Polycystic ovary syndrome throughout a woman’s life

Group of interest in Reproductive Endocrinology (GIER) of the Spanish Fertility Society (SEF); Bellver, José; Rodríguez-Tabernero, Luis; Robles, Ana; Muñoz, Elkin; Martínez, Francisca; Landeras, José; García-Velasco, Juan; Fontes, Juan; Álvarez, Mónica; Álvarez, Claudio; Acevedo, Belén

doi:10.1007/s10815-017-1047-7

Cited by 180Ovarian function and disordersReproductive Biology and FertilityEndometriosis Research and Treatment

Polycystic ovary syndrome throughout a woman’s life

Open access

Group of interest in Reproductive Endocrinology (GIER) of the Spanish Fertility Society (SEF), Bellver, José, Rodríguez-Tabernero, Luis, Robles, Ana, Muñoz, Elkin, Martínez, Francisca, Landeras, José, García-Velasco, Juan +4 more·2018·Journal of Assisted Reproduction and Genetics

DOI 10.1007/s10815-017-1047-7PMC PMC5758469

Open this paper in CoChat — free account

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-aged women and the main cause of infertility due to anovulation. However, this syndrome spans the lives of women affecting them from in-utero life until death, leading to several health risks that can impair quality of life and increase morbidity and mortality rates. Fetal programming may represent the beginning of the condition characterized by hyperandrogenism and insulin resistance which leads to a series of medical consequences in adolescence, adulthood, and old age. Menstrual and fertility problems evolve into metabolic complications as age advances. An early and precise diagnosis is important for an adequate management of PCOS, especially at the extreme ends of the reproductive lifespan. However, many different phenotypes are included under the same condition, being important to look at these different phenotypes separately, as they may require different treatments and have different consequences. In this way, PCOS exhibits a great metabolic complexity and its diagnosis needs to be revised once again and adapted to recent data obtained by new technologies. According to the current medical literature, lifestyle therapy constitutes the first step in the management, especially when excess body weight is associated. Pharmacotherapy is frequently used to treat the most predominant manifestations in each age group, such as irregular menses and hirsutism in adolescence, fertility problems in adulthood, and metabolic problems and risk of cancer in old age. Close surveillance is mandatory in each stage of life to avoid health risks which may also affect the offspring, since fetal and post-natal complications seem to be increased in PCOS women.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s10815-017-1047-7

Cites

144 of 144 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Although PCOS can be diagnosed in adolescence, many young individuals may not know they have PCOS or do not receive a diagnosis until they experience infertility.
“Although it can be diagnosed in adolescence, many young individuals may not know they have PCOS or do not receive a diagnosis until they experience infertility [3, 9, 24–29].”
From Challenges in diagnosis and health care in polycystic ovary syndrome in Canada: a patient view to improve health care (2023) · cites this paper as [25]
The Childhood and adolescence section says PCOS diagnosis is more challenging in adolescence and gives criteria for diagnosing it. The Adulthood: fertility passage says infertility is a main reason women with PCOS come to the clinic. Neither passage establishes that many young people are unaware they have PCOS or remain undiagnosed until they experience infertility. (LLM, conf=0.84)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

