Circular RNA: A novel and potential regulator in pathophysiology of schizophrenia
Abstract
Circular RNAs (CircRNAs) are a sub-class of non-coding RNA, which are covalently closed at the ends through a non-canonical process called, backsplicing from the precursor linear RNAs. These molecules are involved in several biological phenomena including regulation of gene expression, synaptic plasticity, and cognition. Several studies have shown that circRNA are present abundantly inside the mammalian brain and they are believed to be associated with the development of neurons and neuronal functions. It is also evident that alterations in intracellular and extracellular levels of circRNAs are linked with various neurological and neuropsychiatric disorders including schizophrenia (SZ). Detailed studies of circRNAs are required to decode the molecular mechanism behind the onset of SZ and the related biological activities during disease progression. This can help unravel their role in this neurobehavioral disorder and develop effective therapeutics against the disease. The present review mainly focuses on the expression and activities of the circRNAs in the post-mortem brain, peripheral blood, and exosomes. It also gives an insight into the role of circRNA interaction with RNA binding proteins (RBPs) and nucleotide modification and their therapeutic potential in the context of schizophrenia.
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circRNAs are abundantly expressed in the brain and are involved in the pathogenesis of neuropsychiatric disorders, impacting neuron development, cognitive function, and synaptic plasticity.
“circRNAs are abundantly expressed in the brain. And also, circRNAs are involved in the pathogenesis of neuropsychiatric disorders, impacting neuron development, cognitive function, and synaptic plasticity290–292.”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [292]
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“And also, circRNAs are involved in the pathogenesis of neuropsychiatric disorders, impacting neuron development, cognitive function, and synaptic plasticity 290 – 292 .”
BackgroundBiological hypotheses, risk factors, and biomarkers of schizophrenia
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- Authors
- Singh, M., Dwibedy, S. L. L., Biswal, S. R., Muthuswamy, S., Kumar, A., & Kumar, S.
- Affiliations
- National Institute of Technology Rourkela (IN)
- Banaras Hindu University (IN)
- Corresponding author
- Kumar, Santosh
- ORCID
- Venue
- Metabolic Brain Disease
- Published
- 2022-04-18
- Volume
- 37
- Issue
- 5
- Pages
- 1309-1316
- ISSN
- 0885-7490 (ISSN-L)
- 1573-7365
- OpenAlex
- W4223955530
- Cited by
- 15
- References
- 51
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 7 · 2022: 2
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolic Brain Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Science and Engineering Research Board (EEQ/2018/000022)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- circular RNA, schizophrenia, back-splicing, non-coding RNA, RNA-binding proteins, RNA modification, exosomes, postmortem brain, peripheral blood biomarkers, gene expression regulation, synaptic plasticity, neuropsychiatric disorders, therapeutic potential
- MeSH terms
- RNA, Circular, Animals, Brain, Mammals, RNA, Schizophrenia, Exosomes
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