Cited by 73Plant Micronutrient Interactions and EffectsPlant nutrient uptake and metabolismHeavy metals in environment

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Low-molecular-weight ligands in plants: role in metal homeostasis and hyperaccumulation

Seregin, I. V., Kozhevnikova, A. D.·2021·Photosynthesis Research

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Abstract

Mineral nutrition is one of the key factors determining plant productivity. In plants, metal homeostasis is achieved through the functioning of a complex system governing metal uptake, translocation, distribution, and sequestration, leading to the maintenance of a regulated delivery of micronutrients to metal-requiring processes as well as detoxification of excess or non-essential metals. Low-molecular-weight ligands, such as nicotianamine, histidine, phytochelatins, phytosiderophores, and organic acids, play an important role in metal transport and detoxification in plants. Nicotianamine and histidine are also involved in metal hyperaccumulation, which determines the ability of some plant species to accumulate a large amount of metals in their shoots. In this review we extensively summarize and discuss the current knowledge of the main pathways for the biosynthesis of these ligands, their involvement in metal uptake, radial and long-distance transport, as well as metal influx, isolation and sequestration in plant tissues and cell compartments. It is analyzed how diverse endogenous ligand levels in plants can determine their different tolerance to metal toxic effects. This review focuses on recent advances in understanding the physiological role of these compounds in metal homeostasis, which is an essential task of modern ionomics and plant physiology. It is of key importance in studying the influence of metal deficiency or excess on various physiological processes, which is a prerequisite to the improvement of micronutrient uptake efficiency and crop productivity and to the development of a variety of applications in phytoremediation, phytomining, biofortification, and nutritional crop safety.

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Authors: Seregin, I. V., & Kozhevnikova, A. D.
Affiliations: Timiryazev Institute of Plant Physiology (RU)
Corresponding author: Seregin, I. V.
ORCID: Seregin, I. V.
Kozhevnikova, A. D.
Venue: Photosynthesis Research
Publisher: Springer Science and Business Media LLC
Published: 2020-07-11
Volume: 150
Issue: 1-3
Pages: 51-96
ISSN: 0166-8595 (ISSN-L)
1573-5079
DOI: 10.1007/s11120-020-00768-1
OpenAlex: W3041383585
Cited by: 73
References: 481
Citations by year: 2026: 13 · 2025: 10 · 2024: 15 · 2023: 9 · 2022: 13 · 2021: 11 · 2020: 2
FWCI: 0.74
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Photosynthesis Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Micronutrient Interactions and Effects
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant nutrient uptake and metabolism
Physical Sciences › Environmental Science › Pollution › Heavy metals in environment
Keywords: low molecular weight ligands, metal homeostasis, metal hyperaccumulation, nicotianamine, histidine, phytochelatins, phytosiderophores, organic acids, metal transport, metal detoxification, metal sequestration, metal tolerance, phytoremediation, phytomining, biofortification, micronutrient uptake, ionomics
MeSH terms: Homeostasis, Ligands, Metals, Plants, Plant Physiological Phenomena

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Low-molecular-weight ligands in plants: role in metal homeostasis and hyperaccumulation

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