RETRACTED: Unilateral ovarian drilling in polycystic ovarian syndrome: a prospective randomized study
Youssef, H., & Atallah, M. M. (2007) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60373-2 · Cited by 49 · see citing works
Retracted
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
(2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.10.004 · Cited by 9,050 · see citing works
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)
The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group (2004) · Human Reproduction · doi:10.1093/humrep/deh098 · Cited by 6,138 · see citing works
The Diagnosis of Polycystic Ovary Syndrome during Adolescence
Witchel, S. F., Oberfield, S., Rosenfield, R. L., Codner, E., Bonny, A., Ibáñez, L., Pena, A., Horikawa, R., Gomez-Lobo, V., Joel, D., et al. (2015) · Hormone Research in Paediatrics · doi:10.1159/000375530 · Cited by 3,113 · see citing works
Polycystic Ovary Syndrome
Franks, S. (1995) · New England Journal of Medicine · doi:10.1056/nejm199509283331307 · Cited by 2,463 · see citing works
The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report
Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H. F., Futterweit, W., Janssen, O. E., Legro, R. S., Norman, R. J., Taylor, A. E., et al. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.06.035 · Cited by 2,132 · see citing works
Amenorrhea associated with bilateral polycystic ovaries
Stein, I. F., & Leventhal, M. L. (1935) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(15)30642-6 · Cited by 2,121 · see citing works
Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group
Fauser, B. C. J. M., Tarlatzis, B. C., Rebar, R. W., Legro, R. S., Balen, A. H., Lobo, R., Carmina, E., Chang, J., Yildiz, B. O., Laven, J. S. E., et al. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.09.024 · Cited by 1,976 · see citing works
Insulin Resistance and the Polycystic Ovary Syndrome Revisited: An Update on Mechanisms and Implications
Diamanti-Kandarakis, E., & Dunaif, A. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1034 · Cited by 1,947 · see citing works
Diagnosis and Treatment of Polycystic Ovary Syndrome: An Endocrine Society Clinical Practice Guideline
Legro, R. S., Arslanian, S. A., Ehrmann, D. A., Hoeger, K. M., Murad, M. H., Pasquali, R., & Welt, C. K. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2350 · Cited by 1,919 · see citing works
Bariatric Surgery versus Intensive Medical Therapy for Diabetes — 3-Year Outcomes
Schauer, P. R., Bhatt, D. L., Kirwan, J. P., Wolski, K., Brethauer, S. A., Navaneethan, S. D., Aminian, A., Pothier, C. E., Kim, E. S. H., Nissen, S. E., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1401329 · Cited by 1,901 · see citing works
Overweight, obesity and central obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis
Lim, S. S., Davies, M. J., Norman, R. J., & Moran, L. J. (2012) · Human Reproduction Update · doi:10.1093/humupd/dms030 · Cited by 939 · see citing works
A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome
Boomsma, C. M., Eijkemans, M. J. C., Hughes, E. G., Visser, G. H. A., Fauser, B. C. J. M., & Macklon, N. S. (2006) · Human Reproduction Update · doi:10.1093/humupd/dml036 · Cited by 852 · see citing works
Use of an aromatase inhibitor for induction of ovulation in patients with an inadequate response to clomiphene citrate
Mitwally, M. F. M., & Casper, R. F. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01705-2 · Cited by 801 · cited 1× · see citing works
“5mg/day for 5 to 10 days starting 3–7 days after menses [79].”
Background
Lifestyle changes in women with polycystic ovary syndrome
Lim, S. S., Hutchison, S. K., Van Ryswyk, E., Norman, R. J., Teede, H. J., & Moran, L. J. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007506.pub4 · Cited by 725 · see citing works
The management of anovulatory infertility in women with polycystic ovary syndrome: An analysis of the evidence to support the development of global who guidance
Balen, A. H., Morley, L. C., Misso, M., Franks, S., Legro, R. S., Wijeyaratne, C. N., Stener-Victorin, E., Fauser, B. C. J. M., Norman, R. J., & Teede, H. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmw025 · Cited by 705 · see citing works
Prevalence, phenotype and cardiometabolic risk of polycystic ovary syndrome under different diagnostic criteria
Yildiz, B. O., Bozdag, G., Yapici, Z., Esinler, I., & Yarali, H. (2012) · Human Reproduction · doi:10.1093/humrep/des232 · Cited by 704 · see citing works
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility
Tang, T., Lord, J. M., Norman, R. J., Yasmin, E., & Balen, A. H. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003053.pub5 · Cited by 698 · see citing works
Pregnancy complications in women with polycystic ovary syndrome
Palomba, S., de Wilde, M. A., Falbo, A., Koster, M. P. H., La Sala, G. B., & Fauser, B. C. J. M. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv029 · Cited by 691 · see citing works
Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome
Legro, R. S., Brzyski, R. G., Diamond, M. P., Coutifaris, C., Schlaff, W. D., Casson, P. R., Christman, G. M., Huang, H., Yan, Q., Alvero, R. J., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1313517 · Cited by 671 · see citing works
High prevalence of moderate and severe depressive and anxiety symptoms in polycystic ovary syndrome: a systematic review and meta-analysis
Cooney, L. G., Lee, I., Sammel, M. D., & Dokras, A. (2017) · Human Reproduction · doi:10.1093/humrep/dex044 · Cited by 631 · see citing works
American Association of Clinical Endocrinologists, American College of Endocrinology, and androgen excess and PCOS society disease state clinical review: guide to the best practices in the evaluation and treatment of polycystic ovary syndrome–part 1
Goodman, N. F., Cobin, R. H., Futterweit, W., Glueck, J. S., Legro, R. S., & Carmina, E. (2015) · Endocrine Practice · doi:10.4158/ep15748.dsc · Cited by 623 · see citing works
Polycystic Ovary Syndrome
McCartney, C. R., & Marshall, J. C. (2016) · New England Journal of Medicine · doi:10.1056/nejmcp1514916 · Cited by 619 · see citing works
Gonadotrophin-releasing hormone antagonists for assisted reproductive technology
Al-Inany, H. G., Youssef, M. A. F. M., Ayeleke, R. O., Brown, J., Lam, W. S., & Broekmans, F. J. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001750.pub4 · Cited by 612 · see citing works
Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis
Barry, J. A., Azizia, M., & Hardiman, P. J. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu012 · Cited by 603 · see citing works
Outcomes of Pregnancy after Bariatric Surgery
Johansson, K., Cnattingius, S., Näslund, I., Roos, N., Lagerros, Y. T., Granath, F. N., Stephansson, O., & Neovius, M. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1405789 · Cited by 548 · see citing works
Genetic, hormonal and metabolic aspects of PCOS: an update
De Leo, V., Musacchio, M. C., Cappelli, V., Massaro, M. G., Morgante, G., & Petraglia, F. (2016) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-016-0173-x · Cited by 484 · see citing works
Diagnosis of polycystic ovary syndrome (PCOS): revisiting the threshold values of follicle count on ultrasound and of the serum AMH level for the definition of polycystic ovaries
Dewailly, D., Gronier, H., Poncelet, É., Robin, G., Leroy, M., Pigny, P., Duhamel, A., & Catteau-Jonard, S. (2011) · Human Reproduction · doi:10.1093/humrep/der297 · Cited by 483 · see citing works
Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence
Qiao, J., & Feng, H. L. (2011) · Human Reproduction Update · doi:10.1093/humupd/dmq032 · Cited by 479 · see citing works
Premature Adrenarche - A Common Condition with Variable Presentation
Utriainen, P., Laakso, S. M., Liimatta, J., Jääskeläinen, J., & Voutilainen, R. (2015) · Hormone Research in Paediatrics · doi:10.1159/000369458 · Cited by 474 · see citing works
Epidemiology and Adverse Cardiovascular Risk Profile of Diagnosed Polycystic Ovary Syndrome
Lo, J. C.-M., Feigenbaum, S. L., Yang, J., Pressman, A. R., Selby, J. V., & Go, A. S. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2430 · Cited by 414 · see citing works
Maternal serum androgens in pregnant women with polycystic ovarian syndrome: possible implications in prenatal androgenization
Sir‐Petermann, T. (2002) · Human Reproduction · doi:10.1093/humrep/17.10.2573 · Cited by 412 · see citing works
A meta-analysis of outcomes of conventional IVF in women with polycystic ovary syndrome
Heijnen, E., Eijkemans, M. J. C., Hughes, E. G., Laven, J. S. E., Macklon, N., & Fauser, B. C. J. M. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmi036 · Cited by 387 · see citing works
American Association Of Clinical Endocrinologists, American College Of Endocrinology, And Androgen Excess And Pcos Society Disease State Clinical Review: Guide To The Best Practices In The Evaluation And Treatment Of Polycystic Ovary Syndrome - Part 2
Goodman, N. F., Cobin, R. H., Futterweit, W., Glueck, J. S., Legro, R. S., & Carmina, E. (2015) · Endocrine Practice · doi:10.4158/ep15748.dscpt2 · Cited by 361 · see citing works
The diagnosis of polycystic ovary syndrome in adolescents
Carmina, E., Oberfield, S. E., & Lobo, R. A. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.03.008 · Cited by 339 · see citing works
POSITION STATEMENT: Glucose Intolerance in Polycystic Ovary Syndrome—A Position Statement of the Androgen Excess Society
Salley, K. E. S., Wickham, E. P., Cheang, K. I., Essah, P. A., Karjane, N. W., & Nestler, J. E. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1549 · Cited by 339 · see citing works
Combined lifestyle modification and metformin in obese patients with polycystic ovary syndrome. A randomized, placebo-controlled, double-blind multicentre study
Tang, T., Glanville, J., Hayden, C. J., White, D., Barth, J. H., & Balen, A. H. (2006) · Human Reproduction · doi:10.1093/humrep/dei311 · Cited by 335 · see citing works
Metformin and lifestyle modification in polycystic ovary syndrome: systematic review and meta-analysis
Naderpoor, N., Shorakae, S., de Courten, B., Misso, M. L., Moran, L. J., & Teede, H. J. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv025 · Cited by 334 · see citing works
Cardiometabolic Aspects of the Polycystic Ovary Syndrome
Randeva, H. S., Tan, B. K., Weickert, M. O., Lois, K. B., Nestler, J. E., Sattar, N. A., & Lehnert, H. (2012) · Endocrine Reviews · doi:10.1210/er.2012-1003 · Cited by 323 · see citing works
Obstetric complications in women with polycystic ovary syndrome: a systematic review and meta-analysis
Qin, J. Z., Pang, L. H., Li, M. J., Fan, X. J., Huang, R. D., & Chen, H. Y. (2013) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-11-56 · Cited by 317 · see citing works
Metformin versus placebo from first trimester to delivery in polycystic ovary syndrome: a randomized, controlled multicenter study
Vanky, E., Stridsklev, S., Heimstad, R., Romundstad, P., Skogøy, K., Kleggetveit, O., Hjelle, S., von Brandis, P., Eikeland, T., Flo, K., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0853 · Cited by 315 · see citing works
Risk of adverse pregnancy outcomes in women with polycystic ovary syndrome: population based cohort study
Roos, N., Kieler, H., Sahlin, L., Ekman-Ordeberg, G. E., Falconer, H., & Stephansson, O. (2011) · BMJ · doi:10.1136/bmj.d6309 · Cited by 315 · see citing works
Molecular Abnormalities in Oocytes from Women with Polycystic Ovary Syndrome Revealed by Microarray Analysis
Wood, J. R., Dumesic, D. A., Abbott, D. H., & Strauss, J. F. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2123 · Cited by 307 · see citing works
Development of polycystic ovary syndrome: involvement of genetic and environmental factors
Franks, S., McCarthy, M. I., & Hardy, K. (2005) · International Journal of Andrology · doi:10.1111/j.1365-2605.2005.00623.x · Cited by 304 · see citing works
Pregnancy outcomes in women with polycystic ovary syndrome: a metaanalysis
Kjerulff, L. E., Sanchez‐Ramos, L., & Duffy, D. A. (2011) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2011.03.021 · Cited by 299 · see citing works
Polycystic ovarian syndrome: Pathophysiology, molecular aspects and clinical implications
Diamanti-Kandarakis, E. (2008) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399408000598 · Cited by 294 · see citing works
Lifestyle changes in women with polycystic ovary syndrome
Moran, L. J., Hutchison, S. K., Norman, R. J., & Teede, H. J. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007506.pub3 · Cited by 292 · see citing works
Short-term and long-term sequelae in intrauterine growth retardation (IUGR)
Longo, S., Bollani, L., Decembrino, L., Comite, A. D., Angelini, M., & Stronati, M. (2012) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2012.715006 · Cited by 288 · see citing works
