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Cited by 128Phytochemicals and Medicinal PlantsParkinson's Disease Mechanisms and TreatmentsMedicinal Plants and Neuroprotection

The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.

Neuroprotective role of Withania somnifera root extract in maneb-paraquat induced mouse model of parkinsonism

Prakash, Jay, Yadav, Satyndra Kumar, Chouhan, Shikha, Singh, Surya Pratap·2013·Neurochemical Research
DOI 10.1007/s11064-013-1005-4
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Abstract

Parkinson's disease (PD) is a neurodegenerative disorder and these days a lot of emphasis is given on the treatment of this disease using herbal medicines. The present study evaluates the neuroprotective effect of Withania somnifera (Ws) root extract on Parkinsonian mice. The mice were divided into three groups; the first group served as control, the second group was given maneb (MB) and paraquat (PQ) and the last group was administered MB-PQ along with Ws root extract for 3, 6 and 9 weeks. The behavioral studies showed a significant improvement in the motor movement patterns and gripping ability of Ws root extract exposed Parkinsonian mice. Tyrosine hydroxylase (TH) immunostaining was reduced in the substantia nigra of MB-PQ exposed mice, while Ws co-exposure restored TH immunostaining significantly. Additionally, our results also demonstrate generation of oxidative stress in the nigrostriatal region of MB-PQ exposed mice. There was a marked decline in the level of catalase and a simultaneous increase in the level of nitrite and lipid peroxidation in Parkinsonian mice. Thus, the Ws root extract have shown to counteract the pro-oxidants and their associated oxidative stress in the PD model studied here. Our results clearly indicate the usefulness of Ws root extract in providing protection against MB-PQ induced nigrostriatal dopaminergic neurodegeneration and marked improvement in the behavioral, anatomical and the biochemical deformities.

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Research works printed but not linked: 2

  1. Fahn S (2000) The spectrum of levodopa-induced dyskinesias. Ann Neurol 4:2–11
  2. Rajasankar S, Manivasagam T, Albert Singh T, Krishnamurti A, Ramanathan M (2007) Prophylactic effect of Withania somonifera against MPTP induced Parkin-son’s disease in mice. Cell Tissue Res 7:975–979

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Metadata

Authors
Prakash, J., Yadav, S. K., Chouhan, S., & Singh, S. P.
Affiliations
Banaras Hindu University (IN)
Corresponding author
Singh, Surya Pratap
ORCID
Singh, Surya Pratap
Venue
Neurochemical Research
Publisher
Springer Science and Business Media LLC
Published
2013-02-22
Volume
38
Issue
5
Pages
972-980
ISSN
  • 0364-3190 (ISSN-L)
  • 1573-6903
DOI
10.1007/s11064-013-1005-4
OpenAlex
W2055407191
Cited by
128
References
59
Citations by year
2026: 7 · 2025: 9 · 2024: 8 · 2023: 14 · 2022: 11 · 2021: 15 · 2020: 13 · 2019: 5 · 2018: 7 · 2017: 11 · 2016: 9 · 2015: 8 · 2014: 5 · 2013: 5
FWCI
21.35
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Neurochemical Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords
Withania somnifera, ashwagandha root extract, Parkinson's disease, maneb, paraquat, neuroprotection, oxidative stress, dopaminergic neuron loss, substantia nigra, tyrosine hydroxylase, nigrostriatal pathway, catalase, lipid peroxidation, motor behavior, herbal medicine
MeSH terms
Animals, Disease Models, Animal, Maneb, Paraquat, Plant Extracts, Plant Roots, Neuroprotective Agents, Parkinsonian Disorders, Withania, Mice

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