Cited by 399Algal biology and biofuel productionPlant biochemistry and biosynthesisPhotosynthetic Processes and Mechanisms

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Secondary ketocarotenoid astaxanthin biosynthesis in algae: a multifunctional response to stress

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Lemoine, Yves, Schoefs, Benoît·2010·Photosynthesis Research

DOI 10.1007/s11120-010-9583-3

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Abstract

Under stressful environments, many green algae such as Haematococcus pluvialis accumulate secondary ketocarotenoids such as canthaxanthin and astaxanthin. The carotenogenesis, responsible for natural phenomena such as red snows, generally accompanies larger metabolic changes as well as morphological modifications, i.e., the conversion of the green flagellated macrozoids into large red cysts. Astaxanthin accumulation constitutes a convenient way to store energy and carbon, which will be used for further synthesis under less stressful conditions. Besides this, the presence of high amount of astaxanthin enhances the cell resistance to oxidative stress generated by unfavorable environmental conditions including excess light, UV-B irradiation, and nutrition stress and, therefore, confers a higher survival capacity to the cells. This better resistance results from the quenching of oxygen atoms for the synthesis itself as well as from the antioxidant properties of the astaxanthin molecules. Therefore, astaxanthin synthesis corresponds to a multifunctional response to stress. In this contribution, the various biochemical, genetic, and molecular data related to the biosynthesis of ketocarotenoids by Haematococcus pluvialis and other taxa are reviewed and compared. A tentative regulatory model of the biochemical network driving astaxanthin production is proposed.

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Reactive oxygen species: Metabolism, oxidative stress, and signal transduction
Apel, K., & Hirt, H. (2004) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.55.031903.141701 · Cited by 11,723
Oxidative stress, antioxidants and stress tolerance
Mittler, R. (2002) · Trends in Plant Science · doi:10.1016/s1360-1385(02)02312-9 · Cited by 10,790
THE WATER-WATER CYCLE IN CHLOROPLASTS: Scavenging of Active Oxygens and Dissipation of Excess Photons
Asada, K. (1999) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.50.1.601 · Cited by 4,038
Antioxidants, Oxidative Damage and Oxygen Deprivation Stress: a Review
Blokhina, O. B. (2002) · Annals of Botany · doi:10.1093/aob/mcf118 · Cited by 4,018
Microalgal triacylglycerols as feedstocks for biofuel production: perspectives and advances
Hu, Q., Sommerfeld, M., Jarvis, E., Ghirardi, M., Posewitz, M., Seibert, M., & Darzins, A. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03492.x · Cited by 3,745
Plant salt tolerance
Zhu, J. (2001) · Trends in Plant Science · doi:10.1016/s1360-1385(00)01838-0 · Cited by 3,595
Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
Chandel, N. S., Maltepe, E., Goldwasser, E., Mathieu, C. E., Simon, M. C., & Schumacker, P. T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11715 · Cited by 1,926
P LANT M ITOCHONDRIA AND O XIDATIVE S TRESS : Electron Transport, NADPH Turnover, and Metabolism of Reactive Oxygen Species
Møller, I. M. (2001) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.52.1.561 · Cited by 1,662
Haematococcus astaxanthin: applications for human health and nutrition
Guerin, M., Huntley, M. E., & Olaizola, M. (2003) · Trends in Biotechnology · doi:10.1016/s0167-7799(03)00078-7 · Cited by 1,495
THE 1-DEOXY-D-XYLULOSE-5-PHOSPHATE PATHWAY OF ISOPRENOID BIOSYNTHESIS IN PLANTS
Lichtenthaler, H. K. (1999) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.50.1.47 · Cited by 1,420
The biosynthesis and nutritional uses of carotenoids
Fraser, P. D. (2003) · Progress in Lipid Research · doi:10.1016/j.plipres.2003.10.002 · Cited by 1,405
Handbook of Plant and Crop Stress
Pessarakli, M. (1999) · CRC Press eBooks · doi:10.1201/9780824746728 · Cited by 1,327
Astaxanthin: a review of its chemistry and applications
Higuera-Ciapara, I., Félix-Valenzuela, L., & Goycoolea, F. M. (2006) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690590957188 · Cited by 1,287
Commercial potential for Haematococcus microalgae as a natural source of astaxanthin
Lorenz, R. T., & Cysewski, G. R. (2000) · Trends in biotechnology · doi:10.1016/s0167-7799(00)01433-5 · Cited by 1,190
Sugar Sensing and Signaling in Plants
Rolland, F., Moore, B. D., & Sheen, J. (2002) · The Plant Cell · doi:10.1105/tpc.010455 · Cited by 1,188
Role of the Arabidopsis Glucose Sensor HXK1 in Nutrient, Light, and Hormonal Signaling
Moore, B. D., Zhou, L., Rolland, F., Hall, Q., Cheng, W., Liu, Y., Hwang, I., Jones, T., & Sheen, J. (2003) · Science · doi:10.1126/science.1080585 · Cited by 1,174
Causes of Photooxidative Stress and Amelioration of Defense Systems in Plants
Foyer, C. H., & Mullineaux, P. M. (2019) · CRC Press eBooks · doi:10.1201/9781351070454 · Cited by 967
GENES AND ENZYMES OF CAROTENOID BIOSYNTHESIS IN PLANTS
Cunningham, F. X., & Gantt, E. (1998) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.49.1.557 · Cited by 966
Cytochromes P450: a success story.
Werck‐Reichhart, D., & Feyereisen, R. (2000) · Genome biology · doi:10.1186/gb-2000-1-6-reviews3003 · Cited by 962
Mechanism of Inhibition of Protein-tyrosine Phosphatases by Vanadate and Pervanadate
Huyer, G., Liu, S., Kelly, J., Moffat, J., Payette, P., Kennedy, B. P., Tsaprailis, G., Gresser, M. J., & Ramachandran, C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.2.843 · Cited by 815
ALTERNATIVE OXIDASE: From Gene to Function
Vanlerberghe, G. C., & McIntosh, L. (1997) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.48.1.703 · Cited by 796
Rapid Stimulation of an Oxidative Burst during Elicitation of Cultured Plant Cells
Apostoł, I., Heinstein, P. F., & Low, P. S. (1989) · PLANT PHYSIOLOGY · doi:10.1104/pp.90.1.109 · Cited by 684
Sugar sensing in higher plants.
Jang, J.-C., & Sheen, J. (1994) · The Plant Cell · doi:10.1105/tpc.6.11.1665 · Cited by 679
Safety valves for photosynthesis
Niyogi, K. (2000) · Current Opinion in Plant Biology · doi:10.1016/s1369-5266(00)00113-8 · Cited by 663
Light intensity regulation of cab gene transcription is signaled by the redox state of the plastoquinone pool.