Identifying Children at Risk for Polycystic Ovary Syndrome
Rosenfield, R. L. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2012 · Cited by 288 · see citing works
Complications and challenges associated with polycystic ovary syndrome: current perspectives
Palomba, S., Santagni, S., Falbo, A., & La Sala, G. B. (2015) · International Journal of Women's Health · doi:10.2147/ijwh.s70314 · Cited by 287 · see citing works
A nomogram to predict the probability of live birth after clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility
Imani, B., Eijkemans, M. J. C., te Velde, E. R., Habbema, J. D. F., & Fauser, B. C. J. M. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02929-6 · Cited by 262 · see citing works
Treatment of infertility in women with polycystic ovary syndrome: approach to clinical practice
de Melo, A. S., Ferriani, R. A., & Navarro, P. A. (2015) · Clinics · doi:10.6061/clinics/2015(11)09 · Cited by 257 · see citing works
Metformin and lifestyle modification in polycystic ovary syndrome: systematic review and meta-analysis
Naderpoor, N., Shorakae, S., de Courten, B. V., Misso, M. L., Moran, L., & Teede, H. J. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmv063 · Cited by 256 · see citing works
Prevalence of non alcoholic fatty liver disease in premenopausal, posmenopausal and polycystic ovary syndrome women. The role of estrogens
Gutiérrez-Grobe, Y., Ponciano‐Rodríguez, G., Ramos, M. H., Uribe, M., & Méndez‐Sánchez, N. (2010) · Annals of Hepatology · doi:10.1016/s1665-2681(19)31616-3 · Cited by 246 · see citing works
Emotional distress is a common risk in women with polycystic ovary syndrome: a systematic review and meta-analysis of 28 studies
Veltman-Verhulst, S. M., Boivin, J., Eijkemans, M. J. C., & Fauser, B. J. C. M. (2012) · Human Reproduction Update · doi:10.1093/humupd/dms029 · Cited by 215 · see citing works
The Outcome of 150 Babies Following the Treatment With Letrozole or Letrozole and Gonadotropins
Biljan, M. M., Hemmings, R., & Brassard, N. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.07.230 · Cited by 206 · cited 1× · see citing works
“A potential risk of teratogenic effects of letrozole was suggested in a preliminary report [80], but subsequent studies have discarded them [78].”
Background
The Polycystic Ovary Post-Rotterdam: A Common, Age-Dependent Finding in Ovulatory Women without Metabolic Significance
Johnstone, E. B., Rosen, M. P., Neril, R., Trevithick, D., Sternfeld, B., Murphy, R. C., Addauan-Andersen, C., McConnell, D. S., Pera, R. A. R., & Cedars, M. I. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0202 · Cited by 200 · see citing works
Oligoanovulation with Polycystic Ovaries But Not Overt Hyperandrogenism
Dewailly, D., Catteau-Jonard, S., Reyss, A.-C., Leroy, M., & Pigny, P. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1054 · Cited by 198 · see citing works
Endometrial gene expression in the window of implantation is altered in obese women especially in association with polycystic ovary syndrome
Bellver, J., Martínez-Conejero, J. A., Labarta, E., Alamá, P., de Melo, M. A. B., Remohi, J. A., Pellicer, A., & Horcajadas, J. A. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.03.021 · Cited by 196 · see citing works
Self-citation
Clomiphene and anti-oestrogens for ovulation induction in PCOS
Brown, J., Farquhar, C. M., Beck, J., Boothroyd, C. V., & Hughes, E. G. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002249.pub4 · Cited by 193 · see citing works
Polycystic ovary syndrome and environmental toxins
Rutkowska, A. Z., & Diamanti‐Kandarakis, E. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.08.031 · Cited by 191 · see citing works
Lifestyle Modification Programs in Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis
Domecq, J. P., Prutsky, G., Mullan, R. J., Hazem, A., Sundaresh, V., Elamin, M. B., Phung, O. J., Wang, A., Hoeger, K., Pasquali, R., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2385 · Cited by 184 · see citing works
Serum testosterone levels decrease in middle age in women with the polycystic ovary syndrome
Winters, S. J., Talbott, E. O., Guzick, D. S., Zborowski, J. V., & McHugh-Pemu, K. P. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00641-x · Cited by 182 · see citing works
Diagnosing and preventing inherited disease: The use of first polar bodies for preimplantation diagnosis of aneuploidy
Munné, S., Dailey, T., Sultan, K., GRIFO, J. A., & Cohen, J. (1995) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a136027 · Cited by 164 · see citing works
Hormonal alterations in PCOS and its influence on bone metabolism
Krishnan, A., & Muthusami, S. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0405 · Cited by 160 · see citing works
Polycystic ovary syndrome, adipose tissue and metabolic syndrome
Delitala, A. P., Capobianco, G., Delitala, G., Cherchi, P. L., & Dessole, S. (2017) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-017-4429-2 · Cited by 159 · see citing works
Premature adrenarche: novel lessons from early onset androgen excess
Idkowiak, J., Lavery, G. G., Dhir, V., Barrett, T. G., Stewart, P. M., Krone, N., & Arlt, W. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0223 · Cited by 158 · see citing works
Environmental determinants of polycystic ovary syndrome
Merkin, S. S., Phy, J. L., Sites, C. K., & Yang, D. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.05.011 · Cited by 158 · see citing works
Reconciling the Definitions of Polycystic Ovary Syndrome: The Ovarian Follicle Number and Serum Anti-Müllerian Hormone Concentrations Aggregate with the Markers of Hyperandrogenism
Dewailly, D., Pigny, P., Soudan, B., Catteau-Jonard, S., Decanter, C., Poncelet, É., & Duhamel, A. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0334 · Cited by 155 · see citing works
Gestational Diabetes and Type 2 Diabetes in Reproductive-Aged Women With Polycystic Ovary Syndrome
Joham, A. E., Ranasinha, S., Zoungas, S., Moran, L., & Teede, H. J. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2007 · Cited by 150 · see citing works
Lifecycle of polycystic ovary syndrome (PCOS): from in utero to menopause
Welt, C. K., & Carmina, E. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2375 · Cited by 148 · see citing works
Polycystic Ovary Syndrome in Adolescence
Buggs, C., & Rosenfield, R. L. (2005) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2005.04.005 · Cited by 143 · see citing works
Increased risk of preterm delivery and pre‐eclampsia in women with polycystic ovary syndrome and hyperandrogenaemia
Naver, K. V., Grinsted, J., Larsen, S. O., Hedley, P. L., Jørgensen, F. S., Christiansen, M., & Nilas, L. (2014) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.12558 · Cited by 141 · see citing works
The phenotype of polycystic ovary syndrome ameliorates with aging
Brown, Z. A., Louwers, Y. V., Fong, S. L., Valkenburg, O., Birnie, E., de Jong, F. H., Fauser, B. C. J. M., & Laven, J. S. E. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.09.002 · Cited by 139 · see citing works
Treatment strategies for women with WHO group II anovulation: systematic review and network meta-analysis
Wang, R., Kim, B. V., van Wely, M., JOHNSON, N. P., Costello, M., Zhang, H., Ng, E. H. Y., Legro, R. S., Bhattacharya, S., Norman, R. J., et al. (2017) · BMJ · doi:10.1136/bmj.j138 · Cited by 132 · see citing works
The serine phosphorylation hypothesis of polycystic ovary syndrome: a unifying mechanism for hyperandrogenemia and insulin resistance
Bremer, A. A., & Miller, W. L. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.02.091 · Cited by 131 · see citing works
The pathogenesis of infertility and early pregnancy loss in polycystic ovary syndrome
van der Spuy, Z. M., & Dyer, S. (2004) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2004.06.001 · Cited by 127 · see citing works
Impaired Glucose Tolerance in Pregnant Women With Polycystic Ovary Syndrome
RADON, P. A., MCMAHON, M. J., & MEYER, W. R. (1999) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(99)00252-5 · Cited by 123 · see citing works
Early Metformin Therapy (Age 8–12 Years) in Girls with Precocious Pubarche to Reduce Hirsutism, Androgen Excess, and Oligomenorrhea in Adolescence
Ibáñez, L., López-Bermejo, A., Díaz, M., Marcos, M. V., & de Zegher, F. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0555 · Cited by 123 · see citing works
An assessment of lifestyle modification versus medical treatment with clomiphene citrate, metformin, and clomiphene citrate–metformin in patients with polycystic ovary syndrome
Karimzadeh, M. A., & Javedani, M. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.02.078 · Cited by 118 · see citing works
The use of first polar bodies for preimplantation diagnosis of aneuploidy
Munné, S., Dailey, T., Sultan, K., GRIFO, J. A., & Cohen, J. (1995) · Molecular Human Reproduction · doi:10.1093/molehr/1.2.94 · Cited by 118 · see citing works
Consensus on infertility treatment related to polycystic ovary syndrome.
Hong, K. (2008) · Human Reproduction · doi:10.1093/humrep/dem426 · Cited by 117 · see citing works
Reproductive hormone levels and anthropometry in postmenopausal women with polycystic ovary syndrome (PCOS): A 21-year follow-up study of women diagnosed with PCOS around 50 years ago and their age-matched controls
Schmidt, J., Brännström, M., Landin-Wilhelmsen, K., & Dahlgren, E. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2959 · Cited by 113 · see citing works
Clinical spectrum of premature pubarche: Links to metabolic syndrome and ovarian hyperandrogenism
Ibáñez, L., Díaz, R., López-Bermejo, A., & Marcos, M. V. (2009) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-008-9096-y · Cited by 106 · see citing works
Diagnostic criteria for PCOS: Is there a need for a rethink?
Dewailly, D. (2016) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2016.03.009 · Cited by 103 · see citing works
Polycystic ovary syndrome
Ruutiainen, K., & Seppälä, M. T. (1991) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/00001703-199106000-00004 · Cited by 99 · see citing works
Pathogenesis of polycystic ovary syndrome: multifactorial assessment from the foetal stage to menopause
de Melo, A. S., Dias, S. V., Cavalli, R. D. C., Cardoso, V. C., Bettiol, H., Barbieri, M. A., Ferriani, R. A., & Vieira, C. S. (2015) · Reproduction · doi:10.1530/rep-14-0499 · Cited by 99 · see citing works
Adolescent girls with polycystic ovary syndrome showing different phenotypes have a different metabolic profile associated with increasing androgen levels
Fruzzetti, F., Perini, D., Lazzarini, V., Parrini, D., & Genazzani, A. R. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.06.004 · Cited by 95 · see citing works
Pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization
Sterling, L., Liu, J., Okun, N. B., Sakhuja, A., Sierra, S., & Greenblatt, E. M. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.11.019 · Cited by 89 · see citing works
Lack of association between polycystic ovary syndrome and embryonic aneuploidy
Weghofer, A., Munné, S., Chen, S., Barad, D. H., & Gleicher, N. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.12.018 · Cited by 86 · see citing works
Vitamin D and aspects of female fertility
Voulgaris, N., Papanastasiou, L., Piaditis, G. P., Angelousi, A. G., Kaltsas, G., Mastorakos, G. P., & Kassi, E. N. (2017) · HORMONES · doi:10.14310/horm.2002.1715 · Cited by 86 · see citing works
Polycystic ovaries after precocious pubarche: relation to prenatal growth
Ibáñez, L., Jaramillo, A., Enríquez, G., Miró, E., López‐Bermejo, A., Dunger, D. B., & de Zegher, F. (2006) · Human Reproduction · doi:10.1093/humrep/del395 · Cited by 84 · see citing works
Low-Grade Chronic Inflammation in Pregnant Women With Polycystic Ovary Syndrome: A Prospective Controlled Clinical Study
Palomba, S., Falbo, A. I., Chiossi, G., Orio, F., Tolino, A., Colao, A., Sala, G. B. L., & Zullo, F. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1214 · Cited by 83 · see citing works
Ovulation induction in perspective
Homburg, R. (2002) · Human Reproduction Update · doi:10.1093/humupd/8.5.449 · Cited by 83 · see citing works
Contraception use and pregnancy outcomes in women with polycystic ovary syndrome: data from the Australian Longitudinal Study on Women's Health
Joham, A. E., Boyle, J. A., Ranasinha, S., Zoungas, S., & Teede, H. J. (2014) · Human Reproduction · doi:10.1093/humrep/deu020 · Cited by 82 · see citing works
Epidemiology and Comorbidities of Polycystic Ovary Syndrome in an Indigent Population
Sirmans, S. M., Parish, R. C., Blake, S., & Wang, X. (2014) · Journal of Investigative Medicine · doi:10.1097/01.jim.0000446834.90599.5d · Cited by 79 · see citing works
