Calcium signalling and Alzheimer's disease

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., & Selkoe, D. J. (2002) · Nature · doi:10.1038/416535a · Cited by 4,291 · see citing works

Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126 · see citing works

Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms

Citri, A., & Malenka, R. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301559 · Cited by 2,323 · see citing works

Regulation of NMDA receptor trafficking by amyloid-β

Snyder, E. M., Nong, Y., Almeida, C. G., Paul, S., Moran, T., Choi, E. Y., Nairn, A. C., Salter, M. W., Lombroso, P. J., Gouras, G. K., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1503 · Cited by 1,561 · see citing works

A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60

Cao, X., & Südhof, T. C. (2001) · Science · doi:10.1126/science.1058783 · Cited by 1,202 · see citing works

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer’s Disease

Busche, M. A., Eichhoff, G., Adelsberger, H., Abramowski, D., Wiederhold, K.-H., Haass, C., Staufenbiel, M., Konnerth, A., & Garaschuk, O. (2008) · Science · doi:10.1126/science.1162844 · Cited by 1,125 · see citing works

AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss

Hsieh, H., Boehm, J., Sato, C., Iwatsubo, T., Tomita, T., Sisodia, S., & Malinow, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.035 · Cited by 1,042 · see citing works

Calcium dyshomeostasis and intracellular signalling in alzheimer's disease

LaFerla, F. M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn960 · Cited by 970 · see citing works

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

Bezprozvanny, I., & Mattson, M. P. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.06.005 · Cited by 938 · see citing works

Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy.

Cingolani, L. A., & Goda, Y. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2373 · Cited by 831 · see citing works

The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease

Westerman, M. A., Cooper-Blacketer, D., Mariash, A., Kotilinek, L., Kawarabayashi, T., Younkin, L. H., Carlson, G. A., Younkin, S. G., & Ashe, K. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01858.2002 · Cited by 714 · see citing works

Regulatory mechanisms of AMPA receptors in synaptic plasticity

Derkach, V. A., Oh, M. C., Guire, E. S., & Soderling, T. R. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2055 · Cited by 708 · see citing works

Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

Jacobsen, J. S., Wu, C.-C., Redwine, J. M., Comery, T. A., Arias, R., Bowlby, M., Martone, R., Morrison, J. H., Pangalos, M. N., Reinhart, P. H., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600948103 · Cited by 701 · see citing works

Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations

Tu, H., Nelson, O. L., Bezprozvanny, A., Wang, Z., Lee, S.-F., Hao, Y.-H., Serneels, L., Strooper, B. D., Yu, G., & Борисович, Б. И. (2006) · Cell · doi:10.1016/j.cell.2006.06.059 · Cited by 691 · see citing works

Effects of secreted oligomers of amyloid β‐protein on hippocampal synaptic plasticity: a potent role for trimers

Townsend, M., Shankar, G. M., Mehta, T., Walsh, D. M., & Selkoe, D. J. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.103754 · Cited by 619 · see citing works

Aβ plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks

Kuchibhotla, K. V., Goldman, S. T., Lattarulo, C. R., Wu, H.-Y., Hyman, B. T., & Bacskai, B. J. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.008 · Cited by 614 · see citing works

Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo

Klyubin, I., Walsh, D. M., Lemere, C. A., Cullen, W. K., Shankar, G. M., Betts, V., Spooner, E. T., Jiang, L., Anwyl, R., Selkoe, D. J., et al. (2005) · Nature Medicine · doi:10.1038/nm1234 · Cited by 489 · see citing works

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

Cheung, K., Shineman, D. W., Müller, M., Cárdenas, C., Mei, L., Yang, J., Tomita, T., Iwatsubo, T., Lee, V. M. ‐., & Foskett, J. K. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.015 · Cited by 449 · see citing works

Calcium Signaling and Amyloid Toxicity in Alzheimer Disease

Demuro, A., Parker, I., & Stutzmann, G. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r109.080895 · Cited by 409 · see citing works

Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits

Palop, J. J., Jones, B., Kekonius, L., Chin, J., Yu, G.-Q., Raber, J., Masliah, E., & Mucke, L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1133381100 · Cited by 402 · see citing works

Calcium hypothesis of Alzheimer’s disease

Berridge, M. J. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0736-1 · Cited by 384 · see citing works

Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store

Thibault, O., Gant, J. C., & Landfield, P. W. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00295.x · Cited by 379 · see citing works

Bcl-2 Protein Family Members: Versatile Regulators of Calcium Signaling in Cell Survival and Apoptosis

Rong, Y., & Distelhorst, C. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.021507.105852 · Cited by 357 · see citing works

Enhanced Ryanodine Receptor Recruitment Contributes to Ca2+Disruptions in Young, Adult, and Aged Alzheimer's Disease Mice

Stutzmann, G. E., Smith, I. F., Caccamo, A., Oddo, S., LaFerla, F. M., & Parker, I. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0739-06.2006 · Cited by 327 · see citing works

