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Benzo[a]pyrene exposure promotes RIP1-mediated necroptotic death of osteocytes and the JNK/IL-18 pathway activation via generation of reactive oxygen species

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Matrix stiffness aggravates osteoarthritis progression through H3K27me3 demethylation induced by mitochondrial damage

Kan, T., Li, H., Hou, L., Cui, J., Wang, Y., Sun, L., Wang, L., Yan, M., & Yu, Z. (2024) · iScience · doi:10.1016/j.isci.2024.110507 · Cited by 15 · see citing works

Sclerostin's role in bone–muscle crosstalk and osteoporosis pathogenesis

Shahid, H., Morya, V. K., & Noh, K.-C. (2025) · Osteoporosis and Sarcopenia · doi:10.1016/j.afos.2025.06.004 · Cited by 15 · see citing works

Irisin Protects against Loss of Trabecular Bone Mass and Strength in Adult Ovariectomized Mice by Stimulating Osteoblast Activity

Storlino, G., Dicarlo, M., Zerlotin, R., Pignataro, P., Sanesi, L., Suriano, C., Oranger, A., Mori, G., Passeri, G., Colucci, S. C., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129896 · Cited by 15 · see citing works

Echinacoside alleviates osteoarthritis in rats by activating the Nrf2-HO-1 signaling pathway

Tan, Z., & Zhang, B. (2022) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2022.2088384 · Cited by 14 · see citing works

Carvacrol induces osteogenic differentiation of BMSCs and alleviates osteolysis in aged mice by upregulating lncRNA NEAT1 to promote SIRT1 expression

Xu, Z., Wang, Z., Ma, W., & Huang, Z. (2023) · Aging Pathobiology and Therapeutics · doi:10.31491/apt.2023.12.124 · Cited by 12 · see citing works

Exercise-Based Interventions Are Effective in the Management of Patients with Thumb Carpometacarpal Osteoarthritis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Karanasios, S., Mertyri, D., Karydis, F., & Gioftsos, G. (2024) · Healthcare · doi:10.3390/healthcare12080823 · Cited by 10 · see citing works

Irisin improves delayed bone repair in diabetic female mice

Kinoshita, Y., Takafuji, Y., Okumoto, K., Takada, Y., Ehara, H., Mizukami, Y., Kawao, N., Jo, J., Tabata, Y., & Kaji, H. (2022) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-022-01353-3 · Cited by 10 · see citing works

Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health

Pereira, L. J., Andrade, E. F., Barroso, L. C., de Lima, R. R., Macari, S., Paiva, S. M., & Silva, T. A. (2022) · Brazilian Oral Research · doi:10.1590/1807-3107bor-2022.vol36.0055 · Cited by 10 · see citing works

Irisin in the modulation of bone and cartilage homeostasis: a review on osteoarthritis relief potential

Zhang, M., Xiong, W., Qiao, R., Li, M., Zhang, C., Yang, C., Zhu, Y., He, J., & Ma, Z. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1570157 · Cited by 9 · see citing works

Fxyd5 activates the NF‑κB pathway and is involved in chondrocytes inflammation and extracellular matrix degradation

Song, L., Li, X., Sun, Q., & Zhao, Y. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12650 · Cited by 9 · see citing works

Effect of myokines on bone tissue metabolism: a systematic review

Jaśkiewicz, Ł., Romaszko-Wojtowicz, A. M., Chmielewski, G., Kuna, J., & Krajewska–Włodarczyk, M. (2025) · Bone · doi:10.1016/j.bone.2025.117654 · Cited by 10 · see citing works

Electroacupuncture Upregulates HIF-1α and SOX9 Expression in Knee Osteoarthritis

Tong, J., Deng, C., Sun, G., Zhou, J. M., Zhong, P., Wang, T., Zeng, Y., Wu, Q., Liao, Y., Luo, F., et al. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/2047097 · Cited by 8 · see citing works

