Cited by 330Advanced Drug Delivery SystemsAdvancements in Transdermal Drug DeliveryNanoparticle-Based Drug Delivery

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Suprachoroidal Drug Delivery to the Back of the Eye Using Hollow Microneedles

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Patel, Samirkumar R., Lin, Angela S. P., Edelhauser, Henry F., Prausnitz, Mark R.·2011·Pharmaceutical Research

DOI 10.1007/s11095-010-0271-yPMC PMC3038673

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Abstract

Purpose In this work, we tested the hypothesis that microneedles provide a minimally invasive method to inject particles into the suprachoroidal space for drug delivery to the back of the eye.Methods A single, hollow microneedle was inserted into the sclera, and infused nanoparticle and microparticle suspensions into the suprachoroidal space. Experiments were performed on whole rabbit, pig, and human eyes ex vivo. Particle delivery was imaged using brightfield and fluorescence microscopy as well as microcomputed tomography.Results Microneedles were shown to deliver sulforhodamine B as well as nanoparticle and microparticle suspensions into the suprachoroidal space of rabbit, pig, and human eyes. Volumes up to 35 μL were administered consistently. Optimization of the delivery device parameters showed that microneedle length, pressure, and particle size played an important role in determining successful delivery into the suprachoroidal space. Needle lengths of 800-1,000 μm and applied pressures of 250-300 kPa provided most reliable delivery.Conclusions Microneedles were shown for the first time to deliver nanoparticle and microparticle suspensions into the suprachoroidal space of rabbit, pig and human eyes. This shows that microneedles may provide a minimally invasive method for controlled drug delivery to the back of the eye.

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Authors: Patel, S. R., Lin, A. S. P., Edelhauser, H. F., & Prausnitz, M. R.
Affiliations: Georgia Institute of Technology (US)
Emory University (US)
Corresponding author: Edelhauser, Henry F.
Prausnitz, Mark R.
ORCID: Patel, Samirkumar R.
Lin, Angela S. P.
Prausnitz, Mark R.
Venue: Pharmaceutical Research
Publisher: Springer Science and Business Media LLC
Published: 2010-09-21
Volume: 28
Issue: 1
Pages: 166-176
ISSN: 0724-8741 (ISSN-L)
1573-904X
DOI: 10.1007/s11095-010-0271-y
PMC: PMC3038673
OpenAlex: W1977812165
Cited by: 330
References: 27
Citations by year: 2026: 21 · 2025: 26 · 2024: 30 · 2023: 24 · 2022: 17 · 2021: 31 · 2020: 26 · 2019: 18 · 2018: 19 · 2017: 22 · 2016: 25 · 2015: 19 · 2014: 14 · 2013: 13 · 2012: 16
FWCI: 8.28
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Pharmaceutical Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Eye Institute (R24EY017045)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: hollow microneedles, nanoparticle delivery, microparticle delivery, sclera, sulforhodamine B, injection pressure, needle length, particle size
MeSH terms: Animals, Choroid, Drug Carriers, Pharmaceutical Preparations, Humans, Intraocular Pressure, Microinjections, Microscopy, Fluorescence, Needles, Rabbits, Retina, Sclera, Swine, Drug Delivery Systems, Nanoparticles, Injections, Intraocular, In Vitro Techniques

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Suprachoroidal Drug Delivery to the Back of the Eye Using Hollow Microneedles

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