Beneficial effect of virgin coconut oil on alloxan-induced diabetes and microbiota composition in rats
Abstract
The gut microbiota is composed of a diverse population of obligate and facultative anaerobic microorganisms which are shown to influence host metabolism and immune homeostasis. This study investigated the effects of virgin coconut oil on the weekly fasting glycaemia, daily food and water intake and weekly body mass gain over 16 weeks, as well as the changes in composition of gut microbiota in both non-diabetic and alloxan-induced diabetic rats. Although the intake of virgin coconut oil did not decrease the diabetes-induced hyperglycemia, it affected the secondary parameters, such as food and water intake and average body mass gain. Furthermore, its potential to positively affect the fecal microbiome was proved, since it significantly increased the abundance of probiotic bacteria, such as Lactobacillus, Allobaculum and Bifidobacterium species.
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Medium-chain fatty acids increase the abundance of Bifidobacterium, Bacteroides, and Prevotella and decrease the abundance of Clostridium histolyticum or Helicobacter in animal studies.
“Results from animal studies show that medium-chain fatty acids (7-12 carbons) increase the abundance of Bifidobacterium, Bacteroides, and Prevotella and decrease the abundance of Clostridium histolyticum or Helicobacter (119, 124-126).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [125]
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Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
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- Authors
- Djurasevic, S., Bojic, S., Nikolic, B., Dimkic, I., Todorovic, Z., Djordjevic, J., & Mitic-Culafic, D.
- Affiliations
- University of Belgrade (RS)
- Venue
- Plant Foods for Human Nutrition
- Published
- 2018-08-31
- Volume
- 73
- Issue
- 4
- Pages
- 295-301
- ISSN
- 0033-5134 (ISSN-L)
- 0921-9668
- 1573-9104
- OpenAlex
- W2889431018
- Cited by
- 38
- References
- 26
- Citations by year
- 2025: 4 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 6 · 2019: 8 · 2017: 1
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Plant Foods for Human Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Inorganic Chemistry › Coconut Research and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- virgin coconut oil, alloxan-induced diabetes, gut microbiota, fasting blood glucose, food and water intake, weight gain, probiotic bacteria, Lactobacillus, Bifidobacterium, Allobaculum, fecal microbiota, dietary fat
- MeSH terms
- Gastrointestinal Microbiome, Coconut Oil, Animals, Body Weight, Diabetes Mellitus, Experimental, Eating, Feces, Male, Rats, Wistar, Probiotics
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