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Binational Cultural Adaptation of the keepin’ it REAL Substance Use Prevention Program for Adolescents in Mexico
Open accessAbstract
Sharp increases in substance use rates among youth and the lack of evidence-based prevention interventions in Mexico are a major concern. A team of investigators from Mexico and the USA are actively addressing this gap by culturally adapting keepin' it REAL (kiR)-a former US SAMHSA model program-for Mexico. This paper reports on the processes and outcomes of the cultural adaptation of kiR for adolescents in Mexico. Multiple forms of data informed this cultural adaptation, including focus groups with students about gendered and violence experiences with substance use, feedback from teachers who previously implemented the original versions of kiR, lesson fidelity observations, and external expert reviews. The culturally adapted version of kiR integrates Ecological Validity and Cultural Sensitivity Models in the adaptation process. The process encompassed surface structure adaptations, like updating language, graphics, and videos, as well as deep structure adaptation components including cultural norms, attitudes, and beliefs salient among Mexican adolescents. Youth reported receiving alcohol offers from family members, links between substance use and violence, and that shifting gender norms result in more females initiating substance use offers. In adapted kiR activities, students practice navigating substance use offers in these contexts. This approach to cultural adaptation led to a true collaborative between investigators in two countries. This study advances knowledge about how to undertake cultural adaptations of efficacious US-based prevention programs in international settings.
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Culturally adapted programs can enhance engagement and optimize resources by building upon proven programs.
“Developing a new program from scratch requires significant resources, therefore, culturally adapted programs can enhance engagement and optimize resources by building upon proven programs (Marsiglia et al., 2019).”
From Exploring Cultural Adaptations: A Scoping Review on Adolescent Mental Health and Substance Use Prevention Programs (2025) · cites this paper as Marsiglia et al., 2019
The Introduction’s Cultural Adaptation section (page unavailable) says that adapting a program to its audience can increase engagement while preserving the core components that made it efficacious. The Conclusion (page unavailable) likewise describes adapting an established curriculum. Our copy does not say that developing a program from scratch requires significant resources or that adaptation optimizes resources. (LLM, conf=0.86)
Experimental — accuracy not yet measuredDeveloping a new program from scratch requires significant resources.
“Developing a new program from scratch requires significant resources, therefore, culturally adapted programs can enhance engagement and optimize resources by building upon proven programs (Marsiglia et al., 2019).”
From Exploring Cultural Adaptations: A Scoping Review on Adolescent Mental Health and Substance Use Prevention Programs (2025) · cites this paper as Marsiglia et al., 2019
The Introduction (Cultural Adaptation; page unavailable) says culturally relevant adaptations can make participants more engaged and receptive, and the Conclusion describes adapting an existing curriculum while preserving its core elements. Neither passage says that developing a program from scratch requires significant resources or that adaptation optimizes resources. (LLM, conf=0.84)
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Citations
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Culturally Grounded Substance Use Prevention: An Evaluation of the keepin' it R.E.A.L. Curriculum
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Self-citationA scoping study of frameworks for adapting public health evidence-based interventions
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Corpus-Espinosa, C., Mac Fadden, I., del Carmen Torrejón-Guirado, M., & Lima-Serrano, M. (2025) · Prevention Science · doi:10.1007/s11121-025-01779-x · Cited by 14
Metadata
- Authors
- Marsiglia, F. F., Medina-Mora, M. E., Gonzalvez, A., Alderson, G., Harthun, M., Ayers, S., Gutiérrez, B. N., Corona, M. D., Melendez, M. A. M., & Kulis, S.
- Affiliations
- Arizona State University (US)
- Universidad Autónoma de Nuevo León (MX)
- Corresponding author
- Ayers, Stephanie
- Venue
- Prevention Science
- Published
- 2019-07-05
- Volume
- 20
- Issue
- 7
- Pages
- 1125-1135
- ISSN
- 1389-4986 (ISSN-L)
- 1573-6695
- PMC
- PMC6721982
- OpenAlex
- W2954194295
- Cited by
- 36
- References
- 5
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 10 · 2022: 8 · 2021: 7 · 2020: 2
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Prevention Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R01DA038657)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Youth, Drugs, and Violence
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Adolescent Health and Behaviors
- Keywords
- keepin' it REAL, substance use prevention, adolescents, cultural adaptation, binational collaboration, Mexico, alcohol consumption, gender norms, violence, ecological validity, cultural sensitivity
- MeSH terms
- Adolescent, Female, Health Promotion, Humans, Interviews as Topic, Male, Mexico, Students, Focus Groups, Substance-Related Disorders, Qualitative Research, Cultural Competency
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