The Association Between Quadriceps Strength and Synovitis in Knee Osteoarthritis: An Exploratory Study From the Osteoarthritis Initiative

Gong, Z., Li, S., Cao, P., Ruan, G., Zhang, Y., Zeng, Q., He, Z., Li, S., Chen, R., Zheng, P., et al. (2022) · The Journal of Rheumatology · doi:10.3899/jrheum.220538 · Cited by 8 · see citing works

Exercise mimetics: molecular mechanisms, biological and therapeutic effects

Zhang, J., Shao, Q., 程腾, Lin, J., Tang, Y., Lu, H., Zhang, Y., Yu, Z., & Cao, L. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00483-8 · Cited by 8 · see citing works

Coactivator Associated Arginine Methyltransferase 1 Modulates Cartilage Degeneration and Chondrocyte Apoptosis in Osteoarthritis by Regulating ERK1 /2 Signaling Pathway

Yuan, J., Tian, J., Liu, R., Qiu, X., He, D., He, G., Zhang, T., Li, P., Zhao, B., & Wang, Y. (2025) · Aging Cell · doi:10.1111/acel.70122 · Cited by 7 · see citing works

Irisin in domestic animals

Lai, E., & Unniappan, S. (2023) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2023.106787 · Cited by 6 · see citing works

Therapeutic Potential of Targeting Ferroptosis in Periprosthetic Osteolysis Induced by Ultra-High-Molecular-Weight Polyethylene Wear Debris

Ogawa, T., Yokota, S., Chen, L., Ogawa, Y., Nishida, Y., Tokuhiro, T., Alhasan, H., Yutani, T., Shimizu, T., Takahashi, D., et al. (2025) · Biomedicines · doi:10.3390/biomedicines13010170 · Cited by 5 · see citing works

Metabolic crosstalk between skeletal muscle and cartilage tissue: insights into myokines in osteoarthritis

Shirvani, H., Shamsoddini, A., Bazgir, B., McAinch, A. J., Najjari, A., & Arabzadeh, E. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-11072-3 · Cited by 5 · see citing works

β2-microglobulin induced apoptosis of tumor cells via the ERK signaling pathway by directly interacting with HFE in HER2-overexpressing breast cancer

Li, K., Chai, D., Ren, S., Lian, X., Shi, X., Xu, Y., Bao, L., Yang, S., Liang, Y., Li, X., et al. (2024) · BMC Cancer · doi:10.1186/s12885-024-12757-x · Cited by 5 · see citing works

Articular cartilage degeneration and aberrant osteocyte perilacunar/canalicular remodeling in subchondral bone of patients with developmental dysplasia of the hip

Ye, T., Yan, J., Kan, T., Xie, G., Zhang, Z., Yin, W., Zhao, B., Yu, Z., & Chu, L. (2025) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-025-08419-z · Cited by 5 · see citing works

Protective role of irisin on bone in osteoporosis: a systematic review of rodent studies

Li, J., Fu, X., Shi, H., Jing, J., Zheng, Q., & Xu, Z. (2025) · Osteoporosis International · doi:10.1007/s00198-025-07470-9 · Cited by 6 · see citing works

Combination of UHPLC‐QE‐MS and Network Pharmacology to Reveal the Mechanism of Fufang‐Duzhong‐Jiangu Granules for Treating Knee Osteoarthritis

Wang, W., Luan, F., Shi, Y., Zhang, X., Guo, D., Sun, J., Zou, J., & Yuan, P.-W. (2024) · Biomedical Chromatography · doi:10.1002/bmc.6051 · Cited by 4 · see citing works

BNTA attenuates temporomandibular joint osteoarthritis progression by directly targeting ALDH3A1: An in vivo and in vitro study

He, K., Lin, H., Zhang, S., Ou, Y., Lu, J., Chen, W., Zhou, Y., Lin, Y., Lin, Y., Su, J., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110963 · Cited by 4 · see citing works

Nitric oxide-caused rabbit chondrocyte apoptosis is linked to cytoskeletal protein proteolysis anomaly through intracellular JNK and ERK signal pathways