Escoubas, J.-M., Lomas, M. W., LaRoche, J., & Falkowski, P. G. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.22.10237 · Cited by 662
Stress Responses in Plants: Adaptation and Acclimation Mechanisms
Alscher, R., & Cumming, J. (1990) · Medical Entomology and Zoology · Cited by 617
Photosynthetic control of chloroplast gene expression
Pfannschmidt, T., Nilsson, A., & Allen, J. F. (1999) · Nature · doi:10.1038/17624 · Cited by 617
Carotenogenesis in the green alga Haematococcus pluvialis : Cellular physiology and stress response
Boussiba, S. (2000) · Physiologia Plantarum · doi:10.1034/j.1399-3054.2000.108002111.x · Cited by 591
Production and Action of Active Oxygen Species in Photosynthetic Tissues
Asada, K. (2019) · CRC Press eBooks · doi:10.1201/9781351070454-3 · Cited by 588
Glucose repression in yeast
Carlson, M. (1999) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(99)80035-6 · Cited by 578
Astaxanthin from Microbial Sources
Johnson, E. A., & An, G.-H. (1991) · Critical Reviews in Biotechnology · doi:10.3109/07388559109040622 · Cited by 509
Comprehensive Natural Products II
(2010) · Elsevier eBooks · doi:10.1016/c2009-1-28362-6 · Cited by 464
Structure and functional analysis of a marine bacterial carotenoid biosynthesis gene cluster and astaxanthin biosynthetic pathway proposed at the gene level
Misawa, N., Satomi, Y., Kondô, K., Yokoyama, A., Kajiwara, S., Saito, T., Ohtani, T., & Miki, W. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.22.6575-6584.1995 · Cited by 456
Antioxidant activity of β‐carotene‐related carotenoids in solution
Terao, J. (1989) · Lipids · doi:10.1007/bf02535085 · Cited by 434
Perspectives on Oxygen Sensing
Semenza, G. L. (1999) · Cell · doi:10.1016/s0092-8674(00)81957-1 · Cited by 385
On the Factors Which Determine Massive β-Carotene Accumulation in the Halotolerant Alga Dunaliella bardawil
Ben‐Amotz, A., & Avron, M. (1983) · PLANT PHYSIOLOGY · doi:10.1104/pp.72.3.593 · Cited by 365
Enhanced Carotenoid Biosynthesis by Oxidative Stress in Acetate-Induced Cyst Cells of a Green Unicellular Alga, Haematococcus pluvialis
Kobayashi, M., Kakizono, T., & Nagai, S. (1993) · Applied and Environmental Microbiology · doi:10.1128/aem.59.3.867-873.1993 · Cited by 360
Commercial production of astaxanthin from Haematococcus pluvialis using 25,000-liter outdoor photobioreactors
Olaizola, M. (2000) · Journal of Applied Phycology · doi:10.1023/a:1008159127672 · Cited by 359
Mutations in the Arabidopsis Gene IMMUTANS Cause a Variegated Phenotype by Inactivating a Chloroplast Terminal Oxidase Associated with Phytoene Desaturation
Carol, P., Stevenson, D., Bisanz, C., Breitenbach, J., Sandmann, G., Mache, R., Coupland, G., & Kuntz, M. (1999) · The Plant Cell · doi:10.1105/tpc.11.1.57 · Cited by 351
Astaxanthin and canthaxanthin are potent antioxidants in a membrane model
Palozza, P., & Krinsky, N. I. (1992) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(92)90675-m · Cited by 346
Regulation of chloroplast membrane function: protein phosphorylation changes the spatial organization of membrane components.
Staehelin, L. A., & Arntzen, C. J. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.5.1327 · Cited by 333
Carotenoid content of chlorophycean microalgae: factors determining lutein accumulation in Muriellopsis sp. (Chlorophyta)
Del Campo, J. (2000) · Journal of Biotechnology · doi:10.1016/s0168-1656(99)00178-9 · Cited by 323
Glucose-sensing mechanisms in eukaryotic cells
Rolland, F., Winderickx, J., & Thevelein, J. M. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)01805-9 · Cited by 313
Molecular and biochemical characterization of herbicide-resistant mutants of cyanobacteria reveals that phytoene desaturation is a rate-limiting step in carotenoid biosynthesis
Chamovitz, D., Sandmann, G., & Hirschberg, J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85341-3 · Cited by 299
The IMMUTANS Variegation Locus of Arabidopsis Defines a Mitochondrial Alternative Oxidase Homolog That Functions during Early Chloroplast Biogenesis
Wu, D., Wright, D. A., Wetzel, C. M., Voytas, D. F., & Rodermel, S. R. (1999) · The Plant Cell · doi:10.1105/tpc.11.1.43 · Cited by 291
Carotenoid biosynthesis in microorganisms and plants
Sandmann, G. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb18961.x · Cited by 290
Control of Gene Expression by Redox Potential and the Requirement for Chloroplast and Mitochondrial Genomes
Allen, J. F. (1993) · Journal of Theoretical Biology · doi:10.1006/jtbi.1993.1210 · Cited by 279
Production of astaxanthin by the green microalga Chlorella zofingiensis in the dark
Ip, P.-F., & Chen, F. (2005) · Process Biochemistry · doi:10.1016/j.procbio.2004.01.039 · Cited by 270
ACCUMULATION OF OLEIC ACID IN HAEMATOCOCCUS PLUVIALIS (CHLOROPHYCEAE) UNDER NITROGEN STARVATION OR HIGH LIGHT IS CORRELATED WITH THAT OF ASTAXANTHIN ESTERS 1
Zhekisheva, M., Boussiba, S., Khozin‐Goldberg, I., Zarka, A., & Cohen, Z. (2002) · Journal of Phycology · doi:10.1046/j.1529-8817.2002.01107.x · Cited by 267
Induced β-Carotene Synthesis Driven by Triacylglycerol Deposition in the Unicellular AlgaDunaliella bardawil1
Rabbani, S., Beyer, P., Lintig, J. V., Hugueney, P., & Kleinig, H. (1998) · PLANT PHYSIOLOGY · doi:10.1104/pp.116.4.1239 · Cited by 263
Photosynthesis, pigments and ultrastructure of the alpine snow alga Chlamydomonas nivalis
Remias, D., Lütz‐Meindl, U., & Lütz, C. (2005) · European Journal of Phycology · doi:10.1080/09670260500202148 · Cited by 256
Evidence of mitochondrial involvement in the transduction of signals required for the induction of genes associated with pathogen attack and senescence
Maxwell, D. P., Nickels, R. L., & McIntosh, L. (2002) · The Plant Journal · doi:10.1046/j.1365-313x.2002.01216.x · Cited by 249
Changes in pigments profile in the green alga Haeamtococcus pluvialis exposed to environmental stresses
Boussiba, S., Bing, W., Yuan, J.-P., Zarka, A., & Chen, F. (1999) · Biotechnology Letters · doi:10.1023/a:1005507514694 · Cited by 247
EVIDENCE A PHOTOPROTECTIVE FOR SECONDARY CAROTENOIDS OF SNOW ALGAE1
Bidigare, R. R., Ondrusek, M. E., Kennicutt, M. C., Iturriaga, R. H., Harvey, H. R., Hoham, R. W., & Macko, S. A. (1993) · Journal of Phycology · doi:10.1111/j.1529-8817.1993.tb00143.x · Cited by 244
Metabolic engineering of astaxanthin production in tobacco flowers
