MHC Class I Molecules and PirB Shape Neuronal Morphology by Affecting the Dendritic Arborization of Cortical Neurons
Abstract
Neuronal MHC class I proteins have been previously reported to regulate synaptic plasticity. Several reports indicate MHC class I proteins are expressed early during development of the nervous system, suggesting they may also play a role in neuronal development. Using cultured cortical neurons, we show MHC class I proteins aggregate at specific sites in neuronal cell bodies, which overlap with the actin cytoskeleton. Knockout of MHC class I in cultured neurons increases total dendritic length and the number of branch points. These effects are abolished by reintroducing MHC class I expression. Similarly, blocking of MHC class I proteins or PirB by an MHCI antibody or a soluble PirB ectodomain respectively, mimics the knock out phenotype of increased dendritic branching. This effect is correlated with decreased phosphorylation of both LIMK and cofilin, suggesting it may be mediated by an induction of cofilin activity. Finally, layer II and III cortical neurons in the sensorimotor region of an MHC class I deficiency mouse model show increased dendritic growth and branching. Altogether, our results suggest MHC class I plays a role in inhibiting or limiting the degree of dendrite arborization during the development of cortical neurons.
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H2-K and H2-D limit the levels of Ca2+-permeable AMPA receptors in the lateral geniculate nucleus.
“limit the levels of Ca2+-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the lateral geniculate nucleus.21,22,26,27,28,29”
From An innate immune response to adeno-associated virus genomes decreases cortical dendritic complexity and disrupts synaptic transmission (2024) · cites this paper as [29]
H2-K and H2-D negatively regulate dendritic complexity and the frequency and amplitude of miniature excitatory postsynaptic currents (mEPSCs) in hippocampal and cortical neurons.
“H2-K and H2-D also negatively regulate dendritic complexity and the frequency and amplitude of miniature excitatory postsynaptic currents (mEPSCs) in hippocampal and cortical neurons”
From An innate immune response to adeno-associated virus genomes decreases cortical dendritic complexity and disrupts synaptic transmission (2024) · cites this paper as [29]
A growing number of immune proteins have been identified that play central roles in neuronal homeostasis, where they negatively regulate neurite length, dendritic complexity, and synaptic transmission, and many are upregulated by TLR9.
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From An innate immune response to adeno-associated virus genomes decreases cortical dendritic complexity and disrupts synaptic transmission (2024) · cites this paper as [29]
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- Authors
- Shen, Y., Zhao, H., Li, P., Peng, Y., Cui, P., Miao, F., Zhang, Y., Zhang, A., & Zhang, J.
- Affiliations
- Southeast University (CN)
- Zhongda Hospital Southeast University (CN)
- Corresponding author
- Zhang, Jianqiong
- Venue
- Neurochemical Research
- Published
- 2018-11-08
- Volume
- 44
- Issue
- 2
- Pages
- 312-322
- ISSN
- 0364-3190 (ISSN-L)
- 1573-6903
- OpenAlex
- W2900324069
- Cited by
- 14
- References
- 31
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 1
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neurochemical Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81571615)
- The Natural Science Foundation of Jiangsu Province of China (BK20151421)
- the Fundamental Research Funds for the Central Universities (2242018k30004)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- MHC class I, PirB, dendritic branching, cortical neurons, neuronal development, actin cytoskeleton, LIM kinase, cofilin, dendritic length, sensorimotor cortex
- MeSH terms
- Animals, Cells, Cultured, Dendrites, Mice, Inbred C57BL, Neuronal Plasticity, Neurons, Receptors, Immunologic, Histocompatibility Antigens Class I, Mice, Knockout, Dendritic Spines
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