PirB regulates a structural substrate for cortical plasticity.
Open accessAbstract
Experience-driven circuit changes underlie learning and memory. Monocular deprivation (MD) engages synaptic mechanisms of ocular dominance (OD) plasticity and generates robust increases in dendritic spine density on L5 pyramidal neurons. Here we show that the paired immunoglobulin-like receptor B (PirB) negatively regulates spine density, as well as the threshold for adult OD plasticity. In PirB(-/-) mice, spine density and stability are significantly greater than WT, associated with higher-frequency miniature synaptic currents, larger long-term potentiation, and deficient long-term depression. Although MD generates the expected increase in spine density in WT, in PirB(-/-) this increase is occluded. In adult PirB(-/-), OD plasticity is larger and more rapid than in WT, consistent with the maintenance of elevated spine density. Thus, PirB normally regulates spine and excitatory synapse density and consequently the threshold for new learning throughout life.
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Genetic deletion of the PirB receptor mimicked the effect of monocular deprivation on spine motility.
“Genetic deletion of the PirB receptor mimicked the effect of monocular deprivation on spine motility (Djurisic et al., 2013).”
From Spatiotemporal dynamics of dendritic spines in the living brain (2014) · cites this paper as Djurisic et al., 2013
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- Authors
- Djurisic, M., Vidal, G. S., Mann, M., Aharon, A., Kim, T., Ferrao Santos, A., Zuo, Y., Hübener, M., & Shatz, C. J.
- Affiliations
- Stanford University (US)
- Max Planck Society (DE)
- University of California, Santa Cruz (US)
- Max Planck Institute of Neurobiology, D-82152 Martinsried, Germany; and
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-12-03
- Volume
- 110
- Issue
- 51
- Pages
- 20771-20776
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3870667
- OpenAlex
- W2043928194
- Cited by
- 79
- References
- 43
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 9 · 2021: 5 · 2020: 8 · 2019: 4 · 2018: 11 · 2017: 4 · 2016: 8 · 2015: 8 · 2014: 8 · 2013: 1
- FWCI
- 4.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH094449, R01MH09449)
- National Eye Institute (EY02858, R01EY002858, F31EY023518, R37EY002858)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- PirB, ocular dominance plasticity, monocular deprivation, dendritic spine density, spinal stability, long-term potentiation, long-term depression, miniature synaptic currents, synaptic plasticity, cortical plasticity, learning and memory
- MeSH terms
- Animals, Learning, Receptors, Immunologic, Long-Term Potentiation, Pyramidal Cells, Mice, Knockout, Excitatory Postsynaptic Potentials, Dominance, Ocular, Mice
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