Elective Single Embryo Transfer: an update to UK Best Practice Guidelines
Harbottle, S. J., Hughes, C., Cutting, R., Roberts, S. A., Brison, D. R., & On Behalf Of The Association Of Clinical Embryologists & The (ACE) British Fertility Society (BFS) (2015) · Human Fertility · doi:10.3109/14647273.2015.1083144 · Cited by 78 · see citing works
Placental STAT3 signaling is activated in women with polycystic ovary syndrome
Maliqueo, M. A., Poromaa, I. S., Vanky, E., Fornes, R., Benrick, A., Åkerud, H., Stridsklev, S., Labrie, F., Jansson, T., & Stener‐Victorin, E. (2015) · Human Reproduction · doi:10.1093/humrep/deu351 · Cited by 77 · see citing works
Maternal and neonatal outcomes in pregnant women with PCOS: comparison of different diagnostic definitions
Kollmann, M., Klaritsch, P., Martins, W. P., Guenther, F., Schneider, V., Herzog, S. A., Craciunas, L., Lang, U. E., Obermayer-Pietsch, B. M., Lerchbaum, E., et al. (2015) · Human Reproduction · doi:10.1093/humrep/dev187 · Cited by 77 · see citing works
Oocyte euploidy, pronuclear zygote morphology and embryo chromosomal complement
Gianaroli, L., Magli, M. C., Ferraretti, A. P., Lappi, M., Borghi, E., & Ermini, B. (2006) · Human Reproduction · doi:10.1093/humrep/del334 · Cited by 76 · see citing works
Cumulative live-birth rate in women with polycystic ovary syndrome or isolated polycystic ovaries undergoing in-vitro fertilisation treatment
Li, R., Lee, V. C. Y., Lau, E. Y. L., Yeung, W. S. B., Ho, P. C., & Ng, E. H. Y. (2013) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-013-0151-6 · Cited by 71 · see citing works
Comparison of oocyte quality and intracytoplasmic sperm injection outcome in women with isolated polycystic ovaries or polycystic ovarian syndrome
Sahu, B., Öztürk, Ö., Ranieri, M., & Serhal, P. F. (2007) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-007-0462-x · Cited by 71 · see citing works
Early metformin therapy to delay menarche and augment height in girls with precocious pubarche
Ibáñez, L., López‐Bermejo, A., Díaz, M., Marcos, M. V., & de Zegher, F. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.08.052 · Cited by 66 · see citing works
Interventions for hirsutism (excluding laser and photoepilation therapy alone)
van Zuuren, E. J., Fedorowicz, Z., Carter, B., & Pandis, N. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010334.pub2 · Cited by 65 · see citing works
Combined Lifestyle Modification and Metformin in Obese Patients with Polycystic Ovary Syndrome: A Randomized, Placebo-controlled, Double-blind Multicentre Study
Tang, T. H., Glanville, J., Hayden, C. J., White, D. M., Barth, J. H., & Balen, A. H. (2006) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000197800.07214.dc · Cited by 65 · see citing works
Effects of polycystic ovarian syndrome on in vitro fertilization–embryo transfer outcomes are influenced by body mass index
McCormick, B. A., Thomas, M. A., Maxwell, R. A., Williams, D. B., & Aubuchon, M. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.10.077 · Cited by 65 · see citing works
Aromatase Inhibitors for Ovulation Induction
Palomba, S. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-4235 · Cited by 64 · see citing works
Adverse pregnancy outcomes with assisted reproductive technology in non-obese women with polycystic ovary syndrome: a case-control study
Han, A. R., Kim, H. O., Cha, S. W., Park, C. W., Kim, J. Y., Yang, K. M., Song, I. O., Koong, M. K., & Kang, I. S. (2011) · Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine · doi:10.5653/cerm.2011.38.2.103 · Cited by 63 · see citing works
Is a GnRH Antagonist Protocol Better in PCOS Patients? A Meta-Analysis of RCTs
Lin, H., Li, Y., Lin, L., Wang, W., Yang, D., & Zhang, Q. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091796 · Cited by 62 · see citing works
Avoiding ovarian hyperstimulation syndrome with the use of gonadotropin-releasing hormone agonist trigger
Fatemi, H. M., & García-Velasco, J. A. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.02.004 · Cited by 62 · see citing works
Self-citation
Monitoring plasma concentrations to individualize treatment with clomiphene citrate
Rostami‐Hodjegan, A., Lennard, M. S., Tucker, G. T., & Ledger, W. J. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.07.044 · Cited by 57 · see citing works
Defining the role of bariatric surgery in polycystic ovarian syndrome patients
Malik, S. M. (2012) · World Journal of Diabetes · doi:10.4239/wjd.v3.i4.71 · Cited by 56 · see citing works
Endocrine evaluation of hirsutism
Mihailidis, J., Dermesropian, R., Taxel, P., Luthra, P., & Grant-Kels, J. M. (2017) · International Journal of Women’s Dermatology · doi:10.1016/j.ijwd.2017.02.007 · Cited by 53 · see citing works
Sonographic evaluation of polycystic ovaries
Zhu, R., Wong, Y. C., & Yong, E. (2016) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2016.02.005 · Cited by 53 · see citing works
Efficacy of metformin on pregnancy complications in women with polycystic ovary syndrome: a meta-analysis
Feng, L., Lin, X.-F., Wan, Z.-H., Hu, D., & Du, Y.-K. (2015) · Gynecological Endocrinology · doi:10.3109/09513590.2015.1041906 · Cited by 50 · see citing works
Metabolic profile in women with polycystic ovary syndrome across adult life
Echiburú, B., Crisosto, N., Maliqueo, M. A., Pérez‐Bravo, F., de Guevara, A. L., Hernández, P., Cavada, G., Rivas, C., Clavel, A., & Sir‐Petermann, T. (2016) · Metabolism · doi:10.1016/j.metabol.2016.01.006 · Cited by 50 · see citing works
Polycystic ovarian syndrome: clinical and biological diagnosis
Bachelot, A. (2016) · Annales de biologie clinique · doi:10.1684/abc.2016.1184 · Cited by 49 · see citing works
Mono-ovulation in women with polycystic ovary syndrome: a clinical review on ovulation induction
Petersen, K. B., Pedersen, N. G., Pedersen, A. T., Lauritsen, M. P., & Freiesleben, N. L. C. (2016) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2016.03.006 · Cited by 48 · see citing works
Adolescent Oligomenorrhea (Age 14–19) Tracks Into the Third Decade of Life (Age 20–28) and Predicts Increased Cardiovascular Risk Factors and Metabolic Syndrome
Glueck, C. J., Woo, J. G., Khoury, P. R., Morrison, J. A., Daniels, S. R., & Wang, P. (2015) · Metabolism · doi:10.1016/j.metabol.2015.01.005 · Cited by 44 · see citing works
Gonadotrophins for ovulation induction in women with polycystic ovarian syndrome
Weiss, N. S., Nahuis, M. J., Bayram, N., Mol, B. W., van der Veen, F., & van Wely, M. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010290.pub2 · Cited by 44 · see citing works
Agonist trigger: what is the best approach? Agonist trigger with vitrification of oocytes or embryos
García-Velasco, J. A. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.12.010 · Cited by 43 · see citing works
Self-citation
Polycystic ovaries and eating disorders: are they related?
Michelmore, K. F., Balen, A. H., & Dunger, D. B. (2001) · Human Reproduction · doi:10.1093/humrep/16.4.765 · Cited by 42 · see citing works
Low aneuploidy rate in early pregnancy loss abortuses from patients with polycystic ovary syndrome
Wang, Q., Luo, L., Lei, Q., Lin, M., Huang, X., Chen, M.-H., Zeng, Y., & Zhou, C. (2016) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2016.04.006 · Cited by 42 · see citing works
Pregnancy and perinatal outcomes in women with polycystic ovary syndrome and twin births: a population‐based cohort study
Løvvik, T. S., Wikström, A., Neovius, M., Stephansson, O., Roos, N., & Vanky, E. (2015) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.13339 · Cited by 41 · see citing works
Ovulation induction with a starting dose of 50 IU of recombinant follicle stimulating hormone in WHO group II anovulatory women: the IO-50 study, a prospective, observational, multicentre, open trial
Calaf, J., Ruiz-Balda, J. A., Sarrió, A. R., Fernández, V., Trigo, I. C., Parga, J. L. G., Batres, C. G., & Escudero, F. (2003) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2003.02290.x · Cited by 41 · see citing works
Dietary intervention versus metformin to improve the reproductive outcome in women with polycystic ovary syndrome. A prospective comparative study
Qublan, H. S., Yannakoula, E. K., Al-Qudah, M. A., & El-Uri, F. I. (2007) · Saudi Medical Journal · doi:10.15537/1658-3175.4126 · Cited by 40 · see citing works
Ovarian Drilling in PCOS: Is it Really Useful?
Lebbi, I., Temime, R. B., Fadhlaoui, A., & Féki, A. (2015) · Frontiers in Surgery · doi:10.3389/fsurg.2015.00030 · Cited by 39 · see citing works
Features of Polycystic Ovary Syndrome in adolescence.
Tsikouras, P. N., Liatsikos, S. A., Manav, B., Zervoudis, S., Poiană, C., Nikolaos, T. P., Petros, P., Dimitraki, M., Koukouli, C., Galazios, G. C., et al. (2015) · Europe PMC (PubMed Central) · Cited by 36 · see citing works
Chronic ultra-low dose follicle-stimulating hormone regimen for patients with polycystic ovary syndrome: one click, one follicle, one pregnancy
Orvieto, R., & Homburg, R. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.09.009 · Cited by 32 · see citing works
Ovarian volume in normal and hyperandrogenic adolescent women
Fruzzetti, F., Campagna, A. M., Perini, D., & Carmina, E. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.03.026 · Cited by 31 · see citing works
Low‐dose pioglitazone and low‐dose flutamide added to metformin and oestro‐progestagens for hyperinsulinaemic women with androgen excess: add‐on benefits disclosed by a randomized double‐placebo study over 24 months
Ibáñez, L., López‐Bermejo, A., Díaz, M., Enríquez, G., del Río, L., & de Zegher, F. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03472.x · Cited by 31 · see citing works
A systematic review and meta-analysis of metformin among patients with polycystic ovary syndrome undergoing assisted reproductive technology procedures
Huang, X., Wang, P., Tal, R., Lv, F., Li, Y., & Zhang, X. (2015) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2015.04.046 · Cited by 29 · see citing works
Primary Amenorrhea
Marsh, C. A., & Grimstad, F. W. (2014) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000000111 · Cited by 25 · see citing works
Low-dose flutamide for hirsutism: into the limelight, at last
de Zegher, F., & Ibáñez, L. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.119 · Cited by 23 · see citing works
Comparison ofin vitrofertilisation success in patients with polycystic ovary syndrome and tubal factor
Nejad, E. S. T., Saedi, T., Saedi, S., Rashidi, B. H., Nekoo, Z. A., & Jahangiri, N. (2010) · Gynecological Endocrinology · doi:10.3109/09513590.2010.501872 · Cited by 22 · see citing works
Phosphodiesterases in the rat ovary: effect of cAMP in primordial follicles
Petersen, T. S., Stahlhut, M., & Andersen, C. Y. (2015) · Reproduction · doi:10.1530/rep-14-0436 · Cited by 19 · see citing works
Comparison of two contraceptive pills containing drospirenone and 20 μg or 30 μg ethinyl estradiol for polycystic ovary syndrome *
Bhattacharya, S. M., Jha, A., & DasMukhopadhyay, L. (2015) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2015.06.065 · Cited by 19 · see citing works
How to recognize PCOS: results of a web-based survey at IVF-worldwide.com
Ning, N., Balen, A. H., Brezina, P. R., Leong, M. K. H., Shoham, Z., Wallach, E. E., & Zhao, Y. (2013) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2013.01.009 · Cited by 18 · see citing works
Drilling: medical indications and surgical technique
Hueb, C. K., Júnior, J. A. D. D., Abrão, M. S., & Filho, E. K. (2015) · Revista da Associação Médica Brasileira · doi:10.1590/1806-9282.61.06.530 · Cited by 15 · see citing works
Multiple Pregnancy after Gonadotropin-Intrauterine Insemination: An Unavoidable Event?
Fong, S. A., Palta, V., Oh, C., Cho, M. M., Loughlin, J. S., & McGovern, P. G. (2011) · ISRN Obstetrics and Gynecology · doi:10.5402/2011/465483 · Cited by 9 · see citing works
Digital womens health based on wearables and big data
Stein, P., Falco, L., Kuebler, F., Annaheim, S., Lemkaddem, A., Delgado-Gonzalo, R., Verjus, C., & Leeners, B. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.07.339 · Cited by 7 · see citing works
Controlled ovarian hyperstimulation in women with polycystic ovarian syndrome with or without intrauterine insemination
Wiser, A., Shalom‐Paz, E., Reinblatt, S. L., Holzer, H. E. G., & Tulandi, T. (2011) · Gynecological Endocrinology · doi:10.3109/09513590.2011.634938 · Cited by 6 · see citing works
Committee Opinion No. 663 Summary
(2016) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000001478 · Cited by 5 · see citing works
Choices in the treatment of anovulatory polycystic ovary syndrome
Homburg, R. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9781107478343.014 · Cited by 1 · see citing works