The dysregulation of intracellular calcium in Alzheimer disease

Supnet, C. B., & Борисович, Б. И. (2010) · Cell Calcium · doi:10.1016/j.ceca.2009.12.014 · Cited by 324 · see citing works

Alzheimerʼs PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid β-peptide

Guo, Q., Furukawa, K., Sopher, B. L., Pham, D. G., Xie, J., Robinson, N., Martin, G. M., & Mattson, M. P. (1996) · Neuroreport · doi:10.1097/00001756-199612200-00074 · Cited by 320 · see citing works

Presenilin-1 Mutations Increase Levels of Ryanodine Receptors and Calcium Release in PC12 Cells and Cortical Neurons

Chan, S. L., Mayne, M. B., Holden, C. P., Geiger, J. D., & Mattson, M. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000040200 · Cited by 314 · see citing works

SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production

Green, K. N., Demuro, A., Akbari, Y., Hitt, B. D., Smith, I. F., Parker, I., & LaFerla, F. M. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200706171 · Cited by 305 · see citing works

A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP

Leissring, M. A., Murphy, M. P., Mead, T. R., Akbari, Y., Sugarman, M. C., Jannatipour, M., Anliker, B., Müller, U., Säftig, P., Strooper, B. D., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072033799 · Cited by 273 · see citing works

Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: Reduced oxidative stress and preserved mitochondrial function

Guo, Q., Christakos, S., Robinson, N., & Mattson, M. P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3227 · Cited by 220 · see citing works

Mitochondrial Ca2+ Overload Underlies Aβ Oligomers Neurotoxicity Providing an Unexpected Mechanism of Neuroprotection by NSAIDs

Sanz‐Blasco, S., Valero, R. A., Rodríguez‐Crespo, I., Villalobos, C., & Núñez, L. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002718 · Cited by 219 · see citing works

Calcineurin Links Ca2+Dysregulation with Brain Aging

Foster, T. C., Sharrow, K., Masse, J. R., Norris, C. M., & Kumar, A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-11-04066.2001 · Cited by 214 · see citing works

Deviant Ryanodine Receptor-Mediated Calcium Release Resets Synaptic Homeostasis in Presymptomatic 3xTg-AD Mice

Chakroborty, S., Goussakov, I. V., Miller, M. B., & Stutzmann, G. E. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2047-09.2009 · Cited by 209 · see citing works

Gain-of-Function Enhancement of IP 3 Receptor Modal Gating by Familial Alzheimer’s Disease–Linked Presenilin Mutants in Human Cells and Mouse Neurons

Cheung, K., Mei, L., Mak, D. D., Hayashi, I., Iwatsubo, T., Kang, D. E., & Foskett, J. K. (2010) · Science Signaling · doi:10.1126/scisignal.2000818 · Cited by 208 · see citing works

Calcium dysregulation in Alzheimer's disease

Bojarski, Ł., Herms, J. W., & Kuźnicki, J. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.10.002 · Cited by 202 · see citing works

Introduction and Overview

KHACHATURIAN, Z. S. (1989) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1989.tb12485.x · Cited by 199 · see citing works

The Pathogenesis of Alzheimers Disease—Is It a Lifelong “Calciumopathy”?

Stutzmann, G. E. (2007) · The Neuroscientist · doi:10.1177/1073858407299730 · Cited by 195 · see citing works

Role of Presenilins in Neuronal Calcium Homeostasis

Zhang, H., Sun, S., Herreman, A., Strooper, B. D., & Борисович, Б. И. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1554-10.2010 · Cited by 181 · see citing works

Enhanced caffeine‐induced Ca2+release in the 3xTg‐AD mouse model of Alzheimer's disease

Smith, I. F., Hitt, B. D., Green, K. N., Oddo, S., & LaFerla, F. M. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03332.x · Cited by 164 · see citing works

Increased intraneuronal resting [Ca²⁺] in adult Alzheimer’s disease mice

Lopez, J. R., Lyckman, A., Oddo, S., LaFerla, F. M., Querfurth, H. W., & Shtifman, A. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05135.x · Cited by 162 · see citing works

ER Calcium and Alzheimer’s Disease: In a State of Flux

Mattson, M. P. (2010) · Science Signaling · doi:10.1126/scisignal.3114pe10 · Cited by 161 · see citing works

Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice

Dineley, K. T., Hogan, D., Zhang, W.-R., & Taglialatela, G. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.03.010 · Cited by 149 · see citing works

Lack of Pathology in a Triple Transgenic Mouse Model of Alzheimer’s Disease after Overexpression of the Anti-Apoptotic Protein Bcl-2

Rohn, T. T., Vyas, V., Hernandez-Estrada, T., Nichol, K. E., Christie, L.-A., & Head, E. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5620-07.2008 · Cited by 146 · see citing works

Deranged Calcium Signaling in Purkinje Cells and Pathogenesis in Spinocerebellar Ataxia 2 (SCA2) and Other Ataxias

Kasumu, A. W., & Борисович, Б. И. (2010) · The Cerebellum · doi:10.1007/s12311-010-0182-9 · Cited by 134 · see citing works

