EFSA’s scientific activities and achievements on the risk assessment of genetically modified organisms (GMOs) during its first decade of existence: looking back and ahead
Abstract
Genetically modified organisms (GMOs) and derived food and feed products are subject to a risk analysis and regulatory approval before they can enter the market in the European Union (EU). In this risk analysis process, the role of the European Food Safety Authority (EFSA), which was created in 2002 in response to multiple food crises, is to independently assess and provide scientific advice to risk managers on any possible risks that the use of GMOs may pose to human and animal health and the environment. EFSA's scientific advice is elaborated by its GMO Panel with the scientific support of several working groups and EFSA's GMO Unit. This review presents EFSA's scientific activities and highlights its achievements on the risk assessment of GMOs for the first 10 years of its existence. Since 2002, EFSA has issued 69 scientific opinions on genetically modified (GM) plant market registration applications, of which 62 for import and processing for food and feed uses, six for cultivation and one for the use of pollen (as or in food), and 19 scientific opinions on applications for marketing products made with GM microorganisms. Several guidelines for the risk assessment of GM plants, GM microorganisms and GM animals, as well as on specific issues such as post-market environmental monitoring (PMEM) were elaborated. EFSA also provided scientific advice upon request of the European Commission on safeguard clause and emergency measures invoked by EU Member States, annual PMEM reports, the potential risks of new biotechnology-based plant breeding techniques, evaluations of previously assessed GMOs in the light of new scientific publications, and the use of antibiotic resistance marker genes in GM plants. Future challenges relevant to the risk assessment of GMOs are discussed. EFSA's risk assessments of GMO applications ensure that data are analysed and presented in a way that facilitates scientifically sound decisions that protect human and animal health and the environment.
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Several groups reviewing the evidence for health hazards of genetic modification have found no evidence for harms, but methods for such evaluation remain heterogeneous.
“Several groups reviewing the evidence for health hazards of genetic modification have found no evidence for harms;130-134 however, methods for such evaluation remain heterogeneous.135-139”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [139]
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Mozaffarian, D. (2016) · Circulation · doi:10.1161/circulationaha.115.018585 · Cited by 2,216 · see citing works
Meissle, M., Naranjo, S. E., & Romeis, J. (2022) · Environmental Evidence · doi:10.1186/s13750-022-00272-0 · Cited by 41 · see citing works
“The obtained list was compared with Devos et al. [26], who reviewed EFSAs work in the past 10 years.”
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Self-citationMeissle, M., Naranjo, S. E., Kohl, C., Riedel, J., & Romeis, J. (2014) · Environmental Evidence · doi:10.1186/2047-2382-3-7 · Cited by 13 · see citing works
- Authors
- Devos, Y., Aguilera, J., Diveki, Z., Gomes, A., Liu, Y., Paoletti, C., du Jardin, P., Herman, L., Perry, J. N., & Waigmann, E.
- Affiliations
- European Food Safety Authority (IT)
- Instituut voor Landbouw en Visserijonderzoek (BE)
- Corresponding author
- Devos, Yann
- Venue
- Transgenic Research
- Published
- 2013-08-21
- Volume
- 23
- Issue
- 1
- Pages
- 1-25
- ISSN
- 0962-8819 (ISSN-L)
- 1573-9368
- OpenAlex
- W2129740820
- Cited by
- 95
- References
- 146
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 1 · 2022: 10 · 2021: 2 · 2020: 7 · 2019: 8 · 2018: 7 · 2017: 14 · 2016: 11 · 2015: 15 · 2014: 9 · 2013: 2 · 2012: 1
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Transgenic Research (publishedVersion)
- PubMed (publishedVersion)
- ORBi (University of Liège) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetically Modified Organisms Research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural safety and regulations
- Social Sciences › Sociology and Political Science › Risk Perception and Management
- Keywords
- genetically modified organisms, EFSA, GMO risk assessment, scientific opinion, post-market environmental monitoring, safeguard clauses, emergency measures, GMO regulation, food and feed safety
- MeSH terms
- Animals, Biotechnology, European Union, Humans, Risk Assessment, Animals, Genetically Modified, Plants, Genetically Modified, Food, Genetically Modified
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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