Flagged first, then by citations

2 of the 146 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

Wood JR, Dumesic DA, Abbott DH, Strauss JF III. Molecular abnormalities inoocytes from women with polycystic ovary syn- drome revealed by microarray analysis. J Clin Endocrinol Metab. 2007;92:705-13.
Nejad ES, Saedi T, Saedi S, Rashidi BH, Nekoo ZA, Jahangiri N. Comparison of in vitro fertilisation success in patients with poly- cystic ovary syndrome and tubal factor. Gynecol Endocrinol. 2011;27:117-20.

Sorted by citations

Recent advances in the understanding and management of polycystic ovary syndrome
Rocha, A. L., Oliveira, F. R., Azevedo, R. C., Silva, V. A., Peres, T. M., Candido, A. L., Gomes, K. B., & Reis, F. M. (2019) · F1000Research · doi:10.12688/f1000research.15318.1 · Cited by 142 · see citing works
“Intrauterine growth retardation or small for gestational age (or both) and high levels of androgens during the intrauterine period could lead to an increased production of glucocorticoids which may induce epigenetic modifications and increase the risk of PCOS 35 .”
Background
Natural Molecules in the Management of Polycystic Ovary Syndrome (PCOS): An Analytical Review
Iervolino, M., Lepore, E., Forte, G., Laganà, A. S., Buzzaccarini, G., & Unfer, V. (2021) · Nutrients · doi:10.3390/nu13051677 · Cited by 98 · see citing works
“Therefore, administration of omega-3 fatty acids should be specific only for PCOS women who already exhibit inflammatory and cardiovascular-related symptoms, which usually occur between 40 and 45 years of age [94,95].”
Background
Risk of Cardiovascular and Cerebrovascular Events in Polycystic Ovarian Syndrome Women: A Meta-Analysis of Cohort Studies
Zhang, J., Xu, J., Qu, Q.-Q., & Zhong, G.-Q. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.552421 · Cited by 97 · see citing works
“Moreover, PCOS patient’s metabolic disturbances also cause hypertension that mainly changes vascular function as caused by hyperinsulinemia (43).”
Background
Polycystic ovarian syndrome: Environmental/occupational, lifestyle factors; an overview
Kshetrimayum, C., Sharma, A., Mishra, V. V., & Kumar, S. (2019) · Journal of the Turkish-German Gynecological Association · doi:10.4274/jtgga.galenos.2019.2018.0142 · Cited by 93 · see citing works
Ovarian aging in humans: potential strategies for extending reproductive lifespan
Cavalcante, M. B., Sampaio, O. G. M., Câmara, F. E. A., Schneider, A., Ávila, B. M., Prosczek, J. B., Masternak, M. M., & Campos, A. R. (2023) · GeroScience · doi:10.1007/s11357-023-00768-8 · Cited by 96 · see citing works
Vitamin D and aspects of female fertility
Voulgaris, N., Papanastasiou, L., Piaditis, G. P., Angelousi, A. G., Kaltsas, G., Mastorakos, G. P., & Kassi, E. N. (2017) · HORMONES · doi:10.14310/horm.2002.1715 · Cited by 86 · see citing works
An update of polycystic ovary syndrome: causes and therapeutics options
Rababa’h, A. M., Matani, B. R., & Yehya, A. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e11010 · Cited by 73 · see citing works
Serum bisphenol A concentrations correlate with serum testosterone levels in women with polycystic ovary syndrome
Konieczna, A., Rachoń, D., Owczarek, K., Kubica, P., Kowalewska, A., Kudłak, B., Wasik, A., & Namieśnik, J. (2018) · Reproductive Toxicology · doi:10.1016/j.reprotox.2018.09.006 · Cited by 70 · see citing works
“Not only is the diagnosis of PCOS still debatable, but also its pathogenesis; hence, together with the genetic and metabolic predispositions [12, 13], environmental factors, such as endocrine disrupting chemicals (EDCs), may contribute to its development [14, 15].”
Background
Developmental programming of the female reproductive system—a review
Yao, S., López‐Tello, J., & Sferruzzi-Perri, A. N. (2020) · Biology of Reproduction · doi:10.1093/biolre/ioaa232 · Cited by 72 · see citing works
Cardio-Metabolic Disease and Polycystic Ovarian Syndrome (PCOS): A Narrative Review
Sangaraju, S. L., Yepez, D., Grandes, X. A., Manjunatha, R. T., & Habib, S. (2022) · Cureus · doi:10.7759/cureus.25076 · Cited by 71 · see citing works
“PCOS is a disorder that can affect females right from their fetal life up until their death, with several complications in between, that affect their mortality and morbidity as well as decrease their quality of life [12].”
Background
Challenges in diagnosis and health care in polycystic ovary syndrome in Canada: a patient view to improve health care
Sydora, B. C., Wilke, M. S., McPherson, M., Chambers, S., Ghosh, M., & Vine, D. F. (2023) · BMC Women's Health · doi:10.1186/s12905-023-02732-2 · Cited by 60 · see citing works
“” educate/train clinicians 35 [25.5] ◦ “More doctors need to know about PCOS!”
BackgroundInfluential
Anti-Müllerian hormone (AMH) in the Diagnosis of Menstrual Disturbance Due to Polycystic Ovarian Syndrome
Abbara, A., Eng, P. C., Phylactou, M., Clarke, S. A., Hunjan, T., Roberts, R. E., Vimalesvaran, S., Christopoulos, G., Islam, R., Purugganan, K., et al. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00656 · Cited by 61 · see citing works
Comparative Analysis of Lower Genital Tract Microbiome Between PCOS and Healthy Women
Tu, Y., Zheng, G., Ding, G., Wu, Y., Xi, J., Ge, Y., Gu, H., Wang, Y., Sheng, J., Liu, X., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.01108 · Cited by 57 · see citing works
“PCOS is becoming the most common cause of sterility in reproductive-aged women (Wang et al., 2015; Bellver et al., 2018; Patel, 2018).”
Background
Psychiatric Disorders, Self-Esteem, and Quality of Life in Adolescents with Polycystic Ovary Syndrome
Çoban, Ö. G., Tulacı, Ö. D., Adanır, A. S., & Önder, A. (2019) · Journal of Pediatric and Adolescent Gynecology · doi:10.1016/j.jpag.2019.07.008 · Cited by 54 · see citing works
The evolutionary biology of endometriosis
Dinsdale, N., Nepomnaschy, P., & Crespi, B. (2021) · Evolution, Medicine, and Public Health · doi:10.1093/emph/eoab008 · Cited by 53 · see citing works
Pregnancy outcomes in women with polycystic ovarian syndrome
D’Alterio, M. N., Sigilli, M., Succu, A. G., GHISU, V., Laganà, A. S., Sorrentino, F., Nappi, L., Tinelli, R., & Angioni, S. L. (2021) · Minerva Obstetrics and Gynecology · doi:10.23736/s2724-606x.21.04758-4 · Cited by 49 · see citing works
Prevalence and Etiology of Eating Disorders in Polycystic Ovary Syndrome: A Scoping Review
Lalonde-Bester, S., Malik, M., Masoumi, R., Ng, K., Sidhu, S., Ghosh, M., & Vine, D. F. (2024) · Advances in Nutrition · doi:10.1016/j.advnut.2024.100193 · Cited by 50 · see citing works
“Androgens are considered orexigenic, stimulating appetite, disrupting impulse control, and have been associated with binge eating behaviors in those with PCOS [66,67, 97,125,131,132].”
Background
Micronuclei and disease – Report of HUMN project workshop at Rennes 2019 EEMGS conference
Fenech, M. F., Holland, N., Kirsch‐Volders, M., Knudsen, L. E., Wagner, K., Stopper, H., Knasmüller, S., Bolognesi, C., El‐Zein, R. A., & Bonassi, S. (2020) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2020.503133 · Cited by 45 · see citing works
Polycystic Ovary Syndrome in Adolescence
Deans, R. (2019) · Medical Sciences · doi:10.3390/medsci7100101 · Cited by 44 · see citing works
Optimized polycystic ovarian disease prognosis and classification using AI based computational approaches on multi-modality data
Shanmugavadivel, K., S, M. D. M., Mahesh, T. R., Al‐Shehari, T., Alsadhan, N. A., & Yimer, T. E. (2024) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-024-02688-9 · Cited by 44 · see citing works
“Not everyone can afford to get tested or scanned [13].”
Background
Low aneuploidy rate in early pregnancy loss abortuses from patients with polycystic ovary syndrome
Wang, Q., Luo, L., Lei, Q., Lin, M., Huang, X., Chen, M.-H., Zeng, Y., & Zhou, C. (2016) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2016.04.006 · Cited by 42 · see citing works
Efficacy of electroacupuncture in regulating the imbalance of AMH and FSH to improve follicle development and hyperandrogenism in PCOS rats
Shi, Y., Li, L., Zhou, J., Sun, J., Chen, L., Zhao, J., Wu, L., Cui, Y., Wu, L., & Wu, H. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108687 · Cited by 41 · see citing works
Combination therapy of curcumin and fecal microbiota transplant: Potential treatment of polycystic ovarian syndrome
Corrie, L., Gulati, M., Vishwas, S., Kapoor, B., Singh, S. K., Awasthi, A., & Khursheed, R. (2021) · Medical Hypotheses · doi:10.1016/j.mehy.2021.110644 · Cited by 40 · see citing works
A landscape analysis of the potential role of polyphenols for the treatment of Polycystic Ovarian Syndrome (PCOS)
Rani, R., Hajam, Y. A., Kumar, R., Bhat, R. A., Rai, S., & Rather, M. A. (2021) · Phytomedicine Plus · doi:10.1016/j.phyplu.2021.100161 · Cited by 43 · see citing works
<p>Binge eating in patients with polycystic ovary syndrome: prevalence, causes, and management strategies</p>
Krug, I., Giles, S., & Paganini, C. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s168944 · Cited by 50 · see citing works
“Diagnostic overshadowing of PCOS symptoms may also impede a reliable diagnosis, and concealment and shame of disordered eating symptoms, or the health care professionals’ dearth of knowledge and skill sets in identifying and treating ED symptoms may also contribute to variable prevalence estimates.(17,59)”
Background
Should anti-Müllerian hormone be a diagnosis criterion for polycystic ovary syndrome? An in-depth review of pros and cons
Vale-Fernandes, E., Pignatelli, D., & Monteiro, M. P. (2025) · European Journal of Endocrinology · doi:10.1093/ejendo/lvaf062 · Cited by 38 · see citing works
Catechins from oolong tea improve uterine defects by inhibiting STAT3 signaling in polycystic ovary syndrome mice
Hong, G., Wu, H., Ma, S., & Su, Z. (2020) · Chinese Medicine · doi:10.1186/s13020-020-00405-y · Cited by 38 · see citing works
Is polycystic ovary syndrome associated with risk of female sexual dysfunction? A systematic review and meta-analysis
Zhao, S., Wang, J., Xie, Q., Luo, L., Zhu, Z., Liu, Y., Luo, J., & Zhao, Z. (2019) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2018.11.030 · Cited by 36 · see citing works
Dietary Patterns and Polycystic Ovary Syndrome: a Systematic Review
XENOU, M., & Gourounti, K. (2021) · MAEDICA – a Journal of Clinical Medicine · doi:10.26574/maedica.2020.16.3.516 · Cited by 36 · see citing works
The Global Burden of Polycystic Ovary Syndrome in Women of Reproductive Age: Findings from the GBD 2019 Study
Jiang, B. (2025) · International Journal of Women s Health · doi:10.2147/ijwh.s490836 · Cited by 35 · see citing works
An update on PCOS in adolescents
Fitzgerald, S., DiVasta, A. D., & Gooding, H. C. (2018) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000636 · Cited by 30 · see citing works
Role of Artificial Intelligence in PCOS Detection
Agrawal, A., Ambad, R., Lahoti, R., Muley, P. A., & Pande, P. S. (2022) · Journal of Datta Meghe Institute of Medical Sciences University · doi:10.4103/jdmimsu.jdmimsu_278_22 · Cited by 30 · see citing works
Effects of Nutrition on Metabolic and Endocrine Outcomes in Women with Polycystic Ovary Syndrome: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials
Moslehi, N., Zeraattalab-Motlagh, S., Rahimi Sakak, F., Shab-Bidar, S., Tehrani, F. R., & Mirmiran, P. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuac075 · Cited by 28 · see citing works
Serum chemerin level in women with PCOS and its relation with the risk of spontaneous abortion
Yang, X., Quan, X., Lan, Y., Wei, Q., Ye, J., Yin, X., Ji, Z., Xing, H., & Yang, Y. (2018) · Gynecological Endocrinology · doi:10.1080/09513590.2018.1462316 · Cited by 27 · see citing works
Circular RNA expression profiling in the fetal side of placenta from maternal polycystic ovary syndrome and circ_0023942 inhibits the proliferation of human ovarian granulosa cell
