Cited by 76Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Ultrastructural Localization of Intraneuronal Aβ-Peptide in Alzheimer Disease Brains

Gómez-Ramos, Pilar, Asunción Morán, M.·2007·Journal of Alzheimer's Disease

Abstract

Autopsied brain tissue from Alzheimer's disease patients and old non-demented controls was studied after immunocytochemistry with the 4G8 monoclonal antibody that recognizes amyloid-beta peptides. Intraneuronal 4G8-positive reaction product was detected in all of the studied brains. The same brain regions in the Alzheimer's disease samples consistently showed both more immunopositive neurons and more stained reaction product per neuron than those from the non-demented brains. Ultrastructurally, the immunopositive reaction product accumulated in clusters of cytoplasmic elements that had a lipofuscin-like appearance, showed a fibrogranular content and were also closely apposed to lipid droplets located either on their periphery or within them. The most strongly 4G8-immunopositive elements had diffuse limits with their fibrogranular content free in the cytoplasm, whereas elements either without or showing only light immunoreaction had a limiting membrane. All immunopositive neurons displayed a similar pattern of clumping heterochromatin. The hypothetical neurotoxic role of intraneuronal amyloid-beta peptides free in the cytoplasm is discussed as is the possible relationship between the amyloid-beta peptides recognized by the 4G8 antibody and the lipid droplets which would presumably contain esterified cholesterol.

Integrity signals

Registry

Crossref · 10.3233/jad-2007-11109

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Gómez-Ramos, P., & Asunción Morán, M.
Affiliations
Department of Anatomy, Histology and Neuroscience, School of Medicine, Autónoma University of Madrid, Spain
Venue
Journal of Alzheimer's Disease
Published
2007-03-01
Volume
11
Issue
1
Pages
53-59
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W1597345104
Cited by
76
References
36
Citations by year
2025: 3 · 2024: 7 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 7 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 7 · 2015: 4 · 2014: 3 · 2013: 1 · 2012: 6
FWCI
3.10
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
intraneuronal amyloid-beta, Alzheimer's disease
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Brain, Inclusion Bodies, Cholesterol Esters, Cytoplasm, Female, Humans, Immunoenzyme Techniques, Lipofuscin, Male, Microscopy, Electron, Neurons, Reference Values, Ultrasonography, Amyloid beta-Peptides

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review