The DOI matches its Crossref record; 481 of the 481 references it cites were found in a registry or an index.
Low-molecular-weight ligands in plants: role in metal homeostasis and hyperaccumulation
Abstract
Mineral nutrition is one of the key factors determining plant productivity. In plants, metal homeostasis is achieved through the functioning of a complex system governing metal uptake, translocation, distribution, and sequestration, leading to the maintenance of a regulated delivery of micronutrients to metal-requiring processes as well as detoxification of excess or non-essential metals. Low-molecular-weight ligands, such as nicotianamine, histidine, phytochelatins, phytosiderophores, and organic acids, play an important role in metal transport and detoxification in plants. Nicotianamine and histidine are also involved in metal hyperaccumulation, which determines the ability of some plant species to accumulate a large amount of metals in their shoots. In this review we extensively summarize and discuss the current knowledge of the main pathways for the biosynthesis of these ligands, their involvement in metal uptake, radial and long-distance transport, as well as metal influx, isolation and sequestration in plant tissues and cell compartments. It is analyzed how diverse endogenous ligand levels in plants can determine their different tolerance to metal toxic effects. This review focuses on recent advances in understanding the physiological role of these compounds in metal homeostasis, which is an essential task of modern ionomics and plant physiology. It is of key importance in studying the influence of metal deficiency or excess on various physiological processes, which is a prerequisite to the improvement of micronutrient uptake efficiency and crop productivity and to the development of a variety of applications in phytoremediation, phytomining, biofortification, and nutritional crop safety.
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“Several species of ferns, liverworts, and mosses hyperaccumulate Ni from their habitats (Seregin and Kozhevnikova, 2021).”
From Plant hyperaccumulators: a state-of-the-art review on mechanism of heavy metal transport and sequestration (2025) · cites this paper as Seregin and Kozhevnikova, 2021
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Cited by
Sorted by citations
Metal and metalloid toxicity in plants: an overview on molecular aspects
Angulo-Bejarano, P. I., Puente-Rivera, J., & Cruz-Ortega, R. (2021) · Plants · doi:10.3390/plants10040635 · Cited by 357
Edgar, V.-N., Fabián, F.-L., Mario, P.-C. J., & Ileana, V.-R. (2021) · Applied Sciences · doi:10.3390/app11072982 · Cited by 91
Reducing heavy metal contamination in soil and water using phytoremediation
Zhakypbek, Y., Kossalbayev, B. D., Belkozhayev, A. M., Murat, T., Tursbekov, S., Abdalimov, E., Pashkovskiy, P., Kreslavski, V., Kuznetsov, V., & Allakhverdiev, S. I. (2024) · Plants · doi:10.3390/plants13111534 · Cited by 86
Bhat, B. A., Rather, M. A., Bilal, T., Nazir, R., Qadir, R. U., & Mir, R. A. (2025) · Frontiers in Plant Science · doi:10.3389/fpls.2025.1631378 · Cited by 68
Metadata
- Authors
- Seregin, I. V., & Kozhevnikova, A. D.
- Affiliations
- Timiryazev Institute of Plant Physiology (RU)
- Corresponding author
- Seregin, I. V.
- Venue
- Photosynthesis Research
- Published
- 2020-07-11
- Volume
- 150
- Issue
- 1-3
- Pages
- 51-96
- ISSN
- 0166-8595 (ISSN-L)
- 1573-5079
- OpenAlex
- W3041383585
- Cited by
- 73
- References
- 481
- Citations by year
- 2026: 13 · 2025: 10 · 2024: 15 · 2023: 9 · 2022: 13 · 2021: 11 · 2020: 2
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Photosynthesis Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant nutrient uptake and metabolism
- Physical Sciences › Environmental Science › Pollution › Heavy metals in environment
- Keywords
- low molecular weight ligands, metal homeostasis, metal hyperaccumulation, nicotianamine, histidine, phytochelatins, phytosiderophores, organic acids, metal transport, metal detoxification, metal sequestration, metal tolerance, phytoremediation, phytomining, biofortification, micronutrient uptake, ionomics
- MeSH terms
- Homeostasis, Ligands, Metals, Plants, Plant Physiological Phenomena
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