Zhao, C., Zhou, Y., Shen, X., Gong, M., Lu, Y., Fang, C., Chen, J., & Ju, R. (2020) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-020-05495-5 · Cited by 26 · see citing works
HOMA-IR for predicting clinical pregnancy rate during IVF
Song, H., Yu, Z., Li, P., Wang, Y., & Shi, Y. (2021) · Gynecological Endocrinology · doi:10.1080/09513590.2021.1952976 · Cited by 26 · see citing works
“PCOS is a common but complex reproductive and endocrine-metabolic disorder and a primary cause of infertility among women of childbearing age [10].”
Background
Letrozole-stimulated endometrial preparation protocol is a superior alternative to hormone replacement treatment for frozen embryo transfer in women with polycystic ovary syndrome, a cohort study
Wang, X., Li, Y., Tan, H., Cai, S., Ma, S., Peng, Y., Guo, H., Li, X., Tang, Y., Zhang, S., et al. (2023) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-023-01154-x · Cited by 26 · see citing works
“…phosphorylation of insulin receptors and IRS-1 secondary to intracellular serine kinases in PCOS, which results in decreased insulin-mediated activation of PI3-K and resistance to the metabolic actions of insulin has been postulated that the same kinase may inhibit insulin signaling in PCOS [29].”
Background
Self-Concept, Depression, and Anxiety Levels of Adolescents with Polycystic Ovary Syndrome
Almış, H., Orhon, F. Ş., Bolu, S., & Almış, B. H. (2020) · Journal of Pediatric and Adolescent Gynecology · doi:10.1016/j.jpag.2020.12.011 · Cited by 24 · see citing works
The Relationship Between Insulin Resistance and Obesity and Serum Anti-Mullerian Hormone Level in Chinese Women with Polycystic Ovary Syndrome: A Retrospective, Single-Center Cohort Study
Zhao, H., Zhou, D., Liu, C., & Zhang, L. (2023) · International Journal of Women s Health · doi:10.2147/ijwh.s393594 · Cited by 23 · see citing works
“The former include growth factors, cytokines, and inhibin in the follicular fluid, and the latter includes FSH deficiency, LH hypersecretion, high androgen levels in the ovaries and adrenal gland, IR, and hyperinsulinemia.(43,44) AMH is recognized as the primary hormonal regulator of ovarian follicular development by…”
Background
Increased homozygosity due to endogamy results in fitness consequences in a human population
Swinford, N., Prall, S. P., Gopalan, S., Williams, C. M., Sheehama, J., Scelza, B. A., & Henn, B. M. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2309552120 · Cited by 25 · see citing works
“In addition to untreated venereal disease (45, 46), conditions such as polycystic ovarian syndrome and endometriosis can affect a woman’s ability to become pregnant (47, 48).”
Role of polyphenols in remodeling the host gut microbiota in polycystic ovary syndrome
Zhou, P., Feng, P., Liao, B., Fu, L. N., Shan, H., Cao, C., Luo, R., Peng, T., Liu, F.-T., & Li, R. (2024) · Journal of Ovarian Research · doi:10.1186/s13048-024-01354-y · Cited by 25 · see citing works
“Hyperandrogenemia is an essential endocrine feature of PCOS, and the andro-gen-excessive environment can inhibit follicle development and maturation, resulting in follicular atresia and decreased ovarian estradiol levels [26].”
Background
Early pregnancy metabolic factors associated with gestational diabetes mellitus in normal-weight women with polycystic ovary syndrome: a two-phase cohort study
Zheng, W., Huang, W., Zhang, L., Tian, Z., Qi, Y., Wang, T., Zhang, L., & Li, G. (2019) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-019-0462-6 · Cited by 25 · see citing works
Polycystic ovary syndrome and risk of pre‐eclampsia: A national register‐based cohort study
Valdimarsdottir, R., Vanky, E., Elenis, E., Lindström, L., Junus, K., Jonsson, M., Poromaa, I. S., & Wikström, A. (2023) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.17734 · Cited by 24 · see citing works
“4,5 6–9 Pre-eclampsia is a severe pregnancy complication with a global incidence of 3–5%.”
Background
Bariatric Surgery on Reproductive Outcomes: the Impact According to the Diagnosis of Polycystic Ovarian Syndrome and Surgical Procedures
Casals, G., Andreu, A., Barral, Y., Ventosa, S., Redondo, M., Torres, F., Ibarzábal, A., Manau, D., Carmona, F., Vidal, J., et al. (2021) · Obesity Surgery · doi:10.1007/s11695-021-05297-x · Cited by 23 · see citing works
“The impact of obesity and WL strategies on reproduction is especially relevant in women diagnosed with polycystic ovarian syndrome (PCOS) as their ovulatory disorders and perinatal complications are exacerbated in the presence of obesity [8, 9].”
Background
Qualitative study of self-reported experiences of infertile women with polycystic ovary syndrome through on-line discussion forums
Authier, M., Normand, C., Jego, M., Gaborit, B., Boubli, L., & Courbiere, B. (2020) · Annales d'Endocrinologie · doi:10.1016/j.ando.2020.07.1110 · Cited by 23 · see citing works
Variation among human populations in endometriosis and PCOS A test of the inverse comorbidity model
Crespi, B. J. (2021) · Evolution Medicine and Public Health · doi:10.1093/emph/eoab029 · Cited by 21 · see citing works
“PCOS is found in about 5–15% of women of reproductive age and impacts substantially upon health, fertility and well-being [11, 12].”
Background
Perceived Stress Scale Among Adolescents with Polycystic Ovary Syndrome
Khafagy, G. M., Sayed, I. T. E., Abbas, S. M., & Soliman, S. (2020) · International Journal of Women s Health · doi:10.2147/ijwh.s279245 · Cited by 21 · see citing works
Polycystic Ovarian Syndrome in Adolescents
Adone, A., & Fulmali, D. G. (2023) · Cureus · doi:10.7759/cureus.34183 · Cited by 20 · see citing works
“Regular check-ups and close surveillance are necessary for every stage of life, like adolescence, reproductive age, and old age, to reduce complications and risks that could affect the patient's offspring as it is genetically transferred [25].”
Background
Killer-cell immunoglobulin-like receptors associated with polycystic ovary syndrome
Elpídio, L. N. S., de Alencar, J. B., Tsuneto, P. Y., Alves, H. V., Toretta, M. T., Taura, S. K. I., Visentainer, J. E. L., & Sell, A. M. (2018) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2018.08.003 · Cited by 20 · see citing works
A Systematic Review of Inflammatory Markers in Polycystic Ovary Syndrome (PCOS) and Meta-Analysis of Interleukin-6 (IL-6) in Case-Control Studies
Bansal, B., Kishore, A. T., Kathiresan, S., Ghachi, A. F., Pradhan, S., Paul, S., Chaturvedi, K., Singh, M. P., Patil, S., Johnson, L. S., et al. (2025) · Cureus · doi:10.7759/cureus.82350 · Cited by 23 · see citing works
Comparison of metabolic and obesity biomarkers between adolescent and adult women with polycystic ovary syndrome
de Medeiros, S. F., de Medeiros, M. A. S., Barbosa, B. B., Yamamoto, M. M. W., & Maciel, G. A. R. (2020) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-020-05867-x · Cited by 18 · see citing works
“Despite pelvic ultrasound had not been recommended for the diagnosis of PCOS before 8 years post-menarche [12, 13, 33], polycystic ovary morphology (PCOM) was defined by established criteria for adolescents and adults [7, 33, 34] using vaginal transducer with a frequency of 5–8 MHz (Toshiba Xario SSA-660A, Toshiba Med…”
Method
ApoB48-Lipoproteins Are Associated with Cardiometabolic Risk in Adolescents with and without Polycystic Ovary Syndrome
Vine, D. F., Beilin, L. J., Burrows, S., Huang, R.-C., Hickey, M., Hart, R., Proctor, S. D., & Mori, T. A. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa061 · Cited by 17 · see citing works
Objectification and ambiguity of body image in women with Polycystic Ovary Syndrome: A mixed-method study
Yin, M. X. C., Leng, L.-L., Liang, Z., Chen, X.-Y., Chan, C., & Chan, C. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.05.028 · Cited by 17 · see citing works
Polycystic Ovary Syndrome: A Literature Review With a Focus on Diagnosis, Pathophysiology, and Management
Waghmare, S. V., & Shanoo, A. (2023) · Cureus · doi:10.7759/cureus.47408 · Cited by 23 · see citing works
“There were four main phenotypes reported based on the Rotterdam criteria (Figure 2 ) [2,3].”
Fertility treatment pathways and births for women with and without polycystic ovary syndrome—a retrospective population linked data study
Moss, K. M., Doust, J. A., Copp, T., Homer, H. A., & Mishra, G. D. (2023) · Fertility and Sterility · doi:10.1016/j.fertnstert.2023.11.008 · Cited by 16 · see citing works
Mendelian Randomization Analysis Identified Potential Genes Pleiotropically Associated with Polycystic Ovary Syndrome
Sun, Q., Gao, Y. J., Yang, J., Lu, J., Feng, W., & Wen, Y. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00776-z · Cited by 15 · see citing works
Polycystic ovarian syndrome and miscarriage in IVF: systematic revision of the literature and meta-analysis
Matorras, R., Pijoán, J. I., Laínz, L., Díaz-Núñez, M., Sainz, H., Pérez-Fernández, S., & Moreira, D. (2022) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-022-06757-0 · Cited by 15 · see citing works
“Introduction Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, with a prevalence of between 8 and 13% depending on the population studied and definitions used [1, 2, 3].”
Background
Mechanism of cryptotanshinone to improve endocrine and metabolic functions in the endometrium of PCOS rats
Liu, Y.-C., Wang, J., Li, J., Guo, Y., Han, F., Lu, W., & Wu, Q. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117346 · Cited by 13 · see citing works
Proteomic sift through serum and endometrium profiles unraveled signature proteins associated with subdued fertility and dampened endometrial receptivity in women with polycystic ovary syndrome
Rashid, N., Nigam, A., Jain, S. K., Naqvi, S. H., & Wajid, S. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03171-3 · Cited by 13 · see citing works
RETRACTED ARTICLE: Long non-coding RNA HLA-F antisense RNA 1 inhibits the maturation of microRNA-613 in polycystic ovary syndrome to promote ovarian granulosa cell proliferation and inhibit cell apoptosis
Li, X., Zhu, L., & Luo, Y. (2022) · Bioengineered · doi:10.1080/21655979.2022.2070965 · Cited by 12 · see citing works
“As a common type of hormonal disorder, polycystic ovary syndrome (PCOS) mainly affects women at their reproductive age [1,2].”
Retracted
Sex Hormones, Gonad Size, and Metabolic Profile in Adolescent Girls Born Small for Gestational Age with Catch-up Growth
Petraitienė, I., Valūnienė, M., Jarienė, K., Šeibokaitė, A., Albertsson-Wikland, K. G., & Verkauskienė, R. (2019) · Journal of Pediatric and Adolescent Gynecology · doi:10.1016/j.jpag.2019.11.001 · Cited by 12 · see citing works
Prevalence of depression among women with polycystic ovary syndrome in mainland China: a systematic review and meta-analysis
Hong, Z., Wu, P., Zhuang, H., Chen, L., Hong, S., & Qin, J. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-06378-8 · Cited by 11 · see citing works
Fat Mass and Obesity Association gene Polymorphism in PCOS Iraqi Women
Ibraheem, Q. A., Obaidy, L. H. A. A., Nasir, G. A., & Al‐Obaidi, M. T. (2020) · Baghdad Science Journal · doi:10.21123/bsj.2020.17.3(suppl.).1103 · Cited by 11 · see citing works
“In this study the age had no significant association in the PCOS because all 68 participants were in the same age, even though PCOS can affect women over wide range of their fertility life (12-55) years.”
Background
Assessment of THADA gene polymorphisms in a sample of Colombian women with polycystic ovary syndrome: A pilot study
Alarcón-Granados, M. C., Moreno-Ortíz, H., Esteban-Pérez, C., Ferrebuz-Cardozo, A., Camargo-Villalba, G., & Forero-Castro, M. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09673 · Cited by 12 · see citing works
Harnessing SIRT1 activators for effective PCOS treatment: A new frontier