Mann, V., Harker, M., Pecker, I., & Hirschberg, J. (2000) · Nature Biotechnology · doi:10.1038/78515 · Cited by 239
Transformation of the Green Alga Haematococcus pluvialis with a Phytoene Desaturase for Accelerated Astaxanthin Biosynthesis
Steinbrenner, J., & Sandmann, G. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.01461-06 · Cited by 226
Singlet oxygen quenching ability of astaxanthin esters from the green alga Haematococcus pluvialis
Kobayashi, M., & Sakamoto, Y. (1999) · Biotechnology Letters · doi:10.1023/a:1005445927433 · Cited by 223
Regulation of Two Carotenoid Biosynthesis Genes Coding for Phytoene Synthase and Carotenoid Hydroxylase during Stress-Induced Astaxanthin Formation in the Green Alga Haematococcus pluvialis
Steinbrenner, J., & Linden, H. (2001) · PLANT PHYSIOLOGY · doi:10.1104/pp.125.2.810 · Cited by 221
Mode of Action of the Massively Accumulated β-Carotene of Dunaliella bardawil in Protecting the Alga against Damage by Excess Irradiation
Ben‐Amotz, A., Shaish, A., & Avron, M. (1989) · PLANT PHYSIOLOGY · doi:10.1104/pp.91.3.1040 · Cited by 212
Expression of an exogenous isopentenyl diphosphate isomerase gene enhances isoprenoid biosynthesis in Escherichia coli
Kajiwara, S., Fraser, P. D., Kondô, K., & Misawa, N. (1997) · Biochemical Journal · doi:10.1042/bj3240421 · Cited by 210
Singlet Oxygen and Peroxyl Radicals Regulate Carotenoid Biosynthesis in Phaffia rhodozyma
Schroeder, W. A., & Johnson, E. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.31.18374 · Cited by 209
Light induction of carotenoid biosynthesis genes in the green alga Haematococcus pluvialis: regulation by photosynthetic redox control
Steinbrenner, J., & Linden, H. (2003) · Plant Molecular Biology · doi:10.1023/a:1023948929665 · Cited by 203
A Plastid Terminal Oxidase Associated with Carotenoid Desaturation during Chromoplast Differentiation
Josse, E., Simkin, A. J., Gaffé, J., Labouré, A., Kuntz, M., & Carol, P. (2000) · PLANT PHYSIOLOGY · doi:10.1104/pp.123.4.1427 · Cited by 202
In Vitro Characterization of Astaxanthin Biosynthetic Enzymes
Fraser, P. D., Miura, Y., & Misawa, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6128 · Cited by 197
Chemoprevention of mouse urinary bladder carcinogenesis by the naturally occurring carotenoid astaxanthin
Tanaka, T., Morishita, Y., Suzui, M., Kojima, T., Okumura, A., & Mori, H. (1994) · Carcinogenesis · doi:10.1093/carcin/15.1.15 · Cited by 196
Sugar-based growth, astaxanthin accumulation and carotenogenic transcription of heterotrophic Chlorella zofingiensis (Chlorophyta)
Sun, N., Wang, Y., Li, Y., Huang, J., & Chen, F. (2008) · Process Biochemistry · doi:10.1016/j.procbio.2008.07.014 · Cited by 195
ASTAXANTHIN ACCUMULATION IN HAEMATOCOCCUS PLUVIALIS (CHLOROPHYCEAE) AS AN ACTIVE PHOTOPROTECTIVE PROCESS UNDER HIGH IRRADIANCE 1
Wang, B., Zarka, A., Trebst, A., & Boussiba, S. (2003) · Journal of Phycology · doi:10.1111/j.0022-3646.2003.03-043.x · Cited by 188
Antioxidant role of astaxanthin in the green alga Haematococcus pluvialis
Kobayashi, M., Kakizono, T., Nishio, N., Nagai, S., Kurimura, Y., & Tsuji, Y. (1997) · Applied Microbiology and Biotechnology · doi:10.1007/s002530051061 · Cited by 185
Enhanced production of astaxanthin by the green microalga Chlorella zofingiensis in mixotrophic culture
Ip, P.-F., Wong, K.-H., & Chen, F. (2004) · Process Biochemistry · doi:10.1016/j.procbio.2003.08.003 · Cited by 184
Accumulation and antioxidant activity of secondary carotenoids in the aerial microalga Coelastrella striolata var. multistriata
Abe, K., Hattori, H., & Hirano, M. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2005.10.026 · Cited by 182
Pessarakli, M. (ed.): Handbook of plant and crop stress
Pospišilová, J. (1994) · Biologia Plantarum · doi:10.1007/bf02921182 · Cited by 180
Increased Carotenoid Production by the Food Yeast Candida utilis through Metabolic Engineering of the Isoprenoid Pathway
Shimada, H., Kondô, K., Fraser, P. D., Miura, Y., Saito, T., & Misawa, N. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.7.2676-2680.1998 · Cited by 178
Cloning and expression inEscherichia coli of the gene encoding β‐C‐4‐oxygenase, that converts β‐carotene to the ketocarotenoid canthaxanthin inHaematococcus pluvialis
Lotan, T., & Hirschberg, J. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00368-j · Cited by 176
Production of the Carotenoids Lycopene, β-Carotene, and Astaxanthin in the Food Yeast Candida utilis
Miura, Y., Kondô, K., Saito, T., Shimada, H., Fraser, P. D., & Misawa, N. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.4.1226-1229.1998 · Cited by 176
Ketocarotenoid Biosynthesis Outside of Plastids in the Unicellular Green Alga Haematococcus pluvialis
Grünewald, K., Hirschberg, J., & Hagen, C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006400200 · Cited by 175
Astaxanthin, Oxidative stress, Inflammation and Cardiovascular Disease
Fassett, R. G., & Coombes, J. S. (2009) · Future Cardiology · doi:10.2217/fca.09.19 · Cited by 173
Biosynthesis of astaxanthin in tobacco leaves by transplastomic engineering
Hasunuma, T., Miyazawa, S., Yoshimura, S., Shinzaki, Y., Tomizawa, K., Shindo, K., Choi, S. K., Misawa, N., & Miyake, C. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03559.x · Cited by 169
Production of ketocarotenoids by microalgae
Margalith, P. (1999) · Applied Microbiology and Biotechnology · doi:10.1007/s002530051413 · Cited by 165
Regulation of carotenoid biosynthetic genes expression and carotenoid accumulation in the green alga Haematococcus pluvialis under nutrient stress conditions
Vidhyavathi, R., Venkatachalam, L., Sarada, R., & Ravishankar, G. A. (2008) · Journal of Experimental Botany · doi:10.1093/jxb/ern048 · Cited by 164
Isolation and functional identification of a novel cDNA for astaxanthin biosynthesis from Haematococcus pluvialis, and astaxanthin synthesis in Escherichia coli
Kajiwara, S., Kakizono, T., Saito, T., Kondô, K., Ohtani, T., Nishio, N., Nagai, S., & Misawa, N. (1995) · Plant Molecular Biology · doi:10.1007/bf00043657 · Cited by 163
Consumption of oxygen by astaxanthin biosynthesis: A protective mechanism against oxidative stress in Haematococcus pluvialis (Chlorophyceae)
Li, Y., Sommerfeld, M. R., Chen, F., & Hu, Q. (2008) · Journal of Plant Physiology · doi:10.1016/j.jplph.2007.12.007 · Cited by 162
[36] Enhancement and determination of astaxanthin accumulation in green alga Haematococcus pluvialis