Chen, Q., Kao, X., Gao, Y., Chen, J., Dong, Z., & Chen, C. (2022) · Molecular & Cellular Toxicology · doi:10.1007/s13273-022-00241-1 · Cited by 3 · see citing works

Swimming exercise alleviates pathological bone features in curdlan-injected SKG mice by inducing irisin expression

Lee, S. H., Nam, B., Youn, J., Lee, K. H., & Jo, S. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122894 · Cited by 3 · see citing works

The Effect of Physical Activity on the Secretory Function of Muscles and Bone Tissue in Humans

Траверсе, Г., Горошко, В. І., & Danylchenko, S. I. (2023) · Ukraïnsʹkij žurnal medicini bìologìï ta sportu · doi:10.26693/jmbs08.01.050 · Cited by 2 · see citing works

Recent Advances in Promoting Bone Regeneration in Type 2 Diabetes Using Drug Delivery Vehicles and Vehicle‐Free Therapeutics

Afsharian, Y. P., Rahimnejad, M., Rabiee, S. M., Feizi, F., & Seitz, H. (2025) · Advanced Therapeutics · doi:10.1002/adtp.202400400 · Cited by 2 · see citing works

Fat Extract Modulates Calcium Signaling and Protects against Hyperactive Osteoclastogenesis in Bone Remodeling with Antioxidant Capacity

Yang, Y., Xu, M., Kan, T., Wang, Y., Zhang, S., Deng, M., Zhang, W., Li, H., & Yu, Z. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202200330 · Cited by 2 · see citing works

Mediating role of effusion-synovitis in knee pain worsening following quadriceps weakness: data from the osteoarthritis initiative

Gong, Z., Ao, D., Li, T., & Li, L. (2025) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-025-09113-w · Cited by 1 · see citing works

The mechanosensitive protein ANTXR1 is involved in maintaining cartilage homeostasis in post-traumatic osteoarthritis

Miao, Z., Liu, J., Cheng, P., Shen, Y., Tang, J., Zhu, J., Liu, W., Zhou, X., & Jing, H. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1625333 · Cited by 1 · see citing works

Molecular insights into irisin’s role in the regulation of programmed cell death: mechanisms and therapeutic potential

Yang, Y., Pullisaar, H., Reseland, J. E., & Ma, J. (2025) · Journal of Molecular Medicine · doi:10.1007/s00109-025-02623-z · Cited by 1 · see citing works

Sex specific effects of irisin on the skeleton

Shimonty, A., & Bonewald, L. F. (2026) · Bone Research · doi:10.1038/s41413-026-00542-4 · Cited by 1 · see citing works

INFLUENCE OF SECRETORY FUNCTION OF SKELETAL MUSCLE ON REHABILITATION

Траверсе, Г. М., Горошко, В. І., & Hordiienko, O. V. (2023) · Реабілітаційні та фізкультурно-рекреаційні аспекти розвитку людини (Rehabilitation & recreation) · doi:10.32782/2522-1795.2023.14.12 · Cited by 1 · see citing works

Irisin protects against IL-1β-induced chondrocytes injury by activating the ERK signaling pathwayPreprint

Chen, Y., Liao, T., Zhou, X., Zeng, N., Wang, H., Yan, Z.-P., Cheng, L., & Ni, G. (2022) · Research Square · doi:10.21203/rs.3.rs-1730641/v1 · Cited by 1 · see citing works

The role of sclerostin and irisin on bone and muscle of orchiectomized ratsPreprint

Zhou, B., Zhang, Q., Lin, X., Hu, J., Zhao, D., Jiang, Y., Xing, X., & Li, M. (2022) · Research Square · doi:10.21203/rs.3.rs-2054982/v1 · Cited by 1 · see citing works

The truth behind irisin: A descriptive review on the physiology of an exercise-inducible wonder hormone

Feenstra, W. (2021)