Loss of calbindin-28K immunoreactive neurones from the cortex in Alzheimer-type dementia

Ichimiya, Y., Emson, P. C., Mountjoy, C. Q., Lawson, D. E. M., & Heizmann, C. W. (1988) · Brain Research · doi:10.1016/0006-8993(88)90210-7 · Cited by 115 · see citing works

Amyloid-β-(1-42) Increases Ryanodine Receptor-3 Expression and Function in Neurons of TgCRND8 Mice

Supnet, C. B., Grant, J., Kong, H., Westaway, D. A., & Mayne, M. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606736200 · Cited by 100 · see citing works

Loss of calbindin‐D28k from aging human cholinergic basal forebrain: Relation to neuronal loss

Geula, C., Bu, J., Nagykery, N. G., Scinto, L. F. M., Chan, J. A.-W., Joseph, J. T., Parker, R. A., & Wu, C. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10475 · Cited by 95 · see citing works

Human ataxias: a genetic dissection of inositol triphosphate receptor (ITPR1)-dependent signaling

Schorge, S., van de Leemput, J., Singleton, A., Houlden, H., & Hardy, J. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.02.005 · Cited by 85 · see citing works

Familial Alzheimer's Disease Mutations in Presenilins: Effects on Endoplasmic Reticulum Calcium Homeostasis and Correlation with Clinical Phenotypes

Nelson, O. L., Supnet, C. B., Liu, H., & Борисович, Б. И. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100159 · Cited by 79 · see citing works

The amyloid beta ion channel hypothesis of Alzheimer’s disease

Shirwany, N. A., Payette, D. J., Xie, J., et al. (2007) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.a934 · Cited by 77 · see citing works

Calcium, membranes, aging, and Alzheimer's disease

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Calcium signalling remodelling and disease

Berridge, M. J. (2012) · Biochemical Society Transactions · doi:10.1042/bst20110766 · Cited by 391 · see citing works

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease

Oksanen, M., Petersen, A. J., Naumenko, N., Puttonen, K., Lehtonen, Š., Gubert Olivé, M., Shakirzyanova, A., Leskelä, S., Sarajärvi, T., Viitanen, M., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.10.016 · Cited by 332 · see citing works

Soluble forms of tau are toxic in Alzheimer's disease

Kopeikina, K., Hyman, B., & Spires-Jones, T. (2012) · Translational Neuroscience · doi:10.2478/s13380-012-0032-y · Cited by 232 · see citing works

ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease

Lane-Donovan, C., & Herz, J. (2017) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.12.001 · Cited by 157 · see citing works

The Coming of Age of the Angiotensin Hypothesis in Alzheimer’s Disease: Progress Toward Disease Prevention and Treatment?

Kehoe, P. G. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-171119 · Cited by 133 · see citing works

Cilia interactome with predicted protein-protein interactions reveals connections to Alzheimer’s disease, aging and other neuropsychiatric processes

Karunakaran, K. B., Chaparala, S., Lo, C. W., & Ganapathiraju, M. K. (2020) · Scientific Reports · doi:10.1038/s41598-020-72024-4 · Cited by 56 · see citing works

Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer’s disease

Mustaly-Kalimi, S., Gallegos, W., Marr, R. A., Gilman-Sachs, A., Peterson, D. A., Sekler, I., & Stutzmann, G. E. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2211999119 · Cited by 55 · see citing works

Cytosolic calcium: Judge, jury and executioner of neurodegeneration in Alzheimer's disease and beyond

Webber, E. K., Fivaz, M., Stutzmann, G. E., & Griffioen, G. (2023) · Alzheimer's & Dementia · doi:10.1002/alz.13065 · Cited by 50 · see citing works

Cardiac calcium signalling pathologies associated with defective calmodulin regulation of type 2 ryanodine receptor: Ca2+signalling consequences of defective CaM binding to RyR2

Damon, B. J., Yamaguchi, N., Cleemann, L. N., et al. (2021) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/tkv6-m515

[Cellular calcium ion signalling--from basic research to benefits for patients].

Gustafsson, A. J., & Islam, M. S. (2005) · PubMed · Cited by 3 · see citing works

Enhanced Ryanodine‐Mediated Calcium Release in Mutant PS1‐Expressing Alzheimer's Mouse Models

Stutzmann, G. E., Smith, I. F., Caccamo, A., Oddo, S., Parker, I., & LaFerla, F. M. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1379.025 · Cited by 118 · see citing works

Dysregulation of RyR Calcium Channel Causes the Onset of Mitochondrial Retrograde Signaling

Chowdhury, A. R., Srinivasan, S., Csordás, G., Hajnóczky, G., & Avadhani, N. G. (2020) · iScience · doi:10.1016/j.isci.2020.101370 · Cited by 14 · see citing works

Modeling the Crosstalk between Ryanodine and IP3 Receptors in Cardiac Myocytes

Jones, D. C., & Sobie, E. A. (2021) · Biophysical Journal · doi:10.1016/j.bpj.2020.11.1091