Preparation of solid lipid nanoparticles as drug carriers for levothyroxine sodium with in vitro drug delivery kinetic characterization
Abstract
The aim of this work was to produce and characterize solid lipid nanoparticles (SLN) containing levothyroxine sodium for oral administration, and to evaluate the kinetic release of these colloidal carriers. SLNs were prepared by microemulsion method. The particle size and zeta potential of levothyroxine sodium-loaded SLNs were determined to be around 153 nm,-43 mV (negatively charged), respectively by photon correlation spectroscopy. The levothyroxine entrapment efficiency was over 98%. Shape and surface morphology were determined by TEM and SEM. They revealed fairly spherical shape of nanoparticles.SLN formulation was stable over a period of 6 months. There were no significant changes in particle size, zeta potential and polydispersity index and entrapment efficiency, indicating that the developed SLNs were fairly stable.
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The solid lipid nanoparticles were stable over 6 months.
“Of note, these solid lipid nanoparticles were stable over 6 months (276).”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [276]
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- Authors
- Rostami, E., Kashanian, S., & Azandaryani, A. H.
- Affiliations
- Islamic Azad University of Kermanshah (IR)
- Razi University (IR)
- Corresponding author
- Kashanian, S.
- Venue
- Molecular Biology Reports
- Published
- 2014-02-11
- Volume
- 41
- Issue
- 5
- Pages
- 3521-3527
- ISSN
- 0301-4851 (ISSN-L)
- 1573-4978
- OpenAlex
- W1963490643
- Cited by
- 40
- References
- 35
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 3
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Molecular Biology Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- solid lipid nanoparticles, levothyroxine sodium, oral drug delivery, drug carriers, microemulsion method, drug release kinetics, encapsulation efficiency, particle size, zeta potential, nanoparticle stability, antithyroid drugs
- MeSH terms
- Drug Carriers, Kinetics, Lipids, Particle Size, Thyroxine, Drug Delivery Systems, Nanoparticles, In Vitro Techniques
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