Glioblastoma exosomes reprogramming the tumor microenvironment and evading therapeutic challenges
Abstract
Glioblastoma (GBM) leverages exosomes to drive tumor progression, immunosuppression, and therapy resistance through transfer of oncogenic miRNAs, circRNAs, and proteins. These vesicles reprogram the tumor microenvironment (TME) by activating pathways such as TREM1 in microglia and STAT3-mediated vasculogenic mimicry. Exosomal nucleic acids, including circZNF800 and miR-374b-3p, serve as non-invasive biomarkers for recurrence and treatment monitoring. Advances in engineering, such as Angiopep-2-functionalized exosomes for blood-brain barrier penetration and CRISPR-Cas9-loaded vesicles targeting resistance genes, highlight their therapeutic potential. Challenges in heterogeneity, standardization, and scalable production underscore the need for interdisciplinary innovation to translate exosome-based strategies into clinical practice.
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Extracellular vesicles regulate cell migration in several cancer types, including glioblastoma.
“In this context, extracellular vesicles (EVs) have emerged as important mediators, regulating cell migration in several cancer types, including GB.”
From Optimized Wound Healing Assay to Study Extracellular Vesicle-Driven Glioblastoma Cell Migration (2026) · cites this paper as [32]
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Wang, J., Peng, B., Li, T., & Wang, T. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1859282 · Cited by 2 · see citing works
Salam, S. A., Tanoy, N. M., Sabuj, M. S. S., Rahman, M. J., Sadekuzzaman, M., Chowdhury, S., Jahan, E., Siddiqui, M. S. I., Park, B., & Akanda, M. R. (2026) · Pathology - Research and Practice · doi:10.1016/j.prp.2026.156585 · Cited by 1 · see citing works
Optimized Wound Healing Assay to Study Extracellular Vesicle-Driven Glioblastoma Cell Migration
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“EVs are key players in regulating GB pathological features, including cell invasiveness and migration [30–32].”
- Authors
- Tatode, A., Premchandani, T., Chaudhary, A. A., Ali, M. A. M., Qutub, M., Taksande, J., Khan, R., Hussain, U. M., & Umekar, M.
- Affiliations
- Imam Mohammad ibn Saud Islamic University (SA)
- Jamia Hamdard (IN)
- Rashtrasant Tukadoji Maharaj Nagpur University (IN)
- Corresponding author
- Chaudhary, Anis Ahmad
- Qutub, Mohammad
- ORCID
- Venue
- Molecular Biology Reports
- Published
- 2026-02-19
- Volume
- 53
- Issue
- 1
- Pages
- 400-400
- ISSN
- 0301-4851 (ISSN-L)
- 1573-4978
- OpenAlex
- W7130509814
- Cited by
- 3
- References
- 68
- Citations by year
- 2026: 3
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Molecular Biology Reports (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University (IMSIU-DDRSP2501)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Keywords
- glioblastoma, exosomes, tumor microenvironment, exosomal microRNAs, circular RNA, TREM-1, microglia, STAT3, vasculogenic mimicry, recurrence biomarkers, treatment resistance, Angiopep-2, blood-brain barrier penetration, exosome engineering
- MeSH terms
- RNA, Circular, Animals, Brain Neoplasms, Glioblastoma, Humans, Biomarkers, Tumor, MicroRNAs, Exosomes, Tumor Microenvironment
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