Comparative effects of β-carotene and fucoxanthin on retinol deficiency induced oxidative stress in rats
Abstract
This study aimed at comparing antioxidant potential of fucoxanthin (FUCO) with beta-carotene in relieving lipid peroxidation (Lpx) caused by retinol deficiency (RD) in rats. RD rats (n = 45) were fed a dose of either beta-carotene (0.81 mumol) or FUCO (0.83 mumol). Plasma and liver lipid peroxide levels and activity of antioxidant enzymes catalase (CAT) and glutathione transferase (GST) were measured for 8 h. Results revealed that RD increased (P < 0.05) Lpx in plasma and liver by 34.3% and 19.4%, while the CAT activity in plasma (89%) and liver microsomes (91%) and GST in liver homogenate (31%) and liver microsomes (30%) were decreased (P < 0.05) compared to control (rats fed basal diet). FUCO suppressed (P < 0.05) the Lpx level by 7-85% (plasma) and 24-72% (liver) as compared to beta-carotene (51-76%, 33-65%) over a period of 8 h. The activity of CAT in plasma and liver microsomes was higher (P < 0.05) in FUCO (90-95%, 85-93%) and beta-carotene (87-96%, 79-91%) groups as compared to RD group. Similarly, the activity of GST in liver and its microsomes was also elevated (P < 0.05) in FUCO (44-51%, 22-51%) and beta-carotene (19-54%, 30-43%) groups as compared to RD group. Results demonstrate that FUCO has greater potential than beta-carotene in modulating Lpx, CAT, GST in plasma and liver of RD rats.
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Fucoxanthin is reported to have higher antioxidant effects than β-Carotene in tests of rat liver and plasma.
“Fucoxanthin is reported to have higher antioxidant effects than β-Carotene in tests of rat liver and plasma [223, 224].”
From The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products (2018) · cites this paper as [224]
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
Ohkawa, H., Ohishi, N., & Yagi, K. (1979) · Analytical Biochemistry · doi:10.1016/0003-2697(79)90738-3 · Cited by 29,460 · see citing works
Colowick, S. P., Joshi, M. D., Jagannathan, & KAPLAN, N. O. (1966) · Cited by 26,137 · see citing works
Aebi, H. (1984) · Methods in Enzymology · doi:10.1016/s0076-6879(84)05016-3 · Cited by 25,696 · see citing works
Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178 · see citing works
Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride–methanol
Morrison, W. R., & Smith, L. M. (1964) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40190-7 · Cited by 6,005 · see citing works
Free Radicals in Biology and Medicine
Land, E. T. (1990) · International Journal of Radiation Biology · doi:10.1080/09553009014552071 · Cited by 4,868 · see citing works
[10] Assay of inorganic phosphate, total phosphate and phosphatases
Ames, B. N. (1966) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(66)08014-5 · Cited by 3,372 · see citing works
Free radicals, antioxidants, and nutrition
Fang, Y.-Z., Yang, S., & Wu, G. (2002) · Nutrition · doi:10.1016/s0899-9007(02)00916-4 · Cited by 2,568 · see citing works
Sachindra, N. M., Sato, E., Maeda, H., Hosokawa, M., Niwano, Y., Kohno, M., & Miyashita, K. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071848a · Cited by 516 · see citing works
Antioxidant potentials of vitamin A and carotenoids and their relevance to heart disease
Palace, V. P., Khaper, N., Qin, Q., & Singal, P. K. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00266-4 · Cited by 482 · see citing works
Flecha, B. G., Llesuy, S., & Boveris, A. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90002-k · Cited by 439 · see citing works
Matsuno, T. (2001) · Fisheries Science · doi:10.1046/j.1444-2906.2001.00323.x · Cited by 375 · see citing works