Moharir, S. R., Talamadla, M. K., Bhardwaj, P., Banerjee, A., Dey, R. J., & Sekhar, K. V. G. C. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118361 · Cited by 11 · see citing works
Inhibition of sestrin 1 alleviates polycystic ovary syndrome by decreasing autophagy
Xu, X., Song, X., Xu, X., Yanluan, Z., Xu, L., & Shen, L. (2021) · Aging · doi:10.18632/aging.202872 · Cited by 10 · see citing works
Reduced cardiovascular risks in women with endometriosis or polycystic ovary syndrome carrying a common functional IGF1R variant
Powell, M. J., Fuller, S., Gunderson, E. P., & Benz, C. C. (2022) · Human Reproduction · doi:10.1093/humrep/deac059 · Cited by 9 · see citing works
Síndrome dos ovários policísticos: aspectos clínicos e impactos na saúde da mulher
Cavalcante, I. D. S., Mendes, I. P. G., Silva, M. L. L. D. S., Barbosa, G. S. L., Hasegawa, L. E. M., Veiga, A. V. M., Ferraz, I. C., Gomes, F. E. S., & dos Santos, L. M. D. S. A. (2021) · Research Society and Development · doi:10.33448/rsd-v10i2.12398 · Cited by 9 · see citing works
Role of Metformin in the Management of Polycystic Ovarian Syndrome-Associated Acne: A Systematic Review
Shamim, H., Jean, M., Umair, M., Muddaloor, P., Farinango, M., Ansary, A., Dakka, A., Nazir, Z., White, C. T., Habbal, A. B., et al. (2022) · Cureus · doi:10.7759/cureus.28462 · Cited by 15 · see citing works
“Figure 3 demonstrates the effects of PCOS at different stages of life [26].”
Background
Do Health Literacy and Awareness of Polycystic Ovary Syndrome Predict the Lifestyle Choices of Arabic-Speaking Female University Students
Maamari, R. A., Hashmi, I. A., Dhuli, A. A. A., Abri, A. A., Ghaithi, A. A., & Sinan, S. A. (2023) · Iranian Journal of Nursing and Midwifery Research · doi:10.4103/ijnmr.ijnmr_355_22 · Cited by 8 · see citing works
“[5] In the Middle Eastern countries, cardiovascular diseases are already the leading cause of mortality for women.”
Background
Polycystic ovary syndrome and gestational diabetes mellitus association to pregnancy outcomes: A national register‐based cohort study
Valdimarsdottir, R., Vanky, E., Elenis, E., Ahlsson, F., Lindström, L., Junus, K., Wikström, A., & Poromaa, I. S. (2024) · Acta Obstetricia et Gynecologica Scandinavica · doi:10.1111/aogs.14998 · Cited by 9 · see citing works
Advancement in early diagnosis of polycystic ovary syndrome: biomarker-driven innovative diagnostic sensor
Nandi, A., Singh, K. D., & Sharma, K. (2025) · Microchimica Acta · doi:10.1007/s00604-025-07187-w · Cited by 9 · see citing works
“Symptoms like irregular periods and weight gain are often considered normal alterations due to stress or life-style [19, 86].”
Regenerative Medicine Perspectives in Polycystic Ovary Syndrome
Arjmand, B., Alaei, S., Heravani, N. F., Alavi-Moghadam, S., Payab, M., Ebrahimpour, M., Aghayan, H. R., Goodarzi, P., & Larijani, B. A. (2021) · Advances in experimental medicine and biology · doi:10.1007/5584_2021_623 · Cited by 8 · see citing works
Relation of serum vitamin D level in polycystic ovarian syndrome (PCOS) patients to ICSI outcome
Omran, E., Ramzy, A. M., Shohayeb, A., Farouk, N., Soliman, M., Baz, H., & Sharaf, M. F. (2020) · Middle East Fertility Society Journal · doi:10.1186/s43043-020-00034-3 · Cited by 7 · see citing works
Sexual and reproductive health aspects in women with polycystic ovary syndrome: An integrative review
Kalhor, M., Mohammadi, E., Shahali, S., Amini, L., & Moghaddam-Banaem, L. (2022) · International Journal of Reproductive BioMedicine (IJRM) · doi:10.18502/ijrm.v20i9.12062 · Cited by 6 · see citing works
“, 2018 (6) Review -No mention about grey literature -No mention about the characteristics of the included studies -No mention of the scientific quality of the included studies 75%”
BackgroundInfluential
Metabolic association of serum prolactin in polycystic ovary syndrome: A retrospective analysis of 840 patients in Bangladesh
Kamrul-Hasan, A. B. M., & Aalpona, F. T. Z. (2023) · Endocrine and Metabolic Science · doi:10.1016/j.endmts.2023.100153 · Cited by 6 · see citing works
Role of Vitamin E in Pregnancy
Siddiqui, M. A., Ahmad, U., Ali, A., Ahsan, F., & Haider, M. F. (2021) · Biochemistry · doi:10.5772/intechopen.97268 · Cited by 6 · see citing works
Endocrine-disrupting chemicals and PCOS: A novel contributor in the etiology of the syndrome
Diamanti‐Kandarakis, E., Papalou, O., & Kandaraki, E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823045-9.00015-8 · Cited by 6 · see citing works
The Triad Of PCOS, Infertility And Metformin
Khan, A., Karim, N., & Ainuddin, J. A. (2018) · Journal of Bahria University Medical and Dental College · doi:10.51985/jbumdc2018144 · Cited by 6 · see citing works
A Pilot Trial: Fish Oil and Metformin Effects on ApoB-Remnants and Triglycerides in Women With Polycystic Ovary Syndrome
Vine, D. F., Proctor, E., Weaver, O. R., Ghosh, M., Maximova, K., & Proctor, S. D. (2021) · Journal of the Endocrine Society · doi:10.1210/jendso/bvab114 · Cited by 6 · see citing works
Chronic Estrus Disrupts Uterine Gland Development and Homeostasis
Stewart, C. A., Stewart, M. D., Wang, Y., Mullen, R. D., Kircher, B. K., Liang, R., Liu, Y., & Behringer, R. R. (2022) · Endocrinology · doi:10.1210/endocr/bqac011 · Cited by 6 · see citing works
Combined Oral Contraceptives for Polycystic Ovary Syndrome: Pro and Contra (Review)
Мазеркина, И. А., Davydov, I. G., & Сергеевна, А. О. (2024) · Safety and Risk of Pharmacotherapy · doi:10.30895/2312-7821-2024-12-2-214-229 · Cited by 5 · see citing works
Serum kisspeptin as a promising biomarker for PCOS: a mini review of current evidence and future prospects
Kokori, E., Olatunji, G. D., Komolafe, R., Ogieuhi, I. J., Ukoaka, B. M., Ajayi, I., & Aderinto, N. (2024) · Clinical Diabetes and Endocrinology · doi:10.1186/s40842-024-00190-9 · Cited by 5 · see citing works
Effect of satapushpa churnam with tila tailam in oligomenorrhea associated with polycystic ovarian syndrome
Jacob, J., Vijayakumar, N., & Olickal, J. J. (2021) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2021.06.015 · Cited by 5 · see citing works
“Polycystic Ovarian Syndrome (PCOS) is one of those diseases caused by an altered lifestyle, affecting the capacity to give birth to children [1].”
Background
Polycystic Ovary Syndrome (PCOS)
Hechtman, L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-43044-9.00209-0 · Cited by 6 · see citing works
A Deeper Assessment of ω3-Poly-Unsaturated Fatty Acids in Polycystic Ovary Syndrome Management. Comment on Regidor et al. Chronic Inflammation in PCOS: The Potential Benefits of Specialized Pro-Resolving Lipid Mediators (SPMs) in the Improvement of the Resolutive Response. Int. J. Mol. Sci. 2021, 22, 384
Unfer, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810114 · Cited by 5 · see citing works
First ovarian response to gonadotrophin stimulation in rats exposed to neonatal androgen excess
Chávez‐Genaro, R., & Anesetti, G. (2018) · Journal of Molecular Histology · doi:10.1007/s10735-018-9800-5 · Cited by 5 · see citing works
High androgen level causes recurrent miscarriage and impairs endometrial receptivity
Su, Y., & Shi, H. (2021) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v18i7.27 · Cited by 5 · see citing works
Polycystic Ovary Syndrome
Messinis, I. E., Messini, C. I., & Daponte, A. I. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108582322.015 · Cited by 5 · see citing works
Therapeutic effects of stevia aqueous extract alone or in combination with metformin in induced polycystic ovary syndrome rats: Gene expression, hormonal balance, and metabolomics aspects
Saedi, A., Zarei, S., Vatanparast, M., Hajizadeh, M. R., Hosseiniara, R., Esmaeili, O. S., Mohammad-Sadeghipour, M., Mirzaei, Z., & Mahmoodi, M. (2024) · Annales Pharmaceutiques Françaises · doi:10.1016/j.pharma.2024.08.008 · Cited by 4 · see citing works
Effects of green coffee supplementation on paraoxonase-1 activity and malondialdehyde levels in Iranian women with polycystic ovary syndrome: a randomized clinical trial
Ildarabadi, A., Dastjerdi, M. V., Ghorbanpour, M., Mousavi, A., Meshkani, M., Yekaninejad, M. S., & Saedisomeolia, A. (2024) · Osong Public Health and Research Perspectives · doi:10.24171/j.phrp.2024.0187 · Cited by 4 · see citing works
“PCOS is associated with autoimmune responses and is defined as a polygenic, multifactorial, systemic, and inflammatory disease involving imbalanced steroid levels, which suggests a connection to unhealthy lifestyle factors [ 5 ].”
Impaired Carbohydrate Metabolism and Excess of Lipid Accumulation in Offspring of Hyperandrogenic Mice
Aburto-Hernández, C., Barrera, D., Ortiz-Hernández, R., Espinoza‐Simón, E., Parra-Gámez, L., González, J., Escobar, M. L., Vázquez‐Nin, G. H., Echeverría-Martínez, O., & Torres‐Ramírez, N. (2022) · Metabolites · doi:10.3390/metabo12121182 · Cited by 4 · see citing works
“is strongly related to metabolic diseases [25], begi n g in childhood and puberty of patients [26], we cided to analyze some metabolic parameters in 3-month-old pups.”
Background
Role of complementary and alternative medicine in polycystic ovary syndrome
Siddique, R., & Mehmood, M. H. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-87932-3.00031-1 · Cited by 4 · see citing works
Risk of Mental Disorders in Polycystic Ovary Syndrome: Retrospective Cohort Study of a Korean Nationwide Population-Based Cohort
Kim, Y., Chae, K., Kim, S., Kang, S. Y., Yoon, H., & Namkung, J. (2025) · International Journal of Women s Health · doi:10.2147/ijwh.s490673 · Cited by 3 · see citing works
“Clinical and biochemical manifestations of PCOS change with age, 55 and obesity was related to PCOS 55 and mental health 56 both.”
Polycystic ovary syndrome and chronic pain among females and individuals of childbearing age: A scoping review
Sacca, L., Okwaraji, G., Densley, S., Marciniak, A., Knecht, M. K., Wilson, C., Pilitsis, J. G., & Hopkins, D. K. (2024) · SAGE Open Medicine · doi:10.1177/20503121241262158 · Cited by 3 · see citing works
“45,46 Ovarian androgen secretion capacity declines with age in both healthy women and in women with PCOS; however, it remains enhanced in females and individuals with PCOS until the late reproductive years.”
Background
Polycystic Ovary Syndrome
Nasseh, A., & Sarvaideo, J. L. (2020) · Springer eBooks · doi:10.1007/978-3-030-50695-7_6 · Cited by 3 · see citing works
Ovarian Endocrine Status and ART 0utcomes in Women within PCOS Based on Different Testosterone Levels
Falahati‐pour, S. K., Pourmasumi, S., & Mirhashemi, E. S. (2023) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/ijem.ijem_360_22 · Cited by 3 · see citing works
“Vitamin D3 and fasting blood sugar were 21.31±9.18 (ng/mL) and 97.90 ± 16.21 (mg/dL) respectively [Table 1].”
BackgroundInfluential
Effect Of Letrozole Versus Clomiphene Citrate Plus Estradiol Valerate In Patient With Polycystic Ovarian Syndrome with Inadequate Response To Clomiphene Citrate
alhibshi, L., Sarhan, A.-M., & abdo, A. (2019) · Zagazig University Medical Journal · doi:10.21608/zumj.2019.17162.1530 · Cited by 3 · see citing works
Prevalencia del síndrome de ovario poliquístico en mujeres colombianas con acné en la etapa adulta
Mantilla-Villabona, L. Y., Vergara, J. I., Barrera, D. L., Ríos, X. P., Wandurraga-Sánchez, E. A., & Gómez, S. E. S. (2023) · Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica · doi:10.29176/2590843x.1682 · Cited by 2 · see citing works
“el 1% hasta el 45%; esto es influenciado por factores genéticos y ambientales (18).”
Background
Electrochemical immunosensors targeting hormonal biomarkers for polycystic ovary syndrome: Recent advances and analytical bottlenecks
Nandi, A., Gillespie, S. W., Ice, S. N., Thakur, D., Gaur, Y. K., Singh, K. D., & Sharma, K. (2025) · Biosensors and Bioelectronics X · doi:10.1016/j.biosx.2025.100657 · Cited by 2 · see citing works

