The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Molecular and functional properties of P2X receptors—recent progress and persisting challenges
Open accessAbstract
ATP-gated P2X receptors are trimeric ion channels that assemble as homo- or heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have been found in most, if not all, mammalian tissues and are being discovered in an increasing number of non-vertebrates. Both the first crystal structure of a P2X receptor and the generation of knockout (KO) mice for five of the seven cloned subtypes greatly advanced our understanding of their molecular and physiological function and their validation as drug targets. This review summarizes the current understanding of the structure and function of P2X receptors and gives an update on recent developments in the search for P2X subtype-selective ligands. It also provides an overview about the current knowledge of the regulation and modulation of P2X receptors on the cellular level and finally on their physiological roles as inferred from studies on KO mice.
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Cryopyrin activates the inflammasome in response to toxins and ATP
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Molecular Physiology of P2X Receptors
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The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans
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The P2X7 Receptor: A Key Player in IL-1 Processing and Release
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Liaisons dangereuses: P2X7 and the inflammasome
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Activation of Microglia by Amyloid β Requires P2X7 Receptor Expression
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Cited by
The P2X7 Receptor in Infection and Inflammation
Di Virgilio, F., Dal Ben, D., Sarti, A. C., Giuliani, A. L., & Falzoni, S. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.020 · Cited by 1,267
The P2X7 Receptor in Inflammatory Diseases: Angel or Demon?
Savio, L. E. B., de Andrade Mello, P., da Silva, C. G., & Coutinho-Silva, R. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00052 · Cited by 437
Update of P2X receptor properties and their pharmacology: IUPHAR Review 30
Illes, P., Müller, C. E., Jacobson, K. A., Grutter, T., Nicke, A., Fountain, S. J., Kennedy, C., Schmalzing, G., Jarvis, M. F., Stojilkovic, S. S., et al. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15299 · Cited by 313
Self-citationP2X7 Interactions and Signaling – Making Head or Tail of It
Kopp, R., Krautloher, A., Ramírez-Fernández, A., & Nicke, A. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00183 · Cited by 217
Self-citationMechanosensitive ion channels push cancer progression
Pethő, Z., Najder, K., Bulk, E., & Schwab, A. (2019) · Cell Calcium · doi:10.1016/j.ceca.2019.03.007 · Cited by 125
Metadata
- Authors
- Kaczmarek-Hájek, K., Lörinczi, É., Hausmann, R., & Nicke, A.
- Venue
- Purinergic Signalling
- Published
- 2012-05-01
- Volume
- 8
- Issue
- 3
- Pages
- 375-417
- ISSN
- 1573-9538 (ISSN-L)
- 1573-9546
- OpenAlex
- W2036287567
- Cited by
- 223
- References
- 18
- FWCI
- 13.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
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