Boussiba, S., Fan, L., & Vonshak, A. (1992) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(92)13140-s · Cited by 160
Production and analysis of secondary carotenoids in green algae
García, M. O., Torres, E., Fidalgo, P., & Abalde, J. (2000) · Journal of Applied Phycology · doi:10.1023/a:1008173807143 · Cited by 159
The hexose carrier from Chlorella
Sauer, N., & Tanner, W. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)81489-9 · Cited by 156
Signaling pathways from the chloroplast to the nucleus
Beck, C. F. (2005) · Planta · doi:10.1007/s00425-005-0021-2 · Cited by 156
Characterization of astaxanthin esters in Haematococcus pluvialis by liquid chromatography–atmospheric pressure chemical ionization mass spectrometry
Miao, F., Lu, D., Li, Y., & Zeng, M. (2006) · Analytical Biochemistry · doi:10.1016/j.ab.2006.03.006 · Cited by 154
Differential expression of two isopentenyl pyrophosphate isomerases and enhanced carotenoid accumulation in a unicellular chlorophyte
Sun, Z., Cunningham, F. X., & Gantt, E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.19.11482 · Cited by 153
Algal carotenoids 51. Secondary carotenoids 2. Haematococcus pluvialis aplanospores as a source of (3S,3'S)-astaxanthin esters
Grung, M., D'Souza, F. M. L., Borowitzka, M., & Liaaen-Jensen, S. (1992) · Journal of Applied Phycology · doi:10.1007/bf02442465 · Cited by 151
Hyper-accumulation of astaxanthin in a green algaHaematococcus pluvialis at elevated temperatures
Tjahjono, A. E., Hayama, Y., Kakizono, T., Terada, Y., Nishio, N., & Nagai, S. (1994) · Biotechnology Letters · doi:10.1007/bf01021659 · Cited by 151
Snow algae from northwest Svalbard: their identification, distribution, pigment and nutrient content
Müller, T., Bleiß, W., Martin, C.-D., Rogaschewski, S., & Fuhr, G. (1998) · Polar Biology · doi:10.1007/s003000050272 · Cited by 149
Astaxanthin-Rich Algal Meal and Vitamin C Inhibit Helicobacter pylori Infection in BALB/cA Mice
Wang, X., Wïllén, R., & Wadström, T. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.9.2452-2457.2000 · Cited by 149
Effects of light intensity, light quality, and illumination cycle on astaxanthin formation in a green alga, Haematococcus pluvialis
Kobayashi, M., Kakizono, T., Nishio, N., & Nagai, S. (1992) · Journal of Fermentation and Bioengineering · doi:10.1016/0922-338x(92)90271-u · Cited by 148
Metabolic engineering of novel ketocarotenoid production in carrot plants
Jayaraj, J., Devlin, R. H., & Punja, Z. K. (2007) · Transgenic Research · doi:10.1007/s11248-007-9120-0 · Cited by 143
Comparison of the accumulation of astaxanthin in Haematococcus pluvialis and other green microalgae under N-starvation and high light conditions
García, M. O., Valero, J. F., Herrero, C., & Abalde, J. (2001) · Biotechnology Letters · doi:10.1023/a:1010510508384 · Cited by 143
Bleaching Herbicide Norflurazon Inhibits Phytoene Desaturase by Competition with the Cofactors
Breitenbach, J., Zhu, C., & Sandmann, G. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0106751 · Cited by 142
The Hexose‐Proton Symport System of Chlorella vulgaris
Komor, E., & Tanner, W. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03476.x · Cited by 136
Response of arctic snow and permafrost algae to high light and nitrogen stress by changes in pigment composition and applied aspects for biotechnology
Leya, T., Rahn, A., Lütz, C., & Remias, D. (2009) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2008.00641.x · Cited by 135
Nutrient Limitation is the Main Regulatory Factor for Carotenoid Accumulation and for Psy and Pds Steady State Transcript Levels in Dunaliella salina (Chlorophyta) Exposed to High Light and Salt Stress
Coesel, S., Baumgartner, A., Teles, L. M., Ramos, A., Henriques, N., Cancela, M. L., & Varela, J. C. S. (2008) · Marine Biotechnology · doi:10.1007/s10126-008-9100-2 · Cited by 134
Antioxidant activity of Haematococcus pluvialis cells grown in continuous culture as a function of their carotenoid and fatty acid content
Cerón, M. C., García‐Malea, M. C., Rivas, J., Acién, F. G., Fernández-Sevilla, J. M., Río, E. D., Guerrero, M. G., & Molina, E. (2006) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0743-5 · Cited by 134
Pigment and Structural Changes in Chlorella zofingiensis upon Light and Nitrogen Stress
Bar, E., Rise, M., Vishkautsan, M., & Arad, S. M. (1995) · Journal of Plant Physiology · doi:10.1016/s0176-1617(11)82019-5 · Cited by 127
INHIBITION OF ASTAXANTHIN SYNTHESIS UNDER HIGH IRRADIANCE DOES NOT ABOLISH TRIACYLGLYCEROL ACCUMULATION IN THE GREEN ALGA HAEMATOCOCCUS PLUVIALIS (CHLOROPHYCEAE)1
Zhekisheva, M., Zarka, A., Khozin‐Goldberg, I., Cohen, Z., & Boussiba, S. (2005) · Journal of Phycology · doi:10.1111/j.0022-3646.2005.05015.x · Cited by 127
AGROBACTERIUM ‐MEDIATED TRANSFORMATION IN THE GREEN ALGA HAEMATOCOCCUS PLUVIALIS (CHLOROPHYCEAE, VOLVOCALES) 1
Shanmugam, K., Chandrashekar, A., Ravishankar, G. A., & Sarada, R. (2009) · Journal of Phycology · doi:10.1111/j.1529-8817.2009.00688.x · Cited by 126
Proteomic analysis of molecular response to oxidative stress by the green alga Haematococcus pluvialis (Chlorophyceae)
Wang, S.-B., Chen, F., Sommerfeld, M. R., & Hu, Q. (2004) · Planta · doi:10.1007/s00425-004-1323-5 · Cited by 126
A study in scarlet: enzymes of ketocarotenoid biosynthesis in the flowers of Adonis aestivalis
Cunningham, F. X., & Gantt, E. (2005) · The Plant Journal · doi:10.1111/j.1365-313x.2004.02309.x · Cited by 125
Carotenoids and stress
Young, A. J., & Britton, G. (1990) · Cited by 124
Physiological and morphological processes in the Alpine snow alga Chloromonas nivalis (Chlorophyceae) during cyst formation
Remias, D., Karsten, U., Lütz, C., & Leya, T. (2010) · PROTOPLASMA · doi:10.1007/s00709-010-0123-y · Cited by 123
The effect of salt stress on the production of canthaxanthin and astaxanthin by Chlorella zofingiensis grown under limited light intensity
Pelah, D., Sintov, A., & Cohen, E. (2004) · World Journal of Microbiology and Biotechnology · doi:10.1023/b:wibi.0000040398.93103.21 · Cited by 123
Phytoene Desaturase Is Localized Exclusively in the Chloroplast and Up-Regulated at the mRNA Level during Accumulation of Secondary Carotenoids in Haematococcus pluvialis (Volvocales, Chlorophyceae),
Grünewald, K., Eckert, M., Hirschberg, J., & Hagen, C. (2000) · PLANT PHYSIOLOGY · doi:10.1104/pp.122.4.1261 · Cited by 119
