological Research Institute (IN)
Corresponding author
Baskaran, V.
Venue
Molecular and Cellular Biochemistry
Published
2009-05-07
Volume
331
Issue
1-2
Pages
59-67
ISSN
  • 0300-8177 (ISSN-L)
  • 1573-4919
OpenAlex
W1979553058
Cited by
126
References
50
Citations by year
2026: 2 · 2025: 7 · 2024: 8 · 2023: 9 · 2022: 16 · 2021: 16 · 2020: 7 · 2019: 3 · 2018: 6 · 2017: 7 · 2016: 5 · 2015: 8 · 2014: 5 · 2013: 7 · 2012: 7
FWCI
4.30
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular and Cellular Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
beta-carotene, fucoxanthin, retinol deficiency, lipid peroxidation, oxidative stress, antioxidant enzymes, catalase, glutathione S-transferase, liver microsomes, plasma lipid peroxides, carotenoids
MeSH terms
Sodium-Potassium-Exchanging ATPase, Animals, Antioxidants, Catalase, Chromatography, High Pressure Liquid, Fatty Acids, Glutathione Transferase, Microsomes, Liver, Spectrophotometry, Ultraviolet, Time Factors, Vitamin A, Vitamin A Deficiency, Lipid Peroxidation, Rats, Wistar, Oxidative Stress, beta Carotene, Xanthophylls, Rats

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