Goto, S., Kogure, K., Abe, K., Kimata, Y., Kitahama, K., Yamashita, E., & Terada, H. (2001) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(01)00326-1 · Cited by 357 · see citing works
Woodall, A., Britton, G., & Jackson, M. J. (1997) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(97)00007-x · Cited by 349 · see citing works
Kim, J. (1998) · Carcinogenesis · doi:10.1093/carcin/19.1.81 · Cited by 285 · see citing works
McNulty, H. P., Byun, J., Lockwood, S. F., Jacob, R. F., & Mason, R. P. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.09.010 · Cited by 270 · see citing works
The main seaweed foods in Japan
Nisizawa, K., Noda, H., Kikuchi, R., & Watanabe, T. (1987) · Hydrobiologia · doi:10.1007/bf00046102 · Cited by 260 · see citing works
Asai, A., Sugawara, T., Ono, H., & Nagao, A. (2004) · Drug Metabolism and Disposition · doi:10.1124/dmd.32.2.205 · Cited by 244 · see citing works
Sugawara, T., Baskaran, V., Tsuzuki, W., & Nagao, A. (2002) · Journal of Nutrition · doi:10.1093/jn/132.5.946 · Cited by 211 · see citing works
Self-citationProton‐donative antioxidant activity of fucoxanthin with 1,1‐Diphenyl‐2‐Picrylhydrazyl (DPPH)
Nomura, T., Kikuchi, M., Kubodera, A., & Kawakami, Y. (1997) · IUBMB Life · doi:10.1080/15216549700202761 · Cited by 202 · see citing works
The main seaweed foods in Japan
Nisizawa, K., Noda, H., Kikuchi, R., & Watanabe, T. (1987) · Springer eBooks · doi:10.1007/978-94-009-4057-4_2 · Cited by 180 · see citing works
Selvendiran, K., Singh, J., Krishnan, K. B., & Sakthisekaran, D. (2003) · Fitoterapia · doi:10.1016/s0367-326x(02)00304-0 · Cited by 158 · see citing works
Seaweed Prevents Breast Cancer?
Funahashi, H., Imai, T., Mase, T., Sekiya, M., YOKOI, K., Hayashi, H., Shibata, A., Hayashi, T., Nishikawa, M., Suda, N., et al. (2001) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.2001.tb01119.x · Cited by 147 · see citing works
[64] Glutathione transferase from rat testis
Guthenberg, C., Ålin, P., & Mannervik, B. (1985) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(85)13067-3 · Cited by 117 · see citing works
Effects of Vitamin A on Growth of Vitamin A-Deficient Children: Field Studies in Nepal , ,
West, K. P., LeClerq, S. C., Shrestha, S. R., et al. (1997) · Journal of Nutrition · doi:10.1093/jn/127.10.1957 · Cited by 99 · see citing works
Hiqashi-Okaj, K., Otani, S., & Okai, Y. (1999) · Cancer Letters · doi:10.1016/s0304-3835(99)00047-6 · Cited by 83 · see citing works
Erythrocyte membrane Na+ and K+ activated adenosine triphosphatase in protein-calorie malnutrition
Ss, K. (1978) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/31.4.579 · Cited by 79 · see citing works
Vitamin A and Carotenoids as Antioxidants in a Physiological Context
Olson, J. A. (1993) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.39.supplement_s57 · Cited by 76 · see citing works
[20] Isolation of fucoxanthin and peridinin
Haugan, J. A., Aakermann, T., & Liaaen‐Jensen, S. (1992) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(92)13124-g · Cited by 62 · see citing works
Pajk, T., Rezar, V., Levart, A., & Salobir, J. (2006) · Nutrition · doi:10.1016/j.nut.2005.08.010 · Cited by 62 · see citing works
Effects of diet energy level and tomato powder consumption on antioxidant status in rats
MOREIRA, E., FAGUNDES, R., Filho, D. W., et al. (2005) · Clinical Nutrition · doi:10.1016/j.clnu.2005.08.005 · Cited by 48 · see citing works
β-Carotene 15,15′-Dioxygenase activity in human tissues and cells: evidence of an iron dependency
During, A., Smith, M. K., Piper, J. B., & Smith, J. C. (2001) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(01)00184-x · Cited by 42 · see citing works
Glutamate, glutamine, glutathione, and related compounds.