Employment of reactive oxygen species to enhance astaxanthin formation in Chlorella zofingiensis in heterotrophic culture
Ip, P.-F., & Chen, F. (2005) · Process Biochemistry · doi:10.1016/j.procbio.2005.02.014 · Cited by 117
Morphological changes in the life cycle of the green alga Haematococcus pluvialis
Kobayashi, M., Kurimura, Y., Kakizono, T., Nishio, N., & Tsuji, Y. (1997) · Journal of Fermentation and Bioengineering · doi:10.1016/s0922-338x(97)82794-8 · Cited by 116
Effect of photon flux densities on regulation of carotenogenesis and cell viability of Haematococcus pluvialis (Chlorophyceae)
Li, Y., Sommerfeld, M. R., Chen, F., & Hu, Q. (2009) · Journal of Applied Phycology · doi:10.1007/s10811-009-9453-6 · Cited by 116
Strategies of ultraviolet-B protection in microscopic algae
Xiong, F. S., Komenda, J., Kopecký, J., & Nedbal, L. (1997) · Physiologia Plantarum · doi:10.1111/j.1399-3054.1997.tb04796.x · Cited by 116
Efficient one‐step production of astaxanthin by the microalga Haematococcus pluvialis in continuous culture
Río, E. D., Acién, F. G., García‐Malea, M. C., Rivas, J., Grima, E. M., & Guerrero, M. G. (2005) · Biotechnology and Bioengineering · doi:10.1002/bit.20547 · Cited by 116
Stress-related differential expression of multiple β-carotene ketolase genes in the unicellular green alga Haematococcus pluvialis
Huang, J., Chen, F., & Sandmann, G. (2005) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2005.09.002 · Cited by 111
Interaction of vanadate with phenol and tyrosine: implications for the effects of vanadate on systems regulated by tyrosine phosphorylation.
Tracey, A., & Gresser, M. J. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.3.609 · Cited by 111
Engineering ketocarotenoid biosynthesis in potato tubers
Morris, W. L., Ducreux, L. J. M., Fraser, P. D., Millam, S., & Taylor, M. A. (2006) · Metabolic Engineering · doi:10.1016/j.ymben.2006.01.001 · Cited by 110
Light-driven active uptake of 3-O-methylglucose via an inducible hexose uptake system of Chlorella
Tanner, W. (1969) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(69)90326-x · Cited by 110
Co-regulation of a gene homologous to early light-induced genes in higher plants and beta-carotene biosynthesis in the alga Dunaliella bardawil
Lers, A., Levy, H., & Zamir, A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)92755-9 · Cited by 107
Conversion of β-carotene into astaxanthin: Two separate enzymes or a bifunctional hydroxylase-ketolase protein?
Martin, J. F., Gudiña, E. J., & Barredo, J. L. (2008) · Microbial Cell Factories · doi:10.1186/1475-2859-7-3 · Cited by 105
EFFECT OF TEMPERATURE AND IRRADIANCE ON GROWTH OF HAEMATOCOCCUS PLUVIALIS (CHLOROPHYCEAE)1
Fan, L., Vonshak, A., & Boussiba, S. (1994) · Journal of Phycology · doi:10.1111/j.0022-3646.1994.00829.x · Cited by 104
Methyl jasmonate- or gibberellins A3-induced astaxanthin accumulation is associated with up-regulation of transcription of β-carotene ketolase genes (bkts) in microalga Haematococcus pluvialis
Lu, Y., Jiang, P., Liu, S., Gan, Q., Cui, H., & Qin, S. (2010) · Bioresource Technology · doi:10.1016/j.biortech.2010.03.072 · Cited by 103
A Tale of Two Genomes: Role of a Chloroplast Signal in Coordinating Nuclear and Plastid Genome Expression
Susek, R. E., & Chory, J. (1992) · Australian Journal of Plant Physiology · doi:10.1071/pp9920387 · Cited by 103
Carotenoid hydroxylase from Haematococcus pluvialis: cDNA sequence, regulation and functional complementation
Linden, H. (1999) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(99)00088-3 · Cited by 102
Optical purity of (3S,3'S)-astaxanthin from Haematococcus pluvialis
Renstrøm, B., Borch, G., Skulberg, O. M., & Jensen, S. L. (1981) · Phytochemistry · doi:10.1016/0031-9422(81)83094-4 · Cited by 102
Do carotenoids play a photoprotective role in the cytoplasm of Haematococcus lacustris (Chlorophyta)?
Yong, Y. Y. R., & Lee, Y.-K. (1991) · Phycologia · doi:10.2216/i0031-8884-30-3-257.1 · Cited by 101
Oxidant-Induced Signaling: Effects of Peroxynitrite and Singlet Oxygen
Klotz, L. (2002) · Biological Chemistry · doi:10.1515/bc.2002.047 · Cited by 101
Astaxanthin accumulation in Haematococcus requires a cytochrome P450 hydroxylase and an active synthesis of fatty acids
Schoefs, B., Rmiki, N.-E., Rachadi, J., & Lemoine, Y. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02596-0 · Cited by 100
Self-citation
Effect of carbon/nitrogen ratio on encystment accompanied with astaxanthin formation in a green alga, Haematococcus pluvialis
Kakizono, T., Kobayashi, M., & Nagai, S. (1992) · Journal of Fermentation and Bioengineering · doi:10.1016/0922-338x(92)90041-r · Cited by 98
Cbr, an algal homolog of plant early light-induced proteins, is a putative zeaxanthin binding protein.
Levy, H., Tal, T., Shaish, A., & Zamir, A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36870-x · Cited by 97
Metabolic engineering of ketocarotenoid biosynthesis in higher plants
Zhu, C., Naqvi, S., Capell, T., & Christou, P. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.10.029 · Cited by 96
Enzymic confirmation of reactions involved in routes to astaxanthin formation, elucidated using a direct substrate in vitro assay
Fraser, P. D., Shimada, H., & Misawa, N. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2520229.x · Cited by 95
Accumulation of Secondary Carotenoids in Chlorella zofingiensis
Rise, M., Cohen, E., Vishkautsan, M., Cojocaru, M., Gottlieb, H. E., & Arad, S. M. (1994) · Journal of Plant Physiology · doi:10.1016/s0176-1617(11)81189-2 · Cited by 92
Astaxanthin, a Carotenoid without Vitamin A Activity, Augments Antibody Responses in Cultures Including T-helper Cell Clones and Suboptimal Doses of Antigen
Jyonouchi, H., Sun, S., Tomita, Y., & Gross, M. D. (1995) · Journal of Nutrition · doi:10.1093/jn/125.10.2483 · Cited by 90
Influences of different stress media and high light intensities on accumulation of astaxanthin in the green alga Haematococcus pluvialis
İmamoğlu, E., Dalay, M. C., & Sukan, F. V. (2009) · New Biotechnology · doi:10.1016/j.nbt.2009.08.007 · Cited by 89
Progress in understanding the origin and functions of carotenoid hydroxylases in plants
Tian, L., & DellaPenna, D. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.02.003 · Cited by 88
Does Astaxanthin Protect Haematococcus against Light Damage?
