The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Effect of surface charge on the colloidal stability and in vitro uptake of carboxymethyl dextran-coated iron oxide nanoparticles
Open accessAbstract
Nanoparticle physicochemical properties such as surface charge are considered to play an important role in cellular uptake and particle–cell interactions. In order to systematically evaluate the role of surface charge on the uptake of iron oxide nanoparticles, we prepared carboxymethyl-substituted dextrans with different degrees of substitution, ranging from 38 to 5 groups per chain, and reacted them using carbodiimide chemistry with amine–silane-coated iron oxide nanoparticles with narrow size distributions in the range of 33–45 nm. Surface charge of carboxymethyl-substituted dextran-coated nanoparticles ranged from −50 to 5 mV as determined by zeta potential measurements, and was dependent on the number of carboxymethyl groups incorporated in the dextran chains. Nanoparticles were incubated with CaCo-2 human colon cancer cells. Nanoparticle–cell interactions were observed by confocal laser scanning microscopy and uptake was quantified by elemental analysis using inductively coupled plasma mass spectroscopy. Mechanisms of internalization were inferred using pharmacological inhibitors for fluid-phase, clathrin-mediated, and caveola-mediated endocytosis. Results showed increased uptake for nanoparticles with greater negative charge. Internalization patterns suggest that uptake of the most negatively charged particles occurs via non-specific interactions.
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Ultra-large-scale syntheses of monodisperse nanocrystals
Park, J., An, K., Hwang, Y., Park, J.-G., Noh, H.-J., Kim, J.-Y., Park, J.-H., Hwang, N.-M., & Hyeon, T. (2004) · Nature Materials · doi:10.1038/nmat1251 · Cited by 4,076
The effect of particle design on cellular internalization pathways
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Molecular mechanism and physiological functions of clathrin-mediated endocytosis
McMahon, H. T., & Boucrot, E. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3151 · Cited by 2,223
Magnetic fluid hyperthermia: focus on superparamagnetic iron oxide nanoparticles
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Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181
Nanoparticle colloidal stability in cell culture media and impact on cellular interactions
Moore, T. L., Rodriguez-Lorenzo, L., Hirsch, V., Balog, S., Urban, D., Jud, C., Rothen-Rutishauser, B., Lattuada, M., & Petri-Fink, A. (2015) · Chemical Society Reviews · doi:10.1039/c4cs00487f · Cited by 1,082
Chitosan nanoparticles as a dual drug/siRNA delivery system for treatment of colorectal cancer
Sadreddini, S., Safaralizadeh, R., Baradaran, B., Aghebati-Maleki, L., Hosseinpour-Feizi, M. A., Shanehbandi, D., Jadidi-Niaragh, F., Sadreddini, S., Kafil, H. S., Younesi, V., et al. (2017) · Immunology Letters · doi:10.1016/j.imlet.2016.11.013 · Cited by 101
Drug Targeting Strategies Based on Charge Dependent Uptake of Nanoparticles into Cancer Cells
Saadat, M., Zahednezhad, F., Zakeri-Milani, P., Reza Heidari, H., Shahbazi-Mojarrad, J., & Valizadeh, H. (2019) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/jpps30318 · Cited by 88
Gupta, R., Chauhan, A., Kaur, T., Kuanr, B. K., & Sharma, D. (2022) · Nanoscale · doi:10.1039/d2nr02210a · Cited by 35
Metadata
- Authors
- Ayala, V., Herrera, A. P., Latorre-Esteves, M., Torres-Lugo, M., & Rinaldi, C.
- Venue
- Journal of Nanoparticle Research
- Published
- 2013-07-30
- Volume
- 15
- Issue
- 8
- Pages
- 1874-1874
- ISSN
- 1388-0764 (ISSN-L)
- 1572-896X
- OpenAlex
- W1996242594
- Cited by
- 204
- References
- 6
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- green
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- Ayala, V., Herrera, A. P., Latorre-Esteves, M., Torres-Lugo, M., & Rinaldi, C. (2013). Effect of surface charge on the colloidal stability and in vitro uptake of carboxymethyl dextran-coated iron oxide nanoparticles. Journal of Nanoparticle Research. https://doi.org/10.1007/s11051-013-1874-0
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