Meister, A. (1985) · PubMed · Cited by 40 · see citing works
Ravi Kumar, S., Narayan, B., & Vallikannan, B. (2008) · European Journal of Nutrition · doi:10.1007/s00394-008-0745-4 · Cited by 38 · see citing works
Kaul, S., & Krishnakantha, T. P. (1997) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006829010327 · Cited by 37 · see citing works
Palacios, A., Piergiacomi, V. A., & Catal�, A. (1996) · Molecular and Cellular Biochemistry · doi:10.1007/bf00248464 · Cited by 34 · see citing works
Takahashi, Y. K., Miura, T., & Takahashi, K. (1993) · Journal of Nutrition · doi:10.1093/jn/123.4.634 · Cited by 31 · see citing works
Formulation and evaluation of cereal/legume-based weaning food supplements
Mensa-Wilmot, Y., Phillips, R. D., Lee, J., et al. (2003) · Plant Foods for Human Nutrition · doi:10.1023/b:qual.0000040324.04977.dd · Cited by 30 · see citing works
Raju, M., Lakshminarayana, R., Krishnakantha, T. P., et al. (2006) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-005-9091-5 · Cited by 29 · see citing works
Maruyama, H., Watanabe, K., & YAMAMOTO, I. (1991) · Nutrition and Cancer · doi:10.1080/01635589109514130 · Cited by 29 · see citing works
Gutman, Y., & Katzper-Shamir, Y. (1971) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(71)90365-8 · Cited by 28 · see citing works
Chemoprevention of azoxymethane-induced rat colon carcinogenesis by seatangle, a fiber-rich seaweed
Lee, E.-J., & Sung, M. (2003) · Plant Foods for Human Nutrition · doi:10.1023/b:qual.0000040307.57930.a4 · Cited by 23 · see citing works
Reddy, B. S., Sharma, C., & Mathews, L. (1984) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(84)90011-3 · Cited by 19 · see citing works
Liver microsomal membrane fluidity and lipid characteristics in vitamin A-deficient rats
Hamm, M. W., Chan, V., & Wolf, G. (1987) · Biochemical Journal · doi:10.1042/bj2450907 · Cited by 17 · see citing works
Seaweed Carotenoid, Fucoxanthin, with Highly Bioactive and Nutritional Activities
Miyashita, K. (2006) · Han-gug hae-yang ba-i-o haghoeji/Han-guk haeyang baio hakoeji · Cited by 13 · see citing works
Fucoxanthin as a bioactive and nutritionally beneficial marine carotenoid
Hosokawa, M. (2006) · Medical Entomology and Zoology · Cited by 11 · see citing works
Increased chromium excretion in pregnancy is associated with insulin resistance
Morris, B. W., Samaniego, S., Fraser, R., et al. (2000) · The Journal of Trace Elements in Experimental Medicine · doi:10.1002/1520-670x(2000)13:4 · Cited by 10 · see citing works
The influence of dietary vitamin A intake on microsomal membrane fluidity and lipid composition
Grolier, P., Cisti, A., Daubèze, M., et al. (1991) · Nutrition Research · doi:10.1016/s0271-5317(05)80347-1 · Cited by 8 · see citing works
(2003) · Fitoterapia · doi:10.1016/s0367-326x(02)00326-x · Cited by 2 · see citing works
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Peng, J., Yuan, J.-P., Wu, C.-F., & Wang, J.-H. (2011) · Marine Drugs · doi:10.3390/md9101806 · Cited by 820 · see citing works
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Cornish, M. L., & Garbary, D. J. (2010) · ALGAE · doi:10.4490/algae.2010.25.4.155 · Cited by 290 · see citing works
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- Authors
- Sangeetha, R. K., Bhaskar, N., & Baskaran, V.
- Affiliations
- Central Food Technological Research Institute (IN)
- Corresponding author
- Baskaran, V.
- ORCID
- Baskaran, V.
- Venue
- Molecular and Cellular Biochemistry
- Published
- 2009-05-07
- Volume
- 331
- Issue
- 1-2
- Pages
- 59-67
- ISSN
- 0300-8177 (ISSN-L)
- 1573-4919
- OpenAlex
- W1979553058
- Cited by
- 126
- References
- 50
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 8 · 2023: 9 · 2022: 16 · 2021: 16 · 2020: 7 · 2019: 3 · 2018: 6 · 2017: 7 · 2016: 5 · 2015: 8 · 2014: 5 · 2013: 7 · 2012: 7
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Molecular and Cellular Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- beta-carotene, fucoxanthin, retinol deficiency, lipid peroxidation, oxidative stress, antioxidant enzymes, catalase, glutathione S-transferase, liver microsomes, plasma lipid peroxides, carotenoids
- MeSH terms
- Sodium-Potassium-Exchanging ATPase, Animals, Antioxidants, Catalase, Chromatography, High Pressure Liquid, Fatty Acids, Glutathione Transferase, Microsomes, Liver, Spectrophotometry, Ultraviolet, Time Factors, Vitamin A, Vitamin A Deficiency, Lipid Peroxidation, Rats, Wistar, Oxidative Stress, beta Carotene, Xanthophylls, Rats
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