Fan, L., Vonshak, A., Zarka, A., & Boussiba, S. (1998) · Zeitschrift für Naturforschung C · doi:10.1515/znc-1998-1-217 · Cited by 88
Jasmonic acid affects changes in the growth and some components content in alga Chlorella vulgaris
Czerpak, R., Piotrowska, A., & Szulecka, K. (2006) · Acta Physiologiae Plantarum · doi:10.1007/bf02706531 · Cited by 87
Biosynthesis of ketocarotenoids in transgenic cyanobacteria expressing the algal gene for β‐C‐4‐oxygenase,crtO
Harker, M., & Hirschberg, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00110-5 · Cited by 84
Carotenogenesis in Haematococcus pluvialis
Droop, M. R. (1955) · Nature · doi:10.1038/175042a0 · Cited by 84
HIGH‐LIGHT AND SODIUM CHLORIDE STRESS DIFFERENTIALLY REGULATE THE BIOSYNTHESIS OF ASTAXANTHIN IN CHLORELLA ZOFINGIENSIS (CHLOROPHYCEAE)1
Li, Y., Huang, J., Sandmann, G., & Chen, F. (2009) · Journal of Phycology · doi:10.1111/j.1529-8817.2009.00689.x · Cited by 83
Primary and secondary carotenoids in two races of the green alga Botryococcus braunii
Grung, M., Metzger, P., & Jensen, S. L. (1989) · Biochemical Systematics and Ecology · doi:10.1016/0305-1978(89)90001-x · Cited by 82
The accumulation and metabolism of astaxanthin in Scenedesmus obliquus (Chlorophyceae)
Qin, S., Liu, G., & Hu, Z. (2008) · Process Biochemistry · doi:10.1016/j.procbio.2008.03.010 · Cited by 80
Secondary Carotenoid Accumulation in Haematococcus (Chlorophyceae): Biosynthesis, Regulation, and Biotechnology
Jin, E., & Lee, C. (2006) · Journal of Microbiology and Biotechnology · Cited by 80
Ultrastructural study of Haematococcus lacustris (Girod.) Rostafinski (Volvocales). I. Some aspects of carotenogenesis.
Santos, M. F., & Mesquita, J. F. (1984) · CYTOLOGIA · doi:10.1508/cytologia.49.215 · Cited by 80
Carotenoids. Volume 4: natural functions.
Britton, G., Jensen, S. L., & PFANDER, H. (2008) · Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) · doi:10.1007/978-3-7643-7499-0 · Cited by 80
Astaxanthin biosynthesis enhanced by reactive oxygen species in the green algaHaematococcus pluvialis
Kobayashi, M. (2003) · Biotechnology and Bioprocess Engineering · doi:10.1007/bf02949275 · Cited by 79
Enhanced protection against oxidative stress in an astaxanthin-overproductionHaematococcusmutant (Chlorophyceae)
Hu, Z., Li, Y., Sommerfeld, M. R., Chen, F., & Hu, Q. (2008) · European Journal of Phycology · doi:10.1080/09670260802227736 · Cited by 79
Isolation and characterization of a carotenoid oxygenase gene from Chlorella zofingiensis (Chlorophyta)
Huang, J., Wang, Y., Sandmann, G., & Chen, F. (2005) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-005-0166-8 · Cited by 77
Secondary carotenoids formation by the green alga Chlorococcum sp.
Liu, B., & Lee, Y. K. (2000) · Journal of Applied Phycology · doi:10.1023/a:1008185212724 · Cited by 76
Physiology, ultrastructure and habitat of the ice alga Mesotaenium berggrenii (Zygnemaphyceae, Chlorophyta) from glaciers in the European Alps
Remias, D., Holzinger, A., & Lütz, C. (2009) · Phycologia · doi:10.2216/08-13.1 · Cited by 76
Occurrence and environmental stress responses of two plastid terminal oxidases in Haematococcus pluvialis (Chlorophyceae)
Wang, J., Sommerfeld, M. R., & Hu, Q. (2009) · Planta · doi:10.1007/s00425-009-0932-4 · Cited by 75
Plant cell compartments: selected topics.
Schoefs, B. (2008) · Cited by 74
Self-citation
Synthesis of ketocarotenoids in the seed of Arabidopsis thaliana
Stålberg, K., Lindgren, O., Ek, B., & Höglund, A. (2003) · The Plant Journal · doi:10.1046/j.1365-313x.2003.01919.x · Cited by 73
Enhanced production of free trans-astaxanthin by oxidative stress in the cultures of the green microalga Chlorococcum sp
Yin-Nin, R., & Chen, F. (2001) · Process Biochemistry · doi:10.1016/s0032-9592(01)00157-1 · Cited by 73
Functional aspects of secondary carotenoids in Haematococcus lacustris [Girod] Rostafinski (Volvocales) IV. Protection from photodynamic damage
Hagen, C., Braune, W., & Greulich, F. (1993) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/1011-1344(93)80145-y · Cited by 69
Glucose sensing and the mitochondrial alternative pathway are involved in the regulation of astaxanthin biosynthesis in the dark-grown Chlorella zofingiensis (Chlorophyceae)
Li, Y., Huang, J., Sandmann, G., & Chen, F. (2008) · Planta · doi:10.1007/s00425-008-0775-4 · Cited by 66
Astaxanthin Production by Haematococcus pluvialis under Various Light Intensities and Wavelengths
Park, E., & Lee, C. (2001) · Journal of Microbiology and Biotechnology · Cited by 65
Subcellular Localization of the Inducible Chlorella HUP1 Monosaccharide-H+ Symporter and Cloning of a Co-Induced Galactose-H+ Symporter
Stadler, R., Wolf, K., Hilgarth, C., Tanner, W., & Sauer, N. (1995) · PLANT PHYSIOLOGY · doi:10.1104/pp.107.1.33 · Cited by 63
Expression in Escherichia coli and properties of the carotene ketolase from Haematococcus pluvialis
Breitenbach, J. (1996) · FEMS Microbiology Letters · doi:10.1016/0378-1097(96)00187-5 · Cited by 63
Identification of astaxanthin diglucoside diesters from snow alga Chlamydomonas nivalis by liquid chromatography–atmospheric pressure chemical ionization mass spectrometry
Řezanka, T., Nedbalová, L., Sigler, K., & Cepák, V. (2007) · Phytochemistry · doi:10.1016/j.phytochem.2007.06.025 · Cited by 62
Accumulation of secondary carotenoids in flagellates ofHaematococcus pluvialis(Chlorophyta) is accompanied by an increase in per unit chlorophyll productivity of photosynthesis
Hagen, C., Grünewald, K., Schmidt, S., & MÜLLER, J. (2000) · European Journal of Phycology · doi:10.1080/09670260010001735651 · Cited by 62
Expression in Escherichia coli and properties of the carotene ketolase from Haematococcus pluvialis
Breitenbach, J. ⁄. R., Misawa, N., Kajiwara, S., et al. (1996) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1996.tb08343.x · Cited by 60
Pathway engineering of plants toward astaxanthin production
Misawa, N. (2009) · Plant Biotechnology · doi:10.5511/plantbiotechnology.26.93 · Cited by 59
One amino acid substitution in phytoene desaturase makes Chlorella zofingiensis resistant to norflurazon and enhances the biosynthesis of astaxanthin
