The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
COVID-19 and ischemic stroke: a systematic review and meta-summary of the literature
Open accessAbstract
Acute ischemic stroke (AIS) is a life-threatening complication of coronavirus disease 2019 (COVID-19) infection. Increasing reports suggest an association between COVID-19 and AIS, although the underlying mechanism remains uncertain. We performed a systematic review to characterize the clinical characteristics, neuroimaging findings, and outcomes of AIS in COVID-19 patients. A literature search was performed in PubMed and Embase using a suitable keyword search strategy from 1st December 2019 to 29th May 2020. All studies reporting AIS occurrence in COVID-19 patients were included. A total of 39 studies comprising 135 patients were studied. The pooled incidence of AIS in COVID-19 patients from observational studies was 1.2% (54/4466) with a mean age of 63.4 ± 13.1 years. The mean duration of AIS from COVID-19 symptoms onset was 10 ± 8 days, and the mean NIHSS score was 19 ± 8. Laboratory investigations revealed an elevated mean d -dimer (9.2 ± 14.8 mg/L) and fibrinogen (5.8 ± 2.0 g/L). Antiphospholipid antibodies were detected in a significant number of cases. The majority of AIS neuroimaging patterns observed was large vessel thrombosis, embolism or stenosis (62.1%, 64/103), followed by multiple vascular territory (26.2%, 27/103). A high mortality rate was reported (38.0%, 49/129). We report the pooled incidence of AIS in COVID-19 patients to be 1.2%, with a high mortality rate. Elevated d -dimer, fibrinogen and the presence of antiphospholipid antibodies appear to be prominent in COVID-19 patients with concomitant AIS, but further mechanistic studies are required to elucidate their role in pathogenesis.
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Cites
Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China
Mao, L., Jin, H., Wang, M., Hu, Y., Chen, S., He, Q., Chang, J., Hong, C., Zhou, Y., Wang, D., et al. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.1127 · Cited by 7,166
Tang, N., Bai, H., Chen, X., Gong, J., Li, D., & Sun, Z. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14817 · Cited by 3,559
Neurologic features in severe SARS-CoV-2 infection
Helms, J., Kremer, S., Merdji, H., Clere-Jehl, R., Schenck, M., Kummerlen, C., Collange, O., Boulay, C., Fafi-Kremer, S., Ohana, M., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2008597 · Cited by 2,674
Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19
Zhang, Y., Xiao, M., Zhang, S., Xia, P., Cao, W., Jiang, W., Chen, H., Ding, X., Zhao, H., Zhang, H., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2007575 · Cited by 2,179
Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young
Oxley, T. J., Mocco, J., Majidi, S., Kellner, C. P., Shoirah, H., Singh, I. P., De Leacy, R. A., Shigematsu, T., Ladner, T. R., Yaeger, K. A., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2009787 · Cited by 2,116
Lodigiani, C., Iapichino, G., Carenzo, L., Cecconi, M., Ferrazzi, P., Sebastian, T., Kucher, N., Studt, J.-D., Sacco, C., Bertuzzi, A., et al. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.04.024 · Cited by 2,054
Klok, F. A., Kruip, M. J. H. A., van der Meer, N. J. M., Arbous, M. S., Gommers, D., Kant, K. M., Kaptein, F. H. J., van Paassen, J., Stals, M. A. M., Huisman, M. V., et al. (2020) · Thrombosis Research · doi:10.1016/j.thromres.2020.04.041 · Cited by 1,601
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Cited by
Katsoularis, I., Fonseca-Rodríguez, O., Farrington, P., Lindmark, K., & Fors Connolly, A.-M. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00896-5 · Cited by 582
Siow, I., Lee, K. S., Zhang, J. J. Y., Saffari, S. E., Ng, A., & Young, B. (2021) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2020.105549 · Cited by 116
Devaux, C. A., & Camoin-Jau, L. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1042200 · Cited by 20
Pneumatosis Intestinalis in the Setting of COVID-19: A Single Center Case Series From New York
Miyara, S. J., Becker, L. B., Guevara, S., Kirsch, C., Metz, C. N., Shoaib, M., Grodstein, E., Nair, V. V., Jandovitz, N., McCann-Molmenti, A., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.638075 · Cited by 9
Metadata
- Authors
- Tan, Y.-K., Goh, C., Leow, A. S. T., Tambyah, P. A., Ang, A., Yap, E.-S., Tu, T.-M., Sharma, V. K., Yeo, L. L. L., Chan, B. P. L., & Tan, B. Y. Q.
- Venue
- Journal of Thrombosis and Thrombolysis
- Published
- 2020-07-13
- Volume
- 50
- Issue
- 3
- Pages
- 587-595
- ISSN
- 0929-5305 (ISSN-L)
- 1573-742X
- OpenAlex
- W3040763944
- Cited by
- 319
- References
- 49
- FWCI
- 10.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tan, Y.-K., Goh, C., Leow, A. S. T., Tambyah, P. A., Ang, A., Yap, E.-S., Tu, T.-M., Sharma, V. K., Yeo, L. L. L., Chan, B. P. L., & Tan, B. Y. Q. (2020). COVID-19 and ischemic stroke: a systematic review and meta-summary of the literature. Journal of Thrombosis and Thrombolysis. https://doi.org/10.1007/s11239-020-02228-y
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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