Investigating the movement of intravitreal human serum albumin nanoparticles in the vitreous and retina
Abstract
Purpose To investigate the movement of intravitreally injected human serum albumin nanoparticles (HSA-NP) with respect to nanoparticle surface charge and retinal injury.Methods HSA-NPs were developed by a desolvation technique. HSA-NPs were cationized by covalent coupling of hexamethylenediamine on the particle surface. Either anionic or cationic HSA-NPs were injected to determine the effect of surface charge on intravitreal nanoparticle movement. HSA-NPs were injected intravitreally into both normal and laser photocoagulated eyes to examine the effect of the integrity of retinal tissue on the retinal penetration. The retinal penetration of fluorescence labeled anionic HSA-NPs was investigated by confocal microscopy.Results Anionic particles (-33.3+/-6.1 mV) more easily diffused through the 3-dimensional vitreal network of collagen fibrils than did their cationic counterparts (11.7+/-7.2 mV). In the laser photocoagulated retina, more HSA-NPs were detected in the choroidal space, compared to the normal retina. The immunohistochemical studies indicated that HSA-NPs were taken up into Müller cells.Conclusions The movement of intravitreal nanoparticles depended on both nanoparticles surface charge and retinal injury. The Müller cells might play an important role in the retinal penetration of nanoparticles. The anionic HSA-NP is a promising drug or gene delivery carrier to the sub-retinal space and RPE.
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Strategies such as PEGylation, charge modification, and coating with hyaluronate or chloroquine have been shown to improve retinal transduction in animal models when administered intravitreally.
“Strategies such as PEGylation [271], charge modification [272], and coating with hyaluronate or chloroquine [273,274] have been shown to improve retinal transduction in animal models when administered intravitreally.”
From Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration (2023) · cites this paper as [272]
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Self-citation
- Authors
- Kim, H., Robinson, S. B., & Csaky, K. G.
- Affiliations
- Duke University (US)
- Duke Medical Center (US)
- Corresponding author
- Kim, Hyuncheol
- Venue
- Pharmaceutical Research
- Published
- 2008-10-29
- Volume
- 26
- Issue
- 2
- Pages
- 329-337
- ISSN
- 0724-8741 (ISSN-L)
- 1573-904X
- OpenAlex
- W2026741029
- Cited by
- 174
- References
- 38
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 12 · 2022: 13 · 2021: 15 · 2020: 9 · 2019: 14 · 2018: 15 · 2017: 15 · 2016: 9 · 2015: 14 · 2014: 10 · 2013: 9 · 2012: 5
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Pharmaceutical Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Food and Drug Administration
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- human serum albumin nanoparticles, intravitreal injection, vitreous humor, surface charge, cationic nanoparticles, anionic nanoparticles, laser photocoagulation, retinal damage, Müller cells, choroid, retinal pigment epithelium
- MeSH terms
- Animals, Choroid, Diamines, Diffusion, Drug Carriers, Fluorescent Dyes, Humans, Immunohistochemistry, Particle Size, Retina, Serum Albumin, Surface Properties, Vitreous Body, Bruch Membrane, Microscopy, Confocal, Rats, Laser Therapy, Nanoparticles
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