Liu, J., Zhong, Y., Sun, Z., Huang, J., Sandmann, G., & Chen, F. (2010) · Planta · doi:10.1007/s00425-010-1132-y · Cited by 59
CYTOCHROME f LOSS IN ASTAXANTHIN‐ACCUMULATING RED CELLS OF HAEMATOCOCCUS PLUVIALIS (CHLOROPHYCEAE): COMPARISON OF PHOTOSYNTHETIC ACTIVITY, PHOTOSYNTHETIC ENZYMES, AND THYLAKOID MEMBRANE POLYPEPTIDES IN RED AND GREEN CELLS
Tan, S. Y., Cunningham, F. X., Youmans, M., Grabowski, B., Sun, Z., & Gantt, E. (1995) · Journal of Phycology · doi:10.1111/j.0022-3646.1995.00897.x · Cited by 58
Fatty acid composition of some esterified carotenols
Renstrøm, B., & Liaaen‐Jensen, S. (1981) · Comparative Biochemistry and Physiology Part B Comparative Biochemistry · doi:10.1016/0305-0491(81)90360-6 · Cited by 58
Glucose-induced Expression of Carotenoid Biosynthesis Genes in the Dark Is Mediated by Cytosolic pH in the Cyanobacterium Synechocystis sp. PCC 6803
Ryu, J.-Y., Song, J.-Y., Lee, J., Jeong, S. W., Chow, W. S., Choi, S.-B., Pogson, B. J., & Park, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402541200 · Cited by 57
Growth-associated biosynthesis of astaxanthin in heterotrophic Chlorella zofingiensis (Chlorophyta)
Wang, Y., & Peng, J. (2008) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-008-9692-8 · Cited by 57
The GHOST terminal oxidase regulates developmental programming in tomato fruit
Barr, J., White, W. S., Chen, L., BAE, H., & Rodermel, S. R. (2004) · Plant Cell & Environment · doi:10.1111/j.1365-3040.2004.01190.x · Cited by 56
Occurrence of Astaxanthin in the Flower Petals of Adonis annua L.
Seybold, A., & Goodwin, T. W. (1959) · Nature · doi:10.1038/1841714a0 · Cited by 56
The life history and ecology of the snow alga Chloromonas cryophila sp. nov. (Chlorophyta, Volvocales)
Hoham, R. W., & Mullet, J. E. (1977) · Phycologia · doi:10.2216/i0031-8884-16-1-53.1 · Cited by 54
Two-step process for ketocarotenoid production by a green alga, Chlorococcum sp. strain MA-1
Zhang, D.-H., & Lee, Y.-K. (2001) · Applied Microbiology and Biotechnology · doi:10.1007/s002530000526 · Cited by 51
Cell wall carotenoids in green algae which form sporopollenins
Burczyk, J. (1986) · Phytochemistry · doi:10.1016/s0031-9422(00)81494-6 · Cited by 51
Accumulation of astaxanthin in flagellated cells of Haematococcus pluvialis – cultural and regulatory aspects
Brinda, B. R., Sarada, R., Kamath, B. S., & Ravishankar, G. A. (2004) · CFTRI Institutional Repository · Cited by 49
Carotenoids in photosynthesis: Protection of D1 degradation in the light
Sandmann, G., Kuhn, M. G., & B�ger, P. (1993) · Photosynthesis Research · doi:10.1007/bf00014749 · Cited by 48
Development of Red Pigmentation in Chlorococcum wimmeri (Chlorophyta: Chlorococcales)
Brown, T. E., Richardson, F. L., & Vaughn, M. L. (1967) · Phycologia · doi:10.2216/i0031-8884-6-4-167.1 · Cited by 47
Inhibition of astaxanthin synthesis in the green alga,Haematococcus pluvialis
Harker, M., & Young, A. J. (1995) · European Journal of Phycology · doi:10.1080/09670269500650961 · Cited by 47
Regulation and light-harvesting complex II association of a Dunaliella protein homologous to early light-induced proteins in higher plants.
Levy, H., Gokhman, I., & Zamir, A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37036-x · Cited by 45
SECONDARY CAROTENOID ACCUMULATION IN SCENEDESMUS KOMAREKII (CHLOROPHYCEAE, CHLOROPHYTA)
Hanagata, N., & Dubinsky, Z. (1999) · Journal of Phycology · doi:10.1046/j.1529-8817.1999.3550960.x · Cited by 43
Secondary carotenoid accumulation in flagellates of the green algaHaematococcus lacustris
Grünewald, K., Hagen, C., & Braune, W. (1997) · European Journal of Phycology · doi:10.1080/09670269710001737329 · Cited by 43
Nuclear–chloroplast signalling
Somanchi, A., & Mayfield, S. P. (1999) · Current Opinion in Plant Biology · doi:10.1016/s1369-5266(99)00013-8 · Cited by 42
Esterified, optical pure (3S, 3′S)-astaxanthin from flowers of Adonis annua
Renstrøm, B., Berger, H., & Liaaen‐Jensen, S. (1981) · Biochemical Systematics and Ecology · doi:10.1016/0305-1978(81)90003-x · Cited by 42
β-carotene is the intermediate exported from the chloroplast during accumulation of secondary carotenoids in Haematococcus pluvialis
Grünewald, K., & Hagen, C. (2001) · Journal of Applied Phycology · doi:10.1023/a:1008183328839 · Cited by 39
Functional aspects of secondary carotenoids in Haematococcus lacustris (Girod) Rostafinski (Volvocales)
Hagen, C., Braune, W., Birckner, E., & Nüske, J. (1993) · New Phytologist · doi:10.1111/j.1469-8137.1993.tb03912.x · Cited by 39
Chlorophyll and carotenoid analysis in food products. A practical case-by-case view
Schoefs, B. (2003) · TrAC Trends in Analytical Chemistry · doi:10.1016/s0165-9936(03)00602-2 · Cited by 39
Self-citation
Microalgae as a source for secondary carotenoid production: a screening study
Kopecký, J., Schoefs, B., Loest, K., Štys, D., & Pulz, O. (2000) · Algological Studies/Archiv für Hydrobiologie Supplement Volumes · doi:10.1127/algol_stud/98/2000/153 · Cited by 32
Self-citation
Expression of carotenogenic genes and carotenoid production in Haematococcus pluvialis under the influence of carotenoid and fatty acid synthesis inhibitors
Raman, V., Sarada, R., & Ravishankar, G. A. (2009) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2009.05.005 · Cited by 30
Cloning and Characterization of β-Carotene Ketolase Gene Promoter in Haematococcus pluvialis
Meng, C., Chang-ying, T., Jiang, P., Qin, S., & Tseng, C. (2005) · Acta Biochimica et Biophysica Sinica · doi:10.1111/j.1745-7270.2005.00033.x · Cited by 30
A zeaxanthin protein from Anacystis nidulans
Diversé-Pierluissi, M. A., & Krogmann, D. W. (1988) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(88)90045-x · Cited by 29
Proteomics analysis of proteins in green alga Haematococcus lacustris (Chlorophyceae) expressed under combined stress of nitrogen starvation and high irradiance
Tran, N.-P., Park, J.-K., & Lee, C. (2009) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2009.07.006 · Cited by 29
Methylerythritol Phosphate Pathway
Rohmer, M. (2010) · Elsevier eBooks · doi:10.1016/b978-008045382-8.00702-4 · Cited by 29
Carotenoid hydroxylation – P450 finally!
INOUE, K. (2004) · Trends in Plant Science · doi:10.1016/j.tplants.2004.09.001 · Cited by 28
Carotenoids and Stress in Higher Plants and Algae
Rmiki, N.-E., Schoefs, B., & Lemoine, Y. (1999) · Books in soils, plants, and the environment · doi:10.1201/9780824746728.ch20 · Cited by 28
Self-citation
Biosynthesis of Carotenoids in the Chloroplasts of Algae and Higher Plants
Ladygin, V. G. (2000) · Russian Journal of Plant Physiology · doi:10.1023/a:1026667430591 · Cited by 26
Photosynthetic acclimation and photoprotective mechanism of Haematococcus pluvialis (Chlorophyceae) during the accumulation of secondary carotenoids at elevated irradiation
Qiu, B., & Li, Y. (2006) · Phycologia · doi:10.2216/04-99.1 · Cited by 26
Characteristics of Chlorophyll Formation of the Aerial Microalga Coelastrella striolata var. multistriata and Its Application for Environmental Biomonitoring
Abe, K., TAKIZAWA, H., Kimura, S., & Hirano, M. (2004) · Journal of Bioscience and Bioengineering · doi:10.1016/s1389-1723(04)70239-x · Cited by 25
Saccharides of Different Varieties of Indian Rice
Parihar, D. B. (1955) · Nature · doi:10.1038/175042b0 · Cited by 25
Operation of the Xanthophyll Cycle in Non-Stressed and Stressed Cells of Dunaliella salina Teod. in Response to Diurnal Changes in Incident Irradiation: A Correlation with Intracellular β-Carotene Content
Phillips, L. G., Cowan, A. K., Rose, P. D., & Logie, M. R. R. (1995) · Journal of Plant Physiology · doi:10.1016/s0176-1617(11)82022-5 · Cited by 24
Chromatographic Analysis of Synthesized Astaxanthin—A Handy Tool for the Ecologist and the Forensic Chemist?
Bjerkeng, B. (1997) · The Progressive Fish-Culturist · doi:10.1577/1548-8640(1997)059 · Cited by 23
Über das Euglenarhodon und andere Carotinoide einer roten Euglene. (Carotinoide der Süßwasseralgen, I. Teil.)
Tischer, J. (1936) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1936.239.4-6.257 · Cited by 23

Research works printed but not linked: 9

Foyer CH, Mullineaux PM (1994) Causes of photooxidative stress and amelioration of defense systems in plants. CRC Press, Boca Raton
Hanagata N, Karube I, Chihara M (1996) Bark-inhabiting green algae in Japan (1). Scenedesmus komarekii and Coelastrella multistriata var. multistriata (Scotiellocysteideae, Chlorellaceae, Chlorophyceae). J Jpn Bot 71:87–97
Hirschberg J (1998) Molecular biology of carotenoid biosynthesis. In: Britton G, Liaaen-Jensen S, Pfander H (eds) Carotenoids vol 3: biosynthesis and metabolism. Birkäuser, Basel, pp 149–194
Hui B, Pei L (2005) An overview of carotenoid production and consumption in China. Carotenoid Sci 9:48
Hui Z, Gongshi X, Xuli D (2005) Advance of natural lutein and astaxanthin in China. Carotenoid Sci 9:49
Liu JG, Liu W, Yin MY, Sun YN, Zhang Z, Li YY, Wang ZF, Lin W, Zhang JP, Shi PJ, Zhang XL, Sun YH, Xue YB, Cui XJ (2005) Some scientific and technical approaches to culture Haematococcus pluvialis from laboratory to pilot scale for natural astaxanthin. Carotenoid Sci 9:50
Nebdalova L, Kocianova M, Lukavsky J (2008) Ecology of snow algae in the Giant Mts. Opera Corcon 45:59–68
Olaizola M, Huntley ME (2003) Recent advances in commercial production of astaxanthin from microalgae. In: Fingerman M, Nagabhushanam R (eds) Recent advances in marine biotechnology. Vol. 9: biomaterials and bioprocessing. Science Publishers, Enfield, NH, pp 143–164
von Flotow J (1844) Uber Haematococcus pluvialis. Verh Kais Leopold-Carol Akad Naturf. Nova Acta Acad Caes Leopold-Carolin Nat Curios 20:411–606

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Markou, G., & Nerantzis, E. (2013) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.07.011 · Cited by 815
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See all 399

Authors: Lemoine, Y., & Schoefs, B.
Affiliations: Centre National de la Recherche Scientifique (FR)
Venue: Photosynthesis Research
Publisher: Springer Science and Business Media LLC
Published: 2010-08-13
Volume: 106
Issue: 1-2
Pages: 155-177
ISSN: 0166-8595 (ISSN-L)
1573-5079
DOI: 10.1007/s11120-010-9583-3
OpenAlex: W1991026527
Cited by: 384
References: 215
Citations by year: 2026: 15 · 2025: 26 · 2024: 21 · 2023: 25 · 2022: 28 · 2021: 50 · 2020: 42 · 2019: 31 · 2018: 25 · 2017: 17 · 2016: 20 · 2015: 20 · 2014: 26 · 2013: 21 · 2012: 9
FWCI: 0.42
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
www.springer.com/tdm (tdm)
Locations: Photosynthesis Research (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
LillOA (Université de Lille (University Of Lille)) (submittedVersion, other-oa)
Topics: Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Photosynthetic Processes and Mechanisms
Keywords: astaxanthin biosynthesis, ketocarotenoids, Haematococcus pluvialis, carotenogenesis, oxidative stress, antioxidant activity, red snow, cyst formation, UV-B stress, light stress, metabolic regulation, green algae
MeSH terms: Chlorophyta, Carotenoids, Stress, Physiological, Plastids, Xanthophylls, Biosynthetic Pathways, Eukaryota

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Secondary ketocarotenoid astaxanthin biosynthesis in algae: a multifunctional response to stress

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