Quadriceps Strength is Associated with the Worsening of Intra-Articular Inflammation in Knee Osteoarthritis: An Exploratory Study from the Osteoarthritis InitiativePreprint

Gong, Z., Li, J., Cao, P., Ruan, G., Zhang, Y., Zeng, Q., He, Z., Chen, R., Li, S., Zheng, P., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4071407

Tescalcin Knockdown Improves Inflammation and Chondrocyte Apoptosis in Osteoarthritis Via the ERK1/2 Pathway: In Vitro and in Vivo StudiesPreprint

liu, S., Li, Z., Yang, Y., Piao, L., Wu, D., & Bai, L. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4090399

The Therapeutic Role of Hyperoside in Medial Meniscus Destabilization-Induced Osteoarthritis: A Study on Subchondral Bone RemodelingPreprint

Yang, H., Chen, B., Tang, Y., Liao, Q., Zhang, Z., Liu, W. Y., & Liu, S. (2024) · Research Square · doi:10.21203/rs.3.rs-3858988/v1

Exercise in a Pill: Emerging Therapeutics for Age-Related Orthopedic Diseases

Luo, J., Meng, X., Han, J., Kong, H., Wang, X., & Zhang, X. (2026) · Antioxidants and Redox Signaling · doi:10.1177/15230864251411560

Multimodal magnetic resonance imaging of the vastus medialis for quantitative diagnosis and grading in early-stage knee osteoarthritis and its correlation with severity

Liu, Y., Tian, D.-J., Guo, Y.-P., Wang, W., Li, H., Xu, J.-X., Zhao, D.-D., & Wan, B. (2026) · Scientific Reports · doi:10.1038/s41598-026-37567-y

Exercise-myokine relationships in osteoarthritis

Zhang, Y., Pan, C., Hou, W., Sun, K., & Xu, T. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08080-7

Irisin fails to rescue bone loss in a rat model of chronic kidney disease – mineral bone disorder (CKD-MBD) but interacts with parathyroid hormone (PTH) in vivo and in vitro in IDG-SW3 osteocytes

Wilson, H. E., Chen, N. X., O’Neill, K. D., Metzger, C. E., Srinivasan, S., Stephen, D. J., Blacklock, K. L., Matter, E. K., Bonewald, L. F., Allen, M. R., et al. (2026) · Bone Reports · doi:10.1016/j.bonr.2026.101956

IRISIN attenuates osteoarthritis by inhibiting apoptosis of osteocytes through activating erk signaling pathway

He, Z., Li, H., Zhou, F., Han, X., Chu, L., Zhang, S., Tang, T., & Yu, Z. (2019) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2019.02.298 · Cited by 1 · see citing works

Irisin in Cartilage Homeostasis: Molecular Mechanisms and Therapeutic Implications for Osteoarthritis

Vescio, R. R., Fiordalisi, M. F., Ambrosio, L., Fiorentino, D., de Rinaldis, E., Giacomo, G. D., Russo, F., Denaro, V., Vadalà, G., & Papalia, R. (2026) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk11030343

Irisin recovers osteoarthritic chondrocytes: a muscle-cartilage cross-talk boosted by physical activityPreprint

Vadalà, G., Giacomo, G. D., Ambrosio, L., Cannata, F., Cicione, C., Papalia, R., & Denaro, V. (2020) · doi:10.21203/rs.3.rs-20856/v1 · Cited by 1 · see citing works

Irisin Recovers Osteoarthritic Chondrocytes In Vitro

Vadalà, G., Giacomo, G. D., Ambrosio, L., Cannata, F., Cicione, C., Papalia, R., & Denaro, V. (2020) · Cells · doi:10.3390/cells9061478 · Cited by 61 · see citing works

Irisin in the modulation of bone and cartilage homeostasis: a review on osteoarthritis relief potential

Zhang, M., Xiong, W., Qiao, R., Li, M., Zhang, C., Yang, C., Zhu, Y., He, J., & Ma, Z. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1570157 · Cited by 9 · see citing works