Characteristics of polycystic ovary syndrome throughout life
Louwers, Y. V., & Laven, J. S. E. (2020) · Therapeutic Advances in Reproductive Health · doi:10.1177/2633494120911038 · Cited by 193 · see citing works
POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: The impact of polycystic ovary syndrome on reproductive health: a narrative review
Owens, L. A., & Franks, S. (2025) · Reproduction · doi:10.1530/rep-24-0485 · Cited by 16 · see citing works
Lifecycle of polycystic ovary syndrome (PCOS): from in utero to menopause
Welt, C. K., & Carmina, E. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2375 · Cited by 148 · see citing works
The natural history of polycystic ovary syndrome: commentary on a longitudinal study evaluating changes in phenotype with age
Kim, A. S., & Wild, R. A. (2022) · Fertility and Sterility · doi:10.1016/j.fertnstert.2022.03.003
PCOS from Conception to Menopause: A Review of Our Current Understanding
Whigham, L. D., Durant, M. L., Yaklic, J. L., & Lindheim, S. R. (2014) · CORE Scholar (Wright State University)

Authors: Group of interest in Reproductive Endocrinology (GIER) of the Spanish Fertility Society (SEF), Bellver, J., Rodríguez-Tabernero, L., Robles, A., Muñoz, E., Martínez, F., Landeras, J., García-Velasco, J., Fontes, J., Álvarez, M., Álvarez, C., & Acevedo, B.
Affiliations: Universitat de València (ES)
Hospital Del Mar (ES)
Hospital Universitario Dexeus (ES)
Universidad Rey Juan Carlos (ES)
Hospital Universitario Virgen de las Nieves (ES)
Hospital Universitario Fundación Jiménez Díaz (ES)
Corresponding author: Bellver, José
ORCID: Bellver, José
Muñoz, Elkin
Martínez, Francisca
García-Velasco, Juan
Álvarez, Mónica
Venue: Journal of Assisted Reproduction and Genetics
Publisher: Springer Science and Business Media LLC
Published: 2017-09-27
Volume: 35
Issue: 1
Pages: 25-39
ISSN: 0740-7769 (ISSN-L)
1058-0468
1573-7330
DOI: 10.1007/s10815-017-1047-7
PMC: PMC5758469
OpenAlex: W2758457511
Cited by: 180
References: 146
Citations by year: 2026: 8 · 2025: 18 · 2024: 20 · 2023: 28 · 2022: 25 · 2021: 35 · 2020: 22 · 2019: 13 · 2018: 9 · 2017: 1 · 2016: 1
FWCI: 2.01
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (unspecified)
Locations: Journal of Assisted Reproduction and Genetics (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
RISalud Institutional Health Repository of Andalucía (submittedVersion, other-oa)
Repository of Digital Objects for Teaching Research and Culture (University of Valencia) (submittedVersion, cc-by-nc)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Keywords: polycystic ovary syndrome, PCOS phenotypes, fetal programming, hyperandrogenism, insulin resistance, anovulation, infertility, PCOS diagnosis, lifestyle therapy, pharmacotherapy
MeSH terms: Adolescent, Adult, Female, Humans, Middle Aged, Polycystic Ovary Syndrome, Reproduction, Sexual Maturation, Growth and Development, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Polycystic ovary syndrome throughout a woman’s life

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks