PirB restricts ocular-dominance plasticity in visual cortex
Abstract
Experience can alter synaptic connectivity throughout life, but the degree of plasticity present at each age is regulated by mechanisms that remain largely unknown. Here, we demonstrate that Paired-immunoglobulin–like receptor B (PirB), a major histocompatibility complex class I (MHCI) receptor, is expressed in subsets of neurons throughout the brain. Neuronal PirB protein is associated with synapses and forms complexes with the phosphatases Shp-1 and Shp-2. Soluble PirB fusion protein binds to cortical neurons in an MHCI-dependent manner. In mutant mice lacking functional PirB, cortical ocular-dominance plasticity is more robust at all ages. Thus, an MHCI receptor is expressed in central nervous system neurons and functions to limit the extent of experience-dependent plasticity in the visual cortex throughout life. PirB is also expressed in many other regions of the central nervous system, suggesting that it may function broadly to stabilize neural circuits.
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Several molecular brakes relevant to schizophrenia, other than PNNs, limit critical period plasticity, including myelin signaling through NgR-PirB and dampened nicotinic receptor signaling by Lynx1.
“Several molecular brakes of relevance to schizophrenia (other than PNNs) have been identified to limit critical period plasticity, including myelin signaling through a NgR-PirB complex (2, 74, 75) or dampened nicotinic receptor signaling by Lynx1 (29, 76).”
From Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons (2015) · cites this paper as [75]
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- Authors
- Syken, J., GrandPre, T., Kanold, P. O., & Shatz, C. J.
- Affiliations
- Harvard University (US)
- Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
- Corresponding author
- Shatz, Carla J.
- Venue
- Science
- Published
- 2006-09-22
- Volume
- 313
- Issue
- 5794
- Pages
- 1795-1800
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2003502718
- Cited by
- 340
- References
- 40
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 8 · 2023: 7 · 2022: 9 · 2021: 12 · 2020: 12 · 2019: 19 · 2018: 21 · 2017: 19 · 2016: 20 · 2015: 23 · 2014: 27 · 2013: 28 · 2012: 23
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Eye Institute (F32 EY 1352, EY02858, F32EY013526)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD18655, P30HD018655)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- PirB, ocular dominance plasticity, visual cortex, experience-dependent plasticity, MHC class I receptors, SHP-1, SHP2
- MeSH terms
- Aging, Animals, Brain, Cells, Cultured, Cytoskeletal Proteins, Mice, Inbred C57BL, Mutation, Nerve Tissue Proteins, Neuronal Plasticity, Neurons, Phosphorylation, Protein Binding, Receptors, Immunologic, Recombinant Fusion Proteins, Synapses, Visual Cortex, Histocompatibility Antigens Class I, Protein Tyrosine Phosphatases, In Situ Hybridization, Protein Structure, Tertiary, Dominance, Ocular, Intracellular Signaling Peptides and Proteins, Mice, Protein Tyrosine Phosphatase, Non-Receptor Type 6, Protein Tyrosine Phosphatase, Non-Receptor Type 11
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