Plurality of opinion, scientific discourse and pseudoscience: an in depth analysis of the Séralini et al. study claiming that Roundup™ Ready corn or the herbicide Roundup™ cause cancer in rats
Abstract
A recent paper published in the journal Food and Chemical Toxicology presents the results of a long-term toxicity study related to a widely-used commercial herbicide (Roundup™) and a Roundup-tolerant genetically modified variety of maize, concluding that both the herbicide and the maize varieties are toxic. Here we discuss the many errors and inaccuracies in the published article resulting in highly misleading conclusions, whose publication in the scientific literature and in the wider media has caused damage to the credibility of science and researchers in the field. We and many others have criticized the study, and in particular the manner in which the experiments were planned, implemented, analyzed, interpreted and communicated. The study appeared to sweep aside all known benchmarks of scientific good practice and, more importantly, to ignore the minimal standards of scientific and ethical conduct in particular concerning the humane treatment of experimental animals.
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The conclusions of the Séralini studies have been comprehensively rebutted in the literature and elsewhere by both academicians and regulatory authorities throughout the world.
“The conclusions of the Séralini studies have been comprehensively rebutted in the literature and elsewhere by both academicians and regulatory authorities throughout the world (Arjo et al., 2013; FSANZ, 2011; Grunewald & Bury, 2012).”
From The use of whole food animal studies in the safety assessment of genetically modified crops: Limitations and recommendations (2013) · cites this paper as Arjo et al., 2013
Despite a wealth of studies and literature to the contrary, these isolated and poorly designed studies have resulted in the promulgation of new regulations, including a mandatory 90-d rodent subchronic toxicity feeding study for all new GE approvals in the EU, and have generated a great deal of media attention.
“Despite a wealth of studies and literature to the contrary, these isolated and poorly designed studies have resulted in the promulgation of new regulations, including a mandatory 90-d rodent subchronic toxicity feeding study for all new GE approvals in the EU (Kuiper et al., 2013), and have generated a great deal of media attention (Arjó et al., 2013).”
From Prevalence and impacts of genetically engineered feedstuffs on livestock populations1 (2014) · cites this paper as Arjó et al., 2013
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- Authors
- Arjó, G., Portero, M., Piñol, C., Viñas, J., Matias-Guiu, X., Capell, T., Bartholomaeus, A., Parrott, W., & Christou, P.
- Affiliations
- Universitat de Lleida (ES)
- The University of Queensland (AU)
- University of Georgia (US)
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Corresponding author
- Christou, Paul
- Venue
- Transgenic Research
- Published
- 2013-02-22
- Volume
- 22
- Issue
- 2
- Pages
- 255-267
- ISSN
- 0962-8819 (ISSN-L)
- 1573-9368
- OpenAlex
- W2133860021
- Semantic Scholar
- 01858d04367d27e18363496e81b53dfedb7b554b
- Cited by
- 67
- References
- 30
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 3 · 2015: 11 · 2014: 12 · 2013: 8 · 2012: 1
- FWCI
- 13.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Transgenic Research (publishedVersion)
- PubMed (publishedVersion)
- Repositori ObertUDL (University of Lleida) (publishedVersion)
- University of Canberra Research Portal (submittedVersion)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetically Modified Organisms Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural safety and regulations
- Keywords
- Roundup, glyphosate, transgenic maize, herbicide toxicity, pseudoscience, research misconduct, research ethics, animal welfare in research, scientific credibility, media coverage of science
- MeSH terms
- Glyphosate, Animals, Zea mays, Drug Tolerance, Glycine, Herbicides, Neoplasms, Science, Scientific Misconduct, Cultural Diversity, Food, Genetically Modified, Rats
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