Cited by 128Phytochemicals and Medicinal PlantsParkinson's Disease Mechanisms and TreatmentsMedicinal Plants and Neuroprotection

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Neuroprotective role of Withania somnifera root extract in maneb-paraquat induced mouse model of parkinsonism

Prakash, Jay, Yadav, Satyndra Kumar, Chouhan, Shikha, Singh, Surya Pratap·2013·Neurochemical Research

DOI 10.1007/s11064-013-1005-4

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Abstract

Parkinson's disease (PD) is a neurodegenerative disorder and these days a lot of emphasis is given on the treatment of this disease using herbal medicines. The present study evaluates the neuroprotective effect of Withania somnifera (Ws) root extract on Parkinsonian mice. The mice were divided into three groups; the first group served as control, the second group was given maneb (MB) and paraquat (PQ) and the last group was administered MB-PQ along with Ws root extract for 3, 6 and 9 weeks. The behavioral studies showed a significant improvement in the motor movement patterns and gripping ability of Ws root extract exposed Parkinsonian mice. Tyrosine hydroxylase (TH) immunostaining was reduced in the substantia nigra of MB-PQ exposed mice, while Ws co-exposure restored TH immunostaining significantly. Additionally, our results also demonstrate generation of oxidative stress in the nigrostriatal region of MB-PQ exposed mice. There was a marked decline in the level of catalase and a simultaneous increase in the level of nitrite and lipid peroxidation in Parkinsonian mice. Thus, the Ws root extract have shown to counteract the pro-oxidants and their associated oxidative stress in the PD model studied here. Our results clearly indicate the usefulness of Ws root extract in providing protection against MB-PQ induced nigrostriatal dopaminergic neurodegeneration and marked improvement in the behavioral, anatomical and the biochemical deformities.

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Authors: Prakash, J., Yadav, S. K., Chouhan, S., & Singh, S. P.
Affiliations: Banaras Hindu University (IN)
Corresponding author: Singh, Surya Pratap
ORCID: Singh, Surya Pratap
Venue: Neurochemical Research
Publisher: Springer Science and Business Media LLC
Published: 2013-02-22
Volume: 38
Issue: 5
Pages: 972-980
ISSN: 0364-3190 (ISSN-L)
1573-6903
DOI: 10.1007/s11064-013-1005-4
OpenAlex: W2055407191
Cited by: 128
References: 59
Citations by year: 2026: 7 · 2025: 9 · 2024: 8 · 2023: 14 · 2022: 11 · 2021: 15 · 2020: 13 · 2019: 5 · 2018: 7 · 2017: 11 · 2016: 9 · 2015: 8 · 2014: 5 · 2013: 5
FWCI: 21.35
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Neurochemical Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords: Withania somnifera, ashwagandha root extract, Parkinson's disease, maneb, paraquat, neuroprotection, oxidative stress, dopaminergic neuron loss, substantia nigra, tyrosine hydroxylase, nigrostriatal pathway, catalase, lipid peroxidation, motor behavior, herbal medicine
MeSH terms: Animals, Disease Models, Animal, Maneb, Paraquat, Plant Extracts, Plant Roots, Neuroprotective Agents, Parkinsonian Disorders, Withania, Mice

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Neuroprotective role of Withania somnifera root extract in maneb-paraquat induced mouse model of parkinsonism

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